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All Journal Universa Medicina Jurnal Locus Penelitian dan Pengabdian Indonesian Basic and Experimental Health Sciences
Primisawitri, Pratiwi Prasetya
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Aerospace Engineering Automotive Engineering Decision Sciences, Operations Research & Management Electrical & Electronics Engineering Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Public Health

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Dermoscopy Of Onychomycosis: A Literature Review Primisawitri, Pratiwi Prasetya; Mulianto, Nurrachmat
Indonesian Basic and Experimental Health Sciences Vol. 13 No. 1 (2024): November
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol13iss1pp23-33

Abstract

Background: Onychomycosis is a fungal infection of the nails. Onychomycosis is caused by dermatophytes, non-dermatophyte molds, and non-dermatophyte fungi. Dermoscopy examination has gradually been used as a modern diagnostic method to assess non-invasive nail abnormalities that are easy and inexpensive to visualize abnormal microscopic features of the nail. However, it is still uncommon for medical personnel to diagnose onychomycosis using dermoscopy. Purpose: To provide information on the benefits of the nail dermoscopy technique that can diagnose onychomycosis and describe observable dermoscopic findings. Results: Dermoscopy findings on onychomycosis showed a diverse picture depending on the type. Distal and lateral subungual onychomycosis shows the proximal margin of the onycholytic area with spikes leading to proximal folds and longitudinal striae. White superficial onychomycosis shows large, brittle, irregularly spreading white-yellow patches on the nail's surface. Proximal subungual onychomycosis has one or more transverse white bands on the inner nail plate, while total dystrophic onychomycosis shows longitudinal striae and spikes and irregular distal terminations. Conclusion: Nail dermoscopy improves quality and simplifies examination to establish the diagnosis of onychomycosis because it can guide clinicians in conducting screening, choosing the best time for mycological sampling, and making therapeutic decisions.
Profile of Sexually Transmitted Diseases and The Influence of COVID-19 Pandemic on Sexual Transmitted Infection Testing in Dr. Moewardi General Hospital Ellistasari, Endra Yustin; Mawardi, Prasetyadi; Primisawitri, Pratiwi Prasetya; Octarica , Stella Gracia
Indonesian Basic and Experimental Health Sciences Vol. 13 No. 2 (2025): APRIL
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol13iss2pp34-40

Abstract

Introduction Sexually transmitted infections (STIs) are diseases resulting from bacteria, viruses, or parasites transmitted during vaginal, anal, or oral sexual intercourse. The COVID-19 pandemic markedly influenced STI statistics, leading to potential underreporting of cases and heightened transmission rates. Objective : To analyse the profile of sexually transmitted infections and the influence of COVID-19 on STI assessments at the Dermatology and Venereology (DV) Outpatient Clinic of Dr. Moewardi General Hospital. Method A retrospective study using secondary data derived from medical records and registration logs at DV Outpatient Clinic of Dr. Moewardi General Hospital, spanning from January 2018 to December 2022.   Results 284 new STI cases were documented in the before pandemic lockdown period, however during the pandemic lockdown, there was a significant decline of 149 new cases. After the pandemic lockdown, there was 200 additional cases of STIs. Up to 90 patients with STIs were co-infected with HIV. The predominant instance of STIs was condyloma acuminata., and there was a strong correlation between gender and the incidence of STIs (p=0.000; p<0.05) Conclusion There was a sharp decline in STI cases during the COVID-19 pandemic and a surge in STI cases after the COVID-19 pandemic, predominantly featuring instances of condyloma acuminata and syphilis.
Retinoblastoma tumor suppressor protein is not a risk factor for the location of condyloma acuminatum among adults Primisawitri, Pratiwi Prasetya; Mulianto, ⁠Nurrachmat; Ellistasari, Endra Yustin; Poncorini, Eti; Kariosentono, ⁠⁠Harijono; Widhiati, Suci; Wasita, Brian; Setyawan, Novan Adi; Yudhistira, Muhammad Yurizar
Universa Medicina Vol. 44 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.343-349

Abstract

BackgroundCondylomata acuminata (CA) are sexually transmitted infections primarily caused by low-risk HPV types 6 and 11. Retinoblastoma protein (pRb) interacts with HPV oncoproteins, leading to destabilization, genomic instability, and carcinogenesis. This study aimed to determine whether variations in pRb expression and sexual orientation are risk factors of the anatomical location of CA lesions and to compare differences in pRb expression by sexual orientation. MethodsA cross-sectional study was conducted among 33 patients aged >18 years with clinically and histopathologically confirmed CA. Demographic data, pRb expression assessed via excision biopsy and immunohistochemistry, and relevant risk factors were collected. Statistical analyses including Simple and multiple binary logistic regression were used to analyze the data, with model fit assessed using the Hosmer–Lemeshow test. ResultsWeak pRb expression predominated in anal lesions (92.3%; p=0.018) and among homosexual/bisexual individuals (57.9%; p=0.031), while moderate expression was more common in genital lesions (66.7%; p=0.018) and heterosexual individuals (57.1%; p=0.011). Simple logistic regression  analysis showed that HIV status (OR=11.88; p=0.025), sexual orientation (OR=13.33; p=0.001), and moderate-to-strong pRb expression (OR=24.00; p=0.008; OR=12.00; p=0.048) were associated with lesion location. In the multivariate model, pRb expression was excluded due to multicollinearity. Sexual orientation remained the only independent predictor of lesion location (Adj OR=8.89; p=0.023), with heterosexual individuals more likely to present with genital lesions. ConclusionThe expression of pRb was not a risk factor of the anatomical location of CA, and differed between genital and anal CA. However, sexual orientation emerged as the dominant independent factor associated with lesion location.   
Tatalaksana Platelet Rich Plasma Pada Pasien Chronic Venous Leg Ulcer Adjie, Sugih Primas; Kariosentono, Harijono; Mulianto, Nurrachmat; Dharmawan, Nugrohoaji; Primisawitri, Pratiwi Prasetya
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 12 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i12.4872

Abstract

Latar belakang: Ulkus kronis pada ekstremitas bawah salah satunya yaitu ulkus venosum. Ulkus venosum didefinisikan sebagai lesi terbuka antara sendi lutut dan pergelangan kaki yang terjadi karena penyakit vena. Tantangan dalam mengobati VLU adalah kekambuhan yang sering terjadi maka terapi luka tingkat lanjut harus dipertimbangkan. Platelet rich plasma (PRP) sebagai terapi adjuvan pengobatan ulkus venosum dan menunjukkan hasil yang menjanjikan. Kasus: Seorang laki-laki berusia 55 tahun dengan keluhan luka yang sulit sembuh sejak dua tahun yang lalu. Pemeriksaan status dermatovenereologi pada regio ekstremitas inferior desktra nampak ulkus multipel dengan ukuran terbesar 9 cm x 5 cm x 0.5 cm, dengan dasar eritem dan serum tanpa disertai pus, nekrosis, nekrotik dan darah. Pasien memiliki riwayat hipertensi dan obesitas derajat II dengan Indeks Masa Tubuh (IMT) 44,29. Pasien diberikan terapi Platelet Rich Plasma (PRP) setiap tujuh hari, Kompres luka dengan cairan NaCl 0,9% selama 10 menit dilanjutkan dengan mupirosin 2% salep dan ditutup dengan menggunakan plester hidrokoloid yang dilakukan per 24 jam. Evaluasi pada minggu ke-6 terapi PRP, pasien menunjukkan adanya perbaikan klinis pada luka. Diskusi: Kandungan PRP terdiri dari banyak faktor pertumbuhan untuk mempercepat penyembuhan luka dan angiogenesis. Trombosit mengandung faktor pertumbuhan yang memicu efek biologis yang merupakan kunci dalam proses perbaikan dan regenerasi jaringan.
Co-Authors Adjie, Sugih Primas Brian Wasita Dharmawan, Nugrohoaji Ellistasari, Endra Yustin Kariosentono, Harijono Kariosentono, ⁠⁠Harijono Mulianto, ⁠Nurrachmat Novan Adi Setyawan Nurrachmat Mulianto Octarica , Stella Gracia Poncorini, Eti Prasetyadi Mawardi Widhiati, Suci Yudhistira, Muhammad Yurizar