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All Journal Jurnal Informatika dan Kesehatan Sinov : Media Informasi Penelitian Kabupaten Semarang
Muhammad Alviyan Shutiawan
Unknown Affiliation
Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Medicine & Pharmacology Public Health

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Studi Analisa Kronofarmakologi Penggunaan Obat Ibuprofen pada Pasien Covid-19 di Rawap Inap RSUD Dr. Soedomo Trenggalek Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Ratna Mildawati; Chandra Arifin; Abd Rofiq; Emma Jayanti Besan; Muhammad Nurul Fadel; Charliandri Saputra Wahab; Muhammad Alviyan Shutiawan
Jurnal Informatika dan Kesehatan Vol. 1 No. 1 (2024): IKN : Jurnal Informatika dan Kesehatan
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ikn.v1i1.3024

Abstract

The global COVID-19 pandemic has presented unprecedented challenges to global health. The Dr. Soedomo Regional General Hospital in Trenggalek has been at the forefront of managing COVID-19 patients, with a primary focus on the use of ibuprofen to alleviate symptoms such as fever and pain. Despite the widespread use of ibuprofen, knowledge regarding its interaction with the circadian rhythm, especially in COVID-19 patients, remains limited. This study employed an analytical observational approach with a Cross-Sectional design to analyze the use of ibuprofen in COVID-19 patients at Dr. Soedomo Regional General Hospital in Trenggalek. The study included 100 patients, emphasizing body temperature at three different times. Data analysis revealed a significant decrease in body temperature after therapy, particularly at 4:00 PM. These findings lay the foundation for the development of more targeted and personalized treatment strategies by understanding the body's response patterns to therapy at different times.   Abstrak Pandemi global COVID-19 telah menciptakan tantangan kesehatan global yang belum pernah terjadi sebelumnya. Rumah Sakit Umum Daerah Dr. Soedomo di Trenggalek telah menjadi pusat perhatian dalam menangani pasien COVID-19. Fokus utama adalah penggunaan ibuprofen untuk mengelola gejala, seperti demam dan nyeri. Meskipun ibuprofen umum digunakan, pengetahuan tentang interaksi dengan siklus sirkadian tubuh, terutama pada pasien COVID-19, masih terbatas. Penelitian ini menggunakan pendekatan observasional analitik dengan desain Cross Sectional untuk menganalisis penggunaan ibuprofen pada pasien COVID-19 di RSUD Dr. Soedomo Trenggalek. Hasil penelitian melibatkan 100 pasien, dengan fokus pada suhu tubuh pada tiga waktu berbeda. Analisis data menunjukkan penurunan suhu tubuh yang signifikan setelah terapi, terutama pada pukul 16.00 WIB. Hasil ini memberikan dasar untuk pengembangan strategi pengobatan yang lebih terarah dan personalisasi, dengan memahami pola respons tubuh terhadap terapi pada waktu yang berbeda.
SKRINING FLAVONOID EKSTRAK BUAH PARIJOTO (Medinilla speciosa Blume) ASAL KABUPATEN KUDUS DAN SEMARANG DENGAN PEMBANDING KUERSETIN DAN RUTIN Rissa Laila Vifta; Muhammad Alviyan Shutiawan; Alif Maulidya; Richa Yuswantina
Media Informasi Penelitian Kabupaten Semarang Vol. 3 No. 1 (2021): Juli: Media Informasi Penelitian Kabupaten Semarang
Publisher : Badan Perencanaan Pembangunan, Riset dan Inovasi Daerah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/sinov.v4i1.57

Abstract

Parijoto fruit (Medinilla speciosa Blume) is an epiphytic shrub with a height of 0.45-1.2 meters. Parijoto fruit contains secondary metabolites of flavonoids, anthosionins, glycosides and others which have pharmacological effects as antioxidants, antidiabetic, anticancer, antibacterial, anti-inflammatory. Parijoto plant growth is influenced by temperature, humidity, rainfall and altitude where it grows. This study aims to determine the total flavonoid content in Parijoto fruit from Kudus and Semarang districts. This type of research is an experimental laboratory research using UV-Vis spectrophotometry method using quercetin and rutin as a comparison. The total flavonoids of Parijoto fruit extract from Kudus Regency and Semarang, respectively, with a quarcetin ratio of 81.60 mgQE/g and 76.48 mgQE/g, while with a routine comparison of 79.33 mgRE/g and 73, respectively. 06 mgRE/g. The total flavonoids of the two extracts showed quite strong results, but were significantly different as evidenced by the value of the paired sample t-test between the two extracts with a significance value (2-tailed) <0.05.
Co-Authors Alif Maulidya Chandra Arifin Charliandri Saputra Wahab Emma Jayanti Besan Faisal Akhmal Muslikh Fendy Prasetyawan Muhammad Nurul Fadel Ratna Mildawati Richa Yuswantina Rofiq, Abd vifta, rissa laila Yuneka Saristiana