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All Journal Nusantara Hasana Journal IJF (Indonesia Jurnal Farmasi) Jurnal Informatika dan Kesehatan Galen: Jurnal Ilmu Farmasi dan Kesehatan
Emma Jayanti Besan
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Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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UJI AKTIVITAS ANTIDIABETES EKSTRAK DAUN SIRSAK (Annona muricata L.) PADA MENCIT YANG DIINDUKSI ALOKSAN Muhammad Nurul Fadel; Emma Jayanti Besan
IJF (Indonesia Jurnal Farmasi) Vol 5, No 2 (2020): Indonesia Jurnal Farmasi
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijf.v5i2.1170

Abstract

Diabetes mellitus masih menjadi salah satu penyakit dengan peringkat yang tinggi di Dunia. Penatalaksanaan diabetes yang masih cukup mahal dengan beberapa efek samping obat hipoglikemik oral, membuat tanaman herbal mulai menarik perhatian. Salah satu tanaman yang telah digunakan secara empiris sebagai antidiabetes adalah sirsak (Annona muricata L.) terutama bagian daun sirsak. Penelitian ini bertujuan untuk mengetahui efek dan dosis efektif ekstrak etanol daun sirsak terhadap penurunan kadar glukosa darah. Metode yang digunakan dalam penelitian ini adalah metode induksi aloksan. Hewan uji dibagi menjadi 5 kelompok, masing-masing kelompok terdiri dari 5 ekor. Kelompok I kontrol negatif CMC 0,5%, kelompok II kontrol positif glibenklamid, kelompok III ekstrak etanol daun sirsak 2,8 mg/20 g BB mencit, kelompok IV ekstrak etanol daun sirsak 4,2 mg/20 g BB mencit, kelompok V ekstrak etanol daun sirsak 5,6 mg/20 g BB mencit. Pemberian larutan uji dilakukan selama 14 hari setelah induksi aloksan dan pengukuran dilakukan pada hari ke-7 dan ke-14, Data yang diperoleh dianalisis dengan Kolmogorov-Smirnov dilanjutkan dengan anova satu arah dan uji post hoc. Hasil penelitian menunjukkan bahwa ekstrak etanol daun sirsak mengandung flavonoid, alkaloid, saponin dan tanin yang diduga memiliki aktivitas antidiabetes. Pada dosis 4,2 mg/20 g BB mencit merupakan dosis yang paling efektif dalam menurunkan kadar glukosa darah karena memiliki efek penurunan yang sebanding dengan glibenklamid.
ANALISIS KEMOMETRIKA KANDUNGAN FITOKIMIA DENGAN AKTIVITAS ANTIACNE EKSTRAK BUAH PARIJOTO (Medinilla speciosa Blume) Ameliya, Ameliya; Endang Setyowati; Emma Jayanti Besan
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1521

Abstract

Parijoto fruit has a variety of phytochemical compounds, such as flavonoids and phenolics, that are known to have potential as antiacne agents. This study aims to analyze the relationship between total and total phenolic flavonoid content with the antiacne activity of 70% ethanol extract and ethyl acetate parijoto fruit through chemometric analysis. This study used UV-Vis spectrophotometry to measure total flavonoid and phenolic content, with antiacne activity measured using the disc method at 20%, 30%, and 40% extract concentrations. The results showed that 70% ethanol and ethyl acetate extracts had flavonoid levels of 2.443 ± 0.029 (mgEK/mL) and 0.829 ± 0.013 (mgEK/mL), respectively, while the total phenolics were 4.622 ± 0.004 (mgEAG/mL) and 1.734 ± 0.012 (mgEAG/mL). Tests of antiacne activity against Staphylococcus aureus at concentrations of 20%, 30%, and 40% showed that 70% ethanol extract had strong activity, with consecutive inhibition zones of 11.8 ± 0.29 mm; 13.8 ± 0.29 mm; and 16.8 ± 0.76 mm. Ethyl acetate extract showed moderate activity with an inhibition zone of 7.2 ± 0.29 mm; 8.3 ± 0.58 mm; and 8.8 ± 0.29 mm. Chemometric analysis showed a positive relationship between flavonoid and phenolic content with antiacne activity, both in 70% ethanol extract and ethyl acetate. Ethanol extract of 70% parijoto fruit has higher levels of total flavonoids, total phenolics, and antiacne activity than ethyl acetate.
UJI AKTIVITAS ANTIOKSIDAN DAN FORMULASI SEDIAAN BODY SCRUB KOMBINASI KOPI ROBUSTA (COFFEA CANEPHORA) DAN BERAS PUTIH (ORYZA SATIVA L.) Nanang Saiful Imron; Endang Setyowati; Emma Jayanti Besan
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1524

Abstract

Skin aging is a natural thing that will occur, because humans experience a slowdown in the process of skin cell renewal and collagen production. Body skin care such as body scrubs are used for the purpose of maintaining, caring for skin smoothness, brightening the skin so that it is not dull and releasing dead skin cells. This study aims to evaluate the physical quality and determine the antioxidant activity in the body scrub preparation in combination with robusta coffee and white rice. Organoleptic evaluation of body scrub cream preparations including color, smell and texture. pH testing uses a pH meter that is pre-calibrated using a standard buffer solution. The homogeneity test was carried out by applying 0.5 grams of the preparation to the glass object and then covering it with other glass. The adhesion test aims to find out the preparation when it adheres to the skin. The antioxidant test by way of a 100 ppm test solution is made in a series of concentrations of 20, 40, 60, 80, 100 ppm. The results of this study tested the organoleptic, the 5% formula has a semi-dense texture, dark grayish, the formula 10% and 15% are dark blackish, with a typical aroma of coffee. The best pH research results in the 10% formula are pH 7.50. For FI, FII, FIII meet the requirements of pH physical characteristics test, homogeneity, dispersibility and adhesion test. The results of antioxidant activity DPPH method concentrations of 5%, 10%, and 15% respectively were 66.17; 63,26; 62.56 ppm, which means that its antioxidant activity is strong. The conclusion of this study is that the combination of robusta coffee and white rice can be formulated into a body scrub preparation and has strong antioxidant activity (50-100). The best formulation at a concentration of 15% is 62.56 ppm.
RASIONALITAS PENGGUNAAN ANTIPSIKOTIK PADA PASIEN GANGGUAN BIPOLAR DISORDER DI RSUD DR. LOEKMONO HADI KUDUS PERIODE JANUARI-JUNI 2024 Nila Khumaela Sofwatussuba; Endang Setyowati; Emma Jayanti Besan
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1586

Abstract

Mental disorders around the world according to WHO (World Health Organization) data have the highest number of bipolar sufferers as many as 60 million people. The Indonesian Association of Psychiatric Specialists (PDSKJI) revealed that Bipolar disorder in Indonesia covers around 0.3% to 1.5%. Antipsychotics can have a major effect on overcoming manic episodes, preventing recurrence and treating major depressive disorders. The purpose of this study is to determine the rationality of the use of antipsychotics in bipolar disorder patients at dr. Loekmono Hadi Kudus Hospital. The data analysis method used a non-experimental design with retrospective descriptive analysis with research materials in the form of patient medical records. The results of data collection were 95 selected patients, the majority of bipolar patients were women (76.8%), vulnerable 25-34 years old (27.4%), high school education/equivalent (36.8%), had other jobs (33.7%), used BPJS payment type (96.8%), used single antipsychotic drugs (73.7%), antipsychotics that were often used were quetiapine (24.2%). The results of the evaluation were indicated, the patient was right, the drug was 100% right, and the dose was 98.9% right. The use of antipsychotic drugs in patients with bipolar disorder at dr. Loekmono Hadi Kudus Hospital for the period January – June 2024 can be said to be rational because it is in accordance with the pharmacotherapy handbook 9 th edition and the VA/DoD Clinical Practice Guideline for Management of Bipolar Disorder.
AKTIVITAS ANTIBAKTERI DAN UJI KARAKTERISTIK FISIK CLAY MASK EKSTRAK BUAH PARIJOTO (Medinilla speciosa Blume) Terhadap Bakteri Staphylococcus aureus Alya Narulita; Muhammad Nurul Fadel; Emma Jayanti Besan
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1594

Abstract

Natural ingredients are used as an alternative to the use of synthetic drugs and antibiotics, due to the small side effects caused compared to synthetic drugs. Parijoto fruit (Medinilla speciosa Blume) has many benefits, one of which is as an acne-causing antibacterial with the content of flavonoid compounds, tannins, and saponins. The use of natural ingredients of parijoto fruit in the form of clay mask preparations was chosen because it has advantages and is popular among teenagers compared to other types of masks. This study aims to determine the effectiveness of clay mask preparation with 70% ethanol extract of parijoto fruit in inhibiting the activity of Staphylococus aaureus bacteria using the disc diffusion method. Parijoto fruit is extracted using the maceration method with 70% ethanol solvent to obtain a thick extract, then physical characteristics tests and antibacterial tests are carried out on clay mask preparations. Antibacterial testing of parijoto fruit extract used disc diffusion method with concentrations of 10%, 15%, and 20%. The results of the study showed that 70% ethanol extract clay mask preparations of parijoto fruit had moderate to strong antibacterial effectiveness against S. aureus in formulas F1 (10%), F2 (15%), and F3 (20%) with consecutive inhibition zones of 6.3 mm, 14.1 mm, 15.3 mm. The concentration of F3 (20%) showed the most optimal activity in inhibiting acne-causing S.aureus bacteria.
ANALISIS FITOKIMIA DAN PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK ETANOL DAUN KETAPANG KENCANA (Terminalia mantaly) SECARA SPEKTROFOTOMETRI UV-VIS Veronika Puspita Kumalasari; Zaenal Fanani; Emma Jayanti Besan
Nusantara Hasana Journal Vol. 5 No. 5 (2025): Nusantara Hasana Journal, October 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i5.1714

Abstract

The Ketapang Kencana plant (Terminalia mantaly) is one of the plants with potential as a source of bioactive compounds. Traditionally, various parts of this plant, such as the leaves, stems, and root bark, have been used in several countries to treat diseases such as diabetes, dysentery, and malaria. This study aims to identify the active compounds present in the ethanol extract of Ketapang Kencana leaves and to determine the total flavonoid content of the ethanol extract of Ketapang Kencana leaves. The extraction was carried out using the maceration method with 70% ethanol as the solvent. Phytochemical screening of the ethanol extract of Ketapang Kencana leaves was conducted using specific chemical reagents. The results of the phytochemical screening showed that the ethanol extract of Ketapang Kencana leaves contains alkaloids, flavonoids, saponins, tannins, and triterpenoids. The total flavonoid content of the ethanol extract of Ketapang Kencana leaves, determined using the colorimetric method with UV-Vis spectrophotometry and quercetin as the standard, was found to be 26.847 mgQE/g extract on average.
Studi Analisa Kronofarmakologi Penggunaan Obat Ibuprofen pada Pasien Covid-19 di Rawap Inap RSUD Dr. Soedomo Trenggalek Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Ratna Mildawati; Chandra Arifin; Abd Rofiq; Emma Jayanti Besan; Muhammad Nurul Fadel; Charliandri Saputra Wahab; Muhammad Alviyan Shutiawan
Jurnal Informatika dan Kesehatan Vol. 1 No. 1 (2024): IKN : Jurnal Informatika dan Kesehatan
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ikn.v1i1.3024

Abstract

The global COVID-19 pandemic has presented unprecedented challenges to global health. The Dr. Soedomo Regional General Hospital in Trenggalek has been at the forefront of managing COVID-19 patients, with a primary focus on the use of ibuprofen to alleviate symptoms such as fever and pain. Despite the widespread use of ibuprofen, knowledge regarding its interaction with the circadian rhythm, especially in COVID-19 patients, remains limited. This study employed an analytical observational approach with a Cross-Sectional design to analyze the use of ibuprofen in COVID-19 patients at Dr. Soedomo Regional General Hospital in Trenggalek. The study included 100 patients, emphasizing body temperature at three different times. Data analysis revealed a significant decrease in body temperature after therapy, particularly at 4:00 PM. These findings lay the foundation for the development of more targeted and personalized treatment strategies by understanding the body's response patterns to therapy at different times.   Abstrak Pandemi global COVID-19 telah menciptakan tantangan kesehatan global yang belum pernah terjadi sebelumnya. Rumah Sakit Umum Daerah Dr. Soedomo di Trenggalek telah menjadi pusat perhatian dalam menangani pasien COVID-19. Fokus utama adalah penggunaan ibuprofen untuk mengelola gejala, seperti demam dan nyeri. Meskipun ibuprofen umum digunakan, pengetahuan tentang interaksi dengan siklus sirkadian tubuh, terutama pada pasien COVID-19, masih terbatas. Penelitian ini menggunakan pendekatan observasional analitik dengan desain Cross Sectional untuk menganalisis penggunaan ibuprofen pada pasien COVID-19 di RSUD Dr. Soedomo Trenggalek. Hasil penelitian melibatkan 100 pasien, dengan fokus pada suhu tubuh pada tiga waktu berbeda. Analisis data menunjukkan penurunan suhu tubuh yang signifikan setelah terapi, terutama pada pukul 16.00 WIB. Hasil ini memberikan dasar untuk pengembangan strategi pengobatan yang lebih terarah dan personalisasi, dengan memahami pola respons tubuh terhadap terapi pada waktu yang berbeda.
Prediction of Augenol in Cinnamon (Cinnamomum burmannii) Boiled as a Carminative to Overcome Floating Stomach Rika Wahyu Pujiastini; Fendy Prasetyawan; Yuneka Saristiana; M. Wahyu Ariawan; Muhammad Nurul Fadel; Emma Jayanti Besan
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 1 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i1.2

Abstract

Flatulence (meteorismus) is a common condition caused by excess gas accumulation in the digestive tract. One alternative traditional treatment to overcome this condition is the use of herbal plants, such as cinnamon (Cinnamomum burmannii). This study aims to predict the potential of eugenol, an active compound in cinnamon, as a carminative agent using an in silico approach. Data were obtained from PubChem and analyzed using PASS Online to predict its pharmacological activity. The results of the analysis showed that eugenol has a probability of activity as a carminative of 0.941 and a probability of inactivity of 0.001, indicating high potential in helping to relieve flatulence. Thus, eugenol in cinnamon has the potential as an alternative natural treatment to overcome digestive disorders, especially bloating.
Co-Authors Alya Narulita Ameliya, Ameliya Chandra Arifin Charliandri Saputra Wahab Endang Setyowati Faisal Akhmal Muslikh Fendy Prasetyawan M. Wahyu Ariawan Muhammad Alviyan Shutiawan Muhammad Nurul Fadel Nanang Saiful Imron Nila Khumaela Sofwatussuba Ratna Mildawati Rika Wahyu Pujiastini Rofiq, Abd Veronika Puspita Kumalasari Yuneka Saristiana Zaenal Fanani