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All Journal Acta Chimica Asiana Jurnal Kesehatan Tambusai Jurnal Pepadu
Hafizah, Qori'atul
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Religion Agriculture, Biological Sciences & Forestry Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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SOSIALISASI DAN PELATIHAN PEMBUATAN MINUMAN NUTRASEUTIKAL SERTA PEMERIKSAAN KESEHATAN DI DESA MENINTING, KABUPATEN LOMBOK BARAT Muliasari, Handa; Permatasari, Lina; Dewi, Ni Made Amelia Ratnata; Saputra, Yoga Dwi; Nirmala, Annisa Rizka; Hafizah, Qori'atul; Ananta, Muhammad Naufal Farras; Farobbi, Muhammad Iqbal; Kabir, Mila Mayanti; Alya, Ainun; Amalia, Marshanda Fitri; Rahmayanti, Wulan Desi
Jurnal Pepadu Vol 5 No 1 (2024): Jurnal Pepadu
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/pepadu.v5i1.4062

Abstract

Consuming healthy foods such as nutraceuticals or functional foods is very important to prevent and reduce the risk of degenerative and chronic diseases. Efforts to improve community knowledge and skills related to nutraceuticals are very important, so community service activities are carried out with the aim of providing socialization and training on the production of nutraceutical drinks from local natural ingredients, as well as health checks including blood pressure, blood sugar, cholesterol and uric acid. The partners of this community service activity are PKK women and the community in Kongok Hamlet, Meninting Village, Batulayar District, West Lombok Regency, NTB. The community service activities consist of several stages, namely activity preparation, location survey and coordination with partners, socialization of nutraceutical drinks using PowerPoint slides and leaflets, training on the production of nutraceutical drinks, health checks, and ending with post-tests and activity evaluations using questionnaires. The 56 residents who attended were very enthusiastic in participating in the activities. The results of the questionnaire showed that 35.7% of the participants who attended were able to answer questions related to the socialization material with an average score of 74.3. The results of the activity evaluation questionnaire stated that activities like this are very important to do and the selection and provision of material are very good and clear. Thus, it can be concluded that this community service activity is very beneficial for the community and the socialization and training materials can be understood well by the participants of the community service activity.
FAKTOR - FAKTOR YANG MEMPENGARUHI AKTIVITAS ANTIBAKTERI DAUN MANGROVE (RHIZOPHORA MUCRONATA) TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS Hafizah, Qori'atul; Permatasari, Lina; Muchlishah, Neneng Rachmalia Izzatul
Jurnal Kesehatan Tambusai Vol. 5 No. 2 (2024): JUNI 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i2.28302

Abstract

Kasus resistensi antibiotik menjadi permasalahan serius yang terjadi, salah satunya yaitu resistensi pada strain bakteri Staphylococcus aureus yang disebut MRSA. Resistensi tersebut mendasari perlu dilakukan pencarian obat baru yang berasal dari tanaman dan berpotensi menghambat pertumbuhan S. aureus. Indonesia merupakan negara dengan hutan mangrove terluas di dunia, mencakup 20-22% dari total luas hutan mangrove dunia. Rhizophora mucronata merupakan salah satu spesies mangrove diketahui memiliki kandungan metabolit sekunder flavonoid, fenol, tanin, dan saponin, yang dapat berfungsi sebagai antibakteri. Berbagai penelitian terdahulu melaporkan bahwa ekstrak dan fraksi daun mangrove R. mucronata memiliki aktivitas antibakteri terhadap S. aureus. Namun, berbagai penelitian tersebut menunjukkan hasil diameter zona hambat yang berbeda-beda. Oleh karena itu dilakukan review artikel yang bertujuan untuk mengetahui faktor-faktor yang mempengaruhi aktivitas antibakteri daun mangrove (Rhizophora mucronata) terhadap bakteri Staphylococcus aureus. Review artikel dilakukan dengan metode tinjauan pustaka sistematis berdasarkan data primer dari database elektronik. Hasil review menunjukkan bahwa jenis pelarut yang digunakan dalam proses ekstraksi dapat mempengaruhi polaritas senyawa yang terekstraksi sehingga kemampuan zat untuk larut atau berdifusi pada media uji menjadi berbeda-beda. Perbedaan kandungan senyawa dan perbedaan konsentrasi pada sampel menyebabkan adanya perbedaan diameter zona hambat yang dapat disebabkan karena perbedaan jumlah dan jenis senyawa aktif yang memiliki kemampuan menghambat pertumbuhan bakteri. Kesimpulannya yaitu faktor-faktor yang dapat mempengaruhi aktivitas antibakteri daun mangrove (R. mucronata) terhadap bakteri S. aureus antara lain: jenis pelarut, kandungan senyawa, dan konsentrasi sampel.
Gravity column chromatography of n-hexane fraction of Rhizophora mucronata leaves from West Nusa Tenggara and their antioxidant activity Permatasari, Lina; Muliasari, Handa; Hafizah, Qori'atul; Rizka Nirmala, Annisa; Ilmi, Hilkatul
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.243

Abstract

In the last few decades, many diseases have been caused by Radical Oxidative Stress (ROS) or free radicals. Compounds that act as natural antioxidants have been widely developed to counteract these free radicals. Rhizpora mucronata was a mangrove species reported to possess strong antioxidant activity. However, the research is limited to extracts; fractions with more specific compound components have not been explored. The n-hexane fraction of R. mucronata leaves was reported to have high total flavonoid content (TFC). The TFC has a positive correlation with antioxidant activity. Therefore, this study aimed to simplify the compound components in the n-hexane fraction of R. mucronata leaves using gravity column chromatography (GCG) and determine their antioxidant activity. The n-hexane fraction was fractionated using GCG with increasing solvent polarity (n-hexane, chloroform, ethyl acetate, and methanol). The fractions were tested for antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods. The fractionation using GCG resulted in 80 fractions. These fractions were grouped based on their thin-layer chromatography (TLC) profiles, resulting in 12 groups of fractions (A-L). Fractions D, F, G, H, J, K, and L, the fractions with enough yield, determined their antioxidant activity using the DPPH and ABTS methods. Fractions D and J tested by the DPPH method had IC50 values of 28.68 ± 1.58 ppm and 9.59 ± 0.39 ppm, respectively. Meanwhile, fractions D and J tested by the ABTS method had IC50 values of 15.10 ± 1.00 ppm and 3.16 ± 0.55 ppm, respectively. Meanwhile, fractions F, G, H, K, and L exhibit antioxidant activity with IC50 values greater than 100 ppm. Fractions D and J have potent antioxidant activity, and both were tested using DPPH and ABTS methods. Therefore, fractions D and J can be further developed as natural antioxidants.
Co-Authors Alya, Ainun Amalia, Marshanda Fitri Ananta, Muhammad Naufal Farras Farobbi, Muhammad Iqbal Ilmi, Hilkatul Kabir, Mila Mayanti Muchlishah, Neneng Rachmalia Izzatul Muliasari, Handa Ni Made Amelia Ratnata Dewi Nirmala, Annisa Rizka Permatasari, Lina Rahmayanti, Wulan Desi Rizka Nirmala, Annisa Saputra, Yoga Dwi