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Muliasari, Handa
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Desain Turunan Fluorouinolon Baru sebagai Zat Antibakteri terhadap S. typhimurium melalui Komputasi Kimia Ananto, Agus Dwi; Erwinayanti, Gusti Ayu Putu Sri; Muliasari, Handa
Jurnal Kedokteran Vol 7 No 2 (2018)
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v7i2.172

Abstract

Latar Belakang: Perkembangan kimia komputasi mengalami kemajuan yang sangat cepat beberapa tahun terakhir ini. Hal ini sinergis dengan perkembangan penemuan obat baru yang semakin lama diharapkan semakin efektif dan efisien. Fluorokuinolon memiliki sifat-sifat seperti spektrum antibakteri yang lebar, terserap baik pada saluran cerna, dan masa kerja yang panjang. Penelitian yang mengarah kepada penemuan zat antibakteri baru turunan fluorokuinolon perlu dilakukan. Metode: Pada penelitian ini digunakan senyawa induk dari fluorokuinolon yang kemudian dilakukan optimasi menggunakan metode yang telah divalidasi sebelumnya, yaitu metode semiempirik PM3. Optimasi geometri dari senyawa induk fluorokuinolon dilakukan dengan menggunakan model balls and cylinders yang tersedia pada paket program Hyperchem. Evaluasi persamaan QSAR dilakukan berdasarkan analisis regresi multilinear dan dilakukan menggunakan program SPSS for Windows dengan metode Backward. Hasil: Desain senyawa baru didasarkan pada muatan atom dan menggunakan parameter-parameter hidrofobik, elektronik dan sterik. Perhitungan deskriptor dilakukan dengan metode PM3, sedangkan aktivitas senyawa diperoleh dari literatur. Berdasarkan persamaan terbaik, dirancang senyawa baru turunan fluorokuinolon yaitu senyawa dengan substitusi pada atom C no. 7 dengan propil, siklopropil, butyl dan sikloheksil dengan masing-masing harga MIC sebesar 0,331; 0,181; 0,201 dan 0,811. Senyawa turunan fluorokuinolon baru tersebut dianjurkan untuk disintesis di laboratorium guna pembuktian lebih lanjut. Kesimpulan: Desain senyawa baru turunan fluorokuinolon berdasarkan persamaan terbaik yaitu senyawa dengan substitusi pada atom C no. 7 dengan propil, siklopropil, butyl dan sikloheksil dengan masing-masing harga MIC sebesar 0,331; 0,181; 0,201 dan 0,811.
Review: analysis of optimal conditions of bovine serum albumin (BSA) protein denaturation inhibition method in anti-inflammatory activity testing of various plant leaf extracts Nirmala, Annisa Rizka; Permatasari, Lina; Muliasari, Handa; Deccati, Rizqa Fersiyana
Journal of Agritechnology and Food Processing Vol 3, No 2 (2023)
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jafp.v3i2.20953

Abstract

Inflammation is a manifestation of the immune response to eliminate antigens and a process to respond to tissue damage. There are various drugs to control and suppress inflammation, referred to as anti-inflammatory agents. One method to test anti-inflammatory activity is the inhibition of Bovine Serum Albumin (BSA) protein denaturation. This review article will discuss the stages and optimal conditions in the inhibition of BSA protein denaturation method using various leaf extract samples. Literature was gathered from several journal database websites such as PubMed, ScienceDirect, and Google Scholar with keywords "anti-inflammatory," "inhibition of BSA protein denaturation," and "leaf extract," spanning publication years from 2002 to 2023. The results of anti-inflammatory activity tests can be expressed as either percentage inhibition or IC50 values. Optimal conditions were obtained by preparing a 0.2% BSA solution with Tris Buffer Saline (TBS), maintaining a 9:1 composition ratio between the BSA solution and the sample, and heating at an optimal denaturation temperature of 70 °C. Before conducting tests using this method, it is crucial to ensure that the suspected active compounds with anti-inflammatory activity are not degraded at this heating temperature.
Ekstraksi dan Uji Aktivitas Enzim Bromelin Kasar dari Buah Nanas Dzulqaidah, Intan; Zanuba, Regina Brigita; Alwi, Andi Siti Fatimah; Salsabila, Arista Rizkika Putri; Mursidi, Siswandi; Muliasari, Handa
Journal of Agritechnology and Food Processing Vol 1, No 2 (2021)
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1003.812 KB) | DOI: 10.31764/jafp.v1i2.6974

Abstract

Pineapple (Ananas comosus) is a source of protease enzymes. The protease enzyme present in pineapple is the bromelain enzyme. Bromelain enzymes are widely used in various industrial fields. The purpose of this experiment was to isolate the bromelain enzyme from pineapple plants, to test the activity of the enzyme, and to determine the optimum temperature of the enzyme. Isolation of the bromelain enzyme from pineapple was carried out by precipitating the pineapple fruit filtrate using table salt (NaCl). Then the crude extract of the enzyme obtained was tested on pieces of meat with variations in the testing temperature (room temperature, hot, and cold). The yield of the crude extract of the enzyme obtained from the experiment was 40%. The results of testing the bromelain enzyme activity of pineapple showed that room temperature was the best temperature for the enzyme to tenderize meat compared to hot and cold temperatures.
Studi awal uji aktivitas enzim amilase dari tumbuhan secara kualitatif berdasarkan perbedaan suhu dan konsentrasi substrat Muliasari, Handa; Permatasari, Lina
Journal of Agritechnology and Food Processing Vol 2, No 1 (2022)
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jafp.v2i1.9338

Abstract

Amylase enzyme is a starch hydrolyzing enzyme that has wide applications in the food, beverage and biotechnology industries. One source of the amylase enzyme that is easily obtained is plant seeds and sprouts. This research is a preliminary study to qualitatively test the activity of the crude extract of the amylase enzyme from plants. Amylase enzyme was obtained from green bean sprouts, fresh and dried peanut seeds, and fresh and dried corn seeds. The crude extract of the amylase enzyme was tested for its activity using 1% starch as a substrate with variations in temperature and amount of substrate. The result of starch hydrolysis in the form of reducing sugar was detected using Benedict's reagent. The experimental results showed that the amylase enzyme extracted from green bean sprouts and fresh and dried corn kernels showed activity in breaking down starch at 25oC using 6 mL substrate concentration, while dried peanut seeds showed no activity. The enzyme activity is influenced by temperature and the amount of substrate.
Penentuan Kualitas Minyak Goreng Bekas Setelah Penambahan Adsorben Alami dari Bonggol Jagung dan Ampas Tebu Permatasari, Ni Made Ayu Dinda; Hasanah, Nunung Uswatun; Setiawan, Wahyu Aldi; Diba, Asmara Yauma Putri Farah; Sahila, Dinda; Wulandari, Hesti; Muliasari, Handa
Journal of Agritechnology and Food Processing Vol 1, No 2 (2021)
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1523.553 KB) | DOI: 10.31764/jafp.v1i2.6973

Abstract

Continuous and repeated use of cooking oil at high temperatures accompanied by air and water contact can result in a hydrolysis reaction. The quality of the oil can be determined by carrying out the procedure for determining the free fatty acid content (FFA). Used cooking oil can be purified using an adsorbent/absorbent. Sugarcane bagasse and corn cobs have been widely used as adsorbents, but there has been no study comparing the increase in oil quality with these two adsorbents. This study aims to compare the color of the used cooking oil immersion with bagasse adsorbent and corncob charcoal adsorbent and determine the value of FFA levels of used cooking oil before and after soaking with bagasse adsorbent and corncob charcoal arsoben. The method used is fatty acid adsorption method and alkalimetric titration. From the observations, it was found that the color of the used cooking oil was fading after soaking with 3 types of adsorbents. The color of the immersion with a mixture of 1:1 adsorbent corncob charcoal and bagasse has the highest brightness level. FFA levels of used cooking oil after soaking also decreased from 0.207% to 0.141%; 0.132 %; and 0.094 %. The FFA content of used cooking oil by immersion in a 1:1 mixture of corn cob charcoal and bagasse was the lowest, which means the oil has the highest quality. It can be concluded that a mixture of 1:1 adsorbent of bagasse and corncob charcoal is the best adsorbent.
Efektivitas Formula Krim Tabir Surya Berbahan Aktif Ekstrak Etanol Biji Wali (Brucea javanica L. Merr) Amini, Almira; Hamdin, Candra Dwipayana; Muliasari, Handa; Subaidah, Windah Anugrah
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 1, FEBRUARI 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i1.2066

Abstract

High intensity of ultraviolet (UV) radiation causes several adverse effect such as erythema, sunburn, pigmentation, early senescence, and skin cancer. These effects can be prevented by using sun protection product. Wali (Brucea javanica L. Merr) is one of natural plants that contain phenol and flavonoid. These compounds are proven to have sunscreen effect. The purposes of this studies are to formulate and evaluate the effectivity of oil-in-water-type sunscreen cream using 1% ethanol extract of Wali seed. The sunscreen cream is developed by using a fusion method and the evaluation of the effectivity is conducted in vivo on the skin of mice (Mus musculus). The formulated sunscreen cream is then tested for its physical properties, including homogenity, pH, spreadability, adhesion, and stability. The effectivity of the formulated cream is also tested by observing the formation of erytema on the skin of mice (Mus musculus). Erythema appearing on the mouse skin is analyzed with ImageJ and SPSS v23 using the one way anova method. The results showed that the ethanol extract of Wali seeds could be formulated into sunscreen cream. Furthermore, the formulated cream was also able to protect the mice skin against the formation of erythema significantly compared to negative controls (p
EDUKASI STUNTING DAN PELATIHAN PENGOLAHAN MAKANAN BERBAHAN DASAR IKAN DI DESA MENINTING Permatasari, Lina; Muliasari, Handa; Rachmalia Izzatul Mukhlishah, Neneng; Fersiyana Deccati, Rizqa; Anandia Intan Maulidya, Selvira; Junaida, Alfini; Guban Juniarza, A'yuni; Tasya Kamila, Afifah; Hayyatun Nufus, Fadirah; Patya Putri, Hudaynu; Magfira Nurmalasanti, Nadia; Azariani, Wiwin; M. Rifqi Azami S, Lalu; Tunggal Arya Rezky, Noval; Afriza Faishal, Imam
Jurnal Pepadu Vol 5 No 4 (2024): Jurnal PEPADU
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/pepadu.v5i4.5940

Abstract

Stunting merupakan masalah kurang gizi kronis akibat rendahnya asupan gizi pada 1000 hari pertama kehidupan. Stunting juga didefinisikan dengan kondisi tinggi badan seseorang yang kurang dari normal berdasarkan usia dan jenis kelamin akibat dari malnutrisi kronis yang sudah berlangsung bertahun-tahun. Pola makan merupakan salah satu faktor yang menjadi faktor kejadian stunting. Makanan yang tinggi protein hewani, misalnya ikan, merupakan bahan makanan yang mampu mencegah dan mengobati terjadinya stunting. Desa Meninting merupakan salah satu desa di Daerah Lombok Barat, Nusa Tenggara Barat yang mata pencaharian utamanya yaitu nelayan. Banyak jenis ikan laut yang dihasilkan, namun anak-anak tidak menyukai mengkonsumsi ikan. Oleh karena itu, pengabdian ini bertujuan untuk memberikan edukasi terkait stunting pada Ibu-Ibu di Desa Meninting dan memberikan pelatihan cara pengolahan ikan laut menjadi nugget yang lebih disukai oleh anak. Tahapan pada kegiatan ini meliputi persiapan kegiatan, pelaksanaan sosialisasi berupa edukasi terkait stunting dan pelatihan pengolahan ikan laut (ikan tongkol dan ikan guling-guling) dan evaluasi kegiatan melalui pemberian umpan balik oleh peserta. Berdasarkan hasil pendataan, peserta pengabdian 61% merupakan usia produtif (20-40 tahun) dan 79,5% merupakan Ibu Rumah Tangga. Hasil pengabdian menunjukkan bahwa terjadi peningkatan pengetahuan masyarakat terkait stunting setelah dilakukan edukasi stunting. Sementara itu, pelatihan pembuatan nugget berbahan dasar ikan ini 88% responden menyatakan bahwa acara ini sangat penting. Selain itu, 79% responden meyatakan bahwa pengabdian ini sangat bermanfaat bagi mereka. Hasil pengabdian ini dapat dilanjutkan dengan pelatihan lanjutan terkait pengolahan nugget ikan berskala besar, pengemasan dan pendaftaran produk sehingga selain dapat meningkatkan kesehatan, namun dapat meningkatkan perekonomian masyarakat
Determination of Total Flavonoid Content from Extract and Fractions of Mangrove Leaves (Rhizopora mucronata) Sammanta, Rahula Vijja; Permatasari, Lina; Muliasari, Handa; Rachmalia Izzatul Mukhlishah, Neneng; Fersiyana Deccati, Rizqa
Acta Chimica Asiana Vol. 7 No. 2 (2024)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v7i2.199

Abstract

Indonesia, an archipelagic country, includes Lombok Island, known for its extensive mangrove forests, where Rhizopora mucronata is the dominant species. Rhizopora mucronata, from the Rhizoporaceae family, is known for its antibacterial, antifungal, and antioxidant properties due to its secondary metabolites, including flavonoids. However, research on the flavonoid content of its leaves remains unexplored. This study aimed to determine the total flavonoid content in extracts and fractions of R. mucronata leaves using the UV-Vis spectrophotometric method. Leaves were extracted with 96% ethanol using sonication and fractionated with n-hexane, ethyl acetate, and water. The extract and fractions yielded 42.33%, 43.15%, 40.49%, 9.74%, and 32.49%, respectively. TLC tests indicated the presence of flavonoids marked by blue spots. The flavonoid contents in the extract and fractions were 12,980; 14,160; 23,880; and 25,350 mg Quercetin equivalent/gram sample (mg QE/g). The total flavonoid content was analyzed using One-way ANOVA, showing higher levels in the n-hexane and ethyl acetate fractions than in the ethanol extract and water fraction. The high flavonoid content contributes to the biological activities of R. mucronata leaves.
Exploration of secondary metabolite profile in the n-hexane fraction of Rhizophora mucronata, Avicennia marina, and Sonneratia alba Maziya, Raehanul; Permatasari, Lina; Deccati, Rizqa Fersiyana; Muliasari, Handa; Rahman, Fania; Annas, Zulfiana Fatianingrum; Sammanta, Rahula Vijja
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.231

Abstract

Indonesia is a maritime and archipelagic country with an ocean area of almost two-thirds of its total area, with a coastline stretching 99.123 km from Sabang to Merauke. According to Indonesian Law Number 1 of 2014, it is mentioned that one of the most important biological resources of the coast is mangroves. Some mangrove species commonly found on Lombok Island are Rhizophora mucronata, Sonneratia alba, and Avicennia marina. However, there has not been much exploration of the compound content in these mangroves. Therefore, this study aimed to identify the secondary metabolites of the n-hexane fraction of the three mangrove species using Gas Chromatography-Mass Spectrometry (GC-MS). The leaves of each mangrove species were extracted by sonication method using 96% ethanol solvent, followed by multistage fractionation using n-hexane and water. GC-MS analyzed the n-hexane fraction of each mangrove species. The GC-MS analysis revealed that in the n-hexane fraction of mangrove leaves Rhizophora mucronata and Avicennia marina there were 10 compounds, while Sonneratia alba obtained five compounds. The compounds with the highest intensity in the n-hexane fraction of mangrove leaves of Rhizophora mucronata, Sonneratia alba, and Avicennia marina were squalene (41.71%), ethyl oleate (87.53%), and ethyl oleate (44.02%), respectively. Squalene was reported to have antioxidant and anticancer activities. The ethyl oleate was reported to have bactericidal activity on gram-positive and negative bacteria. The three types of mangrove leaves can be an alternative source of medicine
Anti-Radical Activity Test of Fractions from Ashitaba Herbs (Angelica keiskei) Permatasari, Ni Made Ayu Dinda; Muliasari, Handa; Hanifa, Nisa Isneni; Hidayati, Agriana Rosmalina; Hidajat, Dedianto; Hajrin, Wahida; Rizkika, Adila
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7638

Abstract

Acne vulgaris is a chronic inflammation of the skin’s pilosebaceous unit, caused by oxidative stress due to reactive oxygen species (ROS) release. Oxidative stress conditions can be treated using natural antioxidants, namely ashitaba (Angelica keiskei). In contrast to previous studies that tested column chromatography fraction of the macerated ethanol extract, this study examined the liquid-liquid partition fraction of 80% methanol sonicated extract of Ashitaba herb. This study aims to determine the antiradical activity of various fractions of Ashitaba herb extract against 1,1-diphenyl-2-picrylhidrazyl (DPPH) free radicals. 80% methanol extract of the Ashitaba herb was fractionated using chloroform, ethyl acetate, and water solvents. Each ashitaba herb fraction was identified for the content of flavonoids and phenolic compounds and the antiradical DPPH activity was tested with ascorbic acid standard using a UV-Vis spectrophotometer. The IC50 value of each fraction was statistically analyzed using One-Way ANOVA and Posthoc Tukey. The results of phytochemical identification showed that ashitaba herb fractions positively contain flavonoids and phenolics. Antiradical activity of the chloroform, ethyl acetate, and water fractions against DPPH was indicated by IC50 values of 164.22±5.68 ppm (moderate); 8.70±0.12 ppm (very strong); and 243.60±8.14 ppm (weak). Statistically, each ashitaba herb fraction differed significantly from ascorbic acid (IC50 2.37±0.05 ppm). The ethyl acetate fraction has the strongest antioxidant activity and is in the same category of antioxidant strength as the ascorbic acid standard.
Co-Authors Afriza Faishal, Imam Agus Dwi Ananto, Agus Ali Harris, Ali Alwi, Andi Siti Fatimah Alya, Ainun Amalia, Marshanda Fitri Amini, Almira Anandia Intan Maulidya, Selvira Ananta, Muhammad Naufal Farras Annas, Zulfiana Fatianingrum Annas, Zulfiana Fitrianingrum Azariani, Wiwin Deccati, Rizqa Fersiyana Dedianto Hidajat Diba, Asmara Yauma Putri Farah Dzulqaidah, Intan Erwinayanti, Gusti Ayu Putu Sri Farobbi, Muhammad Iqbal Fersiyana Deccati, Rizqa Guban Juniarza, A'yuni Hafizah, Qori'atul Hajrin, Wahida Hamdin, Candra Dwipayana Hasanah, Nunung Uswatun Hayyatun Nufus, Fadirah Hesti Wulandari Hidayati, Agriana Rosmalina I MADE SUDARMA Ihsan, Muhsinul Ilmi, Hilkatul Jones, Clive Junaida, Alfini Kabir, Mila Mayanti M. Rifqi Azami S, Lalu Magfira Nurmalasanti, Nadia Maziya, Raehanul Megawati Mukhlishah, Neneng Rachmalia Izzatul Mukminah Mursidi, Siswandi Nankervis, Leo Ni Made Amelia Ratnata Dewi Nirmala, Annisa Rizka Nisa Isneni Hanifa Patya Putri, Hudaynu Permatasari, Lina Permatasari, Ni Made Ayu Dinda Priyambodo, Bayu Purwati, Nining Rachmalia Izzatul Mukhlishah, Neneng Rahman, Fania Rahmayanti, Wulan Desi Riadi, Putri Oktaviati Rizka Nirmala, Annisa Rizkika, Adila Sahila, Dinda Salsabila, Arista Rizkika Putri Sammanta, Rahula Vijja Saputra, Yoga Dwi Setiawan, Wahyu Aldi Tasya Kamila, Afifah Tunggal Arya Rezky, Noval Windah Anugrah Subaidah Yayuk Andayani Zahra, Nur Nadhifah Zanuba, Regina Brigita