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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Global Medical and Health Communication The Indonesian Biomedical Journal Jurnal Gizi Klinik Indonesia Jurnal Kedokteran dan Kesehatan PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Katalisator Media Penelitian dan Pengembangan Kesehatan

Ismawati ismawati

Universitas Riau

Author-ID : 919902

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Efek Pemberian Asam Alfa Lipoat pada Histopatologi Aorta Torakalis Tikus Diabetes Melitus Tipe 2 Rijalun Arridho; Ismawati Ismawati; Enikarmila Asni; Ilhami Romus
Jurnal Ilmu Kedokteran Vol 14, No 1 (2020): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v14i1.2020.33-38

Atherosclerosis is arterial wall’s disease initiated by lipid retention, oxidation, and modification, provoking chronic inflmmation ultimately causing stenosis and thrombosis. This study investigated the effect of alpha lipoic acid (ALA) on thoracic aorta type 2 diabetic rat. Fifteen adult male rat of Rattus novergicus Wistar strain were separated into three groups (n=5), there were labelled as control, type 2 diabetes (DM), and DM + ALA. Type 2 diabetic rats were induced by streptozotocin (50 mg/kg bodyweight) and nicotinamide (110 mg/kg bodyweight) and categorized as diabetic rat if blood glucose level >250 mg/dl. Alpha lipoic acid was administered via intraperitoneal (60 mg/kg/day) and conducted for 3 weeks. The measured parameter was atherosclerosis lesion score. Results showed that there was no significant difference in atherosclerosis lesion scores between all groups designed (p=0,071). It can be concluded that ALA did not have a significant effect on atherosclerosis lesion of thoracic aorta type 2 diabetic rat.

Pengaruh Asam Alfa Lipoat Terhadap Kadar Trigliserida pada Tikus Diabetes Melitus Tipe 2 Angel Chen; Ismawati Ismawati; Enikarmila Asni
Jurnal Ilmu Kedokteran Vol 12, No 1 (2018): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Accumulation of triglycerides associated with insulin resistance in type 2 diabetes mellitus (T2DM). Alpha lipoic acid (ALA) has hypotriglyceridemic effects by lowering triglyceride levels in blood and liver. This study aims to analyze effect of ALA on triglyceride levels in type 2 diabetic rats. Fifteen Wistar male rats (±8-12 weeks, 200-250 gram) divided into 3 groups (control, T2DM and T2DM–ALA given for 3 weeks). Diabetes was induced by giving streptozotocin (50 mg/kg.bw) and nicotinamide (110 mg/kg.bw) after 15 minutes intraperitoneally. Diagnosis of T2DM was determined if the rats have perifer blood glucose >250 mg/dL after 3 days. The results showed that triglyceride levels in ALA group (p=0,003) lower than T2DM group, T2DM group (p=0,031) had higher triglyceride level than control and no difference of triglyceride level between T2DM-ALA given group with control (p=0,696). This study concluded that ALA can affect triglyceride levels in T2DM thus prevents occurrence of hypertriglyceridemia.

Gambaran Sarapan dan Status Gizi Pada Mahasiswa Fakultas Kedokteran Universitas Riau Angkatan 2017 Isnani Kurniyanti; Erwin Christianto; Ismawati Ismawati
Jurnal Ilmu Kedokteran Vol 12, No 2 (2018): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Breakfast is an activity of eating and drinking between waking up to 9 am to fulfill some of the daily nutritional needs (15-30% nutritional needs). The benefits of breakfast are maintaining an ideal body weight because breakfast can reduce the amount of food you eat throughout the day. The purpose of this study was to find out the description of breakfast and Body Mass Index (BMI) in students of the Faculty of Medicine, University of Riau in 2017. This research was descriptive study with 121 samples. The results showed 16.3% obese I and 8.1% obese II. Respondents with good breakfast calories tend to have good nutritional status of 50.0%.

Efek Inhibitor Proteasom Terhadap Gambaran Histopatologi Jantung pada Tikus yang diinduksi Aterosklerosis Ilhami Romus; Ismawati Ismawati; Indah Putri Arwandi
Jurnal Ilmu Kedokteran Vol 17, No 1 (2023): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v17i1.2023.66-70

Proteasome inhibitors are compounds that can inhibit the proteasome pathway in carrying out its functions. Proteasome inhibitors have a beneficial effect due to their anti-inflammatory properties. The proteasome inhibitor used in this study was bortezomib. This study aimed to analyze the effect of proteasome inhibitors on cardiac histopathology in atherosclerosis-induced rats. This study used male Rattus novergicus Wistar strain which was divided into 3 groups, namely the control group, the atherosclerosis-induced group and the atherosclerosis-induced group and given bortezomib. The results obtained the mean scores of edema, inflammation and necrosis in the atherosclerosis group were given bortezomib at a dose of 50 g/kgBW were less than the atherosclerosis group. Theese difference were statistically significant (p<0.05). This study concluded that the administration of bortezomib can reduce the Impact of atherosclerotic lesions on the heart muscle.

Co-Authors Angel Chen Dhea Ayu Kartini Surya Putri Dyna, Fitri Elfima Aditya Utami Enikarmila Asni Erwin Christianto Esy Maryanti Ilhami Romus Ilhami Romus Ilhami Romus Ilhami Romus, Ilhami Imelda Tresia Pardede Indah Putri Arwandi Isnani Kurniyanti Ligat Pribadi Sembiring Luthfianty, Elfiah M Derillovyandra Dwi Anugrah Muhammad Fadhillah Arif Mukhyarjon Noviardi Noviardi, Noviardi Permatasari, Nopi Putra, Amrullah Syah Rijalun Arridho Saputra, Nicko Pisceski Kusika Saryono Sonia Dinda Paramitha Sri Yanti Veni Dayu Putri Winarto Winarto

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