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Akafa Andes Tansaba
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Evaluation of Potential in Wonderful Kola (Buchiolizia coreica) Seed Extract on Streptozotocin Induced Type 2 Diabetes in Male Wister Rats Isaac John Umaru; Nwachukwu Favour Onyinyechi; Akafa Andes Tansaba; Chakfa Nanmar; Kerenhappuch Isaac Umaru; Egeonu Stephen Ugoeze; Nanyak Zingfa Galam
African Multidisciplinary Journal of Sciences and Artificial Intelligence Vol 1 No 1 (2024): African Multidisciplinary Journal of Sciences and Artificial Intelligence
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/amjsai.v1i1.3388

Abstract

Diabetes mellitus is referred to as a metabolic disorder in which there is high glucose level in the blood as a result of insulin deficiency, resistance or both. Globally, it has been deducted that the adult population with diabetes will rise by 69% for the year 2030. Thus, Bucholzia Coriacea (B. Coriacea) a perennial plant belonging to the family capparidaceae and genus Bucholzia is popularly known as wonderful kola. It’s also known as wonderful kola, its other name is called Garcinia kola .it has a long history of use in west Africa and central Africa, thus, the study on evaluation of potential in wonderful kola (buchiolizia coreica) seed extract on streptozotocin induced type 2 diabetes in male wister rats. Material and Methods: Fresh seeds of B. coriacea were plucked and washed with distilled water, the filtrate was concentrated using rotary evaporator and water bath. The extract was then weighed and stored in a refrigerator. 100g of crude extract and 1000mg of metformin was properly dissolved in 10ml of distilled water. The rats were carefully selected and separated into cages. 7 albino rats were used for normal control while 4 rats were kept in each of the remaining cages, and 6 replications were obtained, the test was carried out carefully by injecting the alloxan into the rats intraperitoneally and infecting them with diabetes mellitus, the following sets were made: normal group, negative and positive control group, while three groups were for extracts dosage. With exception of the normal control, all the groups were induced with diabetes. The extract (stem bark of Mangifera indica) will be administered orally to the three set of groups separately (i.e., one extract to one set). Determination of Fasting Blood Glucose Level by Intestinal Glucose Absorption. Results: Treatment groups receiving methanol Wonder Kola seed extract showed varying degrees of improvement in these parameters compared to the negative control group. Notably, Group VI, receiving the highest dose of the extract, demonstrated the most significant reduction in urea levels, suggesting a potential protective effect on renal function. The study investigated the effects of Wonder Kola seed extract on serum electrolytes, urea, and creatinine levels in alloxan-induced diabetic albino rats. Notably, significant variations were observed in these biochemical parameters across the different treatment groups. The study assessed the effects of methanol Wonder Kola seed extract on liver enzymes (AST, ALT, ALP) and serum protein levels (total protein, albumin, total bilirubin, direct bilirubin). Significant variations were observed in these parameters among the treatment groups compared to the normal and negative control groups. Treatment with the extract led to notable reductions in liver enzyme levels, indicating potential hepatoprotective effects. Conclusion: The findings of this study demonstrate the potential pharmacological benefits of methanol Wonder Kola seed extract in managing diabetes mellitus and associated complications.
Evaluation of Antibacterial and Anti-Malaria Potential of Wonderful Kola (Buchiolizia coreica) Seed Extract in Male Wister Rats Kerenhappuch Isaac Umar; Akafa Andes Tansaba; Egeonu Stephen Ugoeze; Chakfa Nanmar; Isaac John Umaru
African Multidisciplinary Journal of Sciences and Artificial Intelligence Vol 1 No 1 (2024): African Multidisciplinary Journal of Sciences and Artificial Intelligence
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/amjsai.v1i1.3390

Abstract

One of the areas for the search for new antimalarial drugs is from the claimed antimalarial plants from the African flora. Only few of these claims have been authenticated by scientific investigation. Plants form the major part of treatments used by traditional healers in many societies, Bucholzia Coricea (B. Coriacea) a perennial plant belonging to the family capparidaceae and genus Bucholzia is popularly known as wonderful kola. Earlier studies carried out on different parts of this plant shows that it has great medicinal potentials thus, the evaluation of antibacterial and anti-malaria potential of wonderful kola (Bucholzia Coricea) seed extract in male Wister rats. Material and Methods: Fresh seeds of B. coricea were plucked and washed with distilled water, concentrated using rotary evaporator. Standard antibacterial agent (30 μg) tetracycline, antimicrobial susceptibility test discs and Nutrient agar was used. 100g of crude extract taken into a conical flask, the crude extracts were tested by disc diffusion method on nutrient agar medium. selected bacteria were used to evaluate the antibacterial activities of the crude extracts of Bucholizia Coricea seed, Escherichia coli (ATCC©25922), Salmonella typhi, (ATCC©14028), Staphylococcus aureus (ATCC©25923) and Kliebselia pneumonia, (ATCC©19155). A total of seventy-eight Swiss albino mice (18-25 g) of both sexes were used in the study. Eighteen for acute toxicity study while thirty were used for each of the in vivo antiplasmodial test. Results: antibacterial; higher inhibition was observed at 400µg/mL on Klebsiella pneumonia at 15.14 + 0.07mm when compared to standard 21.19+ 0.03mm. while the curative effect of the extract in P. berghei infected rats at 40mg/kg show significant parasitaemia density to be 30.98+4.30 and pre(D3) was 2.90+0.11mm** with survival time at post (D7) to be 29.67+0.21mm when compared to CQ as standard drug control with 10mg/kg. Conclusion: This study has however stablished the rationale for the traditional use of this plant in Nigeria and like many others, proved that medicinal plants which have folkloric reputations for anti-bacterial and antimalarial properties, thus, as an agent.
Estimation of Kidney Function and Haematological Parameters of Methanol Leaf Extract of Annona senegalensis on Diethyl Nitrosamine-Induced Hepatocellular Carcinoma in Rats Isaac John Umaru; Augustine Absalom; Mary Athanasius Udoh; Mosugu Ovayoza Omolara; Ogar Fonne Okang; Ingwu Joseph Akem; Akafa Andes Tansaba; Otashu Kenneth Frank; Shadrach Philip
African Multidisciplinary Journal of Sciences and Artificial Intelligence Vol 2 No 3 (2025): African Multidisciplinary Journal of Sciences and Artificial Intelligence
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/amjsai.v2i3.7359

Abstract

Hepatocellular carcinoma (HCC) is a major cause of liver-related mortality worldwide, often linked to oxidative stress and hepatotoxicity induced by carcinogens such as diethylnitrosamine (DEN). This study investigates the biochemical and hematological effects of methanol leaf extract of Annona senegalensis on DEN-induced HCC in male albino rats. Thirty rats were divided into six groups: normal control, negative control (DEN-induced), positive control (DEN + silymarin), and three treatment groups receiving A. senegalensis extract at 200 mg/kg, 400 mg/kg, and a combined regimen. DEN exposure significantly elevated serum biomarkers of liver damage, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and bilirubin. Treatment with A. senegalensis extract at 400 mg/kg markedly reduced ALT, AST, and ALP levels compared to the negative control, demonstrating hepatoprotective potential. Hematological analysis revealed a decline in white blood cell (WBC) count across treatment groups, suggesting possible immunosuppressive effects. Red blood cell (RBC) count and hemoglobin (HGB) levels decreased at 200 mg/kg but increased at 400 mg/kg, indicating a dose-dependent erythropoietic effect. Platelet (PLT) counts, elevated in the DEN-induced group, were normalized by the extract. These results suggest that A. senegalensis contains bioactive compounds with hepatoprotective and hematomodulatory activities. While higher doses improved liver function and hematological balance, the observed immunosuppressive tendencies highlight the need for further mechanistic studies. The findings support the therapeutic potential of A. senegalensis in hepatocellular carcinoma management, warranting future preclinical and clinical evaluation.
Evaluation of Antibacterial Activity and Toxicity Effects of Newbouldia Stem Bark Extract Kerenhappuch Isaac Umaru; Isaac John Umaru; Akafa Andes Tansaba; Chakfa Nanmar; Egeonu Stephen Ugoeze
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3350

Abstract

Newbouldia leavis is a boundary tree. it is a medium size angiosperm which belongs to the Bignoniaceae family. It is a fast-growing evergreen shrub or small tree. This study was carried out to investigate antibacterial activity of the methanol extract of Newbouldia stem bark. The antibacterial activity of the methanol extracts was determined by the agar well diffusion method. Three standard bacterial strains: Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae were used for the antibacterial assay. Result of screening plant extracts for antibacterial activity showed that most of the organisms were sensitive to the extract. The antibacterial test utilizing well diffusion assay showed that Gram-positive bacteria were more susceptible to the plant extract compared to Gram-negative bacteria. This study supports the use of Newboulda leavis in traditional medicine as well as highlights the need to further explore the potentials of the plant extract as antibacterial agent.
Hypoglycemic Potentials of Newbouldia laevis Stem Bark Extract in Alloxan-Induced Diabetic Rats Isaac John Umaru; Gabriel Favour Chisom; Kerenhappuch Isaac Umaru; Akafa Andes Tansaba; Chakfa Nanmar; Egeonu Stephen Ugoeze
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3351

Abstract

This study was carried out to investigate the antidiabetic of the methanol extract of Newbouldia stem bark and to determine its safety and toxicity. Alloxan (150 mg/kg) was administered to albino rats via the oral route. The diabetic rats were then placed in 6 groups, following stabilization of hyperglycemia. The first group was non-diabetic, the second and third group were the diabetic control. The next three groups received, each day, 100, 200 and 400 mg/kg body weight of the methanol extract Newbouldia laevis and the second group received a reference standard, metformin (200mg/kg). Treatment was via the oral route for 14 days and fasting blood sugar level was monitored over this period. Acute toxicity (oral and intraperitoneal) studies on the extract was carried out. Blood glucose levels from day 1 to 14 days of treatment increased significantly (p <0.05) in all the treatment groups, except group 3 (positive control) which showed no significant difference compared to the normal control group. This study supports the use of Newbouldia laevis in traditional medicine as well as highlights the need to further explore the potentials of the plant extract as an antidiabetic.
Antibacterial and Antioxidant Capacity of Methanol Root Extract of Mangifera Indica Isaac John Umaru; Sule John Ugbedeojo; Akafa Andes Tansaba; Chakfa Nanmar; Kerenhappuch Isaac Umaru; Egeonu Stephen Ugoeze
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3352

Abstract

Recent years have witnessed enhanced research work reported on plants and plant products. In this regard, plants with traditional therapeutic usage are being screened more efficiently to be considered as a substitution or as a better alternative agent for Human Pathogens. Antioxidant activity, antibacterial, antifungal properties, colour, phytochemical and FT-IR spectral analysis of flowers belonging to Hibiscus moscheutos was determined. Radical scavenging activity of sample extracts were determined based on the percent inhibition of DPPH and ferric reducing antioxidant power (FRAP) assays. Total phenolics were estimated based on the Folin–Ciocalteu method, while, vanillin–HCl and aluminum chloride methods were employed to estimate total tannins and flavonoids in the sample extracts, respectively. To determine total flavonols and anthocyanin contents, spectrophotometric method was employed. For antibacterial activities, modified agar disk diffusion method was adopted. Results: The crude extracts of hexane, dichloromethane, chloroform, ethyl acetate and methanol, extracts with concentration levels at 100, 200, 300 and 400 mg/mL were shown to significantly affect the inhibition of bacterial selected. The presence of phytochemicals compounds possesses the high antibacterial activities of this crude extracts. This study proved that Mangifera Indica crude extracts could be useful for inhibiting the selected pathogens which has an antioxidant potential as well as a natural bacterial agent.
Hepatocurative Effect of Methanol Extract of Newbouldia laevis Leaves in Alloxan-Induced Liver Damage in Albino Rats Isaac John Umaru; Tsokwa Punarimam Rebecca; Akafa Andes Tansaba; Chakfa Nanmar; Kerenhappuch Isaac Umaru; Egeonu Stephen Ugoeze; Tyem Lawal Danjuma
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3354

Abstract

The aim of the study is to evaluate the effect (Hepatocurative and antibacterial potential) of Newboulda laevis leaves in alloxan-induced liver damage in Wister Albino Rats. The leaves of Newbouldia laevis was bought from a local market in Wukari, Taraba State. The leaves of Newbouldia laevis was chop and then pulverized into fine powder. The methanol crude extracts andthirty-two albino Wistar rats weighing 90-220 g was used for this research. Liver toxicity was induced in male rats by an intraperitoneal single dose of 150 mg/kg body weight. samples were subjected to biochemical estimation of liver function. The result showed a significant (p≤0.05) increase in serum AST level for group II (60.6 ± 1.12) which was administered high dose of Alloxan and serves as the negative control group, when compared to the normal control group I (35.09 ± 2.07) which only received feed and water. From the result described in table 4.0 above, it showed a significant (p≤0.05) increase in ALT level for group II (58.11 ± 0.42) negative control when compared with group I (20.00 ± 0.41) normal control. Group III (29.98 ± 0.12) which received standard drug showed a significant decrease in ALT which is a sign that there is some level of repair on the liver cells. Group IV (36.22 ± 0.s70), group V (30.00 ± 0.27) and group VI (29.99 ± 0.12) which received 100, 200 and 400 mg/kg body weight of Newbouldia laevis leaves extract respectively when compared with the negative control group II, showed a significant decrease in ALT level. There was a significant (p≤0.05) increase in ALP level for group II (255.80 ± 1.12) which received Alloxan when compared with the normal control group I (80.21 ± 0.44) providing evidence to support the increase in ALT and AST level in group II, suggestive of liver injury. The treatment groups III, VI, V and VI showed significant (p<0.05) difference, when compared to the negative control group. No significant (p<0.05) difference between group V and VII. It was deduced that the total protein for group II (10.95 ± 0.37) significantly (p<0.05) decreased when compared to the normal control group I (14.13 ± 0.55). This is because low levels of total protein in the blood can occur because of impaired function of the liver. Administration of Newbouldia laevis leaves extract significantly (p<0.05) elevated total protein levels for group IV (10.99 ± 0.41), V (12.76 ± 0.41) and VI (12.98 ± 0.58). Albumin being the most abundant protein in the blood, equally followed same pattern as total protein, with Albumin level of (10.83 ± 0.10), (6.13 ± 0.05), (9.82 ± 0.18) (6.75 ± 0.13), (7.99 ± 0.10) and (9.60 ± 0.13) for group I, II, III, IV, V and V respectively. Thus, emphasizing the potential of the extract as a source agent for medication for ailment and diseases.
Effect of Ethanol Leaf Extract of Annona senegalensis on Lipid Profile and Kidney Function in Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats Isaac John Umaru; Usman Lukman Adamu; Mosugu Ovayoza Omolara; Ogar Fonne Okang; Ingwu Joseph Akem; Akafa Andes Tansaba; Shadrach Philip; Otashu Kenneth Frank
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 3 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i3.7363

Abstract

Liver cancer remains a major global health burden, with hepatocellular carcinoma (HCC) being the most common form and a leading cause of cancer-related deaths. Its progression is often accompanied by metabolic and renal dysfunction, complicating treatment outcomes. While conventional therapies such as chemotherapy, radiotherapy, and targeted drug treatments offer benefits, they are frequently associated with high toxicity and adverse side effects. This discussion highlights the potential of Annona senegalensis as a safer alternative for managing HCC-related complications, particularly in the context of lipid metabolism and renal function. Evidence from experimental studies suggests that the ethanolic leaf extract of A. senegalensis significantly improves lipid profiles by reducing cholesterol levels from 368.57 ± 1.72 in the negative control group to 266.40 ± 0.88, 217.46 ± 0.82, and 182.24 ± 1.20 at 200, 400, and 600 mg/kg doses, respectively, while maintaining favorable HDL levels at higher doses. These findings indicate the extract’s potential to enhance lipid metabolism, lower cardiovascular risk, and provide renal protection during liver cancer progression. Beyond its biochemical effects, the study reinforces the growing relevance of integrating traditional medicinal plants into modern healthcare frameworks as complementary therapeutic options. Overall, A. senegalensis demonstrates promising hepatoprotective, metabolic, and nephroprotective effects, warranting further investigation into its bioactive compounds and clinical applicability.
Hypoglycaemic Potential of Methanol Stem-Bark Extract of Mangifera Indica in Alloxan Induced Diabetic Albino Rats and Its Toxicity Effect to Liver and Kidney Isaac John Umaru; Nkiri Annasthesia Ekubnse; Kerenhappuch Isaac Umaru; Akafa Andes Tansaba; Egeonu Stephen Ugoeze; Chakfa Nanmar
African Journal of Sciences and Traditional Medicine Vol 1 No 1 (2024): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v1i1.3358

Abstract

Mangifera indica (MI), popularly known as mango belong to the genus Mangifera and family Anacardiacea. The leaves, stem bark and roots are used as herbal medicines worldwide. Mango possesses anti-diabetic, anti-bacterial, anti- oxidant, anti-viral and anti-inflammatory properties. This research focuses on the hyperglycemic and antibacterial capacity of methanol stem bark extract of Mango tree in alloxan induced diabetic albino rats to combat its fatal consequences in humans. This work is carried out to determine the hypoglycemic capacity of methanol stem bark extract of Mangifera indica in alloxan-induced diabetic albino rats at different volumes (ml) of administration, to also determine the antibacterial capacity of methanol stem bark extract of Mangifera indica in alloxan-induced diabetic albino rats at different volumes (ml) of administration and to test the efficacy of methanol stem bark extract of Mangifera indica in alloxan-induced diabetic albino rats. Fresh stem bark (trunk) of Mangifera indica were collected in the Federal University Wukari school premises, were air dried for 21 days, pounded into powder, cold macerated in methanol, filtered and extract was gotten. 27 diseased-free (healthy) albino rats which were purchased at Yola, Adamawa State, were kept in different cages to enable proper analysis at the cause of the work. Results of liver function indices showed that treatments with 100 mg/kg, 200mg/kg and 400mg/kg body weight of Mangifera indica stem bark methanolic extract were able to restore liver function parameters at different levels of concentrations. Treatments with standard drug and all the doses of the extract were able to counteract the elevated effect of alloxan in some kidney parameters such as serum urea level at 200mg/kg with (25.23±1.98a) and (1.05 ±0.14a) for creatinine at 200mg/kg respectively. The result of this study shows that the stem back extract possessed as an agent for hypoglycaemic. These can serve as possible source of raw material for pharmaceutical products. However, the extract is found not to be harmful to the liver and kidney and should be used as health remedy for certain diseases such as hyperglycaemic and bacterial effects.
Antibacterial and Antifungal Potential of Methanol Stem–Bark Extract of Mangifera Indica Kerenhappuch Isaac Umaru; Akafa Andes Tansaba; Egeonu Stephen Ugoeze; Chakfa Nanmar; Isaac John Umaru
African Journal of Sciences and Traditional Medicine Vol 1 No 1 (2024): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v1i1.3360

Abstract

Medicinal plants have served through the ages, as a constant source of medicaments for the exposure of variety of diseases. The history of herbal medicine is as old as human civilization. The plants are known to provide a rich source of botanical anthelmintic, antibacterial and insecticides. Mangifera indica (MI), popularly known as mango belong to the genus Mangifera and family Anacardiacea. The leaves, stem bark and roots are used as herbal medicines worldwide. In antibacterial analysis, higher growth inhibition rate was observed at 400 ug/ml for Klebsiella pneumonia with 20.55 + 1.26μg/mL indicating that the extract has effect at a higher concentration than when treated at a lower concentration. In blood glucose level analysis, administration of 100 mg/kg body weight of Mangifera indica stem bark methanolic extract showed reduced blood glucose level in day 14 with 5.11 ± 0.14a of treatment when compared to normal control.
Co-Authors Agbo Chibuike Ekunyi Augustine Absalom Chakfa Nanmar Egeonu Stephen Ugoeze Emmanuel Efongwa Etah Hope Mona Gabriel Favour Chisom Ingwu Joseph Akem Isaac John Umaru Kerenhappuch Isaac Umar Kerenhappuch Isaac Umaru Khalid Yahuza Abbas Mary Athanasius Udoh Mosugu Ovayoza Omolara Nanyak Zingfa Galam Nkiri Annasthesia Ekubnse Nwachukwu Favour Onyinyechi Ogar Fonne Okang Otashu Kenneth Frank Panah Philemon Shadrach Philip Sule John Ugbedeojo Tsokwa Punarimam Rebecca Tyem Lawal Danjuma Usman Ikira Usman Lukman Adamu