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Jurnal Ilmiah Kedokteran Wijaya Kusuma
Published by Universitas Wijaya Kusuma Surabaya
ISSN : 19782071     EISSN : 25805967     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
Jurnal Ilmiah Kedokteran Wijaya Kusuma (JIKW) is a periodically scientific publication that contains articles written in Indonesia or english. JIKW receive articles in the scope of Biomedical Sciences, degenerative diseases, infections, congenital abnormalities and public health. JIKW published twice a year. The articles will be published in JIKW only manuscript that has never be published or published in other journal. Writers who will publish the article please follow the JIKW guidelines. The entire management process both admission and review the article is done by online.
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Articles 390 Documents
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EFEK KADMIUM TERHADAP KADAR GLUKOSA HEPAR TIKUS PUTIH (Rattus norvegicus) IN VITRO Suhartono, Eko
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

Mekanisme kadmium menginduksi toksisitas pada hepar yaitu dengan menimbulkan stres oksidatif. Stres oksidatif menghambat enzim-enzim yang berperan dalam proses metabolisme glukosa. Penelitian ini bertujuan untuk menganalisis perbedaan kadar glukosa pada homogenat hepar. Penelitian ini merupakan penelitian eksperimental laboratorik yang dilakukan pada 4 kelompok: kelompok P0 yang tidak dipajankan Cd, kelompok P1 dipajankan Cd 0,03 mg/L, kelompok P2 dipajankan Cd 0,3 mg/L, dan  kelompok P3 dipajankan Cd 3 mg/L. Hasil penelitian didapatkan rata-rata kadar glukosa pada kelompok P0 sebesar 21.667 μM, kelompok P1 sebesar 33.278 μM, kelompok P2 sebesar 69.889 μM, dankelompok P3 sebesar 150.667 μM. Melalui uji statistik Kruskal-Wallis didapatkan perbedaan yang bermakna p=0,000 (p<0,05) dan uji pos hoc Mann-Whitney juga menunjukkan perbedaan yang bermakna pada semua kelompok. Dapat disimpulkan bahwa semakin tinggi konsentrasi pemajanan Cd terhadap homogenat hepar maka semakin tinggi pula peningkatan kadar glukosa pada hepar tikus.
Effects of Solo Garlic Extract in Decreasing Malondialdehyde (MDA) Levels due to E-Cigarette Exposure Duwairoh, Aliefia Meta
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

The popularity of E-Cigarette has increased significantly over the last decade, and has potential to replace tobacco cigarettes. Aerosol which is produced by E-Cigarette, contains reactive carbonyl and free radicals, inducing oxidative stress and causing inflammation, proliferation, and cell damage. This oxidative stress can be seen through the Malondialdehyde (MDA) levels in the body, and reduced by antioxidant activity in Solo Garlic extract. The aim of this study is analyzing the differences of MDA levels in four treatment groups. 28 white rats were divided into four groups and three of them were exposured by E-Cigarette. This study showed that the highest MDA levels was found in the group which was exposured by E-Cigarette without solo garlic extract (7,179 nmol/ml). MDA levels can be reduced by antioxidant activity shown in the group which was exposured by E-Cigarette and solo garlic extract dose 0,05 gram/day (the smallest dose), amount 3,715 nmol/ml. The average of MDA levels in group which was given by the smallest dose of solo garlic extract, is lower than the control group. So, it can be concluded that using solo garlic extract less than 0,05 gram/day can restore MDA levels to a normal state (4,210 nmol/ml).
EKSTRAK BAWANG PUTIH SIUNG TUNGGAL TERHADAP AKTIVITAS ENZIM LIPOPROTEIN LIPASE PADA TIKUS HIPERKOLESTEROL Brouwer, Juliana Veronica
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

Hiperkolesterolemia merupakan suatu keadaan dimana kadar kolesterol didalam darah mengalami peningkatan diatas angka rata-rata nilai normal yang telah di tetapkan secara standar. Terapi herbal tradisional merupakan terapi alternatif yang dapat digunakan untuk mencegah dan menurunkan kadar trigliserida di dalam darah. Salah satu pilihan terapi yang digunakan adalah bawang putih siung tunggal (Allium Sativum Linn.). Bawang putih siung tunggal memiliki kandungan antioksidan yang kuat yaitu flavonoid, apabila dengan rutin mengkonsumsinya dapat menurunkan kadar trigliserida didalam darah sehingga resiko penyakit degeneratif dapat dikurangi. Flavonoid adalah senyawa golongan polifenol. flavonoid memiliki kemampuan sebagai antikolesterol. Flavonoid bekerja pada banyak enzim dalam pembentukan kolesterol atau trigliserida, salah satunya adalah enzim lipoprotein lipase. Sehingga, apabila aktivitas enzim lipoprotein lipase meningkat, maka proses pembentukan trigliserida melalui mekanisme jalur eksogen di pembuluh darah terhambat sehingga kadar trigliserida dapat menurun. Penelitian ini menggunakan jenis penelitian eksperimental laboratorium dengan design Pre test- Post test Controlled. Menggunakan 5 kelompok dengan masing-masing kelompok menggunakan 5 ekor tikus. uji Paired T-Test  menunjukkan bahwa terdapat perbedaan aktivitas enzim lipoprotein lipase dengan nilai signifikansi (p < 0.05) sedangkan pada uji Manova, nilai signifikansi yang didapatkan adalah (p. < 0.05). Berdasarkan hasil penelitian, dapat disimpulkan bahwa pemberian ekstrak bawang putih siung tunggal dapat meningkatkan aktivitas dari enzim lipoprotein lipase.
PROFIL TRAUMA TORAKS DI RUANG RAWAT INAP BEDAH RSUD GAMBIRAN PERIODE MARET 2017 – MARET 2018 Handoyo, Christophorus Nicholas
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

Trauma menjadi masalah kesehatan masyarakat yang utama di seluruh dunia karena dikaitkan dengan morbiditas dan mortalitas yang tinggi baik di negara maju dan berkembang. Trauma toraks terjadi hampir pada 50% dari semua kecelakaan dan menjadi penyebab penting kematian. Penelitian ini bertujuan untuk mendapatkan data tentang trauma toraks di ruang rawat inap bedah RSUD Gambiran Kediri periode Maret 2017 – Maret 2018. Jenis penelitian ini adalah deskriptif retrospektif dengan menggunakan semua jumlah kasus trauma torak sebanyak 31 pasien dari 545 pasien trauma bedah yang membutuhkan rawat inap. Hasil penelitian mendapatkan kasus trauma toraks paling banyak ialah fraktur iga (29%) yang terjadi pada jenis kelamin laki-laki (93,5%) dan kelompok usia 46-60 tahun (35,5%). Penyebab tersering adalah kecelakaan lalu lintas (80,6%) sedangkan penanganan paling banyak dilakukan ialah penanganan konservatif (100%). Durasi rawat inap pasien trauma toraks paling sering sekitar 1-3 hari (58,1%) dengan hasil akhir trauma toraks yang didapat umumnya sembuh (93,6%).
The Effect of Melinjo Peel Extract in Activity of Lipoprotein Lipase Enzym of The Rats Fed a Hypercholesterolemia Diet Demitri, Athira
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

The intake of saturated fat and cholesterol that comes from food digested in the intestine resulting in free fatty acids, triglycerides, phospholipids, and cholesterol. Triglyceride levels increased can be caused by presence of impaired lipoprotein lipase (LPL) enzyme activity. LPL activity can be increased by flavonoid in plant, like Melinjo peel. The purpose of this study is to measure LPL enzyme activity before and after being given extract of Melinjo peel treatment. This research use true experimental, with study design of pretest posttest control group design. Hypercholesterolemic diet given to rats by oral gavage as much as 1,8 grams for 14 days. Melinjo peel extract were given by oral gavage for 14 days after the hypercholesterolemic diet is given. Statistical analysis used Paired Sample T-Test to compare lipoprotein lipase activity before and after treatment. Then, used MANOVA (Multivariate Analyses of Variance) to see the difference of lipoprotein lipase activity in each group after treatment.Based on statistical analysis showed that there were differences of lipoprotein lipase activity in the hypercholesterolemic diet group, HD+54.15, HD+108.30, and HD+216.60 before and after treatment significant (p. < 0.05). The activity of lipoprotein lipase in the normal diet group compared with the hypercholesterolemic and HD+216.60 group showed a significant difference (p. < 0.05). Melinjo peel extract can increased activity of lipoprotein lipase enzym after treatment, those can be due to the flavonoid in Melinjo peel extract.
Efek Abelmoschus esculentus terhadap Glukosa Darah, Superoksida Dismutase, dan Malondialdehid Rattus norvegicus Diabetes Melitus dengan Induksi Streptozotocin Herliani, Olivia
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

In diabetes mellitus there is an increase in oxidative stress in which oxidants exceed the antioxidant system resulting from the production of oxidant-antioxidant imbalance and/or limited antioxidant defenses. Abelmoschus esculentus (“okra”) is known as lowering blood glucose vegetable by Indonesian. A. esculentus has a high antioxidant activity that can: 1) lower H2O2 level; 2) decrease the amount of ROS; 3) lower •OH level. This study tried to prove that administration of A. esculentus may decrease fasting blood glucose, serum malondialdehyde, and increase superoxide dismutase activity of diabetic male white rats. This research is a pure experimental research, with randomized post test only control group designs, held in 28 days. Thirty one rats were divided into 4 groups randomly: KN = normal control group given 0.1% Na-CMC solution; KDM = DM control group injected with STZ, followed by 0.1% Na-CMC solution; P1 = treatment group 1 injected with STZ, followed by administration of A. esculentus at a dose of 775 mg/kgBW/day; P2 = treatment group 2 injected with STZ, followed by administration of A. esculentus at a dose of 1550 mg/kgBW/day. The result: administration of A. esculentus at doses of 775 mg/kgBW/day and 1550 mg/kgBW/day can not decrease fasting blood glucose and MDA serum level of diabetic male white rats. Giving A. esculentus at a dose of 1550 mg/kgBW/day may increase the activity of SOD erythrocytes of diabetic male white rats.. Conclusions: A. esculentus has the potential to lower blood glucose and MDA serum levels, also increase erythrocyte SOD activity.
Disease Patterns in The Baksos Service Community to Improve Efficient ad Better Quality Soesanto, Danoe
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

Recently there are still many community organizations, educational institutions and political organizations conducting free medical service activities, the purpose of that activities varying depend on the organization. The purpose of this study was to described the implementation and outcomes (the number of people served, gender, characteristics of age and what diseases is the most) that activities, Methods of This study was  a non-experimental research, researcher just observed the subject without  manipulated or intervention. Result of this study was found the number of women 57.71% and the late adult age to > 65 years old more served during social health service activities, whereas most types of diseases were myalgia 24.09% and hypertension 22.40%. Free medical service activities activity still needed by society but for management of non communicable disease need to reevaluated especially problem of monitoring result of treatment and preventive action which can be done but more cost effective compared with curative action. Further research needed about benefit, the impact and effectiveness of charity medical care activities and the cost comparisonbetween curative efforts and preventive efforts in dealing with hypertension.
Jalur Sinyal dan Metabolisme Endocannabinoid: Tinjauan Pustaka Raharjo, Loo Hariyanto; Agusaputra, Harman
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 8, No 1 (2019): EDISI MARET 2019 (available online since April 2019)
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (548.615 KB) | DOI: 10.30742/jikw.v8i1.574

Abstract

Efek biologis dari tumbuhan Cannabis Sativa dimediasi oleh dua buah reseptor dari kelompok G-protein coupled receptor; reseptor cannabinoid 1 (CB1R) dan 2 (CB2R). CB1R lebih banyak didapatkan pada Susunan Saraf Pusat dan berhubungan dengan pemberian terapi pada gangguan neuropsikologis dan penyakit neurodegeneratif. Selain itu endocannabinoid juga memodulasi jalur tranduksi sinyal dan menimbulkan efek pada jaringan perifer. Meskipun cannabionoid memiliki efek terapeutik, tetapi efek psikoaktifnya menyebabkan terbatasnya penggunaan endocannabionoid dalam praktek klinis. Namun kemajuan terkini dalam distribusi fisiologis dan pengaturan fungsional dari endocannabinoid memungkinkan adanya penelitian eksploitasi penggunaan endocannabionoid sebagai bahan terapeutik serta pengembangan obat baru dengan keunggulan farmakologis. Pada tinjauan pustaka ini, kami meninjau secara singkat tentang jalur metabolik dan jalur transduksi sinyal dari dua endocannabionoid utama; Anandamide (AEA) dan 2- arachidonoyglycerol (2-AG) yang mempunyai potensi terapeutik. 
Insiden dan Etiologi Kelumpuhan Saraf III, IV dan VI yang disertai Diplopia Binokuler di RSUD DR. Wahidin Sudirohusodo Dhany, Rini Kusumawar; Tanjung, Yunita; Jennel, Farren
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 8, No 2 (2019): EDISI SEPTEMBER 2019 (available online since Oktober 2019)
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (748.806 KB) | DOI: 10.30742/jikw.v8i2.480

Abstract

The purpose of this study is to determine the incidence and etiology of III, IV and VI nerve paralysis with binocular diplopia in RSUD dr. Wahidin Sudiro Husodo General Hospital Mojokerto. Method of this study was descriptive study using secondary medical record data. Incidence rates are adjusted for age and sex distribution of the population. The mean age of onset was 45.6 years, seven male subjects (58.3%) and five female subjects (41.7%). We identified 12 cases of acquired III, IV and VI nerve palsy over a 4-year period. The most common cause of binocular diplopia was sixth nerve palsy (33.3%), 3 patients experienced partial third nerve palsy (25%), one patient with third nerve palsy with pupil sparing (8.3%). Most common etiology was microvascular (58,3%), neoplasms (16.7%), aneurysms (8.3%) trauma (8.3%), and post meningioma neurosurgery (8.3%). Six patients (50%) with microvascular third nerve palsy had diabetes mellitus, while 1 patient (8.3%) had grade 2 hypertension. The most common cause of binocular diplopia was VI nerve palsy. Risk factors such as hypertension and diabetes mellitus which have a significant effect on diplopia. Patients with N. III, IV and VI palsy need to be done early MRI examination so that complications and progression can be prevented.
Bell's Palsy Adam, Olivia Mahardani
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 8, No 1 (2019): EDISI MARET 2019 (available online since April 2019)
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (941.311 KB) | DOI: 10.30742/jikw.v8i1.526

Abstract

Bell?s palsy didefinisikan sebagai kelumpuhan saraf fasialis satu sisi, dengan penyebabnya tidak diketahui. Beberapa keadaan lain juga dapat menyebabkan kelumpuhan fasialis, misalnya tumor otak, stroke, myasthenia gravis, dan penyakit Lyme. Namun, jika tidak ada penyebab khusus yang dapat diidentifikasi, kondisi ini dikenal sebagai Bell?s palsy yang disebabkan akibat pembengkakan dan tekanan saraf pada foramen stylomastoid dan menyebabkan penghambatan atau kerusakan saraf. Seringkali mata di sisi yang terkena tidak dapat ditutup, lipatan nasolabial dan garis dahi menghilang. Kortikosteroid ditemukan untuk memperbaiki hasil ketika digunakan lebih awal, sementara obat anti-virus belum. Banyak yang menunjukkan tanda perbaikan 10 hari setelah onset, bahkan tanpa pengobatan. Artikel ini bertujuan untuk mengulas Bell?s palsy terutama patofisiologinya. Tingkat keparahannya syaraf menentukan proses penyembuhan Bell?s palsy. 

Page 12 of 39 | Total Record : 390

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