cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
jurnalkedokteranuwks@gmail.com
Editorial Address
Dukuh Kupang XXV/54 Surabaya, Medical Faculty University of Wijaya Kusuma Surabaya, Building C, 2nd Floor C216.
Location
Kota surabaya,
Jawa timur
INDONESIA
Jurnal Ilmiah Kedokteran Wijaya Kusuma
Published by Universitas Wijaya Kusuma Surabaya
ISSN : 19782071     EISSN : 25805967     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
Jurnal Ilmiah Kedokteran Wijaya Kusuma (JIKW) is a periodically scientific publication that contains articles written in Indonesia or english. JIKW receive articles in the scope of Biomedical Sciences, degenerative diseases, infections, congenital abnormalities and public health. JIKW published twice a year. The articles will be published in JIKW only manuscript that has never be published or published in other journal. Writers who will publish the article please follow the JIKW guidelines. The entire management process both admission and review the article is done by online.
Arjuna Subject : -
Articles 390 Documents
 9   10   11   12   13 
The Effect of Spider (Menemerus Bivittatus) Silk Protein Topically Administration for Healing of Incision wound on (Rattus Norvegicus) Strain Wistar Alfaris, Muhammad Yusak; Mansyur, Mas
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 6, No 1 (2017): Edisi Maret 2017
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The healing of wounds is a natural process of the human body but often medicine is used, for example the use of spider silk. The purpose of this research is to know the effect of the use of spider (Menemerus Bivittatus) silk protein used topically for the healing of incision wounds in the inflammatory phase. This research is a laboratory experiment. The subjects of this research are 18 wistar rats (Rattus Norvegicus strain) that are treated in two different ways. The first is control (K1) with the use of normal saline and the second is treatment (Pl) with the use of spider silk protein topically using wound dressing. The selection of samples is done randomly using the simple random sampling. The hypothesis testing uses the Chi Square testing with α = 0.05. The results of this research shows that the use of spider silk protein topically effects the process of incision wound healing (0,005) in the inflammatory phase (0,000) on Wistar rats.
Pharmacogenomics Statins: Biomarkers for Clinical Prediction Suprapti, Herni
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Statins are the most widely prescribed drug for hyperlipidemic therapy and for the prevention of Cardiovascular disease. But although statins are very effective for the prevention of atherosclerosis, there are still patients with CVD. In this case, it is thought to be the influence of genetic factors. There is a static gene link to statin dose required for therapy, but there are still no relevant pharmacogenomic tests for statin therapy guidelines. This article describes basic pharmacogenomic terminology, genes (CETP, HMGCR, SLCO1B1, ABCB1, and CYP3A4 / 5), and progression of statin pharmacogenomic biomarkers for predicted therapeutic outcomes.
Effect Of C-Phycocyanin on Soluble Globoprotein Content (Sgp130) on Trophoblas of Interleukin-6 (Il-6) Wistar Rat Haryanti, Elizabeth; Gondo, Harry K
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 6, No 1 (2017): Edisi Maret 2017
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The placenta is a joint organ of the uterus surface mother and fetus. One of cytokines of the placenta is IL-6 which is essential for normal placental development and successful pregnancy. Sgp130 binds Interleukin-6-sIL-6R complex, so Interleukin-6 signal cannot be passed on. Both factors play an important role in pre-eclampsia which has high levels of IL-6 and sgp130. They are expected to be suppressed by administration of C-phycocyanin. The aim of this study to prove effect of C-phycocyanin on sgp130 levels among wistar rats’ trophoblasts exposed to IL-6. The design of the study was Experiment, Post Test Only Control, analyse with One way Anova. The samples were 25 rats divided four treatment groups. Dose of C-Phycocyanin (10mg, 20mg, 40mg). The results significant difference between control and treatment group IL-6, IL-6 + CPC10, IL-6 + CPC20. But there was no significant difference between control group and IL-6 + CPC40, sig value. 0.214 (sig. <0.05). Conclusion. There is an effect of C-Phycocyanin on Sgp130 levels in wistar rats’ trophoblasts exposed to IL-6 at a dose of C-Phycocyanin 40mg.  
Aktivitas Ekstrak Kulit Mahkota Dewa (Phaleria macrocarpa) Sebagai Teraupetik Diabetes Mellitus Terhadap Glukosa Darah, Leukosit Dan Hemoglobin Pada Tikus Yang Diinduksi Aloksan Candrarisna, Miranti; Kurnianto, Ady
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tujuan Penelitian ini adalah untuk mengetahui efektifitas ekstrak kulit mahkota dewa sebagai terapeutikadiabetes mellitus tipe 1 terhadap profil leukosit dan hemoglobin pada tikus yang diinduksi aloksan. jenis penelitian ini eksperimental dengan menggunakan Rancangan Acak Lengkap (RAL). Sampel Hewan yang digunakan adalah tikus jantan umur 5-6 minggu sebanyak 24 ekor. Kelompok tikus dibagi menjadi tiga kelompok, yaitu kelompok kontrol negatif (diinduksi aloksan 0,2 ml/ip tanpa diobati/P0), kontrol positif: diinduksi aloksan 0,2 ml/ip dan diobati syrupus ekstrak kulit buah mahkota dewa 50% diberikan 1 kali sehari (P1), diinduksi aloksan 0,2 ml/ip dan diobati syrupus ekstrak kulit buah mahkota dewa 50% sebanyak 2 kali sehari (P2). Semua tikus diberikan perlakuan pengobatan kulit buah mahkota dewa 50% selama 10 hari. Pengamatan dilakukan pada hari ke-0, 5, 10. Parameter pengamatan adalah kandungan senyawa aktif tanaman, kadar glukosa darah, profil leukosit (neutrofil, basofil dan eusinofil) dan hemoglobin. Semua data yang diperoleh, dilakukan analisis statistik dengan menggunakan ANOVA dengan taraf kepercayaan 95% (=0,05). Hasil statistik menunjukkan bahwa pada tikus yang diobati syrupus kulit buah mahkota dewa 50% 2 kali sehari (P2) menunjukan hasil yang paling baik daripada kelompok P0 dan P1.Analisis statistik menunjukkan Fhitung > F tabel berarti terdapat perbedaan yang signifikan antara kelompok P2 dengan P0 dan P1 terhadap penurunan glukosa, peningkatan profil leukosit, dan nilai hemoglobin yang normal. Hasil  penelitian ini menunjukan bahwa aktifitas  syrupus kulit buah mahkota dewa50% yang diberikan dua kali sehari paling efektif digunakan sebagai terapeutika diabetes mellitus tipe-1 pada tikus putih yang diinduksi aloksan.
Pengaruh Pemberian Ekstrak Alga Merah (gracilaria verrucosa) terhadap Aktivitas SGPT pada Tikus Putih (rattus norvegicus) Jantan Galur Wistar yang Diinduksi Parasetamol Dosis Tinggi Fikri, Akbar Maharudin; Tehupuring, Sihning EJ
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Administration of high dose paracetamol may increase the metabolic pathways that produce N-acetyl-p-benzoquinonimin (NAPQI). NAPQI is a reactive substance, resulting liver tissue damage and increase SGPT activity. Red algae extract contains flavonoids that act as antioxidants.Objectives: This research aimed to determine the effect of red algae (Gracilaria verrucosa) extract to the activity of serum glutamic pyruvic transaminase (SGPT) in male Wistar rats (Rattus norvegicus) induced by high dose paracetamol.Methodology: This research used 24 animal of Male Wistar rats. These rats were divided into 3 groups: 1) group of rats fed with standard food; 2) group of rats given paracetamol 1750 mg/kg on day 10; and 3) group of rats given red algae extract 200 mg/kg/day on day 1-11 and paracetamol 1750mg/kg on day 10. On day 11, all rats were sacrificed and SGPT activities were measured by spectrophotometry method.Result: Mann-Whitney test results showed significant difference (p = 0.021) between SGPT activity of group of rats fed with standard food (=81.95±10.103 U/L) and group of rats induced by high dose paracetamol (=97.06±11.19 U/L). Furthermore, there was significant difference (p = 0.016) between SGPT activity of group of rats induced by high dose paracetamol (=97.06±11.19 U/L) and group of rats induced by high doses of paracetamol and fed with red algae extract (=82.73±11.233 U/L).Conclusion: The conclusion of this research showed that high dose paracetamol significantly increased SGPT activity and red algae extract significantly decreased SGPT activity because it contains flavonoids that act as antioxidants.
Correlation of Tumor Marker Cancer Antigen (CA-125) against Hemoglobin, Leucocytes, and Platelet Lymphocyte Ratio in Ovarian Cancer Patients at RSUD ULIN Banjarmasin sabarudin, hermin
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

CA-125 is the most commonly used tumor marker in ovarian cancer, its known as the "Gold Standard" for the diagnosis of ovarian cancer. CA-125 allegely related to the inflammatory mechanisms which associated with leukocytes and lymphocytes, as well as Lymphocyte Platelet Ratio. This study is to prove above hypothesis. The objective is to investigate CA-125 correlation as tumor marker of inflammatory hematology examination which consisting of Hemoglobin, leucocytes and PLR as indicator of inflammatory examination in ovarian cancer patient. The method is an observational analytic study with cross sectional retrospective descriptive. The sample is 42 patients medical record who are treated in Oncology Polyclinic RSUD ULIN in October 2014 - October 2017 period. Samples selected by time limitation method. Sampling technique using nonpropability method followed by purposive sampling method. After the data is taken and selected then processed into SPSS for normality test and continued by multiple linear regression test. The results showed that correlation analysis of CA-125 tumor marker on Hb, leukocyte and PLR levels was P = 858b; P value <0.05. The CA-125 relationship to Hb, leucocytes and PLR is a negative relationship (r Hb = -3,463, r leukocytes = -6,117, r PLR = -2.281), which means that more high the Hb, leukocyte and PLR value, conversely CA125 value become more low. The conclusions of this study is there no correlation of CA125 tumor marker against Hb, leucocytes and PLR in ovarian cancer patients. The results of this study indicate that the increasing of CA125 value is negative correlation because it is not followed by decreasing of Hb, increasing of leukocyte and PLR. 
Pengaruh Pemberian Jus Buncis (Phaseolus Vulgaris Linn) Terhadap Kadar Malondialdehide Tikus Model Stres Psikologis oktaviasari, dianti ias
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Psychological stress is often suffered by people with body rhythm disorders, one of whom is a person with sleep disorders upside down. Psychological stress can trigger oxidative stress. Oxidative stress can be overcome by increasing antioxidants, beans as antioxidants are considered to reduce oxodative stress. The objective of the study was to examine the effect of green bean juice on the levels of Malondialdehyde (MDA) in male white wistar strains exposed to psychological stress. The design used in this research is Randomized Post Test Only Group Design. There were 5 groups tested, 2 normal and stress control groups, and 3 treatment groups. Exposure to psychological stress with reverse sleep guard pattern, so that the condition of experimental animals experiencing oxidative stress, then given bean juice with a dose of 4.5 gr / 1 ml in the treatment group. The results showed MDA levels dropped in the first hour and remained down until the 24th hour after the provision of bean juice. The effect of antioxidant flavonoids on beans decreases the amount of free radicals by scavenging mechanisms in free radicals and increases levels of endogenous antioxidants and increases insulin levels. The role of arginine in beans acts as a precursor of the formation of Nitric Oxide (NO) as vasodilator of blood vessels so as to decrease oxidative stress. A single dose of bean juice in experimental animals has been shown to overcome oxidative stress due to exposure to psychological stress since the first hour of green bean juice and its antioxidant activity persisted until the 24th hour.
Pengaruh Pemberian Teh Hijau (Camellia Sinensis) Terhadap Aktivitas Superoksida Dismutase (SOD) Mukty, Marifat Istiqa
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Stres oksidatif dapat dipicu oleh paparan stres psikologis. Stres oksidatif dapat dikurangi dengan konsumsi zat antioksidan eksogen, teh hijau dianggap mampu menurunkan stres oksidatif. Tujuan penelitian ini untuk menguji pengaruh pemberian seduhan teh hijau terhadap glukosa darah, MDA dan aktivitas SOD pada tikus putih jantan Strain Wistar yang dipapar stres psikologis. Rancang bangun yang digunakan pada penelitian ini adalah Randomized Post Test Only Group Design. Terdapat 5 kelompok tikus, 2 adalah kelompok kontrol normal dan kelompok kontrol stres, serta 3 kelompok perlakuan. Sebelumnya tikus diberikan stres psikologis 1 x 24 jam berupa gangguan pola tidur jaga, sehingga didapatkan kondisi hewan coba yang mengalami stres oksidatif, kemudian dilakukan pemberian seduhan teh hijau pada kelompok perlakuan dengan dosis tunggal 3,6 ml/ekor pada jam ke-1 pada kelompok perlakuan 1, jam ke-6 pada kelompok perlakuan 2 dan jam ke-24 pada kelompok perlakuan 3. Analisis statistik menggunakan uji Manova. Hasil Berdasarkan analisis statistik menunjukkan bahwa terdapat perbedaan glukosa darah, dimana kelompok perlakuan menurun setelah jam ke-1 pemberian seduhan teh hijau, dan tetap bertahan di jam ke-6 dan ke-24, begitu pula dengan MDA, kelompok perlakuan menurun setelah jam ke-1 pemberian seduhan teh hijau, dan tetap bertahan di jam ke-6 dan ke-24. Sedangkan aktivitas SOD meningkat pada jam ke-1, kembali meningkat pada jam ke-6 dan meningkat maksimal pada jam ke-24 setelah pemberian teh hijau. Dosis tunggal seduhan teh hijau pada hewan coba yang mengalami stres oksidatif terbukti dapat menetralisir stres oksidatif pada jam ke-1 setelah pemberian teh hijau dan aktivitas antioksidannya masih bertahan sampai 24 jam.
Effect Administration of Ethanol Extract of Bitter Melon (Momordica Charantia L.) On The Reduction of MDA (Malondialdehyde) Levels Serum in Rats Given a High-Fat Diet Andiani, Andiani; harsa, made subhawa
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hyperlipidemia is a disease whichthe effect in increased fat levels in the blood. In hyperlipidemia, the condition of high oxidative stress is obtained due to the oxidation process of LDL (Low Density Lipoprotein) in the body, this condition showed by increased of MDA (Malondialdehyde) levels in serum. Bitter melon (Momordica Charantia L.) contains a lot of active ingredients, one of the ingredients of bitter melon that is thought to have antilipidemic effects is flavonoid compounds. This study was experimental study using a randomized posttest only control group design study with a sample size of 30 male white rats (Rattus norvegicus) wistar strain which was divided into 3 groups, namely K1, K2, and K3. In each group, different treatments are given. Negative control group (K1), given standard feed, water ad libitum; Positive control group (K2), given standard feed, high fat feed with a dose of 2.5 ml water ad libitum; The treatment group (K3) was given a standard diet, high-fat feed with a dose of 2.5 ml water ad libitum and extract of bitter melonat a dose of 250 mg / kg BB by orally every morning for 3 weeks. Data analysis using One Way Anova Test. From the results of the test shows the significance of p-value = 0.000 which is <α (0.05). The results showed that there was an effect of  administration ethanol extract of bitter melon (Momordica charantia L.) to decrease in serum MDA (malondialdehyde) levels in male white wistar rats (Rattus norvegicus) given a high-fat diet.
Water Clover Extract in Liprotein Lipase enzyme Activity of The Rats with High Cholesterol Diet hayudanti, dewinta
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hypertriglyceridemia or high blood triglyceride levels is one of the lipid fraction disorders associated with an increased risk of cardiovascular disease. Flavonoids has an important role as cardioprotection by lowering triglyceride levels. The flavonoids in water clover contain 10,71 mg of extract. This research aims to prove that flavonoids can increase Lipoprotein Lipase enzymes activity. True experimental study used design pre-post test control group design in rats. The sample was selected based on by completed randomized design sampling to be devided into five groups, the control positive (n=5) were only given normal diet, control negative (n=5) were only given high cholesterol diet and treatment groups with three doses (n=15) were given cholesterol diet during the 7 days and water clover extract that intervention during the 14 days. The results of this research can increase activity of Lipoprotein Lipase enzymes as an influence of water clover extract based on Paired T-Test, before and after treatment there was a significant different (p<0.05). Activity of Lipoprotein Lipase enzymes in the negative control group and third treatment showed a significant difference (p.< 0.05) based on MANOVA (Multivariate Analyses of Variance). Conclusions of this research is water clover extract affecting increase Lipoprotein Lipase enzymes activity significantly.

Page 11 of 39 | Total Record : 390

 9   10   11   12   13 

Filter by Year

2009 2025


Reset
Filter By Issues
All Issue Vol 14, No 1 (2025): EDISI MARET 2025 Vol 13, No 2 (2024): September 2024 Vol 13, No 1 (2024): March 2024 Vol 12, No 2 (2023): September 2023 Vol 12, No 1 (2023): March 2023 Vol 11, No 2 (2022): EDISI SEPTEMBER 2022 Vol 11, No 2 (2022): SEPTEMBER 2022 Vol 11, No 1 (2022): Edisi Maret 2022 Vol 11, No 1 (2022): MARET 2022 Vol 10, No 2 (2021): SEPTEMBER 2021 Vol 10, No 1 (2021): MARET 2021 Vol 9, No 1 (2020): MARET 2020 available online since April 2020 Vol 9, No 2 (2020): SEPTEMBER 2020 Vol 8, No 2 (2019): EDISI SEPTEMBER 2019 (available online since Oktober 2019) Vol 8, No 1 (2019): EDISI MARET 2019 (available online since April 2019) Vol 7, No 2 (2018): Edisi September 2018 Vol 7, No 2 (2018): Edisi September 2018 Vol 7, No 1 (2018): edisi Maret 2018 Vol 7, No 1 (2018): edisi Maret 2018 Vol 6, No 2 (2017): EDISI SEPTEMBER 2017 Vol 6, No 1 (2017): Edisi Maret 2017 Vol 6, No 1 (2017): Edisi Maret 2017 Vol 5, No 2 (2016): Edisi September 2016 Vol 5, No 2 (2016): Edisi September 2016 Vol 5, No 1 (2016): Edisi Maret 2016 Vol 5, No 1 (2016): Edisi Maret 2016 Vol 4, No 2 (2015): Edisi Desember 2015 Vol 4, No 2 (2015): Edisi Desember 2015 Vol 4, No 1 (2015): edisi September 2015 Vol 4, No 1 (2015): edisi September 2015 Vol 3, No 2 (2014): edisi Oktober 2014 Vol 3, No 2 (2014): edisi Oktober 2014 Vol 3, No 1 (2014): Edisi Maret 2014 Vol 3, No 1 (2014): Edisi Maret 2014 Vol 2, No 1 (2013): Edisi Mei 2013 Vol 2, No 1 (2013): Edisi Mei 2013 Vol 1, No 2 (2012): Edisi Oktober 2012 Vol 1, No 2 (2012): Edisi Oktober 2012 Vol 1, No 1 (2012): Edisi Juli 2012 Vol 1, No 1 (2012): Edisi Juli 2012 Vol 2, No 1 (2011): Volume II, Nomor 1, Januari 2011 Vol 2, No 3 (2011): Volume Edisi Khusus Desember 2011 No 1 (2011): Edisi Juli 2011 Vol 2, No 1 (2010): Edisi Januari 2010 Vol 2, No 1 (2010): Edisi Januari 2010 2009: edisi khusus Desember 2009 2009: edisi khusus Desember 2009 More Issue