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Jurnal Farmasi Sains dan Komunitas

JFSK
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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 7 Documents

Search results for , issue "Vol 17, No 1 (2020)" : 7 Documents clear

STUDY OF PEAK EXPIRATORY FLOW RATE AMONG VEGETABLE FARMERS USING PESTICIDES IN BOYOLALI DISTRICT, CENTRAL JAVA, INDONESIA Manggala Sariputri; Ari Probandari; _ Hartono; Eti Poncorini Pamungkasari; Isna Qadrijati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

Pesticides exposure affects respiratory system. The study of peak expiratory flow rate (PEFR) as a parameter of lung function changes due to limited pesticide among farmers. This cross-sectional study aims to analyze factors affecting PEFR and formulate a model for predicting PEFR among 76 vegetable farmers using pesticides in Tlogolele Village, Boyolali Regency. Data were collected through questionnaire-based interview and clinical examination. PEFR test was conducted using a peak flow meter while cholinesterase level was investigated using Deutsche Gessellschaftfur Klinische Chemie method. The data were analyzed using unpaired T-test and Pearson test continued by multivariate regression models. The examination showed 75% of subjects had abnormal PEFR. Cholinesterase, body mass index, smoking habits, personal protective equipment usage, pesticide dosage, length of work per day, and last time of spraying did not show a significant correlation with PEFR. On the other hand, age, height, weight, frequency of spraying, and spraying duration showed a significant correlation with PEFR and a prediction equation for PEFR model was obtained as R2=0.268 (p0.001). The developed model will be useful for early detection of abnormal lung function.

HERBS USED AS ANALGESIC BY DAYAK TRIBE IN NORTH KALIMANTAN INDONESIA Irma Novrianti; Faizal Mustamin; Suharjono Suharjono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

Traditional medicines produced from medicinal plants have played an important role in disease treatment in Dayak Tribe, North Kalimantan. Northern Kalimantan belongs to a remote area where health facilities like healthcare center (puskesmas pusat kesehatan masyarakat) and hospital are not easily accessible. This research aims to investigate herbs used by Dayak tribe in North Kalimantan for treating pain. It is a descriptive research applying two research methods i.e. observation and interview. We directly observed the research object and proposed questions to respondents that were traditional healers from each village. The research was conducted in nine villages within three regencies in North Kalimantan. Meanwhile, 38 herbs collected in this research were from 26 families and 34 species. Four species were still locally named. The highest proportion of the herb family used was Asteraceae. The most frequently used part of the herb for medicine was the leaf (60.53%). The main serving methods were by boiling the herb and drinking it (63.15%). Bone pain and stomachache were two main illnesses mostly treated by local herb therapy involving 11 herbs. In conclusion, Dayak tribe in North Kalimantan still used herbs to treat their pain.

THE EFFECT OF TEMPEH EXTRACT GEL ON WOUND HEALING IN DIABETES RAT: OVERVIEW OF TISSUE COLLAGEN, WOUND CLOSURE, EPITHELIALIZATION AND CAPILLARIZATION Ignasius Adi Kurniawan; Rini Dwiastuti; Sri Hartati Yuliani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

The development of wound healing preparations in diabetes conditions needs to be done because the wound healing process in the respective conditions requires longer time. The aim of this study is to measure the effect of tempeh extract gel containing genistein on wound healing in diabetes rats by observing the response parameters of collagen expression, wound closure speed, epithelialization, and capillarization of wound tissue. The results of testing wound closure using a base gel treatment, tempeh extract gel 2.5%, 5%, 7.5% and without treatment indicated that the treated groups of tempeh extract gel 5% and 7.5% have significant effect on diabetes wound healing in the tested animals. This indication is strengthened by the results of the non-treatment groups statistical test with the 5% and 7.5% tempeh extract gel treatment which showed significant difference in influencing the wound closure response, epithelialization and collagen formation in tissue. The results of the statistical in group without treatment with the base treatment group without extract gel and tempeh extract gel 2.5% showed no significant difference in influencing the wound closure response, epithelialization and collagen formation. Statistical test results on capillarization responses indicated that the results were not significantly different from all treatment groups.

COMBINATION UV-VIS SPECTROSCOPY AND PARTIAL LEAST SQUARE FOR DETECTING ADULTERATION PARACETAMOL AND PIROXICAM IN TRADITIONAL MEDICINES Pretty Falena Atmanda Kambira; Dion Notario; Untung Gunawan; Sherina Dhamayanti; Raymunanda Widya Kimla Ningrum; Sondang G.O. Ambarita; Grafty Polin
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

An analytical method based on combination UV-Vis spectroscopy and chemometric was developed for detecting commonly listed adulterants such as paracetamol and piroxicam simultaneously in traditional medicines. No complex sample preparation and separation are required except grinding, dissolving, and filtering. The spectral interferences were resolved by multivariate techniques. Wavelengths selection and number of components optimization were performed by a combination of Genetic Algorithm and Partial Least Square (GA-PLS) followed by backward elimination through Jack-Knife Partial Least Square Regression (JK-PLSR). The capability PLSR model for quantitative analysis was assessed from the coefficient of determination (R2) and root mean square of error prediction/cross-validation (RMSEP/RMSECV) dan predicted residual sum of square (PRESS). Classification performance of PLS Discriminant Analysis (PLS-DA) was evaluated from the area under the receiver operating characteristic curve (AUROCC). For ensuring the sensitivity of the method, the detection limits from the two pseudo-univariate lines were estimated. The R2, RMSEP, RMSECV, AUROCC, and detection limit obtained from the selected models of paracetamol and piroxicam were 0.999, 0.25 mg/L, 0.15 mg/L, 100%, and 0.4 mg/L respectively. Therefore, the proposed method is suitable for the rapid screening of adulterated herbal medicine.

THE USE OF INTERNET AND SOCIAL MEDIA FOR DRUG INFORMATION SERVICES IN PHARMACIES IN YOGYAKARTA PROVINCE: A STUDY OF ASTHMA CARE Fajar Ira Juwita; Aris Widayati; Enade Perdana Istyastono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

Industrial revolution 4.0 is the process of digitizing the industry that leds health services in the era of application of Information and Communication Technology (ICT) called e-health. The application of ICT in Pharmacy is known as e-pharmacy. The role of pharmacists in Drug Information Services by utilizing ICTs has an effect on e-health literacy which ultimately supports the success of patient therapy. This is very important for patients with chronic diseases who are receiving treatment for a long time, one of which is asthma patients. Therefore, this study aims to explore pharmacist perceptions regarding the use of the internet and social media for drug information services, with a case study of services in asthma patients. This research is descriptive with a qualitative approach. Data is collected by interviews using an interview guide that has been validated in a professional judgment. Interviews were conducted with pharmacist participants who provided pharmacy services to asthma patients, who were selected purposively in March to July 2019. Data from interviews were transcribed verbatim, then a thematic analysis was performed. Ethical clearance has been obtained under number 945/ C.16/ FK/ 2019. The results of the study mention the use of the internet and social media indicate the potential capabilities of pharmacists in health services and also the challenges of transformation to the role of pharmacists in the e-pharmacy era. This study also mentions the urgency of establishing regulations regarding e-pharmacy that is driven by the violation from the internet and social media use. Improvement of ICT infrastructure in the pharmacy field as well as the pharmacist's contribution on the provision of drug information for chronic diseases, including asthma, are urgently required.

THE INFLUENCE OF B-CYCLODEXTRIN CONCENTRATIONS AS LIGANDS ON INCLUSION COMPLEXES TO INCREASE THE SOLUBILITY OF IBUPROFEN Rahmah Elfiyani; Anisa Amalia; Alvin Integra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

Ibuprofen is a compound with low solubility but high permeability in water. One method to improve the ability of a substance to dissolve in water is through the formation of inclusion complexes. This study aims to obtain ratio between ibuprofen and b-cyclodextrin which results in inclusion complex with an optimal amount of dissolved ibuprofen. The inclusion complex was made using solvent evaporation method with molar ratio variations of 1: 1, 1: 2, 1: 3, 1: 4 and 1: 5. The results of the inclusion complex were characterized by X-ray diffraction, FTIR, SEM, and DTA. The solubility test was carried out using three different media; they are pH solution 7.4; pH solution 1.5; and distilled water. The solubility test results showed no increase on the ibuprofen solubility of the inclusion complex within medium solutions of pH 7.4 and pH 1.5 whereas in aquades medium there was an increase in the inclusion complex solubility compared to pure ibuprofen. Based on the results, it can be concluded that inclusion complex with molar ratio of 1: 1 shows optimal amount of dissolved ibuprofen compared to other ratio variations in aquadest medium.

MOLECULAR DYNAMICS STUDIES OF FULL HUMAN MATRIX METALLOPROTEINASE 9 LIGANDED WITH N-HYDROXY-2-[(4-PHENYLPHENYL) SULFONYL-PROPAN-2-YLOXYAMINO] ACETAMIDE Roy Gunawan Wicaksono; Maywan Hariono; Enade Perdana Istyastono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

The research presented in this article aimed to provide a full quarternary structure of human matrix metalloproteinase 9 (MMP9) enzyme with a ligand in the catalytic site for structure-based virtual screening. The enzyme plays an important role in wound healing of diabetic foot ulcer. By employing the primary structure of the enzyme obtained from UniProt database (UniProt:P14780), the theoretical structure of full apoenzyme of the human MMP9 (PDB:1LKG), the crystal structures of the catalytic domain (PDB:4H3X) and the hemopexin domain (PDB:1ITV) of the human MMP9, homology modeling studies have been performed. The ligand N-2-(biphenyl-4-yl-sulfonyl)-N-2-(isopropyloxy)-acetohydroxamic acid (CC27) or N-hydroxy-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]acetamide (IUPAC version) from PDB:4H3X was embedded in the catalytic site of the enzyme. The modeling made use of the modules of homology modeling in YASARA structure. Subsequently, molecular dynamics (MD) simulations in YASARA structure were performed to examine the stability of the enzyme. The homology model was found stable after 5.05 ns and the lowest energy of the model was found at the 6.40 ns of the MD production run. This lowest energy snapshot was then energetically minimized and analyzed for its applicability for virtual screening. This optimized model was then stored in Mendeley Data (DOI: 10.17632/4gsb4p75gz.1).

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Florentinus Dika Octa Riswanto

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Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

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Daerah istimewa yogyakarta

INDONESIA

Abstract

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Florentinus Dika Octa Riswanto

Contact Email editorial.jpsc@usd.ac.id

Phone -

Journal Mail Official editorial.jpsc@usd.ac.id

Editorial Address Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Florentinus Dika Octa Riswanto

Contact Email
editorial.jpsc@usd.ac.id

Phone
-

Journal Mail Official
editorial.jpsc@usd.ac.id

Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA