cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Florentinus Dika Octa Riswanto
Contact Email
editorial.jpsc@usd.ac.id
Phone
-
Journal Mail Official
editorial.jpsc@usd.ac.id
Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia
Location
Kab. sleman,
Daerah istimewa yogyakarta
INDONESIA
Jurnal Farmasi Sains dan Komunitas
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 13 Documents
 1   2 
Search results for , issue "Vol 20, No 1 (2023)" : 13 Documents clear
The Association Between Medication Adherence and Blood Pressure Control in End-Stage Renal Disease Patients with Hemodialysis Pande Made Desy Ratnasari; Ketut Tia Pran Anggar Yani; Agustina Nila Yuliawati; Anak Agung Ngurah Putra Riana Prasetya
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004141

Abstract

End-Stage Renal Disease (ESRD) is a severe kidney disorder that contributes to an increased risk of mortality in the world. This condition is often related with hypertension. Low medication adherence was affecting uncontrolled blood pressure in ESRD. The research aimed to analyze the association between medication adherence and blood pressure control in ESRD patients. This cross-sectional study with 77 respondents was conducted in September 2020 at the Dialysis Unit of the Private Hospital “X” Buleleng Bali by purposive sampling technique. The respondents must be ≥18 years, diagnosed with ESRD and hypertension, underwent hemodialysis (HD) twice a week, received the same antihypertensive for 3 months, have complete medical record data, and signed the informed consent form. Patients with cognitive impairment, unable to communicate, pregnant or breastfeeding, and received the Erythropoiesis Stimulating Agent (ESA) treatment were excluded. Kruskal-Wallis test was used in data analysis. Most of the patients were 65 years (80.52%), male (70.13%), primary education (57.14%), without complications (57.1%), and duration of illness 5 years (89.61%). Patients were in the high adherence (61.04%) and 66.23% of patients had uncontrolled blood pressure. The association between medication adherence and blood pressure control was not significant (p=0.478). However, these results show that high medication adherence could impact on good blood pressure control.
The Effect of Education Models on Changed Misconceptions About Long-Term Medication Inducing Renal Impairment Vitarani Dwi Ananda Ningrum; Rahma Yuantari; Irwan Nuryana Kurniawan; Devi Wahyuni
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.003888

Abstract

Medication misconceptions become a factor for nonadherence. Education for Posbindu cadres is required as a community empowerment to reduce predispositions to chronic kidney disease caused by medication nonadherence. This quasi-experimental research involved one group pretest-posttest design aiming to compare four education models for Posbindu cadres in PHCs in Yogyakarta with changes in misconceptions about antihypertensives and antidiabetics in long-term use-induced renal impairment. All models employed the cadre smart module with models 3 and 4 involving health-worker collaboration. The added educational media were posters (model 1), leaflets (model 2), and posters-leaflets (model 4). Misconception changes were assessed using a validated questionnaire. Eighty-six female cadres aged 43.7±8.6 years were involved with the majority being at least high-school graduates without hypertension and diabetes mellitus risk factors. Model 3 significantly affected all knowledge domains with discussion and clarification of understanding becoming the strength of the techniques used therein. The results proved the importance of health-worker collaboration in health promotion to increase public knowledge of health and drug use, but varied education media could give no guarantee of improvements in such misconceptions. Interactive techniques through knowledge construction assisted by health-workers, especially for unfamiliar domains among society, are recommended to improve the effectiveness of similar education.
Wound Healing Effectivity of Ageratum conyzoides L. Leaf Ethanolic Extract (Purple Flower Type), Centella asiatica (L.) Urban Leaf Ethanolic Extract, and Astaxanthin Combination Gel Preparation in Diabetic Animal Model Sarah Sahila; Hendy Suhendy; Yedy Purwandi Sukmawan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.003319

Abstract

The diabetic wounds are one of the global burden diseases. In our previous study, Ageratum conyzoides L. leaf ethanolic extract (purple flower type) 10%, Centella asiatica (L.) Urban leaf ethanolic extract 5%, and astaxanthin 0.1% combination gel preparation showed remarkable wound healing effectivity. However, this wound healing effectivity in the diabetic condition is still unknown. There were three groups used, namely negative group (placebo/gel base), positive group (oxoferin/tetrachlorodecaoxide), and test group (Ageratum conyzoides L. leaf ethanolic extract (purple flower type) 10%, Centella asiatica (L.) Urban leaf ethanolic extract 5%, and astaxanthin 0.1%). Each group consisted of three male Wistar rats. We conducted diabetes induction with alloxan (175 mg/Kg BW i.p) and followed by an incision 1.5 cm on the back. All of these groups were given treatment once daily and monitored for 14 days. The results of the study showed the test group indicated significantly better effectivity than positive and negative groups (p0.05). The percentages of the wound healing effectivity of the test, positive and negative groups were 62.74%, 51.77%, and 41.65%, respectively. Ageratum conyzoides L. leaf ethanolic extract (purple flower type) 10%, Centella asiatica (L.) Urban leaf ethanolic extract 5%, and astaxanthin 0.1% combination gel preparation has excellent potential to be developed as a commercial product to treat diabetic wound conditions..
Gastroprotective Effects of the Combination of Chromolaena odorata L. and Pachyrhizus erosus L. Extracts on Rats with Gastric Ulcer Model Reza Pertiwi; Reza Rahmawati; Aanisah Hanuun; Noval Kurnia Wati; Tesa Pebiani; Ridho Kurnia; Wafa Syahidah; Risky Hadi Wibowo; Doni Notriawan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004521

Abstract

Gastroprotective effects are caused by compounds that can protect the gastric mucosa. Gastroprotective activity provided by plants is due to the presence of a group of secondary metabolite compounds found in the plants. The types of secondary metabolite compounds are flavonoids, tannins, alkaloids and saponins. Chromolaena odorata L. contains tannins, phenols, flavonoids, saponins and steroids, while Pachyrhizus erosus L. is known to contain flavonoids and saponins. This study aimed to determine the gasprotective activity of the combination of Chromolaena odorata L. and Pachyrhizus erosus L. extracts in ethanol-induced rats by observing the parameters of the number of peptic ulcers, protection ratio, and images of gastric histopathology. The research method was to make a combination of Chromolaena odorata L. and Pachyrhizus erosus L. extracts which were given to six treatment groups: normal group without treatment; negative control group; positive control group given sucralfate; and three groups given a combination treatment of Chromolaena odorata L. and Pachyrhizus erosus L. extract with a dose of 100, 200, and 400 mg/kgBW. Treatment was done by oral administration for 14 days. On Day 14, after one hour of treatment, 96% ethanol induction was given orally at a dose of 2 ml/200 gBW except for the normal group. The ulcer index produced by negative control, positive control, the treatment with doses of 100, 200, and 400 were 4.18; 2.98; 2.49; 1.64; and 0.78, respectively. The combination of Chromolaena odorata L. and Pachyrhizus erosus L. extracts can prevent gastric damage in rats caused by ethanol induction.
Optimization of Stearic Acid and Triethanolamine in The Antibacterial Cream Staphylococcus aureus Ethanol Extract of Papaya Seeds (Carica papaya L.): Factorial Design Method Yakub, Jacinda; Setyani, Wahyuning
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.002396

Abstract

The ethanol extraction of papaya seeds provides a synergistic inhibitory effect on Staphylococcus aureus thorugh alkaloids, flavonoids, tannins and saponins. In this research, the ethanol extract of papaya seeds was formulated in cream preparations and optimized. The optimization of stearic acid as the oil phase and TEA as the water phase resulted in a cream with good physical properties and stability. The parameters used to observe the physical properties and stability of the ethanol extract cream of papaya seeds were organoleptic, homogeneity, pH, centrifugation, viscosity, spreadability, and adhesion. Optimization data analysis using Design Expert 12 free trial. The result of optimization is stearic acid contributed most dominantly to the response to increase viscosity by 73.739% and adhesion by 91.695%, while TEA contributed to the increased in dispersibility by 13.107%. The optimum amount of composition used for stearic acid was 5 grams and TEA was 2 grams. The research showed that inhibitory activity of papaya seed ethanol extract at a concentration of 20% was classified as moderate. However, at concentrations of 40%, 60%, 80%, and 100%, the inhibitory activity is quite strong.
Molecular Dynamics Study of Human MTHFR Wild-Type and A222V Mutant-Type: A Computational Approach Michael Resta Surya Yanuar; Dita Maria Virginia; Enade Perdana Istyastono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005727

Abstract

Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme for the homeostasis and metabolism of intracellular folate. However, it is known that one of the commonly found MTHFR gene SNPs (A222V) causes a decrease in activity which decreases folate levels and increases the accumulation of homocysteine in the blood. The purpose of this study was to investigate the molecular dynamics of MTHFR wild-type protein and MTHFR A222V mutant protein in silico. After some preparations, the crystal structure of MTHFR with code 6FCX obtained from the Protein Data Bank was used as the input file for molecular dynamics (MD) simulations. YASARA-Structure was employed for performing 50 ns production run of MD simulations. The deviation of the root-mean-squared deviation value of the backbone atoms (∆RMSDBb) of MTHFR wild-type is consistently less than 2 Å from the beginning of the MD simulations production runs. On the other hand, there is a sudden spike of ∆RMSDBb of MTHFR A222V from 15.01 to 20.00 ns of 2.221 Å. According to the analysis of ∆RMSDBb, MTHFR wild-type protein is considered stable and the MTHFR A222V mutant protein is considered unstable which may lead to various clinical problems for the person possessing this mutation.
Duration of Zidovudine Consumption Correlates with Anemia in People Living with HIV Danis Pertiwi; Muchlis Achsan Udji Sofro; Tri Indah Winarni; Ari Natalia Probandari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004331

Abstract

Anemia is the most common hematological disorder associated with Human Immunodeficiency Virus (HIV). WHO recommends zidovudine (AZT) as one of the first-line drugs for this infection. It is important to note that the drug has the adverse effect of causing anemia. Therefore, this study correlates AZT consumption duration and the incidence of anemia in HIV-infected individuals. This cross-sectional study was conducted at health service facilities using 213 participants. The data were obtained from medical records, and the assessed parameter was hemoglobin (Hb) level after less or more than a year of zidovudine administration. Furthermore, they were analyzed using a Pearson’s coefficient contingency test (p0.05) to evaluate the correlation between groups with and without anemia at each period of drug administration. The results showed a significant correlation (p0.05) between sex and age with anemia incidence in HIV patients administered AZT. The duration of this drug intake in HIV-infected individuals was correlated with anemia (p= 0.024; OR=0.369). This indicates the use of AZT for at least one year may be a protective factor for the incidence of anemia in patients with HIV compared to the group consuming this drug for less than one year.
Patients with COVID-19 Critical Illness Have a Significantly Higher Systemic Immune-Inflammatory Index on Admission Fenty Fenty; Dita Maria Virginia; I Made Adi Ananda Putra; Devie Kristiani; Lisa Kuniasari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005150

Abstract

The severity of Coronavirus Disease-2019 (COVID-19) has been correlated to the massive inflammatory response. Patients with COVID-19 have a higher inflammatory marker. The Systemic Immune-Inflammation Index (SII) can be considered as an indicator of the immune-inflammatory status. Many studies stated that SII could significantly indicate the severity of COVID-19. This research aimed to explore the admission SII score and its association with the severity of hospitalized patients with COVID-19. It was a cross-sectional observational study. Data were collected retrospectively from the electronic medical records (ERM) and Laboratory Information System (LIS).  The severity of COVID-19 and laboratory data on admission were analyzed. There were 180 patients (49.4% males and 50.6% female) with COVID-19 included in this research. Of these 180 patients, 22. 8% were categorized as mild, 18.9 moderate, 37.2% severe, and 21.1% were critical cases. Patients with critical illness had significantly higher SII scores than other groups with a p-value 0.05. SII on admission could be a noticeable predictor of the occurrence of critically ill COVID-19 patients.
Gold Nanoparticles with Natural Ingredients as Anti-Aging: A Systematic Review Agita Dyah Permatasari; Yandi Syukri; Sista Werdyani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004374

Abstract

Aging is a natural process characterized by physiological skin changes. It starts to appear when individuals are in their thirties, making it necessary to use anti-aging products with natural ingredients which are safe even though the penetration is relatively low into the skin. Natural ingredients that can be used are antioxidants that can inhibit aging and can act as bioreductants on gold nanoparticles. Gold nanoparticles can increase penetration into the target cells because of their small size with large surface area. This review article aimed to collect data relating to the development of gold nanoparticles with natural ingredients as anti-aging agents. This review searched through the PubMed and ScienceDirect databases with such keywords as aging, anti-aging, plant extract, antioxidants, and gold nanoparticles. The inclusion criteria were articles in English, available in a full-text version, and published in the last 10 years. Research on the use of natural ingredients as anti-aging agents found that natural ingredients perform better than chemical comparators. Gold nanoparticles are also reported to have been widely used in anti-aging products. Their activity is even better given the low IC50 value and a higher percentage of inhibition compared to those of the extracts without nanoparticle modification. It is reported that gold nanoparticles with natural ingredients as anti-aging agents have a better effect as opposed to purely natural ingredients.
Development and Evaluation of Microemulsion-Based Sunscreen Cream Containing Lycopene from Tomato (Solanum lycopersicum L.) Ritha Pratiwi; Nandiska Maladjili; Evi Sulastri; Yusriadi Yusriadi; Nuur Aanisah; Armini Syamsidi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.003807

Abstract

This study aimed to formulate and determine the sun protection factor (SPF) of sunscreen made from tomato lycopene microemulsion creams. Lycopene was used as the active ingredient with varying concentrations in each formula, namely F1 5%, F2 7.5%, and F3 9%. The preparation of each formula was evaluated by conducting the globule size, polydisperse index, organoleptic test, homogeneity test, pH test, spreadability test, viscosity test, and determination of SPF value. The average globule size was 119 nm which had a uniform size distribution. The physical characteristics test of the cream preparations showed the three had a bright yellow color and lacked odor. The pH test results were 3.2 ± 0.12, 5.54 ± 0.25, 6.48 ± 0.22 for F1, F2, F3, respectively. Viscosity test results were F1 40,893.33 cPs, F2 41,746.67 cPs, and F3 43,106.67 cPs. The values obtained from the dispersion test were F1 6.71±0.63, F2 5.58±0.15, and F3 4.81±0.11. Moreover, F3 with a concentration of 9% tomato lycopene microemulsion met the acceptance criteria for all of the physical properties including low viscosity to promote good spreadability, pH that does not irritate the skin, aesthetic appeal, small particle size, and non-odorous and an SPF value of 4.9. The obtained microemulsion-based sunscreen cream exhibited a good physical property of lycopene besides showing sufficient SPF value.

Page 1 of 2 | Total Record : 13

 1   2 

Filter by Year

2023 2023


Reset
Filter By Issues
All Issue Vol 22, No 1 (2025) Vol 21, No 2 (2024) Vol 21, No 1 (2024) Vol 20, No 2 (2023) Vol 20, No 1 (2023) Vol 19, No 2 (2022) Vol 19, No 1 (2022) Vol 18, No 2 (2021) Vol 18, No 1 (2021) Vol 17, No 2 (2020) Vol 17, No 1 (2020) Vol 16, No 2 (2019) Vol 16, No 1 (2019) Vol 15, No 2 (2018) Vol 15, No 1 (2018) Vol 14, No 2 (2017) Vol 14, No 1 (2017) Vol 13, No 2 (2016) Vol 13, No 1 (2016) Vol 12, No 2 (2015) Vol 12, No 1 (2015) Vol 11, No 2 (2014) Vol 11, No 1 (2014) Vol 10, No 2 (2013) Vol 10, No 1 (2013) Vol 9, No 2 (2012) More Issue