Article Per Year (5 Year)
p-Index From 2020 - 2025
2.862
P-Index
This Author published in this journals
All Journal Natural Science: Journal of Science and Technology Biocelebes JURNAL PHARMASCIENCE MPI (Media Pharmaceutica Indonesiana) Pharmascience Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Biologi Tropis Adi Widya : Jurnal Pengabdian Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) FIKRAH JURNAL PENELITIAN EKONOMI DAN AKUNTANSI (JPENSI) UMI Medical Journal JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan Fikrah : Journal of Islamic Education Jurnal Pengabdian dan Pengembangan Masyarakat Indonesia Jurnal Pengabdian Masyarakat Bangsa Jurnal Pengabdian Farmasi dan Sains Jurnal Sains dan Kesehatan
Evi Sulastri
Program Studi Farmasi, Fakultas MIPA, Universitas Tadulako, Palu-Sulawesi Tengah
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

Published : 27 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 27 Documents
Search

 1   2   3 
Formulasi Mikroemulsi Ekstrak Bawang Hutan dan Uji Aktivitas Antioksidan Sulastri, Evi; Oktaviani, Cristadeolia; Yusriadi, Yusriadi
JURNAL PHARMASCIENCE Vol 2, No 2 (2015): JURNAL PHARMASCIENCE
Publisher : JURNAL PHARMASCIENCE

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRAKBawang hutan mengandung senyawa metabolit sekunder golongan naftokuinon (elecanacin, eleutherin, elutherol, eleutherinon) yang diketahui memiliki aktivitas antioksidan. Beberapa penelitian telah melaporkan tentang aktivitas antioksidan ekstrak yang diformulasi dalam bentuk sediaan tablet dan krim. Penelitian ini bertujuan mengembangkan formula dalam bentuk  mikroemulsi sebagai penghantaran yang efektif untuk mempertahankan aktivitas antioksidan ekstrak bawang hutan.  Mikroemulsi dibuat dengan menggunakan virgin coconut oil (VCO) sebagai fasa minyak, Tween 80 sebagai surfaktan dan gliserin sebagai kosurfaktan. Uji stabilitas fisik yang dilakukan terhadap sediaan meliputi uji organoleptik, pH, viskositas, sentrifugasi dan ukuran globul. Uji aktivitas antioksidan dilakukan secara in-vitro menggunakan metode peredaman DPPH dan menggunakan asam askorbat sebagai kontrol positif. Data hasil pengukuran dianalisis secara statistik menggunakan metode t-student. Hasil penelitian menunjukkan mikroemulsi dengan tampilan visual yang jernih dan ukuran globul < 5 μm. Meskipun sediaan mengalami perubahan pH dan viskositas tapi tidak terjadi pemisahan fase pada penyimpanan selama 28 hari. Hasil uji aktivitas antioksidan mikroemulsi ekstrak secara berturut-turut pada penyimpanan suhu 33°C dan 40°C: pada hari ke-1 menunjukkan nilai IC50 sebesar 101,167 μg/mL dan 89,956 μg/mL  sedangkan hari ke-35 sebesar 127,254 μg/mL dan 101,996 μg/mL. Berdasarkan hasil tersebut, aktivitas antioksidan ekstrak bawang hutan masuk dalam kategori kuat sampai sedang. Kata kunci  : Mikroemulsi, ekstrak bawang hutan (Eleutherine bulbosa (Mill.)Urb.), mutu fisik, antioksidan.  A B S T R A C TBawang hutan have contain secondary metabolite naftokuinon class (elecanacin, eleutherin, elutherol, eleutherinon) which known have antioxidant activities. Some of research reported antioxidant activity of extract which formulated in tablet and cream dosage form. The aim of this study was to developed effectively delivery system of bawang hutan in microemulsion  for maintenance its antioxidant activity. A microemulsion was prepared using an oil phase of  Virgin Coconut Oil (VCO), a surfactant of tween 80 and a  cosurfactant of gliserin. Evaluation of physical stability the microemulsions included analysis of organoleptic, viscosity, centrifugation and globul size. The antioxidant activities was evaluated by in vitro experiments using scavenging asssay of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and using ascorbic acid as positif control. The evaluation result were statistically analyzed using the t-student. The results indicated that a clear microemulsion and the globul size was < 5 μm. Even though, the pH and viscosity were not stable but there are not separated phase after centrifugation on 28 day storage. The antioxidant activity of microemulsion at 33°C dan 40°C storage respectively showed that IC50 values on day 1 is 101.167 μg/mL and 89.956 μg/mL, on day 35 is 127.254 μg/mL and 101.996 μg/mL. According to the result, antioxidant activity of bawang hutan extract is categorized into the powerful to moderate antioxidants. Keywords        :   Microemulsion, Eleutherine bulbosa extract (bawang hutan), Physical stability, Antioxidant.
UJI AKTIVITAS ANTIINFLAMASI GEL EKSTRAK BUAH KAKTUS (OPUNTIA ELATIOR MILL.) PADA TIKUS (RATTUS NORVEGICUS L.) YANG DIINDUKSI LAMDA KARAGENAN Sativa, Oryza; Yuliet, Yuliet; Sulastri, Evi
Natural Science: Journal of Science and Technology Vol 3, No 2 (2014): Volume 3 Number 2 (August 2014)
Publisher : Univ. Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.167 KB)

Abstract

This research is about anti inflammatory activity of cactus fruits (Opuntia elatior Mill.) extract gel in rats (Rattus norvegicus L.) at induced lamda carragenan in purpose to determine anti inflammatory activity, and concentration of cactus fruits extract in the gel that have an anti inflammatory activity which is equal to sodium diclofenac 1% activity, and to determine the effect of variations in the concentration of cactus fruit extract (Opuntia elatior Mill) on the physical stability of the gel. Extract was made by remaseration method using 70% ethanol. Physical stability test was conducted based on organoleptic, pH, viscosity and homogeneity of the gel. Test on Antiinflammatory activity were divided into 5 groups of treatment. Each rats induced by using lambda carrageenan. The first group of rats was given a gel without active ingredient as a negative control, groups of 2nd, 3rd and 4th rats were given gel cactus fruit extract in concentration of 5%, 10% and 15 % respectively, and 5th groups of rats were given diclofenac sodium gel as a positive control. Diameter and volume of inflammation were measured during 6 hours with 30 minute interval. Colected data were statistically analyzed using ANOVA. The results showed that concentration of cactus fruit extract in proportion of 5%, 10% and 15% in the gel preparation showed different conditions on organoleptic observations and homogeneity even though there was no different in the pH and viscosity during 14 days of storage. The results on anti-inflammatory activity testusing concentration of 5%, 10% and 15% have a recuperation effect on inflammation Gel contining 10% of extract has anti inflammatory activity which equal to 1% of sodium diclofenac activityi.e. the percentage of diameter and volume of  inflammation were 63,75% and 20,93%.
Pengaruh Variasi Konsentrasi Zeolit sebagai Builder Agent terhadap Karakteristik Deterjen Cair Evi Sulastri; Ni Ketut Sumarni; Vitasari Vitasari
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 4 (2019): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v2i4.1572

Abstract

This study aimed to determine the effect of various concentrations of zeolite as a buider agent in liquid detergent. Zeolite was synthesized from rice husk ash using solution to gel (sol-gel) method, followed by hydrothermal and then characterized by X-Ray Diffraction (XRD). The synthesized zeolite was then formulated into liquid detergent with sodium lauryl sulfate, glycerin, citric acid, colouring agent, parfume, and three concentrations of zeolite, i.e.: 15% (F1), 20% (F2), and 25% (F3). Liquid detergent was prepared by mixing process using stirrer. The characterizations of liquid detergents were including pH, viscosity, specific gravity, foaming power, foam stability, and detergency power. The XRD showed that the zeolite was type-A zeolite. Moreover, the characterization showed that zeolite with varying concentrations tend to influence in pH, viscosity, and detergency power but relatively similar in specific gravity, foaming power, and foam stability. The result indicated that the detergents with zeolite have better cleaning ability than the control (without builder) and the comparator detergents (with STPP builder). The higher the concentration of zeolite, the higher the detergency power. Therefore, F3 was recommended as formula of detergent with the best detergency power.
Formulasi Mikroemulsi Ekstrak Bawang Hutan dan Uji Aktivitas Antioksidan Evi Sulastri; Cristadeolia Oktaviani; Yusriadi Yusriadi
Jurnal Pharmascience Vol 2, No 2 (2015): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v2i2.5817

Abstract

ABSTRAKBawang hutan mengandung senyawa metabolit sekunder golongan naftokuinon (elecanacin, eleutherin, elutherol, eleutherinon) yang diketahui memiliki aktivitas antioksidan. Beberapa penelitian telah melaporkan tentang aktivitas antioksidan ekstrak yang diformulasi dalam bentuk sediaan tablet dan krim. Penelitian ini bertujuan mengembangkan formula dalam bentuk  mikroemulsi sebagai penghantaran yang efektif untuk mempertahankan aktivitas antioksidan ekstrak bawang hutan.  Mikroemulsi dibuat dengan menggunakan virgin coconut oil (VCO) sebagai fasa minyak, Tween 80 sebagai surfaktan dan gliserin sebagai kosurfaktan. Uji stabilitas fisik yang dilakukan terhadap sediaan meliputi uji organoleptik, pH, viskositas, sentrifugasi dan ukuran globul. Uji aktivitas antioksidan dilakukan secara in-vitro menggunakan metode peredaman DPPH dan menggunakan asam askorbat sebagai kontrol positif. Data hasil pengukuran dianalisis secara statistik menggunakan metode t-student. Hasil penelitian menunjukkan mikroemulsi dengan tampilan visual yang jernih dan ukuran globul < 5 μm. Meskipun sediaan mengalami perubahan pH dan viskositas tapi tidak terjadi pemisahan fase pada penyimpanan selama 28 hari. Hasil uji aktivitas antioksidan mikroemulsi ekstrak secara berturut-turut pada penyimpanan suhu 33°C dan 40°C: pada hari ke-1 menunjukkan nilai IC50 sebesar 101,167 μg/mL dan 89,956 μg/mL  sedangkan hari ke-35 sebesar 127,254 μg/mL dan 101,996 μg/mL. Berdasarkan hasil tersebut, aktivitas antioksidan ekstrak bawang hutan masuk dalam kategori kuat sampai sedang. Kata kunci  : Mikroemulsi, ekstrak bawang hutan (Eleutherine bulbosa (Mill.)Urb.), mutu fisik, antioksidan.  A B S T R A C TBawang hutan have contain secondary metabolite naftokuinon class (elecanacin, eleutherin, elutherol, eleutherinon) which known have antioxidant activities. Some of research reported antioxidant activity of extract which formulated in tablet and cream dosage form. The aim of this study was to developed effectively delivery system of bawang hutan in microemulsion  for maintenance its antioxidant activity. A microemulsion was prepared using an oil phase of  Virgin Coconut Oil (VCO), a surfactant of tween 80 and a  cosurfactant of gliserin. Evaluation of physical stability the microemulsions included analysis of organoleptic, viscosity, centrifugation and globul size. The antioxidant activities was evaluated by in vitro experiments using scavenging asssay of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and using ascorbic acid as positif control. The evaluation result were statistically analyzed using the t-student. The results indicated that a clear microemulsion and the globul size was < 5 μm. Even though, the pH and viscosity were not stable but there are not separated phase after centrifugation on 28 day storage. The antioxidant activity of microemulsion at 33°C dan 40°C storage respectively showed that IC50 values on day 1 is 101.167 μg/mL and 89.956 μg/mL, on day 35 is 127.254 μg/mL and 101.996 μg/mL. According to the result, antioxidant activity of bawang hutan extract is categorized into the powerful to moderate antioxidants. Keywords   :    Microemulsion, Eleutherine bulbosa extract (bawang hutan), Physical stability, Antioxidant.
Pengaruh Pati Pragelatinasi Beras Hitam Sebagai Bahan Pembentuk Gel Tehadap Mutu Fisik Sediaan Masker Gel Peel Off Evi Sulastri; Yusriadi Yusriadi; Dinda Rahmiyati
Jurnal Pharmascience Vol 3, No 2 (2016): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v3i2.5741

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh pati pragelatin beras hitam sebagai pembentuk gel terhadap kestabilan sediaan masker gel peel off dan menguji aktivitas antioksidannya. Formula dibuat dalam beberapa variasi konsentrasi yaitu F0 (kontrol negatif), F1 (3% pati pragelatin), F2 (4% pati pragelatin), F3 (5% pati pragelatin), F4 (6% pati pragelatin) dan F5 (tanpa pembentuk gel). Kemudian dilakukan evaluasi karakteristik mutu fisik dan stabilitas selama 28 hari serta dilakukan uji aktivitas antioksidan. Data hasil evaluasi dianalisis menggunakan metode analisis paired-samples T test. Evaluasi sediaan masker gel peel off selama penyimpanan menunjukkan secara organoleptik masker gel peel off berwarna ungu dan berbau khas dengan kekentalan menurun setelah penyimpanan sedangkan pada pengujian lain seperti pH, viskositas, daya sebar maupun waktu mengering menghasilkan perbedaan yang signifikan selama penyimpanan pada semua formula. Pengujian antioksidan sediaan masker gel menunjukkan aktivitas antioksidan dari sediaan tergolong kelompok intensitas sangat kuat (
Aktivitas Antiinflamasi Gel Ekstrak Rumput Mutiara (Ordelandia corymbosa L.) Pada Tikus (Rattus norvegicus L.) Yang Diinduksikan Karagenan Ince Agus Nurcholis; Yusriadi Yusriadi; Evi Sulastri
Biocelebes Vol. 12 No. 2 (2018)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.781 KB)

Abstract

Pearl grass is usually used in traditional medicine for the treatment of inflammation. This research aims to determine the anti inflammatory activity of pearl grass extract gel in rats induced by carrageenan and to evaluate the physical stability of its formulation during the storage of 14 days. The gel physical stability tests consist of organoleptic test, homogeneity, pH viscosity and dispersive power. Anti inflammatory activity test were divided into 5 treatment groups. Group 1 was given a gel without active ingredients as a negative control, group 2 were given diclofenac sodium gel as a positive control and group 3, 4 and 5 were given pearl grass extract gel at concentration of 5%, 10% and 15%. The measurements of inflammation volume were performed for 6 hours with intervals of 60 minutes. The results showed that all formulas have good physical stability during storage for homogeneity testing but having instability on pH, viscosity and dispersive power. The activity test showed all formulas have anti-inflammation against carrageenan induced rat. Gel with a concentration of 10% (F2) which more effective to reduce inflammation than the other formulas was selected as the most optimum formula. Key words : Gel, extract gel, pearl grass, Ordelandia  corymbosa L., antiinflammatory
Aktivitas Antiinflamasi Gel Ekstrak Rumput Mutiara (Ordelandia corymbosa L.) Pada Tikus (Rattus norvegicus L.) Yang Diinduksikan Karagenan Ince Agus Nurcholis; Yusriadi Yusriadi; Evi Sulastri
Biocelebes Vol. 13 No. 1 (2019)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.331 KB)

Abstract

Pearl grass is usually used in traditional medicine for the treatment of inflammation. This research were aimed to determine the anti inflammatory activity of pearl grass extract gel in rats induced by carrageenan and to evaluate the physical stability of its formulation during the storage of 14 days. The gel physical stability tests consist of organoleptic test, homogeneity, pH viscosity and dispersive power. Anti inflammatory activity test were divided into 5 groups. Group 1 was given a gel without active ingredients as a negative control, group 2 were given diclofenac sodium gel as a positive control and group 3, 4 and 5 were given pearl grass extract gel at concentration of 5%, 10% and 15%, respectively. The measurements of inflammation volume were performed for 6 hours with intervals of 60 minutes. The results showed that all formulas have good physical stability during storage for homogeneity testing but having instability on pH, viscosity and dispersive power. The activity test showed that all formulas have anti-inflammation against carrageenan induced rat. Gel with a concentration of 10% (F2) which more effective to reduce inflammation than the other formulas was selected as the most optimum formula.
UJI AKTIVITAS ANTIBAKTERI KRIM ASAM LAURAT TERHADAP Staphylococcus aureus ATCC 25923 DAN Pseudomonas aeruginosa ATCC 27853 Evi Sulastri; Mappiratu Mappiratu; Annisa Kartika Sari
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 2 (2016): (October 2016)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (183.802 KB) | DOI: 10.22487/j24428744.2016.v2.i2.5955

Abstract

Lauric acid is a saturated fatty acid found in fatty/vegetable oils, especially in palm oil. Lauric acid was reported to posses antiviral and antibacterial property. This study aims to determine the effect of the concentration variance of lauric acid in cream on the stability of the cream physical quality and antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. In this research, lauric acid concentration in cream was varied in 10%, 20%, and 30% and then tested for antibacterial activity using hole plate technique. The results of the evaluation of lauric acid cream preparation of Formula 1, Formula 2 and Formula 3 showed that the organoleptic and homogeneity tests of all formula was no difference during storage time, but the result of pH, viscosity, and dispersive power of all formula has difference during storage time (28 days). The antibacterial test results showed that the highest inhibition diameter was found in the use of lauric acid concentration of 30% for S.aureus (21.589 mm ± 0.18) and P.aeruginosa (14.25 ± 0.37 mm). Based on statistical analysis of the cream produced from the three concentrations of lauric acid, they were not stable because there are significant differences in pH, viscosity, and dispersive power during storage time (28 days). Keywords: lauric acid, antibacterial cream, Staphylococcus aureus, Pseudomonas aeruginosa.
GEL ANTI JERAWAT EKSTRAK DAUN BUTA-BUTA (Excoecaria agallocha L.) DAN PENGUJIAN ANTIBAKTERI Staphylococcus epidermidis Ika Olivia Borman; Yusriadi Yusriadi; Evi Sulastri
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (432.783 KB) | DOI: 10.22487/j24428744.2015.v1.i2.6215

Abstract

Buta-Buta (Excoecaria agallocha L.) leaf is a type of mangrove plants that has antibacterial activity againtsbacteriacausing acne, Staphylococcus epidermidis,. This study aims to formulate buta-buta leaf extract with the concentration of 12.5 % into anti-acne gel using two gels, namely HPMC 8% (Formula 1) and Carbopol 940 2%(Formula 2). Antibacterial activity test was carried out by agar diffusion method using well. The stability and antibacterial activity data during 28 days were analyzed statistically using unpaired t-student with a degree of confidence of 95% (α = 0.05). The evaluation results of anti-acne gel form of buta-buta leaf extract in Formula 2 showedbetter characteristics than Formula 1, which include organoleptic examination, homogenity, pH and viscosity during 28 days. The antibacterial test showed the diameter of inhibition zone of Formula 2 is 11.03 mm ±0,01. The statistic analysis showed a significant difference between Formula 2 with a positive control (klindamisin gel).
Uji Stabilitas Dan Aktivitas Antioksidan Mikroemulsi Likopen Tomat (Solanum lycopersicum L.): Stability Test and Antioxidant Activity of Tomato Lycopene (Solanum lycopersicum L.) Microemulsion Evi Sulastri; Mohamad Ikram; Yuliet Yuliet
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 3 No. 1 (2017): (March 2017)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (167.632 KB) | DOI: 10.22487/j24428744.2017.v3.i1.8134

Abstract

Lycopene is a class of keratonoid that have been proven has antioxidant activity but has limited solubility in water. So as to boost their solubility, in this study conducted in the form of microemulsion formulations. This study aims to get a tomato lycopene extract microemulsion which is stable and has antioxidant effects. The research was initiated to test the antioxidant power of tomato lycopene extract in vitro against DPPH. Tomato lycopene extract microemulsion is formulated based on the optimization of the composition of the base consisting of the VCO as the oil phase, tween 80 as surfactant and glycerin as cosurfactant. Preparations produced were tested for antioxidant activity and their physical and chemical stability testing which include: organoleptic, viscosity, globule size and pH during 28 days of storage. The results showed that tomato lycopene extract formula microemulsion stable composition of tomato lycopene extract 0.3%, VCO 15%, tween 80% and 35% glycerin. The test results obtained physical stability of the microemulsion formula elected tomato lycopene extract has a distinctive scent of aromatic, orange, thick, globule size of <5 μm, viscosity (600, 33 ± 69.29 to 746 cPs ± 8.32), and pH ( 6.27 ± 0.20 to 6.79 ± 0.10). As very strong antioxidant activity with IC50 value of 29.07 ppm.
Co-Authors Annisa Kartika Sari Armini Syamsidi Asriana Sultan Budiarti, Suci Cristadeolia Oktaviani Cristadeolia Oktaviani, Cristadeolia Dinda Rahmiyati Eka Afrika Friskilla Friskilla Ida Royani Ika Olivia Borman Imam Makruf Ince Agus Nurcholis Indarwati Abdullah, Rezky Putri Jamaluddin Jamaluddin Karim, Abdul Mubdi Ardiansar Arifuddin Karim, Marzelina Lubis, Siska Syahfitri Mappiratu Mappiratu Mohamad Ikram Muhammad Sulaiman Zubair Nandiska Maladjili Nawawi, Muh Nela Sharon Ni Ketut Sumarni Nurlina Ibrahim Nuur Aanisah Oryza Sativa Pramita Putri Pramita Putri Rachmat Faisal Syamsu, Rachmat Faisal Rahma Sari, Intan Rahman, Dinda Briliany Ritha Pratiwi Rohaya, Rohaya Sri Sulistiana Sulaiman , Sri Sulistiana Sulaiman, Sri Sulistiana Supriyanto Supriyanto Syamsuddin, Alifah Magfirah Vitasari Vitasari Yuliet Yuliet Yusriadi Yusriadi