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Jurnal Farmasi Sains dan Komunitas

JFSK
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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 247 Documents

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UJI TOKSISITAS SUBKRONIS INFUSA DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) PADA TIKUS: STUDI TERHADAP GAMBARAN MIKROSKOPIS JANTUNG DAN KADAR SGOT DARAH Ignasius Kuncarli; Ipang Djunarko
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Red betel (Piper crocatum Ruiz Pav) is one of the plants used as traditional medicinecommunity. To determine the level of safety of long-term consumption, then tested subchronic toxicity. Thestudy aimed to determine the relationship spectrum of toxic effects of infusion with changes in levels ofserum glutamic oxaloacetic transaminase (SGOT) and cardiac histopathology. The study was purelyexperimental, randomized study design complete unidirectional pattern. A total of 40 Wistar rats (20 malesand 20 females), 2-3 months were divided randomly into 4 groups: control group distilled water and 1.38;2.07; 3.105 g/KgBW of red betel leaf infusion with administration once daily for 28 days. Observationswere made before treatment and on day 28 by orbital sinus sampling through to measurement of bloodlevels of SGOT be analyzed by one way ANOVA and partially dissected mouse to see the damage to theheart. The results showed there was no significant change (p 0.05) in SGOT levels compared the controlgroup. Histology showed no specific changes were observed after administrating 28 days of red betel leafinfusion. The red betel leaf infusion did not cause significant change in SGOT level and histology of heart.Keywords : red betel, subchronic toxicity tests, SGOT, cardiac histology.

KAJIAN MOLEKULER RESISTENSI Candida albicans TERHADAP ANTIFUNGI Damiana Sapta Candrasari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Abstract: Candida albicans is one of the species Candida which mostly cause infection inhuman. Antifungal agent azole, polyene, echinocandin, and flucytosine are commonly used forCandida albicans infection treatment. The increasing using antifungal agent will causeantifungal resistance. Most of this resistance happen through gene mutation. This mutationmay influence efflux pumps, interaction of the drug and the target enzyme, the component offungal structure biosynthesis, and conformation of compound in fungal cell.Keywords: Candida albicans, antifungal agent, resistance, gene mutation

FORMULATION OF SUNSCREEN CREAM OF PARIJOTO FRUIT EXTRACT (Medinilla speciosa Blume) AND IN VITRO SPF VALUE TEST Elsa Tamara Geraldine; Ema Dwi Hastuti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 2 (2018)
Publisher : Sanata Dharma University

Sunscreen preparations are cosmetic preparations used as a protection to reduce the impact of sun exposure whose formulations contain active ingredients to absorb or diffuse sunlight, especially in areas of ultraviolet and infrared wave emissions. One of the potential natural ingredients for a sunscreen is parijoto fruit (Medinilla speciosa Blume). It contains flavonoid compounds that are able to prevent the harmful effects of UV rays. The objective of this research is to find out the formula of sunscreen cream of parijoto extract that meets the good physical quality of cream and to find out the result of SPF value test of parijoto fruit extract as sunscreen cream preparation in Vitro. The design of the study was experimental research conducted in the laboratory. The sample used in this research was parijoto made into thick extract by maceration method. Further, the viscous extract obtained was made to be a sunscreen cream and then tested either its physical evaluation or calculation of SPF value. The results of this study indicate that the preparation of sunscreen cream of parijoto fruit extract included in the extra protection category with the value is 6.66 and can be made into the good and stable preparations. The sunscreen cream of parijoto fruit extract has good physical properties and also has activity as UV protection in vitro.

KADAR HbA1c DAN RASIO LIPID PADA WANITA DEWASA DENGAN OBESITAS SENTRAL Lisa Sudaryanto; Laurensius Imus Ventora; Fenty Fenty
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 2 (2015)
Publisher : Sanata Dharma University

Central obesity was accumulation of fat in the abdominal region. Many studies showed correlations between central obesity and cardiovascular diseases, e.g. diabetes and dyslipidemia. This study was conducted to know the difference between HbA1c and lipid profil between the women with and without central obesity. This study was an analytic observational study with cross-sectional design. Subjects of 52 respondents were healthy adult women staff in campus I, II, III Sanata Dharma University in Yogyakarta and selected using purposive sampling technique. The data of waist circumference, pelvic/hip circumference, HbA1c and lipid profile were collected among the subjects and analyzed with computer with 95% confidence interval. The results of this study showed HbA1c levels and lipid profile were different between the women with and without central obesity, although the difference was not statistically significant.

PROFILE OF ANTICANCER ACTIVITIES OF BROTOWALI (Tinospora crispa L.) PLANTS OFVARIOUS REGIONS IN EAST JAWA Roihatul Mutiah; Laily Nurul Azizah; Rahmi Annisa; Anik Listyana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 2 (2019)
Publisher : Sanata Dharma University

Brotowali (Tinosporacrispa L) is a plant which has potential to be a chemopreventive agent. This study aims to determine the profile of anticancer activity of brotowali stem extracts (Tinosporacrispa L.), from several regions in East Java. The extraction was carried out by maceration method using 80% ethanol solvent. Then, anticancer activity test was carried out on MCF-7 breast cancer cell model using the Microtetrazolium (MTT) Assay method. The results of the anticancer activity test showed that 15 brotowali stem extracts taken from 5 locations in East Java had significant differences in anticancer activity (P 0.05). Brotowali extracts from Kanigoro, Blitar city, had the highest anticancer activity with an IC50 value of 30.64 g / mL.

HUBUNGAN ANTARA AKTIVITAS FISIK DAN ANGKA KECUKUPAN GIZI MAKRONUTRIEN TERHADAP RASIO KOLESTEROL TOTAL/HDL PADA MASYARAKAT PEDESAAN Utari Febrina Supomo Sunu; Galih Permadi; Fenty Fenty
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 1 (2017)
Publisher : Sanata Dharma University

Cardiovascular disease is the number one cause of death in the world. The diseaseis influenced by several factors such as lack of physical activity, imbalanced nutritional intake, and high blood cholesterol levels. The value of the total cholesterol / HDL can predict cardiovascular disease risk factors. The study aims to investigate the relationship between physical activity and Dietary Allowances of the macronutrient and ratio total cholesterol / HDL in rural communities. This is observational analytic with cross-sectional design of the 102 respondents (male: 40, female: 62) in Kepuharjo village, Cangkringan, Sleman, Yogyakarta, with a purposive sampling techniques. Physical activity data were taken using a structured interview (Baecke) and Semi Quantitive Food Frequency Questionnaire (SQFFQ) for data macronutrient, while blood total cholesterol and HDL-cholesterol levels were analyzed using enzymatic methods. The results of the study showed that there is no significant relationship between physical activity and the ratio of total cholesterol / HDL (p = 0.038; CI 95%: 0.98-61.33), dietary allowances of the macronutrient energy and the ratio of total cholesterol / HDL (p = 0.068), protein intake on the ratio of total cholesterol / HDL (p = 1.000), fat intake to the ratio of total cholesterol / HDL (p = 0.081), and the intake of carbohydrates to the ratio of total cholesterol / HDL (p = 0.088). In conclusion there is no significant relationship between physical activity and dietary allowance of macronutrient towards to the ratio of total cholesterol / HDL.

UJI DAYA ANTIBAKTERI DAN IDENTIFIKASI ISOLAT SENYAWA KATEKIN DARI DAUN TEH (Camellia sinensisL. var Assamica) Christina Astutiningsih; Wahyuning Setyani; Himawan Hindratna
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Antibacterial is a substance that can interfere with the growth and metabolism of bacteria, sothat these substances can inhibit growth or even kill bacteria. This research aimed to utilize naturalmaterials as a natural antibacterial. This study investigated the ability of isolates catechins of tea leaves toinhibit Staphylococcus aureus and spectral identification of these catechins. Catechin compounds wasextracted by water, and then fractionated with CHCl3 and ethyl acetate. Ethyl acetate phase wasconcentrated fractionation results using a rotary evaporator for further separation using thin layerchromatography with various mobile. The results of the study showed that the concentration of isolates ofdemonstrated to be effective as antibacterial, with MIC 12.5%. UV spectrum measurement showed that theisolates had a maximum absorption at a wavelength of 279 nm while the FTIR spectrophotometer showedthat isolates catechin-containing functional groups C = C aromatic absorption 1500-1600 nm^-1 and OHgroups, a broad band between 2000 and 3600 nm^-1.Key words: isolates catechins, Staphylococcus aureus, tea leaves, antibacterial

CORRELATION AMONG SLEEP DURATION, BLOOD PRESSURE, AND BLOOD GLUCOSE LEVEL OF MORANGAN PEOPLE, SINDUMARTANI, NGEMPLAK, SLEMAN Gregorius Bhaskara Wikanendra; Rita Suhadi; Christianus Heru Setiawan; Dita Maria Virginia; Phebe Hendra; Fenty Fenty
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 2 (2020)
Publisher : Sanata Dharma University

Sleep deprivation is a risk factor for cardiovascular and metabolic diseases. There was a high prevalence of high blood pressure and type 2 diabetes in Morangan, Yogyakarta Province. This study aims at studying the correlation between sleep duration, systolic blood pressure and fasting blood glucose levels of people in Morangan. This study was a cross-sectional study conducted in cooperation with a public health care program for people in Morangan. Data collection was done using a questionnaire and health screening procedure during the public health care program. Collected data were covering aspects of systolic blood pressure, fasting blood glucose, sleep duration, and sleep habit. There was a high prevalence of high systolic blood pressure (130mmHg; 66.04%) and high fasting blood glucose level (100mg/dL; 39.62%) in Morangan people. There was a significantly positive correlation between sleep duration and systolic blood pressure (p:0.024; r:0.31) but no significant correlation between sleep duration and fasting blood glucose level. The major contributing habits towards sleep deprivation were caffeine consumption and medium pre-sleep routine. The result of this research will provide help in designing an education program for people of Morangan in preventing and treating high blood pressure and type 2 diabetes.

ANALISIS KUANTITATIF ISOFLAVON TEMPE SECARA CEPAT DAN SEDERHANA MENGGUNAKAN METODE KROMATOGRAFI LAPIS TIPIS- DENSITOMETRI Agustina Setiawati; Sri Hartati Yuliani; Enade Perdana Istyastono; Michael Raharja Gani; Evy Fenny Veronica; Dina Christin Ayuning Putri; Reza Eka Putra; David Chandra Putra; Agnes Mutiara Kurniawan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Rapid and simple quantitative analysis isoflavones tempe using densitometric TLChas been done. The mobile phase of the system was chloroform: methanol: ethylacetate (45: 5:0.75). Thin layer chromatography was performed on aluminium TLC plates.Ascending distanceof 1 ?L sample was performanced 10 cm. Then the plate was scanned at 261 nm. A linearrelationship obtained at 0.08 - 2 ?g/spot with r= 0.9986. The LOD and LOQ of isoflavone were0.014 ?g/spot and 0.048 ?g/spot. Genistein contained in tempe was 0.151 0.005 % b/b.

A SURVEY OF ANTIBIOTICS PURCHASED WITHOUT PRESCRIPTION AMONG NON-HEALTH SCIENCE STUDENTS IN JEMBER, INDONESIA Antonius Nugraha Widhi Pratama; Anis Rohmawati; Ema Rachmawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 1 (2018)
Publisher : Sanata Dharma University

Previous research showed that self-medication practice with antibiotics is widespread in developing countries and tertiary students are among these consumers. This study aimed to estimate the prevalence of the use of antibiotics without prescription among non-health science students in Jember and to identify the sources of non-prescription antibiotics. This cross-sectional survey was conducted between April and June 2016 in all non-health science faculties of Universitas Jember. A questionnaire containing four main short questions about antibiotics use and questions related to socio-demographic information was distributed to students who gave consent. A number of 130 (58.5%) respondents admitted to ever acquire antibiotics without the presence of a physician prescription. Self-medication with antibiotics tended to be done by students from rural areas (p=0.04) and without health insurance (p=0.04). The sources of non-prescription antibiotics vary, but pharmacy was the most frequently cited to be the source (n=82; 46.3%). This study showed that the use of antibiotics without prescription among non-health science students and the sale of antibiotics without prescription among pharmacies in Jember are prevalent. Real responses from the government, relevant health professional associations, and education institutions to intervene these problems are significantly needed.

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Florentinus Dika Octa Riswanto

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Daerah istimewa yogyakarta

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Home Page

OAI Link

Editorial Team

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Contact Name Florentinus Dika Octa Riswanto

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Journal Mail Official editorial.jpsc@usd.ac.id

Editorial Address Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

Abstract

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Contact Name
Florentinus Dika Octa Riswanto

Contact Email
editorial.jpsc@usd.ac.id

Phone
-

Journal Mail Official
editorial.jpsc@usd.ac.id

Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA