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Jurnal Farmasi Sains dan Komunitas

JFSK
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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 247 Documents

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KAJIAN FAKTOR DEMOGRAFI TERHADAP KEPUASAN PASIEN JAMINAN KESEHATAN NASIONAL PADA FASILITAS KESEHATAN TINGKAT PERTAMA Putu Dyana Christasani; Satibi Satibi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 1 (2016)
Publisher : Sanata Dharma University

The National Health Insurance (JKN), an Indonesian health care system, has been organized by BPJS Kesehatan using health care assurance mechanism. JKN system gave its service in collaboration with the existing health facilities throughout Indonesia. Primary health facilities named Puskesmas and Klinik Pratama, were playing role as the gate keeper of JKN system in order to provide basic health services optimally. The JKN participants satisfaction could be used as the indicator for measuring the success rate of the JKN system. The patient demographics was being one of several factor affecting the JKN participants satisfaction. This study aimed to examine the relationship between patient demographics and JKN participants satisfaction in Puskesmas and Klinik Pratama located in Sleman, Bantul and Yogyakarta city. This research performed the descriptive analytic using cross sectional survey design. The patientss demographics examined in this study were patients age, patients gender, patients education, patients employment, patients income, and membership status. The data taken quantitatively using questionnaires and equipped with qualitative data from interviewing the patients to obtain all the possible findings in the field. Sampling techniques for primary health facilities was performed by random sampling with total sample of 55 health facilities and purposive sampling with a total sample of 150 respondents. Data were analyzed using Chi-Square method to obtain the relationship between patient demographics and JKN participants satisfaction. The results showed that patients employment, patients income, and membership status were significantly related to the JKN participants satisfaction in Puskesmas and Klinik Pratama.

POLA KUMAN DAN SENSITIVITAS ANTIMIKROBA PADA INFEKSI SALURAN KEMIH Fenty Fenty; Syafada Syafada
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 1 (2013)
Publisher : Sanata Dharma University

Abstract: A urinary tract infections (UTI) is an infection that affects the urinary tract caused bybacteria (most often Escherichia coli). Antimicrobial are used to treat UTI. The sensitivity ofbacterial pattern toward antimicrobials and the bacterials pattern will affect the effectiveness ofUTI treatment. This research was conducted to evaluate the strains of bacterial and sensitivity ofbacterial pattern that caused UTI. A descriptive evaluation and retrospective study was done inthis research. In total 79 cases patient with UTI at Inpatient Unit X hospital in Yogyakarta2011, whose has sensitivity test and sprout up germ culture examination data were included.Patient with UTI at Inpatient Unit which has barren germ culture data and sprout up germ wereexcluded. The common microbes were gram negative bacteria including Escherichia col,Pseudomonas aeruginosa, Klebsiella pneumonia, and Staphylococcus coagulase negative.Gram negative microbes were sensitive to amikasin, imipenem, netilmicin, and fosfomicin. Grampositive microbes were sensitive to nitrofurantoin, vancomicin, imipenem and cefuroxime.Keywords: Urinary Tract Infection, antimicrobial, and sensitivity bacterial pattern.

KEPATUHAN PENGGUNAAN OBAT DAN KUALITAS HIDUP PASIEN HEMODIALISA DI RS PKU MUHAMMADIYAH YOGYAKARTA PERIODE MARET 2015 Endah Karuniawati; Woro Supadmi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 2 (2016)
Publisher : Sanata Dharma University

The adherence holds an important role that can affect the success rate of the therapy and increase the life quality of the patients. Quality of life is an ability to reflect the health in the term of physically, psychology, and socially and the satisfaction of the patients functional and control level. Research aims to understand relations compliance treatment with the quality of life can be measured by MMAS and WHOQOL questioners. The research applied descriptive, non experimental and cross-sectional methods. The aim of the research was to find out the relationship between the medication adherence and the life quality of the hemodialysis patients. The medication adherence data was gathered by MMAS (Morisky Medication Adherence Scale) and the life quality was gathered by WHOQOL (World Health Organization Quality of Life) of hemodialysis patients at PKU Muhammadiyah Yogyakarta Hospital. The research results showed that from 101 respondents the medication adherence in the level of high 58,42 %, level moderate 8 , 91 % and low 32 , 67 %.) .The quality of life of patients of the domain physical, mental, social and environmental at a high rate and low. Relations adherence the use of a drug with the quality of life of significant (p 0,005) in all the domain. Compliance the use of drugs associated with the quality of life of hemodialysis patients at PKU Muhammadiyah Yogyakarta Hospital.

POTENSI TAPE SEBAGAI PANGANAN TRADISIONAL TERHADAP EFEK HEPATOTOKSIK TIKUS TERINDUKSI KARBON-TETRAKLORIDA Gidion Krisnadi Yoseph; Christiana Destia Anggraeni; Ni Luh Putu Dian Prawita Putri; Phebe Hendra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 2 (2013)
Publisher : Sanata Dharma University

Abstract: The purpose of this study was to determine the effect of Tape that has an alcoholiccompound, to the hepatotoxic effect in the rat induced Carbon Tetrachloride. And also determinewhich fermentation time of the Tape can give effect to the hepatotoxic in the rat induced Carbontetrachloride. Healthy rats were randomly divided into 7 groups of 5 animals in each. Group 1received carbon tetrachloride 2ml/kgBW treated intraperitoneal. Group 2-4 were given Tapesuspension 18g/kgBW once daily for 6 days with different fermentation time (3, 5, 7 days). Group5-7 were given Tape suspension 18g/KgBW once daily for 6 days with different fermentationtime and carbon tetrachloride was given on the 7th day. Blood sample from all groups wasobtained by sinus orbitalis after 24 hours application for estimation the serum level oftransaminase. The result showed that Tape suspension had a potential effect to reduce thehepatotoxicity induced by carbon tetrachloride. Tape suspension with 5 days fermentationwas significantly decreased serum level of transaminase (P0,05) upon carbon tetrachlorideinduced hepatic damage in rats.Keywords: hepatotoxicity, tape, fermentation time,carbon tetrachloride

OPTIMIZATION OF OLIVE OIL, TWEEN 80, AND PROPYLENE GLYCOL OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM OF ZINC OXIDE BY D-OPTIMAL METHOD Dian Eka Ermawati; Adi Yugatama; Wening Wulandari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 2 (2020)
Publisher : Sanata Dharma University

The incidence of skin cancer in Indonesia reaches 6-8%, so the skin needs effective protection. Zinc Oxide (ZnO) is a sunscreen with Sun Protecting Factor (SPF) 50 which is able to reduce exposure to Ultraviolet rays. ZnO is difficult to dissolve in water making an obstacle if dispersed in a hydro gel matrix, so it is formulated into a Self-Nanoemulsifying Drug Delivery System (SNEDDS) preparation. SNEDDS formula was made using tween 80 as surfactant, propylene glycol as a co-surfactant, and olive oil. The optimum proportion of the three components was optimized with the D-Optimal method using Design Expert Stat-Ease 9 Trial software. Software obtained 16 formulas which were tested for physical stability response: transmittance value (%) and pH value. SNEDDS optimum formula was compared with the D-Optimal prediction formula using the student's t-test statistical analysis (p0.05), the loading dose of ZnO, Particle Size Analysis, and Zeta Potential. The optimum proportion of propylene glycol, tween 80, and olive oil making up SNEDDS were 9.9%: 81%: 9.1% respectively. The result of the percent transmittance response was 92.30% and the pH value was 7.20. Software prediction results: transmittance value was 92.59% and pH value was 7.37. Statistical analysis of one sample t-test showed no difference between observations and D-Optimal predictions. SNEDDS was able to load 2.0 mg ZnO/gram SNEDDS with a particle size of 150.2 nm; polydispersity index of 0.54 and zeta potential of -28.50 mV. The SPF value of SNEDDS ZnO was 16.

QUALITY OF LIFE OF PATIENTS PRESCRIBED WITH HERBAL MEDICINE Dyah Aryani Perwitasari; Nur Mahdi; Mustika Muthaharah; I Nyoman Kertia
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 2 (2016)
Publisher : Sanata Dharma University

Herbal medicine has been an alternative treatment, instead of modern medicines. However, some of patients could experience adverse drug reaction (ADR) due to the use of herbal medicines. The ADR can decrease patients quality of life (QoL). Objective. This study was aimed to understand the QoL of patients prescribed with herbal medicines. Methods. Patients prescribed with herbal medicines as complementary treatment, in two Public Health Centers of Yogyakarta were recruited. The patients were prescribed with herbal medicines one year before this study was started. Naranjo algorithm was used to identify the ADR. The SF-36 questionnaire was given to the patients as the instrument to measure patients QoL. Results. There were 47 patients participated in this study. Most of the patients are female (62.5%).Ten patients experienced ADR. There are no significant differences between QoL domains in patients experienced ADR and those without ADR. However, the scores of physical function, role physical, general health, social function, role emotional, and mental health in patients without ADR are higher than those with ADR ( p0.05) . Conclusion. There are no significant differences of QoL between patients with and without ADR. In general, the QoL of patients without ADR is higher than those with ADR.

THE EFFECT OF PASAK BUMI ROOTS TOWARDS BLOOD GLUCOSE LEVEL IN GLUCOSE-LOADED MICE Fransisca Fransisca; Gracia Easter Kalangi; Damiana Sapta Candrasari; Phebe Hendra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 1 (2018)
Publisher : Sanata Dharma University

The aim of this research is to evaluate the effect of pasak bumi roots (Eurycoma longifolia Jack) towards the blood glucose level in glucose-loaded mice. The blood glucose-lowering effects were tested using Oral Glucose Tolerance Test (OGTT) method. The mice were given with infusion of pasak bumi roots at the doses of 0.83; 1.67; 3.33 g/kgBW and methanol extract of pasak bumi roots at the doses of 102; 210; 420 mg/kgBW. All treatments were conducted orally, 30 minutes before the administration of glucose (2 g/kgBW). The blood glucose levels were measured at 0 minute before the administration of glucose and at 15, 30, 60, 90, and 120 minutes after the administration of glucose. Blood samples were obtained through the mice tails vena lateralis using glucometer. The blood glucose levels result which were obtained at the 0 until 120 minutes were calculated to obtain AUC. AUV values of each treatment group were analyzed statistically. Based on the results of the research, it can be concluded that the methanol extract of pasak bumi roots has blood glucose-lowering effect at the doses of 210 and 420 mg/kgBW, but infusion of pasak bumi roots does not have effects on lowering the blood glucose level in the glucose-loaded mice.

POTENSI NANOKOLAGEN LIMBAH SISIK IKAN SEBAGAI COSMECEUTICAL Hanny Setyowati; Wahyuning Setyani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 1 (2015)
Publisher : Sanata Dharma University

Abstract: Collagen is the most abundant protein of white connective tissue, comprising approximately 30% of total animal protein. This is a fibrous protein which give strength and flexibility in the tissue and bone, also playing an important role for skin and tendon. The utilization of collagen from fish scales waste become an alternative for medication (pharmaceutical), and daily care as cosmetic, which known by cosmeceutical. Nanotechnology application can be completing of cosmeceutical, not only for cure, but also for daily treatment using an wasted materials changed into beneficial product to be developed. Keywords : collagen, fish scales waste, cosmeceutical

PENGARUH PEMBERIAN MADU HUTAN TERHADAP PROLIFERASI LIMFOSIT PADA HEWAN UJI TIKUS JANTAN GALUR WISTAR Kartika Sari Senas; Yunita Linawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 9, No 2 (2012)
Publisher : Sanata Dharma University

Abstract: Forest honey is produced by wild bees by taking nectars from several kinds of plant.One of active chemicals contained within honey is flavonoid. It is believed as animmunomodulator due to it has role in fighting against free radicals and increasing body immunesystem against disease infection. This research aimed to understand the influences of foresthoney administration to the lymphocyte proliferation on male mice Wistar family. This researchis a pure, experimental with one way, random research design. Total of 20 rats was divided into 4groups. Each group was given honey forest with dose of 0,27; 0.54; 1.08 mL/200 g BW, andnegative control group was given aquadest 2.5 mL/200 g BW. The lymphocyte proliferation ismeasured from the amount of lymphocyte based on Optical Density (OD) values, the read onELISA reader at the wavelength of 550 nm. The result shown that the administration of foresthoney has effect on significance increase the lymphocyte proliferation (p0.05) than negativecontrol on male mice Wistar family.Key words : Foresthoney, lymphocyte proliferation, immunomodulator

APPLICABILITY OF BACTERIAL ENDOTOXIN TEST (BET) FOR SOME RADIOPHARMACEUTICAL STERILE KITS BY THE USE OF TACHYPLEUS AMEBOCYTE LYSATE (TAL) Putra, Amal Rezka; Lestari, Enny; Kurniasih, Dede; Karyadi, Karyadi; Sarmini, Endang; Aries, Arni
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

The application of bacterial endotoxin test (BET) using TAL reagent on radiopharmaceutical kits is very important to conduct. The radiopharmaceutical kits that will be tested are macro aggregated albumin (MAA), tetrofosmin and ethambutol kits. Endotoxin testing stage was TAL 0.25 EU/mL verification test, inhibition/enhancement test, and endotoxin test for sample. Pyrogen testing using rabbits was also performed as a comparison test. The results of the TAL reagent verification test were all samples showed values corresponding to the standards of 2? = (+), 1? = (+), 1/2? = (-), 1/4? = (-), and negative water control (NWC) = (-). Furthermore, inhibition/enhancement tests for MAA, tetrofosmin, and ethambutol products show non-inhibiting or gel-inducing results, which are in accordance with acceptability standards, so that the samples can be tested using TAL reagents. The pH measurement results in each sample were MAA of 6.0, tetrofosmin of 7.0, and ethambutol of 8.0. The results of MAA, tetrofosmin, and ethambutol product testing were a sample = (-), positive product control (PPC) = (+), positive water control (PWC) = (+), and NWC = (-). In addition, the results of pyrogen testing also showed negative for MAA, tetrofosmin, and ethambutol.

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Contact Name Florentinus Dika Octa Riswanto

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Contact Name
Florentinus Dika Octa Riswanto

Contact Email
editorial.jpsc@usd.ac.id

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Journal Mail Official
editorial.jpsc@usd.ac.id

Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

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Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA