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Jurnal Farmasi Sains dan Komunitas

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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 247 Documents

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UJI AKTIVITAS ANTIOKSIDAN MENGGUNAKAN RADIKAL 1,1-DIFENIL-2-PIKRILHIDRAZIL (DPPH) DAN PENETAPAN KANDUNGAN FENOLIK TOTAL FRAKSI ETIL ASETAT EKSTRAK ETANOLIK DAUN BENALU (Dendrophthoe pentandra L. Miq.) YANG TUMBUH DI POHON KEPEL (Stelechocarpus burahol (Bl.) Hook. f.) Willigis Danu Patria; C.J. Soegihardjo
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 1 (2013)
Publisher : Sanata Dharma University

Abstract: Antioxidant has the ability to capture free radicals. These free radicals can oxidizenucleic acids, proteins, lipids or DNA, causing degenerative diseases. Antioxidants compoundfound in plants such as phenolic acids, polyphenols and flavanoids would capture free radicalssuch as peroxide, hydroperoxide or lipid peroxyl and also inhibit the oxidative mechanisms thatshow degenerative diseases. Quercetin and quercetin 3-o-rhamnosida as constituents ofmistletoes (Dendrophthoe pentandra (L.) Miq.), are able to provide antioxidant activity.Mistletoes dried and extracted with 70% ethanol, followed by fractionation with ethyl acetate.Antioxidant activity of ethyl acetate fraction from ethanol extract was calculated using DPPHmethod and obtained IC50 values. The results showed that the ethyl acetate fraction fromethanolic mistletoes leaf extract has antioxidant activity with IC50 value of (12.57 0.7) mg / mL.The content of total phenolic (13.760.9) mg gallic acid equivalents per gram of ethyl acetatefraction from ethanol extract of leaves of the mistletoes.Keywords: Antioxidant, misletoes leaf, Dendrophthoe pentandra, ethyl acetate fraction,ethanolic extract, DPPH, total phenolic..

THE EFFECT OF TEMPEH EXTRACT GEL ON WOUND HEALING IN DIABETES RAT: OVERVIEW OF TISSUE COLLAGEN, WOUND CLOSURE, EPITHELIALIZATION AND CAPILLARIZATION Ignasius Adi Kurniawan; Rini Dwiastuti; Sri Hartati Yuliani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

The development of wound healing preparations in diabetes conditions needs to be done because the wound healing process in the respective conditions requires longer time. The aim of this study is to measure the effect of tempeh extract gel containing genistein on wound healing in diabetes rats by observing the response parameters of collagen expression, wound closure speed, epithelialization, and capillarization of wound tissue. The results of testing wound closure using a base gel treatment, tempeh extract gel 2.5%, 5%, 7.5% and without treatment indicated that the treated groups of tempeh extract gel 5% and 7.5% have significant effect on diabetes wound healing in the tested animals. This indication is strengthened by the results of the non-treatment groups statistical test with the 5% and 7.5% tempeh extract gel treatment which showed significant difference in influencing the wound closure response, epithelialization and collagen formation in tissue. The results of the statistical in group without treatment with the base treatment group without extract gel and tempeh extract gel 2.5% showed no significant difference in influencing the wound closure response, epithelialization and collagen formation. Statistical test results on capillarization responses indicated that the results were not significantly different from all treatment groups.

THERAPY ADHERENCE OF 40-75 Y.O. HYPERTENSION RESPONDENTS USING MORISKY INSTRUMENT IN NGEMPLAK, SLEMAN, DIY (STUDY ON AGE, DEMOGRAPHY, SOCIAL, AND LIFE-STYLE FACTORS) Jasmine, Millatina; Oktawati, Nurjati Dwi; Damasari, Puspa Raras; Suhadi, Rita
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 2 (2017)
Publisher : Sanata Dharma University

Hypertension is systolic blood pressure (SBP) ?140mmHg and/or diastolic blood pessure (DBP) ?90mmHg. The risk factors of hypertension consist of age, life-style, demographic, and social factors. The risk factors have a significant association with antihypertension adherence. Adherence is the suitability of patient behavior to the prescribers recommendations. Morisky instrument can be used to measure the level of hypertension therapy adherence. The aims of this study were to assess respondents profile and therapy adherence based on age, life-style, demographic, social factors among the subjects in Ngemplak, Sleman, Daerah Istimewa Yogyakarta (DIY). Total respondents were 63 respondents. The observational study was done with cross-sectional design. Technique for determining the location used random sampling, data were collected by door to door in the villages of Morangan, Jimat, and Jelapan. Data analysis used chi square with 95% confidence level. There were 23.8% good adherent and 76.2% poor adherent subjects to antihypertensive medication. There was no significant difference between age, life-style, demographic, and social factors to the level of hypertension therapy adherence. However, it was found that controlled blood pressure (p-value0.01) were significantly associated with therapy adherence. This study also found that SBP at age 60-75 years and 40-59 years was significantly different (p-value 0.05).

CORRELATION BETWEEN ANTHROPOMETRIC MEASUREMENTS AND RISK OF ANEMIA AMONG RURAL COMMUNITY IN CANGKRINGAN, SLEMAN Dita Maria Virginia; Fenty Fenty
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 2 (2017)
Publisher : Sanata Dharma University

Anemia has been detected on various age groups. Measurement of hemoglobin (Hb) levels is a standard for deciding anemia conditions. The measurement requires certain costs, medical professional, and is invasive. People in rural areas need an economical, easy and simple examination to identify the risk of anemia. Anthropometric measurement is expected to be an appropriate measurement model for rural communities. The objective of the study is to obtain the best anthropometric measurement predictors for detecting anemia in rural communities. This was an observational study using a cross-sectional design. The inclusion criteria of the subjects of the study were residents of Cangkringan, who were between 40 and 60 years old. The subjects were chosen using random sampling cluster technique. The sample size was 100 respondents and was taken based on cluster. Descriptive analysis was used to determine the prevalence of anemia. Analysis the difference in proportion was conducted using Mann-Whitney. Correlation analysis was performed to determine the relationship between Hb levels and anthropometric measurements by using Spearman. The results showed that only 5% of the subjects are in the status of anemia based on their Hb levels. There is a significant difference between Hb levels in the normal and obese groups based on the waist hip circumference ratios (WHR) (p = 0.002). The waist circumference has a weak correlation (r = 0.238, p = 0.017) and WR has a moderate correlation (r = 0.483, p = 0.000) with Hb levels. The results of this study are not appropriate in which central obese patients should be more at risk of anemia. This study concludes that there is a significant positive moderate correlation between anthropometry, which is the waist circumference parameters and WHR, to the Hb levels in rural communities.

EVALUASI DRUG RELATED PROBLEMS PADA PASIEN GERIATRI DENGAN HIPERTENSI DISERTAI VERTIGO DI RS PANTI RINI YOGYAKARTA AGUSTUS 2013 Kresensiana Yosriani; Maria Wisnu Donowati; Aris Widayati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract : This study aimed to evaluate Drug Related Problems (DRPs) among hypertensive geriatricpatients with vertigo co morbid at Panti Rini Hospital Yogyakarta. This is a non-experimental researchdescriptive evaluative design using a retrospective medical record data. Collected data including patient'sidentity; initial, final, and complication diagnosis; cardiovascular system drugs and antivertigo,laboratory data. The inclusion criteria were ? 60 years with an initial diagnosis of hypertension withvertigo co morbid, used a diuretic drug, and had creatinine test result. Data were analyzed case by caseusing selected literatur. There were 20 cases found. Result of the study showed that 100% of patients usedantihypertensive as the cardiovascular system drugs and 80% patients used antivertigo as nervous systemdrugs. There were 18 cases of DRPs found related to the use of antihypertensive and antivertigo. 1 case ofdosage too low, 8 cases of adverse drug reaction, and 9 cases of dosege too high.Keywords : hypertension with vertigo co morbid, geriatrics, Drug Related Problems

FORMULASI TABLET EFFERVESCENT EKSTRAK DAUN SINGKONG (Manihot utillissima Pohl.) DAN EKSTRAK HERBA PEGAGAN (Centella asiatica (L.) Urban) Serevino L. Ambuk; Agatha Budi Susiana Lestari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 9, No 2 (2012)
Publisher : Sanata Dharma University

Abstract: Asiaticoside compound in gotu kola extract (Centella asiatica (L.) Urban) and rutincompound in extract of cassava leaves (Manihot utillissima Pohl.) has been proofed fordegenerative diseases treatment. Effervescent tablet was chosen to facilitate the herb gotu kolaextract and cassava leaves extract because of fresh sensation and easy to use. The aims of thisstudy was investigated the effect of tartaric acid, sodium bicarbonate, their interactions, anddiscovered the optimum composition in order to producing effervescent tablets for qualityrequirements. Quality requirements term in this study were the moisture content of granule, tablethardness, friability of tablets, dissolution time. The results showed that tartaric acid significantlyinfluenced moisture content of granules, tablets friability, dissolution time of tablets, whilesodium bicarbonate significantly affected tablets hardness. Based on super imposed contourplot, the optimum composition for effervescent tablets was at the level 1000 mg tartaric acid and1120 mg sodium bicarbonate.Keywords: gotu kola extract, cassava leaves extract, effervescent tablet

COMPOUNDING STERILE PREPARATIONS FOR INTENSIVE CARE UNIT PATIENTS (ICU) IN ONE PRIVATE HOSPITAL IN SEMARANG Sara Septi Widayani; Sri Hartati Yuliani; Dina Christin Ayuning Putri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 2 (2018)
Publisher : Sanata Dharma University

Sterile preparations for intravenous injection probably cause greater risk of errors than other preparation treatment routes due to their complex preparation steps. Errors in preparation and compounding stage will affect the quality and stability of the pharmaceutical product obtained. The aim of this study was to evaluate the process of compounding and assess both quality and stability of the parenteral preparations products that resulted from the compounding process for ICUs patients in one private hospital in Semarang, Central Java, Indonesia. This observational analytic study was conducted using accidental sampling technique. The descriptive study results showed that sterile preparation in hospital X was not performed according to the Guidelines for Drug Injection and Handling of Cytostatic Preparations. In order to evaluate the quality of the sterile preparations, three different drugs with the highest prevalence of use: namely ceftriaxone, meropenem and omeprazole were evaluated. It was found that the pH value of omeprazole was not acceptable due to the use of an appropriateness solvent. The sterility tests showed that the preparation products prepared by the nurses were free from microorganisms.

UJI IN SILICO SENYAWA COUMESTROL SEBAGAI LIGAN RESEPTOR ESTROGEN ALFA Felicia Felicia; Enade Perdana Istyastono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 2 (2015)
Publisher : Sanata Dharma University

Breast cancer is a cancer caused by uncontrolled cell growth at breast tissue. One of the most common triggers of breast cancer is overexpression of estrogen receptor alpha (ER?). This researchs goal is to test the ability of coumestrol as the ligand of ER? with in silico method and to discover coumestrols binding pose inside the ER?s binding pocket. Coumestrols ability as ER?s ligand was tested using structure-based virtual screening (SVBS) method by Setiawati et al. (2014) that had been modified by Istyastono (2015). Results analysis was done using decision tree generated from recursive partition and regression tree method (RPART). If coumestrol is a ligand based on decision tree, it is concluded that coumestrol is active as ligand of ER?. At the end of analysis, coumestrols pose inside ER?s binding pocket was visualized using MacPyMol. From the test acknowledged that the smallest ChemPLP value of coumestrols pose was -83.1487. Coumestrol interacts with GLY420, ARG394, and GLU353 using hydrogen bonds. However, coumestrol were perceived as decoy according to decision tree. Hence, coumestrol could not be recognized as ER?s ligand by the protocol. Therefore, development of proper protocol to indentify ligand for ER? is required.

ANTI-DIARRHEAL ACTIVITY OF AQUEOUS EXTRACT OF NAGASARI FLOWERS (Mesua ferrea L.) IN BALB/c MICE INDUCED BY Escherichia coli Putu Monik Ananta Puspitarini; Iman Surya Pratama; Bambang Fajar Suryadi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 2 (2019)
Publisher : Sanata Dharma University

Nagasari (Mesua ferrea L.) is empirically used for curing diarrhea in Nusa Tenggara Barat Province. However, the safety and efficacy of nagasari have not been scientifically validated in animal model. This study evaluates the activity of nagasari flowers aqueous extract in BALB/c mice induced by Escherichia coli to determine the most effective dosage for anti-diarrheal effect. The aqueous extract of nagasari flowers ((0.4% (w/v), 0.8% (w/v), and 1.6% (w/v)) was given to 3 groups of mice whereas negative and positive control groups received aquadestilate and ciprofloxacin 130 mg/kgBW respectively orally once per day for 3 days. The frequency and consistency of feces were observed then the total colony of E. coli in feces was calculated using colony counter. Aqueous extract of nagasari flowers at concentration of 1.6% showed significant inhibitory activity against Escherichia coli compared to positive controls (diarrhea index of 0.425; p0.05 and total colony of E. coli in feces of 100.2; p0.05). This study provides scientific support for the traditional use of aqueous extract of nagasari flowers for the treatment of diarrheal diseases.

EFEK KO-KEMOTERAPI FRAKSI ETIL ASETAT AKAR PASAK BUMI DAN DOXORUBICIN TERHADAP PROLIFERASI DAN EKPRESI BAX JARINGAN PAYUDARA TIKUS SD Tria Zakinah; Laela Hayu Nurani; Sitarina Widyarini
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 1 (2017)
Publisher : Sanata Dharma University

The use of co-chemotherapy agent was needed since there were some toxicities on the normal tissues caused by the use of doxorubicin. The root of Eurycoma longifolia Jack, a part of plant, has a potential activity as co-chemotherapy. This study aimed to determine the effect of co-chemotherapy of ethyl acetate fraction of E. longifolia Jack roots and doxorubicin against cell proliferation activity by AgNOR method and determine expression of Bax protein of breast tissue in rats induced by DMBA. The rats were divided into five groups: I (baseline), II (DMBA 20 mg/kgBW), III (DMBA, doxorubicin 1.12 mg/kg), IV (DMBA, fraction of 100 mg/kg), and V (DMBA, doxorubicin, fractions). All the rats were sacrificed at week 16. Their breast tissue was evacuated. Cell proliferation and expression was observed using AgNOR method and immunohistochemistry, respectively. Results showed the percentage of p-AgNOR obtained by the healthy group, DMBA group, DMBA+Doxorubicin group, DMBA+ethyl acetate fraction of E. longifolia Jack root group, and DMBA+Doxorubicin+Ethyl acetate fraction of E. longifolia group were 00%, 14.672.11%, 1.831.21%, 6.832.03%, and 4.080.95%, respectively. The percentage of Bax expression obtained by the healthy group, DMBA group, DMBA+Doxorubicin group, DMBA+ethyl acetate fraction of E. longifolia Jack root group, and DMBA+Doxorubicin+Ethyl acetate fraction of E. longifolia group were 68.821.52%, 26.863.25%, 44.492.06%, 80.923.27%, and 78.704.87%, respectively. Based on the results, it was concluded that co-chemotherapy agent of ethyl acetate fraction of E. longifolia Jack roots and Doxorubicin could inhibit proliferation and trigger apoptosis through Bax expression in breast tissue of rats induced by DMBA.

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Florentinus Dika Octa Riswanto

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