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Jurnal Farmasi Sains dan Komunitas

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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 247 Documents

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THE EFFECT OF EDUCATIONAL SELF-MEDICATION FOR DYSMENORRHEA TREATMENT USING OVER THE COUNTER DRUGS Betti Dwi Kartikasari; Yustina Emi Setyobudi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 2 (2018)
Publisher : Sanata Dharma University

Self-medication is an attempt to treat the disease felt by using the over-the-counter drug (OTC) which is based on knowledge about the safe and rational treatment. The implementation of the self-medication drug use tends to be misused. The ease in self-medication treatment in community shows the importance of education in the use of medications safely and rationally. Education is carried out appropriately with effective methods and media. This research used quasi-experimental design approach with one group pretest posttest design. The sample of this research was 34 female students from Frateran High School Malang selected using a purposive sampling. The data was analyzed using Paired T-Test. The results of comparison of self-medication treatment using OTC drugs before (pre) and after (post) education provided the significance value obtained 0.000 which is smaller than alpha 0.05. The null hypothesis (H0) can be rejected and concluded that there is a different score in the self-medication treatment using OTC drugs before (pre) and after (post) education. It can be concluded that the education can affect the improvement of knowledge of the students for effectiveness of lowering OTC drugs abuse.

PEMBUATAN DAN UJI AKTIVITAS SEDIAAN UNGUENTA SCARLESS WOUND HEALING DENGAN EKSTRAK BINAHONG (Anredera cordifolia (Ten) Steenis) DAN ZAT AKTIF ANTIINFLAMASI NATRIUM DIKLOFENAK Bertha Nathania; Sri Hartati Yuliani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 2 (2015)
Publisher : Sanata Dharma University

Wounds often leave scars that interfere with skins aesthetic, even lead to health problems, in some of people, scars tend to grow excessively cause of keloid scarring or cuts. One of the causes of scarring wounds is the process of long-term inflammation. Diclofenac sodium is a bitter taste substances. Diclofenac sodium is a selective inhibitor, which inhibit COX-2 in inflammatory processes. Binahong (Anredera cordifolia) is one of the plants in Indonesia, which came from China. Binahong leaves contain saponins, flavonoids, namely quinon, steroids, monoterpenoid, and sesquiterpenoid which has been known as a wound healer. The making of ointment scarless wound healing dosage form is by combining binahong leaves extract and the addition of anti-inflammatory agent diclofenac sodium (F4), which expected to reduce the wound scar on the Switzerland Webster strain mices skin that has bleed with incision method. The test that has been used is histopathology test followed by an extensive calculation of collagen. The calculation data were analyzed using T-test with 95% confidence level. The results from this research indicate that ointment of binahong extract and diclofenac sodium (F4) produce less scar.

PEMAHAMAN MASYARAKAT KECAMATAN MERGANGSAN, GONDOKUSUMAN, UMBULHARJO DAN KOTAGEDE YOGYAKARTA TERKAIT ANTIBIOTIKA Studi Pendahuluan Dalam Pengembangan Materi dan Metode Edukasi Dengan Pendekatan Secara Kualitatif: Diskusi Kelompok Terarah (DKT) Titien Siwi Hartayu; Yosef Wijoyo; Lucia Wiwid Wijayanti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 1 (2013)
Publisher : Sanata Dharma University

Abstract: Antibiotics will be used safely when it is used rationally, and rational use of antibioticsneed an appropriately of knowledge. In accordance to achieve appropriately knowledge aboutantibiotics, it is important to identify the level of knowledge about antibiotics to improve aneducational method and material about antibiotics. As a qualitative study using focus groupdiscussion (FGD) among residence of Four Sub-district in Yogyakarta City, e.g.: Mergangsan,Gondokusuman, Umbulhardjo and Kotagede. There was eight key person of each sub districtinvolved in the study. The inclusion criteria are: Residence of one of the four sub-districts withage above 17 years old, willing to attend the activities. The exclusion criteria are: residence withPharmacy education background, moving limited and mental disability. Results of the studyshow the characteristic demography of the participants are: 5 Female and 3 Male, age rangefrom 40 to 52 years old, with educational level: 5 participants are high school graduated and 3participants are University graduated. All of participants are key person of each sub districtwhose familiar with the residences and the environmental where they are living. All ofparticipants mention that they do not know about antibiotics et all including resistance and otherrisks of irrational use of antibiotics. All of participants asking for complete information aboutantibiotics which simple, accessible and could be socialized through the routine activities inevery sub district e.g.: PKK (mothers gathering). In conclusion, the level of participants'knowledge about antibiotics is still low, and need to be improved. Complete information aboutantibiotics in a simple form has to be developed as an educational material.Keywords: Focus Group Discussion, Antibiotics, Knowledge

THE CORRELATION OF TOTAL FLAVONOID AND TOTAL PHENOLIC WITH ANTIOXIDANT ACTIVITY OF SINGLE BULB GARLIC (Allium Sativum) FROM TAWANGMANGU AND MAGETAN Ika Buana Januarti; Hudan Taufiq; Sulistyaningsih Sulistyaningsih
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 2 (2019)
Publisher : Sanata Dharma University

Flavonoids and phenolics are compounds with hydroxyl groups (-OH) bound to aromatic rings which enable them to react with reactive oxygen species and eliminate free radical activity. Single bulb garlic (Allium sativum var. solo garlic) is known to have antioxidant activity which comes from the phenolic groups. This study aims to determine the correlation of total flavonoid and phenolic levels with the antioxidant activity of ethanolic extracts from single bulb garlic grown in Magetan and Tawangmangu regions. This study included an observational analytic study with a cross-sectional design. Total flavonoid levels were measured by colorimetric method and total phenolic levels were measured by Folin-ciocalteu method using Spectrophotometric UV-Vis. Antioxidant activity was measured by DPPH method at a wavelength of 517 nm. The data analysis used was multiple linear regression. The results showed that the extract of single bulb garlic from Magetan had total flavonoids of 12,1833 0,1943 mg QE/gram, total phenolics of 70,244 mg GAE/gram, and antioxidant activity with an IC50 value of 20,216 ppm. The extract of single bulb garlic from Tawangmangu contained total flavonoids of 14,4833 0,5911 mg QE/gram, total phenolics of 92,222 mg GAE/gram, and antioxidant activity with an IC50 value of 13,777 ppm. The conclusion of this study is that there is a significant correlation of total flavonoid and total phenolic content with antioxidant activity.

KANDUNGAN BETA KAROTEN DAN AKTIVITAS PENANGKAPAN RADIKAL BEBAS TERHADAP DPPH (1,1-difenil 2-pikrilhidrazil) EKSTRAK BUAH BLEWAH (Cucumis melo var. Cantalupensis L) SECARA SPEKTROFOTOMETRI UV-VISIBEL Aprilia Kusbandari; Hari Susanti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 1 (2017)
Publisher : Sanata Dharma University

Cantaloupe (Cucumis melo var. Cantalupensis L.), a fruit containing some compounds, have activity to protect human body from free radical. The beta carotene (provitamin A) was recognized as antioxidant compound. Antioxidants could protect the body from cardiovascular damage caused by free radical. The aims of this study was to determine the levels of beta carotene and antioxidant activity (IC50) from Cucumis melo var. cantalupensis L. extract using DPPH (1,1-diphenyl-2-picrylhydrazyl) method. Cantaloupe was extracted using n-hexan-acetone-methanol ratio (2: 1: 1). Identification of beta carotene was performed using 25% antimony trichloride reagent followed by TLC and UV-Vis spectrum test compared with beta carotene as standard. The content of beta carotene and free radical scavenging activity was measured spectrophotometrically at 425 nm. The beta carotene level of cantaloupe was 3.171 0.150 %. The antioxidant activity, presented as IC50 value of cantaloupe extract, was 12.1370.44 g/mL and the antioxidant activity of standard beta carotene was 2.15 0.172 g/mL. The cantaloupe extract contained beta carotene compunds but the antioxidant activity of extract was lower than beta carotene standard.

POTENSI ANTIMIKROBIA KRIM EKSTRAK RANTING PATAH TULANG (Euphorbia tirucalli Linn.) TERHADAP Propionibacterium acnes ATCC 11827 DAN Candida albicans ATCC 24433 Melina Scandinovita Setiorini; C.J. Soegihardjo; Kianto Atmodjo
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Euphorbia tirucalli L. (Euphorbiaceae) or patah tulang has been used traditionally in Java fortreatment of fungal infections (Propionibacterium acnes causing acne and Candida albicans causingcandidasis). Information on their use is available, but scientific data on their bioactivity and safety ofactions still scanty. A study was conducted on the effect of organic extracts of this plant on fungal strains.Aceton extract were evaluated through the disc diffusion assay. Aceton extract was prepared by Soxhletapparatus for eight hours. Bacteria and yeast test strains were cultured on TSA (Trypthone Soya Agar)and on PDA (Potato Dextrose Agar) for Candida albicans. A 0.5 McFarland standard suspension wasprepared. Sterile paper discs 6 mm in diameter impregnated with 10 ml of the test extract (100 mg/ml)were aseptically placed onto the surface of the inoculated media. Thymol 0,5% and ketokonazol 2% wereused as standards. Discs impregnated with dissolution medium were used as controls. Activity of theextracts was expressed according to zone of inhibition diameter. Dimethylsulfoxide (DMSO) was used forpreparing test extracts (10, 20, 40, 60, 80, 100%) and were tested for Minimum Inhibitory Concentration(MIC) to Propionibacterium acnes and Candida albicans. MIC were obtained that 100% test extract wasgreatest and 10% test extract was weakest. Then, test extracts were prepared by concentrations 10, 9, 8, 7,6, 5%, and the result were the best were 10% test extract to Propionibacterium acnes and 6% test extractto Candida albicans. Antimicrobial test for pharmaceutical preparation, i.e. cream (o/w) were preparedusing 9 and 10% test extracts mixed with cream for testing to Propionibacterium acnes and 5 and 6% testextracts with cream for testing Candida albicans.The final results were 10% test extract had MIC toPropionibacterium acnes and 6% test extract had MIC in cream to Candida albicans.Keywords: Euphorbia tirucalli L., DMSO, Thymol, antimicrobial potency, cream (o/w), Propionibacteriumacnes, Candida albicans

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOLIK DAGING BUAH BUNI (Antidesma bunius (L.) Spreng) TERHADAP Staphylococcus aureus ATCC 25922 dan Escherichia coli ATCC 25923 Brigitta Lynda Rakasiwi; C.J. Soegihardjo
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Abstract: The aim of the study was to determine the antibacterial activity of buni skin-pulpethanolic extract against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC25922. Profile of antibiotic resistance which is growing among Staphylococcus aureus andEscherichia coli need some exploration of antibacterial activity buni skin-pulp because thecontain of anthocyanin which has antibacterial activity. The research was purely experimentalresearch with randomized complete direct sampling design. The extraction method was done bymacerated in ethanol solvent. Tube tests and Thin Layer Chromatography (TLC) were used todetermine the content of the secondary metabolites substance in buni skin-pulp ethanolic extract.Antibacterial activity test was done by diffusion method, then followed with liquid dilutionmethod to determine the Minimum Inhibitory Concentration (MIC) and Minimum BactericidalConcentration (MBC). The antibacterial activity was evaluated based on the result of inhibitionzone diameter then analyzed with Kruskal-Wallis test followed with Mann-Whitney test.The results showed that the chemical substances of the buni skin-pulp ethanolic extract predictedwith TLC assay were phenolic, flavonoids, and anthocyanin compounds. The antibacterialactivity showed that the ethanolic extract only had antibacterial activity against Staphylococcusaureus ATCC 25923 with MIC and MBC values 30% and 33%, respectively.Keywords: antibacterial potency, buni skin-pulp, Staphylococcus aureus, Escherichia coli

THE EFFECT OF HEALTH INSURANCE ON ASTHMA CONTROL IN RESPONDENTS WITH ASTHMA IN YOGYAKARTA, INDONESIA Rita Suhadi; Fenty Fenty; Dita Maria Virginia; Christianus Heru Setiawan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 2 (2018)
Publisher : Sanata Dharma University

Asthma is a chronic disease with recurrent breath shortness. Until now, there is no particular therapy to cure the disease and long-term treatment is needed to control the disease. Health insurance has the benefit to support the asthma therapy. This study aimed to assess the effect of health insurance on the asthma control based on Asthma Control Test (ACT) score. The study was done with a cross-sectional design on respondents with asthma who agreed to sign informed consent forms in Yogyakarta. The asthma respondents (n=36) were selected non-randomly, consisting of 23 respondents with health insurance, including universal health coverage or UHC (n=15), UHC and private insurance (n=7), and private insurance only (n=1). The ratio and categorical data were analyzed with the independent T-test or Mann-Whitney test and chi-square statistics, respectively. The study demonstrated that the profiles and number of medicines were similar between groups, except for lower smoking proportion among health insurance groups; the respondents with and without health insurance had the median ACT score at 22 (partial control) and 15 (bad control) respectively, though the scores were not statistically different. Conclusion: the asthma respondents with and without health insurance were not statistically different in the asthma control.

PEMBUATAN DAN UJI AKTIVITAS SEDIAAN GEL SCARLESS WOUND DENGAN EKSTRAK BINAHONG DAN ZAT AKTIF PIROXICAM Ayaga Divadi; Sri Hartati Yuliani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 2 (2015)
Publisher : Sanata Dharma University

Wound is a condition where the tissue integrity is damaged so that body will attempt to repair the damaged tissue by wound healing mechanism. This mechanism usually results in the scar formed by its inflammatory phase. Binahong (Anredera cordifolia (Ten.) Steenis) contains ascorbic acid and flavonoids which are important for collagen formation, to improve the rate of the wound healing process. Piroxicam can shorten or detain the inflammatory phase by inhibiting the cyclooxygenase (COX) enzymes in the prostaglandine synthesis process, which play an important role in scar formation. The aim of this research is to discover if the combination of piroxicam and binahong extract in the scarless wound gel could offer scar reduction effect. In this research, a gel preparation with binahong extract was combined with piroxicam to develop the scarless wound gel (BinPirox). The research was purely experimental. It was done by conducting a histopathological test followed by collagen area calculation. The data were analyzed by independent sample t-test with 95% significancy level. In this research, the addition of piroxicam was expected to reduce the scar formation on incisional wound of white Swiss Webster mice (Mus musculus). The result showed that BinPirox formed statistically less scar when compared to Bin (a gel preparation with binahong extract).

PENGARUH PEMBERIAN SUBKRONIK EKSTRAK KELOPAK BUNGA ROSELLA (Hibiscus Sabdariffa L.) TERHADAP KADAR SGPT SGOT DAN ALP Nurkhasanah Nurkhasanah; Moch. Saiful Bachri; Nofa Risma Azis
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 2 (2016)
Publisher : Sanata Dharma University

Roselle (Hibiscus sabdariffa L.) has been known as traditional medicinal plants. It needed to evaluate the safety of roselle extract on long-term oral administration. The research aimed to determine the savety of ethanolic extract of roselle calyx. Subchronic toxicity study of ethanolic extract of roselle calyx had been carried out on 60 Sprague Dawleys (SD) rats for 28 days. The roselle extract was administered orally every day, with doses of 50,100 and 200 mg/kgBW. There are 2 satellite groups, kept for another 14 days after the treatment in order to detect a delayed occurrence of toxic effect. Satellite group was given extract 200 mg/kgBW for 28 days and followed aquadest treatment for 14 days. At the end of experiment the blood was collected for meansuring SGPT, SGOT and ALP activity. The result showed that treatment of roselle calyx extract had no significant changes in SGPT SGOT, ALP activity. The delayed effect was not also observed. The ethanolic extract of roselle calyx didnt show toxic effects on the liver on subchronic administration.

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Contact Name
Florentinus Dika Octa Riswanto

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editorial.jpsc@usd.ac.id

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editorial.jpsc@usd.ac.id

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Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

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Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA