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Jurnal Farmasi Sains dan Komunitas

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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 247 Documents

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LIPID AND SILVER NANOPARTICLES GELS FORMULATION OF TEMPEH EXTRACT Felicia Satya Christania; Rini Dwiastuti; Sri Hartati Yuliani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 2 (2019)
Publisher : Sanata Dharma University

Tempeh extract is used in this study as an active ingredient in lipid nanoparticles and reductant in silver nanoparticles because tempeh is an authentic Indonesian food ingredient and is known to have the main content of isoflavones. Gel preparations were chosen to increase the acceptability and stability of lipid and silver nanoparticles. This research is aimed to formulate lipid nanoparticle gel formulations with tempeh extract as active substances and silver nanoparticle gel formulations with tempeh extract as bioreduction. Lipid nanoparticles were made from soy lecithin phospholipids by heating at 600C and sonication method for 30 minutes then the tempeh extract was added just before sonication. Silver nanoparticles were made by adding tempeh extract to the AgNO3 solution at 900C for 30 minutes. The average particle size of tempeh extract lipid nanoparticles was 130.03 nm and silver nanoparticle was 94.76 nm. The average viscosity of tempeh extract lipid nanoparticles gel was 4.02 d.Pa.s and silver nanoparticles was 4.22 d.Pa.s. The average spreadability of tempeh extract lipid nanoparticles gel was 4.37 cm and silver nanoparticles was 4.05 cm. The average pH value of tempeh extract lipid nanoparticles was 7.70 and silver nanoparticles was 7.33.

PENGARUH KONSENTRASI XANTHAN GUM TERHADAP STABILITAS FISIK KRIM VIRGIN COCONUT OIL (VCO) Beti Pudyastuti; Marchaban Marchaban; Rina Kuswahyuning
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 1 (2015)
Publisher : Sanata Dharma University

Abstract: Virgin Coconut Oil (VCO) is a pure oils that is extracted from fresh coconut meat at low temperatures. The formulation of VCO in cream dosage form could retain skin moisture and improve the acceptability. Xanthan gum is one of the emulsifier that used to form oil in water (O/W) cream. The purpose of this research were to determine the effect of xanthan gum concentration to the physical stability of VCO cream. VCO creams were prepared by emulsifying the oil phase and the water phase with the variation of xanthan gum concentration (2.5; 2.7; 2.9; 3.1; 3.3% w/w). Observation of the physical stability of the cream includes organoleptic, emulsion type, droplets size, viscosity, spreadability, adhesion, and ratio of separation volume was conducted until 7th week, and also the freeze-thaw test for three cycles. The results showed that each formulation could produces homogeneous light brown cream with oil in water type. Increasing of xanthan gum concentration would increases viscosity of the cream so that spreadability decreases and adhesion increases during stability study. Ratio of separation volume increased after three cycles of freeze-thaw test. Cream with 3.3% w/w xanthan gum had the optimum physical stability.Keywords : VCO, O/W cream, xanthan gum, physical stability

ISOLASI DAN IDENTIFIKASI SENYAWA ALKALOID BUAH MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl) SECARA SPEKTROFOTOMETRI UV-Vis DAN IR SERTA UJI TOKSISITAS AKUT TERHADAP LARVA Artemia salina Leach Christina Astutiningsih; Frida Nuzulia; Agus Suprijono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 9, No 2 (2012)
Publisher : Sanata Dharma University

Abstract: Fruit Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl) contains alkaloid, tannin,saponin, flavonoid, terpenoid dan lignin. The aim of this study was to elucidate compound fromMahkota Dewa based on the analyses on spectrophotometry UV-Vis, IR and to evaluate thecompound in the Brine Shrimp Lethality Test. On IR spectra revealed the presence of alkaloidamin primer. The isolated alkaloid compound was found to be toxic to brine shrimp with LC5033.8932 ?g/ml.Keywords: alkaloid, Mahkota Dewa, toxicity, Artemia salina Leach

PHAGOCYTOSIS ACTIVITY OF BINAHONG (Anredera cordifolia (Tenore.) Steenis) FROM SECANG, MAGELANG, CENTRAL JAVA, INDONESIA Perdana Priya Haresmita; Dika Sotya Sakti; Nunung Yuniarti; Subagus Wahyuono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

The use of medicinal plants is increasing due to the search for alternative resources to treat diseases such as hypertensions and infection. Along with the development in science, preventive action should take place to prevent our body from suffering from these diseases. This can be done by increasing the human immune status with immunomodulatory agents. Binahong empirically have benefits for wound healing. The purpose of this research was to investigate the immunomodulatory effect of ethanolic extract of binahong leaves. The non-specific modulatory effects of the ethanolic extracts of binahong leaves on the immune systems were measured based on phagocytosis index and phagocytosis capacity. Tests were conducted on strain Balb/C male mice at the age of 6-8 weeks. Mice were administered orally with the extract of binahong leaves (doses of 25, 50, 75 mg/kgBW) for 14 days. The test results with the index parameters and macrophages phagocytosis capacity at doses of 50 and 75 mg/kgBW did not significantly increased when compared with the controls. From these results, we concluded that the ethanolic extract of binahong leaves with a dose of 25, 50 and 75 mg/kgBW cannot significantly the activity of macrophages by phagocytosis index parameters and phagocytosis capacity significantly.

UJI IN SILICO SENYAWA 2,6-DIHIDROKSIANTRAQUINON SEBAGAI LIGAN PADA RESEPTOR ESTROGEN ALFA Felicia Fraulein Setiawan; Enade Perdana Istyastono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 2 (2015)
Publisher : Sanata Dharma University

Previous studies has shown that estrogen receptor alpha that binds to estrogen may increase cancer cell proliferation, thus estrogen receptor alpha can be targeted to cure breast cancer. The aim of this in silico study is to test whether phytoestrogen 2,6-dihydroxyanthraquinone is a ligand of estrogen receptor alpha. Setiawati et al. (2014) has established a valid protocol for Structure Based Virtual Screening using molecular docking software PLANTS 1.2. This protocol is used to test 2,6-dihydroxyanthraquinone as ligand for estrogen receptor alpha. Output from the protocol is analyzed using a post-docking analysis method developed by Istyastono (2015) in R 3.0.2. Visualization of binding pose is generated with PyMOL 1.2. Results show that 2,6-dihydroxyanthraquinone cannot be identified as a ligand of estrogen receptor alpha. The method used in this study is not suitable to identify 2,6-dihydroxyanthraquinone, which is a marginal active substance, as active ligand. Further study to develop a suitable method to identify marginal active substances as ligands in estrogen receptor alpha is needed.

DESAIN DAN SINTESIS SENYAWA ACES (ANALOG CURCUMIN SERIES) DENGAN METODE SOLID PHASE REACTION SEBAGAI SENYAWA ANTIKANKER POTEN DENGAN MEKANISME MENGHAMBAT PROTEIN NF-kB Monica Sabrina Widiapranolo; Eva Mayangsari; Venny Valeria; Jeffry Julianus
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 1 (2013)
Publisher : Sanata Dharma University

Abstract: Analog of curcumin in forms of enone and dienone aromatic is known for their activityas an NF-?B inhibitor. In this study, will be synthesize 2-(4'-N, N-dimethylamino benzilidine)cyclohexane-1,3-dione as an analog that predicted has an activity as an NF-?B inhibitor. Thisresearch was conducted based on the crossed aldol condensation reaction by reacting 3 mmole pN,N-dimethylamino benzaldehide and 6 mmole cyclohexane-1,3-dione with hydrochloric acid asthe catalyst using solid phase reaction method. Based on computational analysis, 2-(4'-N,Ndimethylamino benzilidine) cyclohexane-1,3-dione showed a better interaction with NF-?Bprotein with PLANTSPLP score was -69,7895. The outcome of the reaction was yellow coloredpowder, no odor and soluble in hydrochloric acid 3N. The yield value was 78.8%. Liquidchromatography showed 100% purity. The melting point range was 237.5-240.3C. The resultsof structure elucidation by 1H-NMR, infrared and mass spectroscopy tests indicated thecompound was 2-(4-(dimetilamino)benzilidena)-4-(3-oksosiklohex-1-enil) sikloheksana-1,3-dion.Key words: 2-(4'-N, N-dimethylamino benzilidine) cyclohexane-1,3-dione, crossed aldolcondensation, solid phase reaction.

ANTIOXIDANT AND ANTICANCER ACTIVITIES OF MURBEI (Morus alba L.) STEM EXTRACT ON IN VITRO WiDr CANCER CELLS Asril Burhan; Akbar Awaluddin; Zulham Zulham; Burhanuddin Taebe; Abdul Gafur
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 2 (2019)
Publisher : Sanata Dharma University

Mulberry (Morus alba L.) is considered as an important plant in traditional Chinese medicine, due to its various compounds, including phenols and flavanoids, which have antioxidant properties so that it can be a potential anticancer candidate. This study aimed to determine the antioxidant activity, phenolic content, and potential anticancer activity in Mulberry stem extract. The extraction was done by maceration using ethanol as the solvent, while antioxidant activity test used ABTS (2,2?-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) method, phenolic content determination used Folin-Ciocalteu reagents, and anticancer activity test used the MTT (3-(4,5- dimetiltiazol-2-il)-2,5-difenil tetrazolium bromida) method on WiDr cancer cells and Vero cells. The result of total phenolic Mulberry stem extract was 35.9%, the antioxidant activity value was 83.18 g/mL, the IC50 value for anticancer activity for WiDr cells was 71.24 g/mL and Vero cells IC50 value was 154.241 g/mL. It could be concluded that the Mulberry stem ethanol extract has strong antioxidant activity and has the potential to be an anticancer agent selectively against WiDr cancer cells.

PENCEMARAN SODIUM DODECYLBENZENE SULFONATE (SDBS) PADA IKAN AIR TAWAR: PENENTUAN AKUMULASI DAN MONITORING PENCEMARAN Monica Cahyaning Ratri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 1 (2017)
Publisher : Sanata Dharma University

The research for accumulation determination and monitoring of Sodium Dodecylbenzene Sulfonate (SDBS) contamination in freshwater fish has been conducted. The aims of this research were to determine the interference of protein and ions in analysis, the parameters of validation, the correlation of SDBS concentration in the basin and SDBS accumulation in catfish followed by SDBS analysis in freshwater fish that sold in market in the area of Yogyakarta city. This research was started by isolating SDBS from freshwater fish using soxhlet extraction method and then followed by analysis of SDBS using spectrophotometer UV-Vis with acridine orange (AO) reagent. The results showed that the presence of proteins might be interferre the analysis process, Ca2+ and Mg2+ ions might interfere the analysis process at concentrations 12 mg/L and 6 mg/L. Analytical method validation was performed and showed correlation coefficient values (r) was 0,9981, limit of detection was 0,089 mg/L, limit of quantification was 0,0296 mg/L, RSD 2% and % recovery between 83-107%. The content of the SDBS in fish increased with increasing concentrations of SDBS in water and caused the decrease of Bio-concentration Factor (BCF) value. The concentration of SDBS in the analysis of fish in the market were between 0,0012-0,0029 mg/g, 0,0038-0,0077 mg/g and 0.0008-0,0026 mg/g for catfish, red tilapia and carp, respectively.

AKTIVITAS ANTIBAKTERI LOTION MINYAK KAYU MANIS TERHADAP Staphylococcus epidermidis PENYEBAB BAU KAKI Fitri Apriliyani Tiran; Christofori M.R.R. Nastiti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Trans-cinnamaldehyde is the major chemical compound of cinnamon oil which is potential as anantibacterial agent. Due to this activity, Cinnamon oil can be formulated into a lotion for practical use.This study aimed to determine the antibacterial activity of cinnamon oil and cinnamon oil lotion againstStaphylococcus epidermidis, which causes unacceptable foot odor. This study was a pure experimentalstudy. Stages of this study were starting from the obsevation of antibacterial activity of Cinnamon oilagainst Staphylococcus epidermidis which was done by using diffusion method to determine theconcentrations used in the formulation. Cinnamon oil was then formulated into lotions with variation ofconcentrations of 12; 18; and 24% (w/w) respectively. Furthermore, the quality of lotion based on itsphysical properties such as viscosity and spread-ability, and the antibacterial activity of lotion weredetermined. The inhibition zones then were statistically analyzed by using the Kruskal-Wallis test withassistance of R 2.14.1software. The result showed that cinnamon oil lotion had good physical properties ata concentration of 12% (w/w). Cinnamon oil itself and the formulations had significant activity againstStaphylococcus epidermidis. Moreover, cinnamon oil and its formulation showed similar antibacterialactivity against Staphylococcus epidermidis.Keywords : antibacterial activity, cinnamon oil, lotion, Staphylococcus epidermidis

ANALYTICAL METHOD VALIDATION OF BENZENE USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY IN BEVERAGE CONTAINING SODIUM BENZOATE AND ASCORBIC ACID Melania Perwitasari; Endang Lukitaningsih; Sudibyo Martono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Abstract: Several countries reported discovering benzene in beverages containing benzoic acidand ascorbic acid. Benzoic acid decarboxylation by ascorbic acid will form benzene. AmericanBeverage Association (ABA) recommended the use of accelerated testing to test benzene inbeverages. High Performance Liquid Chromatography (HPLC) is one of several methods toanalyze benzene in a wide variety of samples, but there is no much information providedregarding the validation of analysis method of benzene. Therefore, developing analysis methodof benzene and its validation becomes a current need. The HPLC system consists of Hitachi L-2130 pump, sample injector with 20 L sample loop, and UV detector L-2420 operating at 205nm. The analytical column is a LiChrosorb Phenomenex RP-18 (250 x 4 mm, 10 m, 100 ?), themobile phase is acetonitrile:aquabidest (60:40 v/v) and pumped at a flow rate of 0,8 mL/min.Benzene separated from the matrix and follows the validation requirements. The developedanalytical method showed that resolution was 8.37, r = 0.995 with LOD and LOQ 6.52 ppb and19.75 ppb, with a precise of ?11% and recovery of 80-110%. Accelerated testing indicated thatbenzene levels increased with increasing of the temperature. Beverages containing 400 mg/mL ofascorbic acid and benzoic acid formed benzene which was detected as 699.38 ppb at 25 oC,799.61 ppb at 40 oC, and 808.94 ppb at 60 oC in 48 hours. In conclusion, the method was fullyvalidated and can be utilized to analyze benzene in beverages with the accelerated testing at 60 oC in 48 hours, so that benefits the producers and consumers in the end.Keywords : benzene, HPLC, validation method, ascorbic acid, benzoic acid

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Florentinus Dika Octa Riswanto

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editorial.jpsc@usd.ac.id

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Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

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Daerah istimewa yogyakarta

INDONESIA