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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
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Articles 14 Documents
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Search results for , issue "Vol. 43 No. 2 (2024)" : 14 Documents clear
Health insurance trends from 2004 to 2022: a bibliometric analysis Damayanti, Fitriani Nur; Santosa, Budi; Suparman, Suparman; Kusumawati, Erna; Istiana, Siti
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.240-251

Abstract

The goal of health systems implemented at international, national, or regional level is to improve health effectively and efficiently by all available means, including community efforts, special education, military, and government, thereby improving public health at all levels. Health issues as national issues need top priority. Inequalities in mortality risk are inseparable from issues surrounding the health policy debate. Public health level is assessed through several indicators. Health Policy in law regulates the right to health. Proposed health system goals at international, national, or regional levels are usually not measured by human rights standards and instruments. Universal Health Insurance is expected to provide benefits. Health services are provided as medicines and treatments. This review aimed to determine trends in number of publications and visualize linkages of health insurance topics through bibliometric analysis. This was  a systematic review with steps following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagram using 661 scientific articles published between 2004 and 2022, followed by inclusion and exclusion criteria from Dimensions database. Review of articles was by means of  Vosviewer app. Our study results contributed to research roadmap development on health insurance. The limitation is that app.dimension.ai and google scholar databases are periodically updated, such that bibliometric analysis of health insurance should be repeated in the near future. Because this bibliometric analysis only extracted scientific article data from app.dimension.ai database, further research should add another database for broader and more comprehensive understanding of health insurance.
Comprehensive analysis of the role of NLRC5 in gastrointestinal cancer: a systematic review Rahadiani, Nur; Ghozali, Mohammad; Dewi, Dyah Laksmi
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.229-239

Abstract

BackgroundGastrointestinal (GI) cancer is affecting millions of people globally, leading to high incidence and mortality rates and a heavy economic burden. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are a family of cytosolic pattern recognition receptors that regulate host defense responses against microorganisms. Among these, NLR family CARD domain-containing 5 (NLRC5) is assumed to function as a regulator of proinflammatory responses to intracellular pathogens. NLRC5 has been known to regulate immune responses, although its association with cancer remains controversial. This systematic review aimed to explore the roles and functions of NLRC5 in GI cancers. MethodsThree electronic databases, PubMed, Scopus, and ProQuest, were used for literature searching on March 18, 2024. From 921 articles found, 157 duplicates were removed, 671 were excluded based on title and abstract screening, and 84 were excluded based on full-text assessment, resulting in 19 articles included in this review. ResultsElevated NLRC5 levels have been observed in tumor tissues compared to normal tissues across esophageal, gastric, colorectal, and liver cancers. NLRC5 is also associated with increased tumor cell proliferation, migration, and invasion. Cancer cell sensitivity to 5-fluorouracil chemotherapy was found to be negatively correlated with NLRC5 expression. NLRC5 expression levels and genetic variations were also associated with cancer susceptibility to chemotherapeutic drugs and cancer survival. ConclusionNLRC5 potentially exhibits diverse functions in GI cancers, acting as a biomarker for diagnosis, disease progression, prognostic assessment, and determining therapeutic implications. Further investigations are warranted to explore these mechanisms and their potentials for the development of effective treatment of GI cancers.
Comorbidities, social, and psychological factors associated with headache in adult Indonesians: data from the 5th Indonesian Family Life Survey (IFLS-5) Barus, Jimmy Fransisco Abadinta; Sudharta, Harvey; Suswanti, Ika; Sasmita, Poppy; Widyadharma, I Putu; Turana, Yuda
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.148-156

Abstract

BackgroundHeadache is a significant health problem worldwide, but national data on headaches in Indonesia are unavailable. Various risk factors have been identified as triggers or factors affecting its occurrence and severity. This study aimed to identify factors associated with headache occurrence in Indonesians aged 20 to 65 years. MethodsA cross-sectional study was conducted involving 26,263 participants aged 20 to 65 years. We covered any social, psychological, and comorbidity variables found in the fifth Indonesian Family Life Survey (IFLS) that could be linked to headaches. A multivariate-adjusted logistic regression model was used to estimate the odds ratios (ORs) and 95% confidence intervals (CI).  ResultsThe prevalence of those who had headache once in the past four weeks was 62.1%. Headache was associated with sleep disturbances (OR 2.24; CI 95% 2.11 – 2.36; p<0.001), depression (OR 1.79; CI 95% 1.67-1.92; p<0.001), hypertension (OR 1.79; CI 95% 1.64 – 1.96; p<0.001), female sex (OR 1.64; CI 95% 1.55 – 1.73; p<0.001), early adulthood (OR 1.32; CI 95% 1.24 – 1.42; p<0.001), hypercholesterolemia (OR 1.33; CI 95% 1.15 – 1.52; p = 0.001), poor/moderate sleep quality (OR 1.22; CI 95% 1.15 – 1.29; p<0.001), and low income (OR 1.12; CI 95% 1.05 – 1.19; p = 0.001). ConclusionsThis study demonstrated that sleep disturbances were the dominant risk factor of headache in subjects aged 20 to 65 years. Furthermore, sleep disturbance treatment should especially be considered in patients with a high level of headache.
A retrospective study of the relative utility of electrophoresis in the investigation of serum proteins Campos García, Gusdanis Alberto; Fernández Romay , Yulien; Maddela, Naga Raju; Zamora Cedeño , Aron; Talledo Pinargote , Diego; Howland Álvarez , Ivón
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.157-169

Abstract

BackgroundSerum protein electrophoresis (SPE) is widely used for diagnosis, management and monitoring of different immune disorders. Serum protein alterations provide valuable insights about these disorders. Electrophoresis separates proteins based on their physical properties, and the subsets of these proteins are used in interpreting the results. The purpose of this study was to analyze the results of pathological and non-pathological SPE of Ecuadorian patients. MethodsA retrospective observational study was conducted using data of pathological (871 samples) and non-pathological (752 samples) serum protein electrophoresis data of 1623 patients who attended the Gamma Clinical Laboratory of Portoviejo, province of Manabi, Ecuador. Bivariate and exploratory factorial analysis were done using following parameters: age, sex, survival, laboratory diagnosis according to electrophoretogram. ResultsThe highest frequency of deaths occurred in females (52.9%). The most frequent pathological outcomes were polyclonal hypergammaglobulinemia (49.5%), acute inflammation (21.1%), and monoclonal gammopathy (14.70%). Exploratory factorial analysis revealed that the results of pathological SPE were mainly influenced by albumin and ã-globulin fractions followed by á1-globulin, á2-globulin, and â1-globulin-â2-globulin behavior that differed from non-pathological SPE. The Kaiser-Meyer-Olkin measure was considered adequate for data analysis, and Bartlett’s test of sphericity was highly significant (p<0.001), corroborating that factor analysis is useful for the data set. ConclusionsThis evidence warrants the need for rigorous analysis of globulin concentration in SPE to avoid biased diagnosis based solely on visual inspection of patterns in the electrophoretogram. Special attention should be paid to the relationships between fractions that show the greatest influence on SPE results.
The linkage of perceived neighbourhood environmental safety with travel-time and leisure-time physical activity in adults Lim, Noor Hashimah Hashim; Jamaluddin, Rosita; Majid, M. Rafee; Tsong, Teh Bor; Abidin, Nurdiyana Zainal; Hasnan, Liyana; Hassan, Linda Shafarina
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.170-178

Abstract

Background Having the highest obesity prevalence and physical inactivity among its South East Asian counterparts, it is important for Malaysia to understand the factors contributing to this epidemic. Because low neighbourhood safety is linked to physical inactivity, the objective of this study was to explore perceived neighbourhood safety from traffic and crime with its effects on adults’ travel- and leisure-time physical activities.   Methods This cross-sectional study was conducted on 256 adults. Six items on a 4-point Likert scale from the Neighbourhood Environment Walkability Scale (NEWS) and WHO’s GPAQ questionnaires to record weekly minutes of physical activity were used to measure the variables. Forty-three neighbourhoods from Johor Bahru district were categorised into higher and lower socio-economic status by median housing price per square feet. Structural equation modelling (SEM) was used to analyse the data.   Results Among 256 adults, males were found to be more physically active than females. SEM showed that for every 1 unit increase in neighbourhood socioeconomic status, males’ perceived neighbourhood environmental safety increases by 0.23 unit (p=0.006); however, this does not explain their physical activities. For the females, regardless of neighbourhood socioeconomic status, every 1 unit increase in perceived neighbourhood environmental safety from traffic and crime encourages physical activity to increase by 0.47 unit (p=0.006), especially for leisure purposes. Both genders perceived that street lighting at night and pedestrian visibility are important safety features of the neighbourhood environment.   Conclusion The study outcomes facilitate understanding of causal factors of physical activity through perceived neighbourhood environmental safety, especially among females.   Keywords: Neighbourhood environment safety, neighbourhood socioeconomic status, physical activity, gender, adult
Wound healing activity of topical Phaleria macrocarpa extract in type 2 diabetic rats Sulistyoningrum, Evy; Rosmelia, Rosmelia; Fidianingsih, Ika; Narantika, Shindy Galuh; Cleopatra, Neysa Nurprahutri; Azzahra, Fathimah
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.136-147

Abstract

BackgroundHyperglycemia interrupts wound healing, causing persistent and non-healing wounds. Phaleria macrocarpa extract (PME) has anti-diabetic, anti-inflammatory, antimicrobial, and antioxidant properties. This study aimed to assess P. macrocarpa activity on skin wound healing in diabetic rats. MethodsAn experimental study performed on 25 male Wistar rats. Ointments were prepared by adding vehicle (w/w) to PME at the desired concentration. Diabetes was induced by injecting rats with nicotinamide (NAD) 230 mg/kg and streptozotocin (STZ) 65 mg/kg. After hyperglycemia was confirmed, animals were randomly grouped into: i) normal rats, ii) diabetic rats; iii) diabetic rats + 2.5% ointment; iv) diabetic rats +5% ointment; and v) diabetic rats +10% ointment. Full-thickness skin wounds were induced on the dorsum and treatment was applied daily for 3 and 7 days, respectively. On days 4 and 8, wound closure was measured and animals were sacrificed for tissue samples. Wound healing was evaluated by measuring malondialdehyde (MDA) in tissue homogenates of the dermal wounds and analyzing histological changes by hematoxylin-eosin and Sirius-red staining. ResultsPME 10% ointment improved MDA levels and wound closure of inflammatory and proliferation phases. In inflammatory phase, 5% and 10% ointment reduced inflammation severity compared with diabetic rat group (p<0.05). In proliferation phase, PME 10% ointment group had a higher wound histological score (characterized by epidermal regeneration, fibroblast count, granulation tissue, and angiogenesis), and higher collagen bundle density compared with untreated groups (p<0.05).  ConclusionsTopical P. macrocarpa improves inflammatory and proliferation phases of excision wound healing in type 2 diabetes.
Antioxidants as future medicines: redox homeostasis concept Amani, Patwa
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.133-135

Abstract

Risk factors of early onset type 2 diabetes mellitus in young adults ≤ 40 years old Gunawan, Burhan; Soerachmad, Soesilowati; Hendrawan, Liana Dewi; Titus, Johana; Cendana, Vira
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.179-187

Abstract

BackgroundThe global prevalence of type 2 diabetes mellitus (T2DM) in adolescents and young adults is dramatically increasing. The aim of this study was to explore numerous risk factors for the occurrence of Pre-DM or T2DM in subjects aged ≤40 years. MethodsA cross-sectional study was conducted involving 100 subjects (50 subjects in the Pre-DM/T2DM group and 50 subjects in the Non Pre-DM/T2DM group). Main inclusion criteria: age ≤40 years, registered in our Diabetes and Endocrine Clinic. Data extracted included demographic, lifestyle, anthropometric, psychosocial, and family history data. Statistical analysis by binary logistic regression model. Results were considered significant at p<0.05 ResultsThere were no differences in demographic variables between the two groups. Multivariate analysis showed that cigarette smoking [aOR 3.17 (95% CI: 1.11-11.28)], hypertension [aOR 2.48 (95% CI: 1.23-7.19)] obesity [aOR 5.11 (95% CI: 2.12-8.21)], history of excessive calorie intake [aOR 3.40 (95% CI: 1.54-5.55)], poor stress management [aOR 2.33 (95% CI: 1.04-3.88)], depression [aOR 5.17 (95% CI:1.63-8.26)], short sleep duration [aOR 2.72 (95% CI: 1.25-6.95)], physical inactivity [aOR 6.14 (95% CI: 1.41-9.22)], family history of T2DM [aOR 6.29 (95% CI: 2.61-9.27)], family history of hypertension [aOR 5.26 (95% CI: 2.18-8.91] were significant influential risk factors of Pre-DM/T2DM. ConclusionThe most influential risk factor for the occurrence of early onset T2DM among young adults was family history of T2DM. Screening of family members of T2DM patients may lead to early intervention and reduced risk of subsequent complications.
Contrast media induced nephropathy: case series and review of the literature focusing on management Marciyasa, Putu Agus; Kandarini, Yenny; Mahadita, Gede Wira; Ayu, Nyoman Paramita
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.252-261

Abstract

BackgroundContrast media administration during diagnostic and invasive procedures in high risk patients for nephrotoxicity is a common problem in clinical practice. Radiological procedures using intravascular iodinated contrast injection media have been widely used for therapeutic purposes. Contrast-induced nephropathy (CIN) is a serious complication of angiographic procedures and results from administration of contrast media (CM), which increases morbidity and mortality rates. Case Description                                                                                                                                                                                                               We present these 10 cases with high risk of CIN and diverse characteristics. A new generation iso-osmolar CM (iodixanol) was administered in these cases. Three of the cases experienced CIN events, where one patient experienced an improvement in his condition, but two other patients experienced complications and eventually died due to the underlying disease. The other 6 cases did not experience CIN after receiving CM, which was due to better preparation beforehand. One patient with a history of regular hemodialysis, underwent immediate post-operative dialysis with CM, and no evaluation of the incidence of CIN was required. Conclusion Of the 10 cases observed, 3 of them experienced CIN which was caused by the severity of the patient’s condition and lack of preparation time before the CM procedure. Management of CIN is complex, starting from the pre-treatment evaluation until 72 hours or more after the CM procedure. This case series suggests that even new generation CM (including iodixanol) may be severely nephrotoxic, when administered to high risk patients. The amount of CM given must be below the maximum limit and adjusted to the patient’s condition. Additionally, we review the complex mechanisms involved in management of CM nephrotoxicity.
In-vivo antimalarial activity of Holothuria scabra simplicia in Plasmodium berghei-infected mice Sri Laksemi, Dewa Ayu Agus; Asri Damayanti, Putu Ayu; Sudarmaja, I Made; Tunas, I Ketut; Ratna Sundari, Luh Putu; Rustini, Ni Luh; Budi Apsari, Putu Indah
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.195-201

Abstract

BACKGROUNDMalaria remains one of the major causes of death worldwide. Holothuria scabra has a high nutritional content and many biological effects. The development of alternative anti-malarial drugs is necessary, considering that resistance to the newest anti-malarial drugs has been reported. This research study aimed to determine the anti-malarial effects of Holothuria scabra in mice infected with Plasmodium berghei. METHODSThis was a post-test only control group study conducted on 24 Balb/c mice. Peter’s four-day suppressive test was employed to ascertain the claimed anti-plasmodial effect of the simplicia. Following inoculation with P. berghei, all 24 mice were infected and randomized into 4 groups, namely 3 treatment groups and 1 control group. The control group was given carboxymethyl cellulose, two of the treatment groups were given doses of 10 and 100 mg/kg BW Holothuria scabra, respectively, using Peter’s four-day suppressive test, while the remaining treatment group received a dose of 100 mg/kgBW using the prophylactic method. Data were analyzed using One way ANOVA. RESULTSThe results showed by using both the four-day suppressive test and the prophylactic method, that Holothuria scabra has antimalarial activity. Holothuria scabra at a dose of 100 mg/kg BW was significantly effective in decreasing the percentage of parasitemia (p=0.000) and tended to inhibit the growth of Plasmodium berghei in mice (p=0.054). CONCLUSIONThis study demonstrated that Holothuria scabra possesses anti-plasmodial activity in mice. Hence, the sea cucumber could serve as a potential source of a newer antimalarial agent.

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