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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 602 Documents
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L-arginine improves uterine spiral arterial wall thickness in mouse models of preeclampsia Soetrisno, Soetrisno; Sulistyowati, Sri; Wibowo, Anwar Sandi
Universa Medicina Vol 36, No 2 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.131-137

Abstract

BackgroundPreeclampsia is a major cause of maternal and fetal morbidity and mortality. The imbalance of anti-angiogenic and angiogenic factors plays a role in endothelial dysfunction in preeclampsia. L-arginine is expected to improve the process of spiral artery remodeling. This study aims to examine the use of L-arginine to repair endothelial damage by measuring the thickness of uterine spiral arteries in mouse (Mus musculus) models of preeclampsia.MethodsThe researchers carried out an experimental study using 30 sixteen-day old pregnant Swiss mice (in good health, weighing 20-25 grams), which were randomly divided into 3 groups (each consisting of 10 mice). The groups were as follows: 1) normal pregnancy K(-); 2) preeclampsia model K(+); and 3) preeclampsia model receiving L-arginine (P). The authors performed histopathological examination of the mouse placenta, which had been dissected, embedded in paraffin wax and subsequently stained with hematoxylin and eosin (HE). The results were analyzed in SPSS v. 21 for Windows using Anova with Tukey.ResultsThe mean thickness of spiral arteries in group K(-) was 53.95 + 26.96 mm, in K(+) 96.50 + 16.66 mm, and in P 62.79 + 8.04 mm. Statistically, there were significant differences between groups K(-) and K(+) (p=0.001) and between K(+) and P (p=0.000), but non-significant differences between K(-) and P (p=1.000).ConclusionsThe treatment with L-arginine proved to be effective in repairing endothelial damage by reducing intimal hyperplasia and atherosis and, in turn, the thickness of uterine spiral arteries in mouse models of preeclampsia.
Directly observed treatment increases drug compliance in lymphatic filariasis mass drug administration Rosanti, Tutik Ida; Mardihusodo, Sugeng Juwono; Artama, Wayan T.
Universa Medicina Vol 35, No 2 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.119-127

Abstract

Backgroud. Mass drug administration (MDA) has been one of the strategies for lymphatic filariasis elimination. Since the start of implementation in 2011 in Pekalongan, no study on MDA acceptability has yet been done. The objectives of the study were to determine the microfilaria rate (mf rate) and the risk factors of drug compliance in the MDA program. MethodsA longitudinal study was conducted at Pabean region, Pekalongan City. There were 90 household heads as subjects, who were selected by proportional cluster random sampling. Microfilaria rate (mf rate) was determined by finger blood examination. Drug compliance was measured using questionnaires and observation sheets. Drug compliance observers, filariasis counseling participation, and presence of filariasis patients were factors influencing drug compliance. ResultsMf rate in 2015 was 1.35% and drug compliance rate was 86.80%. Reasons for failing to take drugs were fear of side effects (50%), refusals (25%), laziness (16.7%), and perceiving the drug to be useless (8.3%). The chi-square test shows a significant difference between the presence of drug compliance observer and compliance (p=0.006). Filariasis counseling participation and presence of filariasis patients did not show a significant difference with drug compliance (p= 0.986).ConclusionsFamilies as the source of observers was associated with increased filariasis drug compliance. It is therefore essential to address the issues linked to low compliance to make the program more efficient and achieve the goal of filariasis elimination.
Occipito-cervical meningioma in pregnancy Indiyarti, Riani
Universa Medicina Vol 27, No 3 (2008)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2008.v27.143-149

Abstract

Meningiomas are tumors that are believed to be derived from the cells and vascular elements of the meninges, and grow intracranially or in the vertebral canal. They are most common in women. The growth of meningiomas is stimulated by female sex hormones and thus may progress more rapidly in pregnant women and in women with breast cancer. The patient was a pregnant 39-year old woman (G4P3A0) of 8 months gestation. The clinical symptoms and signs were progressive upper motor neuron quadriparesis, diminished sensory functions from the level of C2 downwards, and loss of bladder and rectal control. Brain and cervical computed tomography (CT) scans done 2 months before admission showed no abnormalities. Induced delivery was terminated by forceps extraction, resulting in a baby of 2,100 g with Apgar score 7/9. After delivery, postcontrast magnetic resonance imaging (MRI) showed a large contrast-enhancing tumor mass of intradural-extramedullary location in the right occipito-cervical region. The tumor had a meningeal tail, extended into the right posterior fossa and caudally to the level of C3, with compression of the spinal cord. The patient underwent a nontotal resection to remove a tumor that microscopically had the features of a meningioma.
Does vitamin E play a role in the primary prevention of stroke? Hidayat, Adi
Universa Medicina Vol 30, No 1 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.1-2

Abstract

A few decades ago it was generally accepted from experimental studies, animal experiments, and epidemiological cohort studies that atherogenesis is linked to oxidative stress and that antioxidant supplementation, notably vitamin E supplementation, is associated with a low incidence of cardiovascular disease (CVD). This view led to the widespread use of vitamin E and other antioxidants for reducing CVD morbidity and mortality. In vitro and animal studies on antioxidant and anti-inflammatory properties of alpha- and gamma-tocopherols also found that these antioxidants had anti-inflammatory properties.
Phaleria macrocarpa reduces glomerular growth factor expression in alloxan-induced diabetic rats Sulistyonongrum Evy; Setiawati Setiawati
Universa Medicina Vol. 32 No. 2 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.71-79

Abstract

BACKGROUNDDiabetic nephropathy (DN) is the most serious complication of diabetes, causingend-stage renal disease throughout the world. Recent studies have reported adirect role of vascular endothelial growth factor (VEGF) and transforming growthfactor-â (TGF-â) in DN pathogenesis. VEGF and TGF-â are expressed early inglomeruli in response to hyperglycemia. Active substances of Phaleriamacrocarpa (PM) pericarp are known to have nephroprotective effects. Thisstudy aimed to evaluate the effects of Phaleria macrocarpa (Scheff.) Boerlpericarp extract on VEGF and TGF-â expression in alloxan-induced diabetic rats.METHODSAn experimental study was conducted on twenty five male albino (SpragueDawley) rats divided into five groups (of five each): normal control; diabetic;diabetic + metformin 100 mg/kgBW; diabetic + methanolic PM extract 250 mg/kgBW; and diabetic + aqueous PM extract 250 mg/kgBW. Diabetes was inducedby alloxan monohydrate 150 mg/BW intraperitoneally. Treatment was given for3 weeks. VEGF and TGF-â expression analysis was performed by means ofimmunohistochemical technique. Differences between groups were assessedby one-way ANOVA.RESULTSVEGF expression in the PM extract group was significantly lower than that in thediabetic group and even metformin group (p<0.01). TGF-â expression inmethanolic PM extract group was significantly lower than in diabetic andmetformin group (p<0.01), but aqueous PM extract group only showedsignificancy when compared with diabetic group (p< 0.01).CONCLUSIONSPhaleria macrocarpa pericarp extract reduces glomerular expression of TGF-âand VEGF in alloxan-induced diabetic rats.
Combination of five clinical data as prognostic factors of mortality after ischemic stroke Pinzon, Rizaldy Taslim; Babang, Fransiska Theresia Meivy; Pramudita, Esdras Ardi
Universa Medicina Vol 36, No 1 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.68-76

Abstract

Background The mortality rate after ischemic stoke is influenced by various factors. Prognosis after ischemic stroke can be predicted using a scoring system to help the doctor to evaluate patient’s condition, neurologic deficits, and possible prognosis as well as make appropriate management decisions. The objective of this study was to identify the factors which determine mortality rates in patients after ischemic stroke and to determine the prognosis of ischemic stroke patients using the predictive mortality score.MethodsThis was a nested case control study using data from the stroke registry and medical records of patients at the Neurology Clinic of Bethesda Hospital Yogyakarta between 2011-2015. Data was analysed using simple and multiple logistic regression analysis. The scoring was analyzed using receiver-operating characteristic (ROC) curve and the cut-off point using area under the curve (AUC).ResultsMultiple logistic regression analysis showed a significant association between mortality of ischemic stroke patients and age (OR: 4.539, 95% CI: 1.974-10.439, p&lt;0.001), random blood glucose (OR: 2.692, 95% CI: 1.580-4.588, p&lt;0.001), non-dyslipidemia (OR: 2.313, 95% CI: 1.395-3.833, p=0.001), complications (OR: 1.609, 95% CI: 1.019-2.540, p=0.041), risk of metabolic encephalopathy (OR: 2.499, 95% CI: 1.244-5.021, p=0.010) and use of ventilators (OR: 17.278, 95% CI: 2.015-148.195, p=0.009).ConclusionsAge, high random blood glucose level, complications, metabolic encephalopathy risk and the use of ventilators are associated with mortality after ischemic stroke. The predictive mortality score can be used to assess the prognosis of patients with ischemic stroke.
Penatalaksanaan tuberkulosis pada kehamilan Meiyanti, Meiyanti
Universa Medicina Vol 26, No 3 (2007)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2007.v26.143-151

Abstract

Tuberkulosis masih menjadi masalah kesehatan di dunia demikian juga tuberkulosis pada kehamilan. Insidens tuberkulosis pada kehamilan makin meningkat. Tuberkulosis pada kehamilan mempunyai gejala klinis yang serupa dengan tuberkulosis pada wanita tidak hamil. Diagnosis mungkin ditegakkan terlambat karena gejala awal yang tidak khas. Tuberkulosis tidak mempengaruhi kehamilan dan kehamilan tidak mempengaruhi manifestasi klinis dan progesivitas penyakit bila diterapi dengan regimen kemoterapi yang tepat dan adekuat. Pemberian regimen yang tepat dan adekuat ini akan memperbaiki kualitas hidup ibu, mengurangi efek samping obat-obat tuberkulosis terhadap janin dan mencegah infeksi yang terjadi pada bayi yang baru lahir. Obat anti tuberkulosis yang diberikan dibagi dalam 2 golongan yaitu obat lini pertama dan lini kedua. Obat lini pertama, kecuali Streptomisin dapat digunakan pada tuberkulosis pada kehamilan. Penggunaan streptomisin dan obat lini kedua (kanamisin, etionamid, kapreomisin) sebaiknya dihindari pada wanita hamil karena efek samping yang akan terjadi pada janin, kecuali dalam keadaan resistensi beberapa obat.
Serum estradiol levels and bone mineral density in postmenopausal women Mawi, Martiem
Universa Medicina Vol 29, No 2 (2010)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2010.v29.90-95

Abstract

Postmenopausal women are at high risk of disease, such as coronary heart disease, stroke, malignancies, dementia and osteoporosis. This is due to decreased levels of estrogen/estradiol, produced mainly in the ovaries, leading to reduced bone mineral density (BMD), which is the gold standard for diagnosis of osteoporosis. The purpose of the present study was to determine the relationship between serum estradiol levels and BMD in postmenopausal women. The study, which was of cross-sectional design, involved 184 postmenopausal women meeting the inclusion criteria, viz. healthy postmenopausal women aged between 47 and 60 years having taken no hormonal medications in the previous 3 years. The subjects were assessed for anthropometric and biochemical characteristics, including BMD and serum estradiol levels. BMD was measured at the lumbar spine, right femoral neck and at the distal radius by the dual-energy X-ray absorptiometry (DXA) instrument. The mean serum estradiol concentration was 7.54 ± 4.65 pg/ml, while in 49.5% of the subjects the estradiol concentration was £ 5 pg/ml. In postmenopausal women with estradiol concentrations of &gt; 5 pg/ml, a significant positive relationship was found between BMD and the T-scores for the femoral neck. Thus the higher the serum estradiol levels, the higher the BMD values for femoral neck region. In conclusion, the results of this study point to estradiol levels as a major factor in determining the BMD values in postmenopausal women.
Aminolevulinate dehydrogenase polymorphisms did not modified lead serum and memory relationship Lantip Rujito; Arini Dewi Setyowati; Saien Saien
Universa Medicina Vol. 31 No. 3 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.184-191

Abstract

BACKGROUND Lead accumulation in the blood widely known affecting the formation of heme and oxygen transport processes in vital organs, Leading to organ failure including the brain synapses. Lead affinity has been recognized influenced by constitutional genotype of aminolevulinate dehydrogenase (ALAD), which encodes for heme synthesis. This research aimed to determine the relationship between plumbum (Pb) and short term memory on each ALAD gene genotyping (ALAD 1-1, ALAD 1-2 or ALAD 2-2) in gas station workers. METHODS Seventy six probands from gas station workers were recruited to participate in this research. Each probands was carried out ALAD genotyping using polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP) method, lead serum level using atomic absorbent spectrophotometer (AAS), and short term memory was measurement by intelligence structure test (IST). RESULTS Proportion of δ ALAD 1-1, 1-2, and 2-2 were 91.8%, 8.2% and 0% respectively. Lead serum showed 15.84 ppb in homozygous 1-1, and 20.79 ppb in heterozygous. Short term memory in the probands varied from 85 until 117, with average in 99.71. There was significant negative relationship between lead serum and short term memory (r=-0.24; p=0.038). However, we could not find any significant correlation in each δ ALAD genotypes. CONCLUSION The δ ALAD genotypes did not modified the relationship between serum lead level and short term memory in gas station workers.
Non-exposure parenting increases risk of bullying behavior in junior high school students Hasan, Surilena; Jessica, Jessica
Universa Medicina Vol 35, No 1 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.56-64

Abstract

Background Bullying behavior is one of many behavioral and disciplinary problems among school students, which has a wide impact on youth, families, schools, and communities. Parenting and the role of parents as good educators (exposure) can prevent mental, emotional and behavioral disorders caused by bullying. The aim of this study was to determine the role of self-esteem and family factors on bullying behavior in junior high schools students.MethodsA cross-sectional study was conducted including 1324 junior high school students of Penjaringan village, North Jakarta. Respondents filled out questionnaires on demographics (age, gender, economic status, educational level), Rosenberg self-esteem questionnaire, strength and difficulties questionnaire, Olweus bullying questionnaire, Hamilton scale for depression, parenting style, and family adaptability and cohesion scales III. Simple and multivariate logistic regression tests were used to analyze the data.ResultsRespondents consisted of 53.5% females and 46.5% males, with an age range of 13-16 years. A total of 45% was involved in bullying (victims, perpetrators, and victims and perpetrators). Gender, self-esteem, family relationships, and parenting were significantly associated with bullying role (p&lt;0.05). Multiple logistic regression analysis showed that self-esteem (odds ratio=23.89; 95% CI:7.899-12.990) and non-exposure parenting (odds ratio=39.11;95% CI: 2.455-8.210) were significantly associated with bullying behavior. ConclusionsNon-exposure parenting was the most relevant risk factor of bullying behavior. Low self-esteem increases the risk of bullying behavior. These findings suggest the need of timely bullying prevention and intervention programs that should have a special focus on families of primary high school students.

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