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Pharmacy Study Program, Faculty of Mathematics and Natural Science, Sam Ratulangi University, Manado, North Sulawesi, Indonesia, 95115
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Kota manado,
Sulawesi utara
INDONESIA
PHARMACON
Published by Universitas Sam Ratulangi
ISSN : 23022493     EISSN : 27214923     DOI : 10.35799
Core Subject : Health,
Medicine & Pharmacology
Pharmacon is the journal published by Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Indonesia (P-ISSN: 2302-2493 E-ISSN: 2721-4923). Pharmacon was established in 2012 and published four times a year. Pharmacon is an open access journal and has been indexed by main indexing Google Scholar, GARUDA, Crossref.
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Articles 24 Documents
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Search results for , issue "Vol 2, No 3 (2013): pharmacon" : 24 Documents clear
UJI EFEK ANTIINFLAMASI EKSTRAK ETANOL DAUN SUJI (DRACAENA ANGUSTIFOLIA ROXB) TERHADAP EDEMA KAKI TIKUS PUTIH JANTAN GALUR WISTAR Narande, Julia Megawati; Wulur, Anne; Yudistira, Adithya
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : PHARMACON

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Abstract

ABSTRACTSuji (Dracaena angustifolia Roxb.) has been used empirically by the people of NorthSulawesi to cure the disease. Flavonoids and steroids in suji leaves suspected to haveantiinflammatroy effects. This study aims to examine the antiinflammatory effects of ethanolextract from suji leaves (Dracaena angustifolia Roxb.) on edema of white males wistar footinduced with 5% white egg solution, and to determine an effective dose of extract to decreasethe edema volume ofrat foot. The test was done using rat hind paw edema or esthablished anartificial inflammation in left foot of white male rats.The treatments were carried out on fivegroups, the positive control group was administered with diclofenac sodium, the negativecontrol group was administered with aquadest, and the extract groups were administered with100 mg/KgBB, 300 mg/KgBB and 1000 mg/KgBB of suji leaf extract. Edema volume weremeasured every hour for 7 hours using a glass tube. The average of edema volume (mL) andtime (hour) was plotted in a curve to form Area Under Curve (AUC). The AUC values wereused to calculate the percentage of antiinflammatory on each group compared to the negativecontrol group. Obtained data were analyzed by one-way ANOVA followed by LSD test withconfident level was 0,05. The result of this study indicate that suji leaf can reduce edemavolume of rat foot that induced with 5% white egg solution and antiinflamatory of ethanolextract from suji leaf 100 mg/KgBB by 33,19 %, 300 mg/KgBB by 14,04 % and 1000mg/KgBB by 5,80 %.Keywords: Suji(Dracaena angustifolia Roxb.), antiinflammatory, edema
Penentuan Nilai Sun Protective Factor (SPF) Secara In Vitro Krim Tabir Surya Ekstrak Etanol Kulit Alpukat Mokodompit, Ade Novia; Edy, Hosea Jaya; Wiyono, Weny
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2385

Abstract

ABSTRACTPeel of avocado (Persea americana Mill) contain efficacious compounds as an antioxydant.This studyhave purpose to determinethe value of Sun Protective Factor (SPF) of sunscreenfrom avocado's peel extract (Persea americana Mill) with aconcentration of5%, 7.5% and10%. In the determination of in vitro SPF valuesusing a spectrophotometer produce SPFvalues obtainedat a concentration of 5% is 3.99, 7.5% is 5.88,10% is 6.81. This study provesthat the use of this creamis notefficaciousas a sunscreen because the value result of SPF notexceed the minimal limit of good sunscreen SPF, that is 15.Key word : Peel of avocado (Persea americana Mill), cream, value of Sun Protective Factor(SPF)
UJI EFEK ANTIPIRETIK EKSTRAK ETANOL DAUN TEMBELEKAN (LANTANA CAMARA L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR Suwertayasa, I Made Putra; Bodhi, Widdhi; Edy, Hosea Jaya
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2375

Abstract

ABSTRACTTembelekan leaves (Lantana camara L.) contains flavonoids that possess antipyretic activityto inhibit prostaglandin. The aim of this study was toexamine the effect of ethanolic extractfrom tembelekan leaves as antipyreticon white male rats strain Wistar induced with DPT-Hb.This study is arandomized complete experimental design. Tested animals were 15 white malewistar rats, weighing 130-180g. Test ed animals were divided into 5 groups : negative group(CMC suspension 2.5ml), positive group (paracetamol), and treatment group of tembelekanleaves extract 720mg/kgBB, 1080mg/kgBB and 1440mg/kgBB. Temperature measurementswere conducted before the rats induced with DPT-Hb, 1 hour after administered with DPTeanalyzed by ANOVA and LSD (Least significant different). The conclusion of this study isethanolic extract from Tembelekan leaves (Lantana camara L.) possess antipyretic activiryon white male rats strain Wistar.Keywords: Tembelekan Leaves, Antipyretics, DPT-HB, Rats
DAMPAK PENYULUHAN PADA PENGETAHUAN MASYARAKAT TERHADAP PEMILIHAN DAN PENGGUNAAN OBAT BATUK SWAMEDIKASI DI KECAMATAN MALALAYANG Meriati, Ni Wayan Eka; Goenawi, Lily Ranty; Wiyono, Weny
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2391

Abstract

ABSTRACTThe efforts of society to heal theirself is called self-medication or swamedikasi. Selfmediacationis usually used to overcome the complaints and minor illnesses such the cough.The cough medicine can not be samed with all kinds of cough. This research is aimed toidentify the impact of socialization on public knowledge toward the selection and the use ofself-medication (swamedikasi ) cough medicine in Malalayang subdistrict. This is anexperimental research with one group pretest-postest design. The collecting process ofsample was done by random sampling technique with 150 respondences. The instrument ofthis research is questioner about cough medicine knowledge comprises of 18 questions andleaflet as the media. Based on the acquired information, the averagely score of publicknowledge in pretest is 64,55 and in postest is 90,11 with probability value (p) = 0.000 < (α)0.05, so H0 is rejected. It shows that there is an influence of socialization toward the selectionand the use of self-medication ( swamedikasi ) cough medicine in Malalayang subdistrict.There is a real difference averagely about the public knowledge before and after socialization.Key words: Socialization, Cough medicine, Self-medication ( swamedikasi )
FORMULASI SALEP EKSTRAK ETANOL DAUN NANGKA (ARTOCARPUS HETEROPHYLLUS LAM.) DAN UJI EFEKTIVITAS TERHADAP PENYEMBUHAN LUKA TERBUKA PADA KELINCI Hamzah, Hamdiyah; Fatimawali, Fatimawali; Yamlean, Paulina V. Y.; Mongi, Jeane
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : PHARMACON

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Abstract

ABSTRACTJackfruit leaves is a plant that work as medicine on healing process of skin diseases,especially in wounds. The purpose of this study is to determine the quality of ointment fromethanolic extract of Jackfruit leaves at the concentration on 5%, 10% and 15% and the effectof the open wound healing in rabbits. Type of this research is laboratory experimental. In thisresearch maceration was done as the extraction method to got the extract of Jackfruit leaves.The ointment of ethanolic extract from jackfruit leaves made within 3 concentrations of 5%,10% and 15%. On the testing ointment using organoleptic test, homogenity test and pH test.The effectiveness assay to heal the open wounds using 5 groups, Betadine ointment (positivecontrol), basic ointment (negative control), the ointment of ethanolic extract from Jackfruitleaves 5%, 10%, and 15% of the 3 rabbits with a 1.5 cm was done and observed until 7 days.The data were processed statistically using One Way ANOVA (Analysis Of Variant) andfollowed by LSD (Least Significant Different). Results of this study showed that the ointmentof ethanolic extract from Jackfruit leaves on the concentration of 5%, 10% and 15% producequalified ointment of organoleptic test, homogenity test and pH test, also give the effect ofopen wound healing in rabbits and the most effective cure is the ointment of ethanolic extractfrom Jackfruit leaves 15%.Keywords: ethanolic extract of Jackfruit leaves, ointment, wound, rabbit.
FORMULASI DAN UJI KELAYAKAN SEDIAAN KRIM ANTI INFLAMASI GETAH TANAMAN PATAH TULANG (Euphorbia tirucalli L) Agral, Omega; Fatimawali, Fatimawali; Yamlean, Paulina V.Y; Supriati, Hamidah Sri
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2313

Abstract

ABSTRACTHas been formulated the latex of pencil tree plant (Euphorbia tirucalli L) to be a cream.Pencil tree plant latex cream formulated with various concentrations of the active substancesi.e 5%, 10%, and 15%. The formulation of pencil tree plant latex cream produced the cramwith good parameter values.Key words : Cream, Pencil Tree Plant (Euphorbia tirucalli L)
FORMULASI SALEP ANTIBAKTERI EKSTRAK ETANOL DAUN TEMBELEKAN (LANTANA CAMARA L) Parwanto, ML Edy; Senjaya, Hardy; Edy, Hosea Jaya
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : PHARMACON

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Abstract

Tembelekan (Lantana camara L) is a wild plant that its leaves contain chemicals such asphenols, flavonoids and alkaloids. Chemical constituents in tembelekan allegedly hasantibacterial ability against Staphylococcus epidermidis. This research aims to create anantibacterial ointment to the active substance ethanol extract of leaves tembelekan.Antibacterial ointment tembelekan ethanol extract of the leaves made in two concentrations,namely 20% and 24%. Conducted quality testing ointment is organoleptic test, homogeneitytest, test and test pH value dispersive power. Quality test results conducted on theconcentration ointment with two parameters meet the organoleptic test, test and test pH valuehomogeneity. Tembelekan leaf extract ointment ethanol concentration of 20% and 24% didnot meet the quality parameters to test dispersive power.Keywords: Ethanol Leaf Extract tembelekan, ointments, test quality.
Formulasi Sirup Analgesik Ekstrak Etanol Daun Songgolangit (Tridax procumbens L.) Tompunu, Citra; Edy, Hosea Jaya; Supriati, Hamidah Sri
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2382

Abstract

ABSTRACTThe aims of this research were to testing the quality of songgolangit leaves ethanol extractanalgesic syrup. Songgolangit leaves ethanol extract analgesic syrup were make with 3various concentrations of active substances which are 40%, 50%, 60% and the quality weretesting. The outcome of quality testing of songgolangit leaves ethanol extract syrup has agood homogeneity. On organoleptic test, songgolangit leaves ethanol extract syrup wassmelling like extract, has a bitter taste, and colored yellow. The pH of songgolangit leavesethanol extract syrup be on the maximum stability which are on 5-7 pH. The average ofcastings time be on the similliar values with the positif control that become a parameter.Key words : analgesic, Tridax procumbens L.
Uji Efek Antidepresan Ekstrak Metanol Jamur Tlethong (Psilocybe cubensis) Pada Tikus Putih Jantan (Rattus norvegicus): ditinjau dari Immobility Time Dengan Metode Forced Swim Test Kurama, Nofri P.; Bodhi, Widdhi; Wiyono, Weny
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2328

Abstract

ABSTRACTTlethong mushroom (Psilocybe cubensis) contains psilocybin that potential as antidepressant.The aim of this research was to examine the effect of Tlethong extract as antidepressant onwhite male wistar (Rattus norvegicus). Antidepressant test were evaluate on white malewistar which divided into 5 groups. The first group were administered with aquadest asnegative control, Second group were administered with amitriptilin as positive control, thirdgroup were administered with Tlethong extract with dose 500 mg/KgBB, 625 mg/KgBB and750 mg/KgBB then tail suspension test were conducted. Immobility time dengan metodeforced swim test. Obtained data were analyzed by one way ANOVA. The result shows thatTlethong extract possess antidepressant activity evaluated by its immobility time using forcedswim test method.Keywords: Antidepressant, immobility time, forced swim test, tail suspension test, Psilocybecubensis
PENGARUH MODAL SOSIAL DAN BUDAYA ORGANISASI TERHADAP KINERJA TENAGA MEDIS DI RSUD KABUPATEN KEPULAUAN TALAUD Edy, Yosua Jaya; Maupa, Haris; Edy, Hosea Jaya
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2392

Abstract

ABSTRACTThis study aims to analyze the direct effect of social capital factors and organizational cultureon the performance of medical personnel in hospitals Talaud Islands. The population in thisstudy is the Civil Servants (PNS) in Talaud Islands who served in hospitals Talaud Islands.Sampling technique in this study is proportional sampling with a sample size of 100 people.In the data analysis using Structural Equation Modelling (SEM), using AMOS program(Analysis of Moment Structure) 20. Structural Equation Modeling (SEM) is a multivariateanalysis technique that was developed to cover the limitations that are owned by the previousanalytical models that have been widely used in statistical research. Stuctural equation model(SEM) can be seen as a combination of factor analysis, path analysis, and regression. Theresults indicate that (1) Social Capital and significant positive effect on the performance ofmedical personnel in hospitals Talaud Islands (2) Organizational culture positive andsignificant impact on the performance of medical personnel in hospitals Talaud Islands.Keywords : Social capital, Organization Culture, Performance

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