cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
pharmacon@unsrat.ac.id
Editorial Address
Pharmacy Study Program, Faculty of Mathematics and Natural Science, Sam Ratulangi University, Manado, North Sulawesi, Indonesia, 95115
Location
Kota manado,
Sulawesi utara
INDONESIA
PHARMACON
Published by Universitas Sam Ratulangi
ISSN : 23022493     EISSN : 27214923     DOI : 10.35799
Core Subject : Health,
Medicine & Pharmacology
Pharmacon is the journal published by Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Indonesia (P-ISSN: 2302-2493 E-ISSN: 2721-4923). Pharmacon was established in 2012 and published four times a year. Pharmacon is an open access journal and has been indexed by main indexing Google Scholar, GARUDA, Crossref.
Arjuna Subject : -
Articles 1,131 Documents
 101   102   103   104   105 
Uji aktivitas antihiperurisemia ekstrak etanol daun salam (Sygium Polyanthum) pada tikus putih (Rattus Norvegicus) Meivita Alfriani Sahensolar; Edwin De Queljoe; Surya Sumantri Abdullah
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42183

Abstract

MEIVITA ALFRIANI SAHENSOLAR . Uji aktivitas antihiperusrisemia ekstrak etanol daun salam (Syzgium Polyanthum) pada tikus putih (Rattus Norvegicus)dibawah bimbingan EDWIN DE QUELJOE sebagai ketua dan SURYA SUMANTRI sebagai anggota.Daun salam memiliki kandungan kimia seperti minyak atsiri yang mengandung sitral, eugenol, tannin, dan flavonoida. Penelitian ini bertujuan untuk mengetahui adanya efek antihiperurisemia ekstrak etanol daun salam dengan 3 tingkatan dosis yaitu, 200mg, 400mg, dan 800mg. Perbandingan daun Salam sebanyak 5 kelompok yang terdiri dari 3 ekor tikus disetiap kelompok perlakuan, yaitu CMC 1% (kontrol negatif), Allopurinol 100mg (kontrol positif), ekstrak etanol daun salam dalam dosis 200mg, 400mg, dan 800 mg,yang diinduksi kalium oksonat. Pengamatan dilakukan selama 6 jam. Data diuji dengan menggunakan ANOVA (Analisis Of Variant) ,uji HOMOGENITAS (Test of Homogenity of Variance) dan dilanjutkan dengan uji LSD (Least Significant Different). Hasil uji statistik menunjukan bahwa Dari ketiga dosis, penurunan kadar asam urat terbaik terdapat pada dosis 400 mg. Kata Kunci: Ekstrak Daun Salam (Syzgium Polyanthum) , Antihiperusemia
Antibacterial Potential Test of Cream Preparation of Ethanol Extract of Matoa Stem Bark (Pometia pinnata) against Staphylococcus aureus. Violeta Gavelentri Melga Tambingon; Paulina Yamlean; Jainer Siampa
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42190

Abstract

Skin diseases can be caused by several factors, one of which is a bacterial infection. One of the bacteria that causes infection is Staphylococcus aureus. The results of previous studies showed that the ethanolic extract of the bark of matoa (Pometia pinnata) had antibacterial potential. This study aims to test the quality of cream preparations including homogeneity test, organoleptic test, pH test, adhesion test and dispersibility test, as well as to test the antibacterial activity of cream preparations ethanol extract of matoa stem bark. The matoa bark extract was obtained by maceration method using 95% ethanol as solvent. The antibacterial activity test was carried out using the well method, with a concentration variation of 0.5%, 1.5%, 2.5% and 3.5%. The test results showed that all the parameters of the test preparation, namely homogeneity test, organoleptic test, pH test, adhesion test and spreadability test met the requirements of the quality of the preparation. Antibacterial testing showed cream preparations with a concentration of 3.5% produced the largest inhibition zone of 8.66 mm which was included in the category of moderate inhibition.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI GEL EKSTRAK ETANOL KULIT BUAH ALPUKAT (Persea americana Mill.) MENGGUNAKAN BASIS NA-CMC DAN KARBOPOL TERHADAP BAKTERI Staphylococcus aureus Tasya Mangkey; Paulina Yamlean; Jainer Siampa
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42198

Abstract

Kulit buah Alpukat (Persea americana Mill.) memiliki kandungan senyawa alkaloid, flavonoid dan saponin yang bersifat sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui daya hambat sediaan gel terhadap bakteri Staphylococcus aureus dan untuk mengetahui karakteristik fisik sediaan gel. Penelitian ini menggunakan metode eksperimental laboratorium. Formulasi sediaan gel ekstrak etanol kulit buah Alpukat dibuat dengan menggunakan basis Na-CMC 3%, 4% dan Karbopol 0,5%, 1,5%. Uji antibakteri sediaan gel ekstrak etanol kulit buah Alpukat menggunakan metode sumuran terhadap bakteri Staphylococcus aureus menghasilkan diameter zona hambat pada basis Na-CMC 3% (27,3 mm), Na-CMC 4% (26,3 mm), Karbopol 0,5% (28 mm), dan Karbopol 1,5% (27,1 mm). Gel dengan zona hambat tertinggi dilanjutkan dengan pengujian fisik. Hasil pengujian fisik sediaan gel memenuhi persyaratan organoleptik, homogenitas, pH, daya lekat dan daya sebar. Dapat disimpulkan bahwa sediaan gel ekstrak etanol kulit buah Alpukat menggunakan basis Na-CMC dan Karbopol memiliki aktivitas antibakteri yang sangat kuat dan memenuhi persyaratan karakteristik fisik sediaan.
Evaluasi Penggunaan Antibiotik pada Pasien Covid-19 di RSUP Prof. Dr. R. D. Kandou Manado Periode Januari-Maret 2021 Christian Aseng; Weny Wiyono; Meilani Jayanti
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42200

Abstract

Covid-19 adalah penyakit infeksi jenis baru yang disebabkan oleh virus Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). Penelitian ini bertujuan untuk mengetahui profil penggunaan dan kuantitas penggunaan antibiotik yang diberikan pada pasien Covid-19 di RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Maret 2021. Didapatkan sebanyak 60 sampel rekam medis, kemudian dianalisis secara kuantitatif menggunakan metode ATC/DDD. Didapat 7 jenis antibiotik yang diberikan pada pasien Covid-19 yaitu  Azitromisin (51,72%), Seftriakson (22,99%), Levofloksasin (17,24%), Sefadroksil (2,30%), Meropenem (2,30%), Moksifloksasin (2,30%) dan Siprofloksasin (1,15%). Diperoleh nilai total DDD/100 pasien-hari sebesar 97,36 DDD/100 pasien-hari, antibiotik Azitromisin memiliki nilai DDD/100 hari-pasien tertinggi sebesar 44,54 DDD/100 pasien-hari, dan antibiotik yang masuk dalam segmen 90% adalah Azitromisin (45,75%), Seftriakson (29,85%) dan Levofloksasin (16,02%).
ISOLATION AND IDENTIFICATION OF FLAVONOID COMPOUNDS ETHANOL EXTRACT OF SUANGGI LEMON PEEL Citrus limon L. Rizya Marchilia Mamahit; Fatimawali Fatimawali; Meilani Jayanti
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42204

Abstract

ABSTRACTSuanggi lemon peel is a plant that is often used as a traditional health therapy. The outer skin of the lemon suanggi (Citrus Limon L.) is rich in oil glands, bright yellow in color with a distinctive and fresh citrus aroma. The purpose of this study was to isolate and identify the class of flavonoid compounds from the rind of lemon suanggi (citrus limon L.) by using the UV-Vis spectrophotometer method. The rind of the suanggi lemon was extracted by maceration method using 95% ethanol as solvent which resulted in a thick extract of suanggi lemon rind. Isolation was carried out by thin layer chromatography (TLC) method with Chloroform: n-hexane (4:2) as the eluent. The fourth spot from the result of Thin Layer Chromatography was positive for containing flavonoid compounds. From the spectrum of the UV-Vis spectrophotometer, it can be assumed that the flavonoid compound is a flavonol group, which can be seen from its wavelength range, which is between 200- 500 nm from its wavelength range of 366 nm.Keywords: lemon suanggi, flavonoids, thin layer chromatography, UV-Vis spectrophotometer.
Antibacterial Activity of Ethanol Extract of Areca Vestiaria Leaves (Areca vestiaria) against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa bacteria Wiranatika Jhonatan Sangkoy; Herny Simbala; Erladys Rumondor
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42307

Abstract

WIRANATIKA SANGKOY. Antibacterial Activity of Ethanol Extract of Areca Vestiaria Leaves (Areca vestiaria) against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa bacteria. Under the guidance of HERNY EI SIMBALA as a leader and ERLADYS RUMONDOR as a member.One of the native plants of Indonesia that is widespread in several areas in Indonesia that has the potential to be developed in research testing antibacterial activity is the areca yaki leaf plant. This study aimed to determine the antibacterial activity of areca yaki (Areca vestiaria) leaves against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa at concentrations of 20%, 40%, and 60%. This research was conducted using the Kirby-Bauer method. From the results of this study, the data obtained that concentrations of 20%, 40%, and 60% of Staphylococcus aureus and Escherichia coli bacteria are concentrations that are included in the moderate group, while Pseudomonas aeruginosa at a concentration of 20% is included in the strong group and 40% and 60% are only included in the moderate group.
PHYTOCHEMICAL SCREENING AND TOXICITY TEST OF MANGROVE LEAF ETHANOL EXTRACT (Bruguiera gymnorrhiza) WITH BRINE SHRIMP LETHALITY TEST (BSLT) METHOD Friyan Criscanus Manopo; Fatimawali Fatimawali; Olvie Datu
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42848

Abstract

Cancer is one of the biggest causes of death in the world. Therefore, efforts to manufacture drugs for cancer treatment continue to be developed. One of the efforts to develop cancer drugs is by using medicinal plants which are empirically used by local communities in various regions. This study aims to analyze the content of secondary metabolites contained in the leaf extract of the Mangrove Bruguiera gymnorrhiza and to determine the potential as an anticancer by determining the LC50 value. The extract was obtained by maceration using 96% ethanol solvent, identification of secondary metabolites by phytochemical screening and to determine the anticancer potential using the BSLT method with data analysis using Microsoft Excel. The phytochemical test results showed that the leaf extract contained alkaloids, flavonoids, saponins, tannins, and did not contain steroid/triterpenoid compounds. The results of the analysis showed that the ethanol extract of mangrove leaf (Bruguiera gymnorrhiza) was highly toxic with an LC50 value of 24.1 µg/ml. 
POTENTIAL OF RED FRUIT (PANDANUS CONOIDEUS CAROTEN LAMK) PAPUA BASED ON LITERATURE REVIEW Hermelina Yosephina Burdam; Herny Simbala; Erladys Rumondor
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42896

Abstract

                              ABSTRACRed fruit plant (Pandanus conoideus Lamk) Papua. is an endemic plant that can grows in almost all areas of Papua, from the lowlands to the highlands. Red Fruit (Pandanus conoideus Lamk,) belongs to the Pandanus family. This plant is widely available Find in Papua, Papua New Guinea, And This Research Aims To know the potential of red fruit (Pandanus conoideus Lamk) Papua based on literature review, research It Uses Qualitative Descriptive Method Aims to Draw, Describe, Explain, Explain, and answer in detail the research results. Based on literature review, red fruit has potential As Socio-Economic Value, As Traditional Medicine, Cure Cancer And tumors, HIV/Aids,High Blood Pressure, Gout, Stroke, Eye Disorders, Osteoporosis, Diabetes Mellitus, Increases Sperm Production in Men, Increases Intelligence, As a Food Source, As Antioxidant, Antidiabetic, Anti-Inflammatory Antibacterial Cardiovascular, Hypertension 
FORMULATION AND ANTIBACTERIAL ACTIVITY TEST OF TOOTHPASTE ETHYL ASETATE FRACTION OF LEILEM LEAVES (Clerodendrum minahassae L.) AGAINTS Streptococcus mutans Anggun Ciquita Nichelse Egam; Hosea Edy; Surya Sumantri Abdullah
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42906

Abstract

Leilem leaves (Clerodendrum minahassae L.) is one type of plant that can be used as an antibacterial because it contains active chemical compounds such as phenols, flavonoids, alkaloids, steroids, and terpenoids. This study aimed to formulate the ethyl acetate fraction of leilem leaves toothpaste that is physically good and to obtain the optimum toothpaste inhibition with dosage concentrations of 7.5%, 10%, and 12.5% against the growth of Streptococcus mutans bacteria. This research uses laboratory experimental method. The results showed that the ethyl acetate fraction toothpaste preparation filled the physical evaluation requirements, that is organoleptic, homogeneity, spreadability, adhesion and pH. The antibacterial activity testing of the leilem leaves fraction toothpaste showed that the average diameter for F1 was 9.75 mm, F2 was 11.75 mm, and F3 was 13.08 mm. Based on the results of the study, it can be concluded that all formulations of the ethyl acetate fraction of leilem leaves provide antibacterial activity and filled the requirements of the physical test of the preparation and the greatest antibacterial activity is at F3 of 13.08 mm with a dosage concentration of 12.5%.
Evaluasi Penyimpanan Obat di Instalasi Farmasi Rumah Sakit Umum GMIM Kalooran amurang Kabupaten Minahasa Selatan Karlah Frylina Kantu; Gayatri Citraningtyas; Imam Jayanto
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42929

Abstract

Depository is a significant stage in medicine administration. A great depository guarantees safety and maintains medicine quality. Hence, it can minimize hospital’s losses caused by spoiled medications. This study aimed to evaluate the medicine depository at GMIM Kalooran Hospital in Amurang. This study employed descriptive observational methods, and data gathering techniques used direct observation to existing systems and interviews. Study findings indicated that medicine Depository at Pharmacy Installation of GMIM Kalooran Hospital in Amurang not was in accordance with the standard of Hospitals pharmaceutical treatment based on Health Regulation number 72 (2016), Director General of Pharmaceutical (2010). However, facilities and infrastructures still required improvements such as insufficient shelves and pallets due to inadequate sizes of warehouses and no installed security systems.  It is highly recommended to notice matters which are not in accordance with the standardized indicators of medicine depository as well as the defective and incompetent facilities.

Page 103 of 114 | Total Record : 1131

 101   102   103   104   105 

Filter by Year

2012 2025


Reset
Filter By Issues
All Issue Vol. 14 No. 3 (2025): PHARMACON Vol. 13 No. 3 (2024): PHARMACON Vol. 13 No. 2 (2024): PHARMACON Vol. 13 No. 1 (2024): PHARMACON Vol. 12 No. 3 (2023): PHARMACON Vol. 12 No. 2 (2023): PHARMACON Vol. 12 No. 1 (2023): PHARMACON Vol. 11 No. 4 (2022): PHARMACON Vol. 11 No. 3 (2022): PHARMACON Vol. 11 No. 2 (2022): PHARMACON Vol. 11 No. 1 (2022): PHARMACON Vol. 10 No. 4 (2021): PHARMACON Vol 10, No 3 (2021): PHARMACON Vol 10, No 2 (2021): PHARMACON Vol 10, No 1 (2021): PHARMACON Vol 9, No 4 (2020): PHARMACON Vol 9, No 3 (2020): PHARMACON Vol 9, No 2 (2020): PHARMACON Vol 9, No 1 (2020) Vol 9, No 1 (2020): PHARMACON Vol 8, No 4 (2019) Vol 8, No 4 (2019): PHARMACON Vol 8, No 3 (2019): PHARMACON Vol 8, No 3 (2019) Vol 8, No 2 (2019): PHARMACON Vol 8, No 2 (2019) Vol 8, No 1 (2019): Pharmacon Vol 7, No 4 (2018): Pharmacon Vol 7, No 3 (2018): Pharmacon Vol 7, No 2 (2018): Pharmacon Vol 7, No 1 (2018): Pharmacon Vol 6, No 4 (2017): Pharmacon Vol 6, No 3 (2017): Pharmacon Vol 6, No 2 (2017): Pharmacon Vol 6, No 1 (2017): Pharmacon Vol 5, No 4 (2016): Pharmacon Vol 5, No 3 (2016): Pharmacon Vol 5, No 2 (2016): Pharmacon Vol 5, No 1 (2016): Pharmacon Vol 4, No 4 (2015): Pharmacon Vol 4, No 3 (2015): Pharmacon Vol 4, No 1 (2015): pharmacon Vol 3, No 4 (2014): pharmacon Vol 3, No 3 (2014) Vol 3, No 2 (2014) Vol 3, No 1 (2014) Vol 2, No 4 (2013) Vol 2, No 3 (2013): pharmacon Vol 2, No 2 (2013): pharmacon Vol 2, No 1 (2013): pharmacon Vol 1, No 2 (2012) Vol 1, No 1 (2012) More Issue