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Paediatrica Indonesiana
Published by Ikatan Dokter Anak Indonesia
ISSN : 00309311     EISSN : 2338476X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.
Arjuna Subject : -
Articles 2,118 Documents
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A young girl with suspected encephalitis caused by avian influenza A (H5N1) infection in Indonesia Juniatiningsih, Anita; Setyanto, Darmawan B; Setiawaty, Vivi; Sedyaningsih, Endang R
Paediatrica Indonesiana Vol 50 No 1 (2010): January 2010
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (219.526 KB) | DOI: 10.14238/pi50.1.2010.62-6

Abstract

A previously healthy two-year-old girl was admitted to the Emergency Unit of Cipto Mangunkusumo Hospital (CMH) Jakarta, on March 23, 2006 with a deterioration of consciousness since four days before admission. She was referred by a district hospital with a working diagnosis of suspect encephalitis, gastroenteritis, and febrile convulsion. History taken from her parents revealed that since eight days before admission she had a mild fever and cough, without rhinorrhea. Her appetite, defecation and urination were normal. Patient was taken to a clinic, where she was diagnosed as having an upper respiratory tract infection, and was given three kinds of medicine (i.e., antipyretic, expectorant and antibiotic).
Duration of active epilepsy as a predictor of seizure control after relapse in child epilepsy Charles Subakti; Madarina Julia; Agung Triono
Paediatrica Indonesiana Vol 60 No 4 (2020): July 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi60.4.2020.202-7

Abstract

Background Epilepsy is a chronic illness that may affect childhood growth and development. Some epilepsy cases are easy to control, either with monotherapy or politherapy antiepilepticdrugs, but many cases are difficult to control. Several factors influence the risk of relapse, but information is limited on factors predictive of seizure control after relapse. Our study investigate patient with epilepsy relaps and see whether the duration of active epilepsy prior to initial remission can be use as a predictor of seizure control after relaps. Objective To assess whether duration of active epilepsy was predictive of seizure control after relapse. Methods This retrospective cohort study was performed in Dr Sardjito Hospital, Yogyakarta, on epileptic relapse patients aged 2 to 18 years , who had achieved remission for at least a 2-year seizure-free interval, and relapsed after antiepileptic drud (AED) discontinuation. We excluded patients with progressive neurological diseases, inborn errors of metabolism, febrile seizures, and those who could not be followed up for at least 2 years, or those with incomplete medical records. Subjects were divided into those who had a duration of active epilepsy prior to initial remission within 6 months and ≥6 months. Time to seizure control after relapse was analysed by Kaplan-Meier survival analysis. Results A total of 80 patients were included in the study. Overall median for seizure control after relapse was 3.6 (95%CI 1.1 to 6.0) months. Median for seizure control after relapse for those who had a duration of active epilepsy prior to initial remission within 6 months and >= 6 months were 3 (95%CI 0.1 to 5.8) months and 12 (95%CI 4.4 to 19.5) months, respectively. Log-rank test revealed no significant difference between groups (P=0.12). Conclusion Duration of active epilepsy prior to initial remission was not a predictor for seizure control after relapse.
Case report of Fanconi syndrome in Wilms tumor Ayu Hutami Syarif; Edward Usfie Harahap; Mururul Aisyi
Paediatrica Indonesiana Vol 60 No 4 (2020): July 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi60.4.2020.223-5

Abstract

Fanconi syndrome is a group of clinical manifestations including aminoaciduria, proteinuria, glycosuria, hypophosphatemia, and metabolic acidosis. It may occur after exposure to certain drugs. The most common causes are antiepileptic, antiviral, antibiotic, and antineoplastic drugs.1 The two most common causes in the antineoplastic regimen are cisplatin and ifosfamide. Ifosfamide, a derivative of cyclophosphamide, has been used to treat pediatric solid tumors.2 Its high efficacy in numerous studies has led to its long-term administration for pediatric malignancies, including Wilms tumor. Along with other treatment modalities, ifosfamide considerably improved the survival rate (90%) of Wilms tumor while only a few cases resulted in Fanconi syndrome.1,3,4 Here we illustrate a case of presumed drug induced Fanconi syndrome in a Wilms tumor patient who previously achieved remission for 10 months.
Use of Xpert MTB/RIF for diagnosis of pediatric tuberculosis in Indonesia Rina Triasih; Amalia Setyati; Dwikisworo Setyowireni; Titik Nuryastuti; Rachma Dewi Isnaini Putri; Emi Rusdiyati
Paediatrica Indonesiana Vol 60 No 4 (2020): July 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi60.4.2020.198-204

Abstract

Background The Xpert MTB/RIF assay demonstrated a better diagnostic value than sputum smear for TB in adults and children. Objective To evaluate the use of Xpert MTB/RIF for TB diagnosis in children. Methods We conducted a prospective study in Yogyakarta, Indonesia, involving 19 primary health centers (PHCs) and one provincial hospital. Children aged 0-14 years with suspected TB who visited the study sites were screened. Subjects underwent history-taking, physical examination, tuberculin skin test, chest X-ray, as well as sputum induction for Xpert MTB/RIF assay, sputum smear, and TB culture. The diagnosis of TB was made by doctors based on the results of investigations, as follows: certain TB (bacteriological confirmation), probable TB, and possible TB. Results Of 80 subjects, 21 (26%) were diagnosed with TB disease (4 certain TB and 17 probable TB). Sputum induction was successfully performed in 79 children. None of the children had positive sputum smears. Mycobacterium tuberculosis was detected by Xpert MTB/RIF in 4 children, accounting for 5% of all children with suspected TB, or 19% among children with TB disease. The 4 Xpert MTB/RIF-positive subjects had severe TB disease and were rifampicin-sensitive. Conclusion Xpert MTB/RIF may improve case finding among children with severe TB disease with negative sputum smear.
Achievement of full enteral feeding using volume advancement in infants with birth weight 1,000 to Teti Hendrayanti; Afifa Ramadanti; Indrayady Indrayady; Raden Muhammad Indra
Paediatrica Indonesiana Vol 60 No 4 (2020): July 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi60.4.2020.173-7

Abstract

Background Early enteral feeding is one of the efforts to improve gastrointestinal adaptability in preterm infants. Volume advancement (VA) enteral feeding has been associated with less time to reach full feeding, which can improve outcomes. Objective To evaluate the duration of VA needed to achieve full enteral feeding (FEF) in low birth weight (LBW) and very low birth weight (VLBW) infants and related factors. Methods This prospective study was done in infants with birth weight 1,000 to <2,000 grams in the Neonatal Ward and NICU of Dr. Moh. Hoesin General Hospital, Palembang, South Sumatera. All infants underwent VA feeding. The time needed to achieve FEF (150 ml/kg/day) was recorded. Several clinical factors were analyzed for possible associations with the success rate of achieving FEF within 10 days of feeding. Results Thirty-five infants were included in this study with a mean gestational age of 31.83 (SD 2.67) weeks. Their median body weight at the start of protocol was 1,400 (range 1,000 – 1,950) grams and 80% had hyaline membrane disease. Median time to achieve FEF was 11 (range 8–21) days, with 48.6% subjects achieving FEF in <=10 days. Gestational age <32 weeks (OR 5.404, 95%CI 0.963 to 30.341), birth weight <1,500 grams (OR 5.248, 95%CI 0.983 to 28.003), and male (OR 4.751, 95%CI 0.854 to 26.437) gender were associated with the failure of achieving FEF within 10 days of feeding, however, no factors remained statistically significant after multivariate analysis. Conclusion Full enteral feedings in infants with birth weight 1,000 to <2,000 grams with VA feeding are achieved within a median of 11 days. Gestational age, birth weight, and gender are not associated with time needed to achieve FEF.
Implementation of Dengue Recurrent Shock Prediction Score in pediatric dengue shock syndrome Armand Setiady Liwan; I Wayan Gustawan; Eka Gunawijaya; Soetjiningsih Soetjiningsih; Ketut Ariawati; I Nyoman Budi Hartawan
Paediatrica Indonesiana Vol 60 No 4 (2020): July 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi60.4.2020.178-85

Abstract

Background Global morbidities due to dengue viral infection increase yearly. The pediatric mortality rate from dengue shock syndrome (DSS) remains high. Early identification of the risk of recurrent shock may serve to increase awareness and reduce mortality. The Dengue Recurrent Shock Prediction Score (DRSPS) is a tool to predict recurrent shock in children with DSS, but the optimal cut-off point in our population is still unknown. Objective To assess the validity of the DRSPS by determining the optimal cut-off point that can be used in Indonesia Methods This cross-sectional prospective study was done at Sanglah Hospital, Denpasar, Bali, from January 2019. Risk of reccurent shock were classify based on DRSPS in all DSS patient, and they were observed whether they will experienced recurrent shock or not. Results Of 56 children with DSS, 27 subjects had recurrent shock and 29 subjects did not. The optimal DRSPS cut-off point was -189.9 for predicting recurrent shock, with 87.4% area under the curve (AUC), 81.5% sensitivity and 82.8% specificity. Conclusion The optimal cut-off point of DRSPS was -189.9 and it has good validity. The results of this study are expected not only to be used as the basis for further study, but to increase physician awareness in treating DSS patients.
Risk factors for sleep problems in infants Hesti Lestari; Audrey Mety Iriani Wahani; Rocky Wilar; Permatami Herwansyah
Paediatrica Indonesiana Vol 60 No 4 (2020): July 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi60.4.2020.186-91

Abstract

Background Sleep disorders in infants can cause developmental problems, suboptimal growth, behavioral disorders, fatigue, irritability, impulsiveness, and poor mother-infant bonding. Objective To evaluate possible risk factors for sleep disorders in infants. Methods This cross-sectional study was conducted in healthy infants aged 3-6 months. Subjects were selected using proportional random sampling from four different primary healthcare facilities in Manado, North Sulawesi. Their parents completed the Brief Infant Sleep Questionnaire. Sleep disorder was defined as the presence of one or more conditions including sleep duration less than 9 hours at night (from 19.00 until 07.00), waking up at night (from 22.00 until 06.00) more than 3 times, and more than 1 hour waking at night. Results Of 112 subjects, 58 (51.8%) were male. Subjects’ mean age was 4.21 (SD 0.829) months and 76 (67.86%) experienced sleep disorders. Sleep disorders had significant associations with low socioeconomic status (OR 17; 95%CI 3.8 to 75.8), middle school or lower maternal education (OR 44.5; 95%CI 9.8 to 202), non-supine sleeping position (OR 8.8; 95%CI 1.9 to 39.7), parental use of electronic devices (OR 156.2; 95%CI 35.1 to 692.9), and non-exclusive breastfeeding (OR 85.2; 95%CI 21.1 to 344.2). Correlative analyses also revealed that electronic media usage had the strongest association with sleep disorders, followed by breastfeeding pattern, maternal education, socioeconomic status, and sleeping position ( 0.839, 0.771, 0.624, 0.433, and 0.309, respectively). However, there were no significant correlations upon multivariate analysis. Conclusion Parental use of electronic media before sleeping is the strongest risk factor for sleep disorders among infants, followed by non-exclusive breastfeeding pattern, low maternal education, low socioeconomic status, and non-supine sleeping position. However, none of these correlations were significant upon multivariate analysis, this show that all these factors influence sleep together
Do low vitamin D levels facilitate renal parenchymal injury? Mervan Bekdas; Billur Calıskan; Seyda Karabork; Seher Acar; Nimet Kabakus
Paediatrica Indonesiana Vol 60 No 4 (2020): July 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi60.4.2020.205-11

Abstract

Background Decreased vitamin D levels lead to an increase in infectious diseases, including urinary tract infections (UTIs). Objective To assess serum vitamin D levels in children with renal parenchymal injury secondary to UTIs. Methods Forty-three upper UTI patients and 24 controls, aged 1–15 years, were included. Vitamin D levels and other laboratory tests were obtained when they first admitted to hospital. 99mTc-labeled dimercaptosuccinic acid (DMSA) scans were performed to evaluate renal parenchymal injury. Results Mean serum 25-hydroxyvitamin D (25(OH)D) was lower in the upper UTI group compared to the control group [18 (SD 9) vs. 23 (SD 10.6) ng/mL, respectively; P=0.045]. The upper UTI group was sub-divided into two groups, those with 22 (51.1%) and without 21 (48.8%) renal parenchymal injury. Mean 25(OH)D was significantly lower in patients with renal parenchymal injury [15.1 (SD 7.1) vs. 21 (SD 9.9) ng/mL, respectively; P=0.03]. The renal parenchymal injury cases were further sub-divided into two groups: 8 patients (36.3%) with acute renal parenchymal injury and 14 (63.6%) with renal scarring (RS), but there was no significant difference in 25(OH)D between these two groups [12.5 (SD 8.9) vs. 16.6 (SD 5.7) ng/mL, respectively; P=0.14). Conclusion Decreased vitamin D is associated with renal parenchymal injury in children with upper UTIs. However, vitamin D is not significantly decreased in renal scarring patients compared to acute renal parenchymal injury patients.
Blood glucose level during induction phase chemotherapy in childhood acute lymphoblastic leukemia Nunki Andria; Annang Giri Moelyo; Muhammad Reza
Paediatrica Indonesiana Vol 60 No 4 (2020): July 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi60.4.2020.197-2

Abstract

Background Steroids and L-asparaginase (L-Asp) are agents used in induction phase chemotherapy for childhood acute lymphoblastic leukemia (ALL). Both agents are often reported to have the side effect of hyperglycemia, and native L-Asp is also reported to cause hypoglycemia. In ALL patients, hyperglycemic events during chemotherapy can cause lower 5-year overall and relapse-free survival. Objective To investigate the incidence of abnormal blood glucose level (BG) as the side effect of prednisone and L-Asp during induction phase chemotherapy, its predisposing factors, and its effect on remission status. Methods This cohort prospective study was conducted in 36 children aged 1-18 years who were newly diagnosed with childhood ALL at Dr. Moewardi Hospital, Surakarta, Central Java. Subjects’ nutritional status consist of wellnourished and undernourishment. Subjects underwent BG monitoring. At the end of induction phase chemotherapy, subjects underwent bone marrow puncture (BMP) evaluation to assess their response to chemotherapy and the effect of abnormal BG on remission status. Results Hypoglycemia, a combination of hypoglycemia and hyperglycemia, hyperglycemia, as well as euglycemia, were experienced by 9, 7, 6, and 14 subjects, respectively. Nutritional status was found to be a significant risk factor for abnormal BG. There was no significant difference in remission status at the end of induction phase chemotherapy between the euglycemic group and abnormal BG groups (P=0.533). Conclusion Abnormal BG during induction phase chemotherapy did not affect remission status at the end of induction phase. Undernourishment is also found to be a predisposing factor in abnormal BG.
Validity and reliability update of the Indonesian version of International Society for Prevention of Child Abuse and Neglect - Child Abuse Screening Tool (ICAST-C) Meita Dhamayanti; Anne Dian Rachmawati; Anindita Noviandhari
Paediatrica Indonesiana Vol 60 No 4 (2020): July 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi60.4.2020.218-23

Abstract

Background In Indonesia, few screening tools for child abuse and neglect are available. The currently-favored tool was adapted from the International Society for Prevention of Child Abuse and Neglect (ISPCAN)-Child Abuse Screening Tool (ICAST-C) questionnaire, consisted of 5 domains child abuse and 59 items. Objective To re-evaluate the validity and reliability of the Indonesian version of ICAST-C. Methods A cross-sectional study was conducted 480 children aged 11–18 years from junior and senior high schools in Bandung, West Java, Indonesia. Subjects were selected using two-stage cluster sampling. A validity test using Spearman’s rank correlation with Rs >=0.3 was considered valid. A reliability test using Cronbach’s alpha formula with alpha score >=0.7 was considered reliable. Results Most items in the Indonesian version of ICAST-C were valid and reliable, except for the following 9 out of 59 items: “anyone in your home used alcohol”, “seen adults in your home use knives”, “insulted you by calling you dumb”, “in order stop or change behavior”, “forbade you from going out”, “pinched you”, “explained to you why something you did was wrong”, “gave you something else to do (in order to stop or change behavior)”, and “took away privileges or money”ICAST-C reliability was good (0.919), however domain of violence exposure (0.483) and neglect (0.445) were not so good Conclusion The updated Indonesian version of ICAST-C is considered valid, reliable as a screening tool for child abuse.

Page 172 of 212 | Total Record : 2118

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