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Journal of Medicine and Health

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Published by Universitas Kristen Maranatha

ISSN : 24425227 EISSN : - DOI : -

Core Subject : Health, Science,

Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Journal of Medicine and Health (JMH) is an open access journal (OAJ), a periodic scientific publication biannually online published on February and August; using review and screening system by peer group reviewer. JMH receives original research articles which related to medicine, health, new developing therapy from traditional medicine or herbs and developing clinical therapy. JMH also receives otiginal review articles, case report, continuing medicine and health study. Articles should be written in good English or Indonesian language.

Arjuna Subject : -

Articles 264 Documents

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Vital Signs Changes of Brick Industry Workers Exposed to Heat Pressure in Sukarami Palembang Syokumawena Syokumawena; Marta Pastari; Rahmad A. Juliansyah; Hanna S.W. Kusuma; Dwi D. Rihibiha
Journal of Medicine and Health Vol. 2 No. 1 (2018)
Publisher : Universitas Kristen Maranatha

Brick workers are exposed to dust contained of mixtures of chemical substances andhigh temperature. Those environmental factors can affect the health status of the workers;mainly the cardiovascular system. The aim of this research was to observe the effect of heatpressure on vital sign of brick factory manufacturing workers in Sukarami Palembang. Theresearch was conducted in RT 07/13 Sungai Durian, Kecamatan Sukarami, Palembang. Thesubjects were 40 people brick workers; 20 workers were exposed to heat pressure and 20workers did not. We found that in the workers with heat pressure exposure,the average vitalsigns before working are blood pressure of 117/76 mmHg, pulse of 77 x/minutes, and bodytemperature of 36,5Â°C and after working are blood pressure of 130/84 mmHg, pulse of 92x/minutes, and body temperature of 38Â°C. In the workers without heat pressure exposure, theaverage vital signs before working are blood pressure of 107/80 mmHg, pulse of 75 x/minutes,and body temperature of 36Â°C and the average vital signs after working are blood pressure of112/81 mmHg, pulse of 79 x/minutes, and body temperature of 37Â°C. Conclusion, heat pressurehas effects on vital sign of brick factory manufacturing workers in Sukarami Palembang.Keywords: blood pressure, body temperature, brick factory pulse, heat pressure

In Vitro Antimicrobial Activity of Javanese Tamarind Leaves Infusion (Tamarindus indica Linn.) in Escherichia coli Caroline Suryadi; Djaja Rusmana; Endang Evacuasiany
Journal of Medicine and Health Vol. 1 No. 1 (2015)
Publisher : Universitas Kristen Maranatha

Escherichia coli is the most common bacteria that cause diarrhea. Based on Kurniawatiâ€™s research, ethanol extract of tamarind leaves has an antimicrobial effect to Escherichia coli. This study aims to determine the antimicrobial effect using disk diffusion method, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of tamarind leaves infusion against Escherichia coli.Â This research was done using a real laboratory experimental design with tamarind leaves infusion and Escherichia coli microbes as the research objects. Zones of inhibition were observed using disk diffusion method by putting the tamarind leaves infusion disks on Mueller-Hinton agars with Ampicillin antibiotic for comparison, followed by observing the MIC using macro broth dilution methodÂ and MBC. The result of disk diffusion showed that tamarind leaves infusion had no zone of inhibition, whereas the mean value of the zones of inhibition of ampicillin is 17.2 mm. The MIC of tamarind leaves infusion is 62.5 mg/mL. Average growth of bacteria Â for the MBC of tamarind leaves infusion at 125 mg/mL and 62.5 mg/mL concentration are 13 CFU/mL and >300 CFU/mL. It can be concluded that tamarind leaves infusion has antimicrobial activity effect against E.coli and that effect is bacteriostatic.Â Keywords: Tamarindus indica Linn, Escherichia coli, MIC, MBC

Iron Intake, Hemoglobin Level, and Red Blood Cell Indices in Adolescents with Obesity Aviyani Aviyani; Ginna Megawati; Susi Susannah
Journal of Medicine and Health Vol. 2 No. 1 (2018)
Publisher : Universitas Kristen Maranatha

Obesity is a condition of excess and abnormal fat accumulation. Obese adolescents are atgreater risk of developing iron deficiency anemia with microcytic hypochromic red blood cells(RBC). Iron deficiency in obesity relates to low iron intake, abnormal iron absorption, andincreased iron utilization. The aim of this study was to determine iron intake, hemoglobin level,and RBC indices in faculty of medicine students with obesity. We used descriptive cross-sectional method, involving year of 2016 students in Faculty of Medicine PadjadjaranUniversity with obesity. Pregnant women and students with previous history of thallasemia oranemia were excluded. Iron intake was assessed using Food Frequency Questionnaire.Hemoglobin level and RBC indices were measured in Hasan Sadikin General Hospital. Ironintake of male subjects were adequate in 62,5% subjects and low in 37,5% subjects. Iron intakein female subjects were adequate in 20% subjects and low in 80% subjects. Male hemoglobinlevel were normal and 20% of female subjects had anemia. All male subjects were normochromnormocytic, 40% female subjects were hypochrom microcytic.Keywords: adolescents, hemoglobin level, iron intake, obesity, red blood cell indices

The Effect of Mangosteen Peel Extract on Sperm Motility and Sperm Count of Swiss Webster Mice Induced by Hard Physical Exercise Ardi Prawira; Stella T. Hasianna; Sylvia Soeng
Journal of Medicine and Health Vol. 1 No. 1 (2015)
Publisher : Universitas Kristen Maranatha

High-intensity physical exercises can increase oxidative stress, causing damage to reproductive system. The purpose of this study was to determine the effect of mangosteen peel extract on sperm motility andÂ sperm count ofÂ Swiss Webster mice induced by high-intensity physical exercise. This was a real experimental with complete randomized design. Twenty fiveÂ male Swiss Webster mice were divided into five groups (n = 5). Negative control (KN) was without any treatment, positive control (KP) was givenÂ treadmill exercise only, the treatment groups (KM1, KM2, KM3) were given mangosteen peel extract orally 2, 4, 8 mg respectively as well as treadmill exercises. The treadmill exercises was conducted for 35 days. The sperm motility (mm/second) and the sperm count (per mm3) were assessed manually using Improved Neaubauer chamber. The result were analyzed using one-way ANOVA followed by Tukey HSD. The result showed high significant differences of sperm motility and sperm count between KM2 and KP, also between KM2 withÂ KM1 andÂ KM3 (p=0,000). The conclusion was mangosteen peel extract improved the sperm motility and sperm count of Swiss Webster mice induced by high-intensity physical exercise with 4 mg as the optimal dose.Â Keywords: mangosteen peel, sperm motility, sperm count

Pre-operative Embolization as Resection Strategy in Brain Tumor with No Neurological Deficit Andi N. Sendjaja; Yogi Rosbianto; Agung B. Sutiono; Bilzardy F. Zulkifli; Roland Sidabutar; Achmad Adam; Muhammad Z. Arifin
Journal of Medicine and Health Vol. 2 No. 1 (2018)
Publisher : Universitas Kristen Maranatha

Meningioma is an intracranial tumor that generally involves meninges. This tumor canbe found along the dura layers at the skull base. Meningioma has vast vascularization from thearteries near dura attachment. Pre-operative embolization technique is an effective strategy toprevent intra-operative complications and better outcomes. The patient was a 24 year-oldwoman who has been complaining of headaches since 2 months ago. The CT Scan resulted in a12 x 9 x 7 cm isodense mass in the left temporoparietal enhanced homogenously by contrast.Pre-operative embolization was performed on the tumor feeding artery as a strategy to preventintra-operative blood loss. A left frontotemporosphenoidal craniotomy was performed 10 daysafter embolization to remove the tumor. A complete resection was successfully achieved withless intraoperative blood loss and without complication. The pathology examination resulted inmeningotheliomatous meningioma. A follow-up picture showed no recurrent tumor afterresection and the patient had no symptoms and neurological deficits until 6 months after thesurgery. In conclusion, meningioma is a common intracranial tumor with a lot of blood supply.However, tumor resection can be safely and efficaciously performed with good pre-operativestrategy.Keywords: brain tumor, embolization, meningioma, resection, skullbase

PHYTOPREVENTIVE EFFECT OF BUAH MERAH (Pandanus conoideus Lam.) OIL IN COLITIS-ASSOCIATED CARCINOGENESIS Adhika, Oeij Anindita
Journal of Medicine and Health Vol. 1 No. 2 (2015)
Publisher : Universitas Kristen Maranatha

Colorectal cancer has provided a paradigm for the connection between inflammation and cancer. Modulation of intracellular signaling involved in chronic inflammatory response by anti-inflammatory agents represents an important strategy in molecular target-based chemoprevention. The aim of this research is to study the effect of buah merah oil onÂ IL-6Â serum level and histopathology of colon in colitis-associated cancer (CAC) mice model. BALB/c mice were randomly divided into four groups. The negative control and buah merah control were given aquabidest and buah merah, respectively, without CAC induction. The AOM/DSS control and buah merah treatment were given azoxymethane (AOM) followed by dextran sulfate sodium (DSS) to induce CAC. The AOM/DSS control was given aquabidest while the buah merah treatment was given buah merah. Data were analyzed by One-Way ANOVA continued with Tukey-HSD. The result showed that IL-6 level in mice administrated with buah merah was significantly lower than the AOM/DSS control (p=0.000). Histopathological analysis scoresÂ of colon were analyzed by Kruskal-Wallis continued with Mann-Whitney. The result showed that histopathological analysis score in buah merah treatment was significantly lower than in the AOM/DSS control (p=0.002). Taken together, buah merah oil lowered IL-6 level and histopathological analysis score of colon in CAC mice model.Â Keywords: CAC, buah merah oil,Â IL-6 level, histopathologicalÂ analysis scores ofÂ colon

STUDY ON RUMPUT MUTIARA (Hedyotis Corimbosa) HERBS AS MEDICINE Andreanus A. Soemardji; Ita N. Anisa; Nareswari Alka Damayanti
Journal of Medicine and Health Vol. 1 No. 2 (2015)
Publisher : Universitas Kristen Maranatha

â€œRumput Mutiaraâ€ or Pearl grass (Hedyotis corymbosa) is one of medicinal plants used empirically by the Indonesian people to cure disease to maintain health. Many people have used pearl grass for a long time. This plant contains hentriacontane, stigmasterol, ursolic acid, oleanolicacid, Î²-sitosterol, sitisterol-D-glucoside, p-coumaric acid, flavonoid-glycosides, â€œbaihua she she cao suâ€ (possibility coumarin analog), iridoid glycosides, alizarin, korogenin, and bonding antragalol.Â Herbaceous plant is used and effetive as a relieve fever (antipyretic), anti-inflammatory, antibacterial, laxative urine(diuretic), removes heat and toxins (detoksikan), blood circulation, anti-cancer, the treatment of peptic ulcers, dysentery, exhausted maternity, and indigestion. This review article is a compilation of Hedyotis corymbosa herb as traditional medicinal plant and pharmacological researches of this herb that can be use as ethnopharmacological and pharmacological information of this medicinal herb.Â Keywords: Â Pearl grass, Hedyotis corymbosa, medicinal plants, ethnopharmacology, pharmacology.

The Effect of Olive Oil Addition into Oatmeal in Lowering Total Blood Cholesterol and LDL (Low Density Lipoprotein) in Wistar Rat Sebastian Hadinata; Heddy Herdiman; Fenny Tanuwijaya
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

Oat contains beta-glucan fiber and olive oil contains unsaturated fatty acids which havebeen proven to decrease blood cholesterol. This research compared the effect between acombination of oatmeal and olive oil and each food as single intake in decreasing total bloodcholesterol and LDL cholesterol. We used 25 rats (Rattus norvegicus L.), divided them into fivegroups; negative control (KN), positive control (KP), olive oil group (KMZ), oatmeal group(KBG), and combination group (KMZ+KBG). The total blood cholesterol and LDL cholesterollevels were measured after 14 days of induction and after 28 days of treatment. Data wereanalyzed using one way ANOVA, continued with LSD test with Î± = 0.05. The result showedthere were 10.85%, 8.85% and 6.60% lower in total blood cholesterol level using KMZ+KBG,KMZ and KBG respectively and 13.85%, 9.33% ,and 8.80% lower in LDL cholesterol levelusing KMZ+KBG, KMZ and KBG respectively. ANOVA test showed a significant decrease ineach treatment. LSD test showed that there was a significant difference between KMZ+KBGcompared to KBG in total blood cholesterol and LDL lowering, but did not showed significantdifference compared to KMZ.Keywords: oatmeal, olive oil, total blood cholesterol, LDL

The Potential of MiRNAs as Biomarkers and Therapy Targets for Cancer Teresa L. Wargasetia
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

MicroRNAs (miRNAs) are involved in the signaling circuits regulation within a cell andtheir deregulation plays an important role in cancer development and progression. In thisreview, we discussed miRNA biogenesis, miRNA function and the effect of miRNA abnormalitiesin cellular pathways that led to transformation of normal cells into cancer cells, as well as theindication of miRNAs as diagnostic and prognostic biomarkers of various types of cancer, asbiomarkers to predict the response to cancer therapy and the potential for development ofmiRNAs as cancer targeted therapy.Keywords: miRNA, cancer, diagnostic biomarker, prognostic biomarker, cancer therapy

The Effect of Ethanol Extract from Mangosteen Pericarps towards Parasitemia in Plasmodium berghei-Inoculated Mice Debora R. Marito; Susy Tjahjani; Khie Khiong
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

Mangosteen pericarps contains fenolic antioxidant, such as xanthone that acts as free radical scavenging substances and preventing heme polymerization. In this research we evaluated the effect of ethanolic extract of mangosteen pericarps on the parasitemia in Plasmodium berghei-inoculated mice and compared its antimalarial activity with artemisinin monotherapy in reducing the parasitemia in Plasmodium berghei-inoculated mice. Deutschland Denken Yoken (DDY) Â mice were randomly divided into 5 groups and inoculated by Plasmodium berghei and given 0.1 mL aquadest (KN), 0.1 mg of artemisinin (KP), 2.5 mg (E1), 0.5 mg (E2) and 0,1 mg (E3) of ethanolic extract from mangosteen pericarps in 0.1 mL aquadest in 3 days. The parasitemia was observed on one day before the treatment, namely on the first day and on the day after the last treatment. We found a highly significant decrease highly significant decrease of the parasitemia in each treatment group compared to the Negative Control group (p < 0.01), and the decrease of parasitemia level in E1 group is similar to the artemisinin monotherapy group (p < 0.05).Â Â Keywords: ethanol extract of mangosteen pericarps, artemisinin, Plasmodium berghei, malaria

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