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Rachmat Kosman
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Fakultas Farmasi UMI, Kampus II, Universitas Muslim Indonesia, Jl. Urip Sumohardjo Km.5, Makassar
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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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PEMERIKSAAN FARMAKOGNOSTIK DAN PROFIL KROMATOGRAFI LAPIS TIPIS TUMBUHAN SARANG SEMUT (Myrmeco diapendans Merr. & Perry) ASAL KABUPATEN TELUK BINTUNI PAPUA BARAT Abd Kadir; Ahmad Najib; Fazlur Rachman
As-Syifaa Jurnal Farmasi Vol 4, No 2 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (378.368 KB) | DOI: 10.33096/jifa.v4i2.83

Abstract

Pharmacognostic assay and Profile of  Thin Layer Chromatography Myrmecodia Plant (Myrmecodia pendens Merr & Perry) from Bintuni Bay, west Papua. Morphologycal Identification showed that Myrmecodia Plant (Myrmecodia pendens Merr & Perry) include magnoliopsida class with steep root system. Leaf anantomy from the leaf showed that anomositic type stomata.Powder extracbility of Myrmecodia Plant (Myrmecodia pendens Merr & Perry) including total ash is 33,92% and insoluble acid ash is 7,78%. While in the water soluble extractive 15,09% and aethanol soluble extractive 5,40%. Chemical identification on the tuberous powder showed that it is consist of tannin (pirogalotanin) and flavanoid. Profile of  Thin layer chromatography obtained total spot more diethyl ether extract equel to 8 spot and n-butanol extract equal to 5 spot with n-hexene : ethyl acetate (8:2( and Chloroform : methanol : water (10:6:0,5).Key words : Pharmacognostic, Myrmecodia pendens, Thin layer chromatography
EFEK HEPATOPROTEKTOR EKSTRAK ETANOL RIMPANG DRINGO (Acorus calamus L.) TERHADAP PENINGKATAN KADAR SGPT TIKUS PUTIH (Rattus norvegicus) Hendra Herman; Sitti Amirah; Triani Putri Ayu
As-Syifaa Jurnal Farmasi Vol 10, No 1 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (534.585 KB) | DOI: 10.33096/jifa.v10i1.335

Abstract

Hepatoprotector is a liver protected-agent of hepatotoxic. This research was aimed to determine the hepatoprotector effect of ethanol extract of dringo rhizome (Acorus calamus L.) and most effective dose as a hepatoprotector. The study using 20 male rats divided into 5 groups. Group I was given the Na-CMC 1%, group II was given a herbal supplement, and group III, IV, and V were given ethanol extract of the rhizome dringo (Acorus calamus L.) with a dose of 50 mg/100 mg, kgBB/kgBB, and 200 mg/kgBB orally for 7 days. At 5th day interval 2 hours after administering the test preparations were given a single dose of 2 g of paracetamol/kgBB in all groups except the Group I. Measurement of levels of SGPT is done before and after the treatment the animal test. From the results of a statistical analysis of Kruskal-Wallis’ test followed by Man-Whitney’s test that dringo Rhizome (Acorus calamus L.) ethanol extracts  has the effect of a hepatoprotector in rats. Extract 50 mg/kgBB dose has the same effect as statistically with herbal supplements’ group (˃ p 0.05).
ETNOFARMASI DAN INVENTARISASI TANAMAN OBAT ASAL DESA LEMBANNA KEC.BONTOBAHARI KAB.BULUKUMBA PROPINSI SULAWESI SELATAN Hasnaeni Hasnaeni
As-Syifaa Jurnal Farmasi Vol 2, No 2 (2010): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v2i2.115

Abstract

Etnofarmacy is the study of how an ethnic community or region in the use of a medicinal plant. Observed result obtained from the inventory data  that is there are several types of plant used by communities in rural Lembanna in the treatment of various diseases of Guajava (Psidium guajava), Papaya (Carica papaya), Mustache cat (Ortoshipon stamineus), Carambola (Averhoa blimbi), Princess shame (Mimosa pudica), Loranthus (Helianthus annus), Chili (Capsicum annum), Noni (Morinda citrifolia), Distance experts (Jatropa carpus), Sirih (Piper betle).Keyword : Etnofarmacy
UJI EFEK ANTIMITOSIS EKSTRAK ETANOL DAUN WUNGU (Graptophyllum pictum (L.) Griff.) DENGAN METODE PENGHAMBATAN PEMBELAHAN SEL TELUR (Tripneustes gratilla L.) TERFERTILISASI Sitti Amirah
As-Syifaa Jurnal Farmasi Vol 7, No 1 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (52.243 KB) | DOI: 10.33096/jifa.v7i1.19

Abstract

Antimitotic assay is one of the toxicity assay methods widely used in detection of cytotoxic activity of new compounds from natural materials. This research aimed to examine the effects of antimitotic and determine the IC50 and IC80 values of the ethanol extract of purple leaves with method of fertilized egg cell division inhibition Tripneustes gratilla L. The cell observation were visually carried out under a microscope by counting the number of cells that divided and did not divide after being incubated for ± 2 hours. The results  of this research showed that the IC50 and IC80 value of ethanol extract of purple leaves are 2,275 x 10-2 µg/ml and 1,54x10-2 mg / ml respectively. Based on the values, the ethanol extract of purple leaves is active as an antimitotic, despite the potential values can be lower than vincristine which can inhibit 80% egg cell Tripneustes gratilla L. fertilized with IC50 and IC80 values of 1,462 x 10-4  µg/ml  and 4.69x10-5 mg/ml.
UJI EFEK HIPOGLIKEMIK EKSTRAK KLOROFORM DAN n-BUTANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L.) PADA MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN Rachmat Kosman
As-Syifaa Jurnal Farmasi Vol 4, No 1 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (215.515 KB) | DOI: 10.33096/jifa.v4i1.147

Abstract

The research About, Hypoglycemic Effect Test Extracts Chloroform and n-Butanol Leaf Belimbing Wuluh (Averrhoa bilimbi L.) Against Mice (Mus musculus) The Induced by Aloksan. This absorvation is done withaim to determine the hypoglycemic of test chloroform and n-butanol leaf belimbing wuluh (Averrhoa bilimbi L.) against mice (Mus musculus) with the main aloksan. This animal abservatian try to inductied. With aloction with the aim to destroy sel-β pancreas and try to rise the animal blood glucose rate. This research utilized 18 male mice divided into 6 groups, each group consisted of 3 male mice. Groop I was given 0,182 gram/kgBB of chloroform extract, groop II was given 0,091 gram/kgBB chloroform extract, groop III was given 0,182 gram/kgBB n-butanol extract and groop IV was given 0,091 gram/kgBB n-butanol extract, and groop V was the positif comparison groop that given glybenclamide sespention and groop VI is the groop with negative control that was given Na CMC 1%. It  was given by feeded with volume of 1 ml/ 30 gBB. The abservatian reault shaw that chloroform ekstrak and n-butanol belimbing wuluh leat (Averrhoa bilimbi L.) has the effect to deerease glucose blood to mice (Mus musculus).Key Words : Hipoglycemic, Avverhoa bilimbi, Aloxan
ANALISIS PEWARNA RHODAMIN B DALAM SAUS TOMAT YANG BEREDAR DI KOTA MAKASSAR SECARA SPEKTROFOTOMETRI UV-VIS St. Maryam; A. Muflihunna; Ulfa Sajadah
As-Syifaa Jurnal Farmasi Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (26.797 KB) | DOI: 10.33096/jifa.v6i2.39

Abstract

Analysis of Rhodamin B dye have done in several tomato sauce produced of Makassar city. The research aims to define and analyze levels of compound Rhodamin B in tomato sauce produced Makassar which is source from the sidewalk traders, and industries households by Thin Layer Chromatography (TLC) method for qualitative analysis and spectrophotometry UV-Vis for quantitative analysis. This research can provide benefits to the public about dangers of consuming food that contain of Rhodamin B dye. Extraction with wool yarn, identified by TLC, and analysis by spectrophotometry UV Vis were covered in this study. Research results showed that the four of tomato sauce produced in makassar city did not contain of Rhodamin B dye and that product can be used by the citizen.Key Words : Rhodamin B, Spectrophotometry UV-Vis, Tomato Sauce.
UJI EFEK HIPOGLIKEMIK KOMBINASI EKSTRAK ETANOL DAUN SAMBILOTO (Andrographis paniculata Nees) dengan AKARBOSE pada TIKUS PUTIH (Rattus norvegicus) TERINDUKSI ALOKSAN Sukmawati Sukmawati; Muhammad Akbar Harsita; Rachmat Kosman
As-Syifaa Jurnal Farmasi Vol 8, No 2 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (106.188 KB) | DOI: 10.33096/jifa.v8i2.203

Abstract

Acarbose and sambiloto have the same mechanism of action in lowering blood glucose levels by inhibiting alfaglukosidase enzymes in the gut. This study aims to determine the hypoglycemic effect and combination effect from ethanol extract of  sambiloto leaves (Andrographis paniculata Nees) with acarbose in rat (Rattus norvegicus) induced alloxan. Twelve Wistar rats were divided into 4 groups; negative control, positive control, and two treatment groups (EEDS 59 mg/kgBW with Acarbose 2,05 mg/kgBB as combination I and  EEDS 234 mg/kgBW with Acarbose 2,05 mg/kgBB as combination II). Diabetes Mellitus  was induced by Aloksan Monohidrate dose 135 mg/kg BB  for three days. Level of blood glucose was measured with glukometer at 2, 4, 6 and 8 day.  Treatment with combinations of EEDS doses 59 and 234 mg/kgBW  and Acarbose 2,05 mg/kgBB for 7 days significantly decreased blood glucose  level (p<0,05) by 48,97 %, and 58,81 %  respectively.
PENGARUH KOMPOSISI HERBAL DALAM MINUMAN TEH HIJAU GAMBUNG HERBAL TERHADAP HAMBATAN α-GLUKOSIDASE Megawati, Megawati; Mulyani, Hani; Minarti, Minarti; Ernawati, Teni; Darmawan, Akhmad
Jurnal Ilmiah As-Syifaa Vol 10, No 2 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (650.017 KB) | DOI: 10.33096/jifa.v10i2.434

Abstract

The aim of this study is to make a formula of green tea that is enriched by other herbs. Green tea drinks are made using the basic ingredients of gambung (THG) green tea enriched with sapodilla leaves (Manilkara zapota (Aw) bay leaves (Syzygium polyanthum (Am), Artocarpus communis (Un) breadfruit leaves, and cinnamon leaves (Cinnamomum verum (K)). The composition of gambung herbal green tea is made by reference to the antidiabetic activity of each herb. All the samples were tested for inhibition of α-glucosidase enzymes and toxicity using the lethality test method for brine shrimp. All samples showed good inhibition of the α-glucosidase enzyme barriers of gamboeng green tea (THG) 82.05%, sapodilla leaves (Aw) 97.81%, breadfruit leaves (Un) 73.34%, bay leaves (Am) 93.80%, cinnamon leaves (K) 91.24 %. The inhibition value of α-glucoside enzymes in the formulation of gamboeng herbal green tea drinks: 96.203% (GKUn) is higher when compared to the GKAm formula (94.78%) and GKAw (62.487%).
IDENTIFIKASI DAN PENETAPAN KADAR SILDENAFIL SITRAT PADA JAMU KUAT LELAKI YANG BEREDAR DI KOTA MAKASSAR Risda Waris; Abd. Kadir; Chairil Akbar
As-Syifaa Jurnal Farmasi Vol 5, No 1 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.949 KB) | DOI: 10.33096/jifa.v5i1.74

Abstract

A studies have been conducted identifying and determining the levels of sildenafil citrate in men vitality herbs that marketed in twon of makassar. This study aims to determine the presence of drugs chemicals substances (BKO) in men vitality herbs that is sildenafil citrate with TLC–Densitometry method. Herbal samples extracted using methanol solvent. Identification test by thin layer chromatography (TLC) using a mobiloe phase of chloroform – ethanol (9.5 : 0,5) indicates that the herbal sample were compared with comparator compounds contains sildenafil citrate. Assay done using a TLC-Densitometry at a maximum wavelength of 292 nm. The results showed levels of sildenafil citrate in men vitality herbs was 0,00827 g/100 g or 0,00827 % per capsule.Key Words : Identifying, Determining, Sildenafil Citrate, Men Vitality Herbs
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN LOSIO EKSTRAK METANOL ALGA HIJAU Caulerpa racemosa Nurlina Nurlina; M Ilham Tomagola; Riskawati Angraini
As-Syifaa Jurnal Farmasi Vol 10, No 1 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.396 KB) | DOI: 10.33096/jifa.v10i1.315

Abstract

Caulerpa racemosa is one type of green algae has the ability to defend against radiation of ultraviolet. Lotion is a liquid or semi-liquid preparation containing one or more active ingredients with a suitable vehicle and provides a comfortable and good feel to the skin. The aim of this research was to obtain the optimum formula based on organoleptic testing, viscosity, pH, flow type, globule of dispersion, and antioxidant activity. The method of this research is experimentally which done by making some design of lotion formulation from methanolic extract of green alga Caulerpa rasemosa. Stability of losio was evaluated include organoleptic testing, pH measurement, type of emulsion, viscosity, flow type, size and distribution of dispersion globule. Determining of effectiveness of lotion as an antioxidant by IC50 value with UV-Vis spectrophotometry method. Results of this research collected and processed statistically with the Completely Randomized Design method, then made the discussion and taken the conclusion. Based on the evaluation, it was found that Losio containing 0.75% methanolic extract of Caulerpa racemosa green algae (Formula III) had the most optimum pharmaceutical stability. And the three losio formulas containing methanol extract of Caulerpa racemosa green algae have antioxidant activity.

Page 13 of 40 | Total Record : 397

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