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Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya
Published by Universitas Muhammadiyah Surabaya
ISSN : 25412272     EISSN : 25489526     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Arjuna Subject : -
Articles 16 Documents
 1   2 
Search results for , issue "Vol 4, No 2 (2020)" : 16 Documents clear
The Level of Effectiveness Use of Quinoline Drugs in COVID-19: A Literature Review M.Dedi Dermawan Dermawan; Afrita Amalia Laitupa; Muslim Andala Putra; Nenny Triastuti
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.4998

Abstract

ABSTRACT          Chloroquine is the first line of medicine in the treatment of malaria. Besides being antimalaria, the chloroquine also can be used as the anti-inflammation in the medicine of arthritis rheumatoid arthritis and lupus erythematosus discoid. Hydroxychloroquine sulfate is 4-aminoquinolin with hydroxylated chloroquine analog, having the same pharmacokinetic as chloroquine which is given orally in hydroxychloroquine sulfate form, processed by gastrointestinal absorption and very faster kidney elimination. The effectiveness of chloroquine and hydroxychloroquine towards COVID-19 in the in vitro experiment showed it could inhibit the duplication of the SARS-CoV-2 virus. The chloroquine function is to stop COVID-19 infection with (EC50) 1,13 μM and (CC50) larger than 100 μM. Meanwhile, the hydroxychloroquine function is to inhibit the attachment and entry of the virus into the host’s cell by enzymatic activation which is the lysosome acidification disorder and antigen presentation as the result of pH increase. Based on the clinical study, the 10 of 12 patients who have lopinavir/ritonavir therapy by virology, the chloroquine group showed RT-PCR negative on day 7, 10, and 14 in compare to lopinavir/ritonavir that showed RT-PCR negative on day 14. On the 9th day, 60% of the patients of chloroquine group showed the CT scan of Lungs image normal instead of the lopinavir/ritonavir at 25%. In the day 14 based on the CT test result, the pulmonary improvement increased twice rather than chloroquine group (Rate Ratio 2.21). It proved that the chloroquine role showed the result of the medicine has a significant effect by cleaning the virus or other clinical matters. The purpose of this literature review is to know the effectiveness quinoline class of drugs which is chloroquine and hydroxychloroquine in COVID-19 disease.Keywords: effectiveness, chloroquine, COVID-19Correspondence: dedydermawan555@gmail.com
Antimalarial activity of goat bile against Plasmodium berghei ANKA infection in BALB/c mice Kholida Nur Aini; Windya Tri Hapsari; Kartika Arum Wardani; Heny Arwati; Willy Sandhika
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.3540

Abstract

Abstract Goat bile has been used by some Indonesian people to treat malaria and increase their stamina. This study aimed to prove whether goat bile toxic or not in BALB/c mice and to verify the antimalarial activity of goat bile at various concentrations in mice infected with Plasmodium berghei ANKA. Acute toxicity test was performed using twenty male BALB/c mice with an average body weight of 25 grams, which were divided into four groups. Mice were given 25%, 50%, and 100% goat bile, respectively, while negative control was given distilled water. Any change in weight, odor, color, agitation, appearance, color of urine and feces, coma, and death, were recorded. A different set of mice were infected with P. berghei ANKA. This study conducted using the posttest only control group design with four treatments and five replications. A four day-treatment of goat bile was given by oral gavage to find out its effect on parasitemia level. Infected mice were divided randomly into 4 groups, where the GBNeg group as negative control was given only distilled water. The GB25, GB50, and GB100 groups were treated with 25%, 50%, and 100% goat bile, respectively. The parasitemia was observed daily on Giemsa-stained tail blood smears of each mice. No death or other sign of toxicity was found in goat bile-treated mice. Goat bile showed anti-malarial activity. The parasitemia in all goat bile treated groups was lower compared with the negative control group. The ED50 of goat bile against the growth of parasite was 48,55 %. Goat bile is a potential source of new antimalarial therapies. Further investigations are recommended to yield new anti-malarial drug candidates. Keywords                :    Goat bile, parasitemia, Plasmodium berghei ANKA, ED50Correspondence     :    heny-a@fk.unair.ac.id
Collagen Type I and Type II Expression Evaluation on Cartilage Defect Regeneration Treated with Dwikora–Ferdiansyah–Lesmono–Purwati (DFLP) Scaffold Supplemented with Adipose–Derived Stem Cells (ASCs) or Secretome: An In-Vivo Study Adrianto Prasetyo Perbowo; Dwikora Novembri Utomo; Lukas Widhiyanto; Primadenny Ariesa Airlangga; Purwati Purwati
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.4377

Abstract

Abstract Cell-based therapies such as Scaffold, stem cells, and secretome, are one of the alternatives to enhance the regeneration of hyaline-like cartilage in cases of cartilage defects. This study is an in-vivo experiment using animal models, in which we apply a composite of DFLP (Dwikora-Ferdiansyah-Lesmono-Purwati) Scaffold and Adipose-Derived Stem Cells (ASCs) or Secretome to an injury model on the distal femoral trochlea of New Zealand White Rabbits. The animals were divided into four groups: (1) control (K); (2) Scaffold only (S); (3) Scaffold + ASCs (SA); (4) Scaffold + Secretome (SS). Animals were terminated in the 12th week, and an immunohistochemistry (IHC) evaluation for Collagen type I and II were done. Statistical analysis shows that collagen type I IHC between groups shows no significant difference (p = 0.546). Collagen type II IHC shows significant difference between groups (p = 0,016). The findings in this study showed that Scaffold + ASCs group and Scaffold + Secretome have better collagen type II expression compared to the control group. DFLP Scaffold composite with ASCs or Secretome shows potential for cartilage regeneration therapy by increasing type II collagen expression as in hyaline-like cartilage which may be used for regenerative therapy for cartilage defects. Keywords             : DFLP Scaffold; Adipose-Derived Stem Cells (ASCs); Secretome; Collagen Type I; Collagen Type IICorrespondence    : ianperbowo@me.com
Medical students' perspectives about distance learning during early COVID 19 pandemic: a qualitative study Muhammad Reza Utama; Yelvi Levani; Ayu Lidya Paramita
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.5000

Abstract

Background: Medical education throughout the world has experienced major changes as a consequence of the presence of the COVID-19 pandemic. The Government of Indonesia has instructed physical distancing so that teaching and learning activities, including in the Faculty of Medicine, must be carried out at home with online methods to reduce the risk of COVID distribution. Objective: to explore undergraduate medical students’ perspectives towards distance learning during early COVID 19 pandemic at Muhammadiyah Surabaya University - Faculty of Medicine (MSU-FM), Indonesia. Methods: a qualitative study of students’ online survey responses had been done. Thematic analysis based on Unified Theory of Acceptance and Usage of Technolgy (UTAUT) constructs was done to ecplore students’ perspectives. Results: Students have a positive perspective related to performance expectancy of distance learning. This factor have been perceived as factor that support the behavior of the use of distance learning in order to increase cognitive involvement in the learning process. However, in this study, other factors conveyed by students limiting their optimal use of current distance learning platform. Conclusion: Students‘ user experiences must be developed and maintained continuously during this pandemic era. Longitudinal studies that investigate the long-term impact of various distance learning platforms‘ usage also need further study.
Thrombocyte Count in Male and Female Adult of Dengue Hemorrhagic Fever Patients Lelyana Sih Afgriyuspita; Heny Arwati; Hartono Kahar
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.3559

Abstract

AbstractThe trend of dengue virus infection in Indonesia has changed from children to older groups. Some studies suggested that different gender might affect the different progression of dengue infection, but its mechanism was unclear. This study analyzed the difference by evaluating the daily thrombocyte count pattern. An analytic observational study with a retrospective design was conducted using the secondary data collected from medical records in Dr. Soetomo General Hospital Surabaya during 2017-2018. The samples were adult patients in the age range of 18-55 years old with DHF but without comorbidity or coinfection. The total number of samples was 40 patients. The average of thrombocyte count in both male and female patients decreased since the 3rd day of illness and reached the lowest level on the 6th day of illness then increased on the 7th day but did not reach the normal range. Although the majority of thrombocyte count in females was lower than males, there was no significant difference in thrombocyte count pattern between them. Keyword: Adult, DHF, Thrombocyte, GenderCorrespondence : heny-a@fk.unair.ac.id
Overlapping Primary and Secondary Syphilis in Human Immunodeficiency Virus (HIV) Patient Nurul Laili Nahlia; Lita Setyowatie
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.4378

Abstract

ABSTRACTCoinfection between syphilis and Human Immunodeficiency Virus (HIV) could have varied clinical manifestations. Overlapping of syphilis stages is accounted for 25% of cases, attributable to the defect of the cellular and humoral immune response. We reported 55 years old man who was sexually active since 25 years ago via genito-genital, genito-anal, genito-oral routes, had multiple sexual partners both male and female, seldom used condom, and always being the insertive. Dermatological examination revealed alopecia non-scarring, a painless solitary ulcer on the collum penis, also multiple erythematous macules, patches, and plaques all over the body. Spirochaeta sp. was found from the base of the ulcer with a darkfield microscope. Histopathology examination revealed secondary syphilis lesion. Venereal Disease Research Laboratory (VDRL) 1:16, Treponema Pallidum Haemagglutination test (TPHA) reactive, HIV Determine rapid test reactive, and CD4 (Cluster of Differentiation 4) T-cell count 111 cells/ µL. He was treated with a single dose of benzathine penicillin G 2,4 million units intramuscular and antiretroviral drugs. On sixth month evaluation, VDRL was non-reactive, and CD4 T-cell count 325 cells/µL. This case shows that overlapping clinical manifestations of primary and secondary syphilis on HIV patients could occur with a good general condition. Immediate treatment of antibiotics for syphilis and antiretroviral could improve the clinical and serological conditions.Keyword: primary syphilis, secondary syphilis, HIVCorrespondence: nurul.laili.nahlia@gmail.com
Comparison of clinical evaluation of post-operation patients of open reduction internal fixation (ORIF) plating proximal humerus using conventional methods and minimally invasive plate osteosynthesis (MIPO) in Surabaya Musa Arafah; Heri Suroto; Erwin Ramawan
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.3119

Abstract

ABSTRACT There are several kinds of approaches in the installation of implants for proximal humerus therapy. At present, minimally invasive surgery is gaining in popularity; this is supported by increasingly good technological developments to optimal the postoperative outcome is more optimal than conventional methods. This study used an analytic retrospective design with samples of post-ORIF Plating MIPO and posted ORIF due to proximal humeral fracture. Evaluation using the instrument of VAS Score, ASES Score, and measurement of range of motion. Statistical tests showed that there was a significant difference in the VAS score at the first evaluation (p = 0.002); the last review was not significant. In ASES Score, abduction, flexion, and external rotation, there were significant differences during the first and last evaluations. Adduction, extension, and internal rotation have no significance. The method of minimally invasive plate osteosynthesis (MIPO) on proximal humeral operative fracture therapy had a better clinical outcome and operating time than post-ORIF plating with conventional methods. As well, the MIPO method on proximal humeral fracture operative therapy based on radiological features has the same union rates compared to post ORIF plating with conventional methods. The method of minimally invasive plate osteosynthesis (MIPO) in operative therapy of neer 2 and 3 proximal humeral fracture has a better clinical outcome than conventional methods.Keywords: proximal humeral fracture, Minimal Invasive Plate Osteosynthesis (MIPO), Open Reduction Internal Fixation (ORIF)Correspondence to: musa_shi911@yahoo.com   
Index and Acknowledgement Yelvi Levani
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.5598

Abstract

Index and Acknowledgement
Electrocardiogram abnormality and Distance Covered during Six Minute Walk Test on Diabetes Mellitus Type 2 Ni Made Elva Mayasari; Adhi Permana; Yudi Fadilah; Namira Amanda
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.3598

Abstract

AbstractDiabetes Mellitus (DM) is a metabolic disease that has the characteristics of hyperglycemia that occurs due to abnormalities of insulin secretion, insulin action, or both. Macrovascular complications are often also referred to as secondary atherosclerosis due to DM, which can cause cerebral vascular disease, coronary arterial disease, and peripheral atrial disease. Diagnostic tools are needed for early detection in cardiovascular diseases which is accurate, inexpensive, comfortable, and available in almost health center. One of the diagnostic tools for early detection of cardiovascular diseases is an electrocardiogram (ECG). Six Minute Walk Test (SMWT) is a simple, objective, inexpensive, and efficient test to assess functional capacity and prognosis. This study aims to [nmem1] see whether there is a correlation between abnormalities of ECG and distance covered during SMWT in DM patients. This study was a cross-sectional study design from DM patients in the Polyclinic of the Muhammadiyah Hospital in Palembang. Forty patients with type 2 DM who fulfilled inclusion and exclusion criteria were selected using a consecutive sampling method. Twenty-seven patients have abnormal ECG, and only thirteen patients had distance covered during SMWT >300m. There is a correlation between abnormalities of ECG and distance covered during SMWT in DM patients with a significance value p = 0.011.Keywords: Diabetes Mellitus type 2, Eelectrocardiogram, Six Minute WalkingCorrespondence author: elva.maya@yahoo.com  
Oxygen saturation among newborns in the first 10 hours of life to detect Critical Congenital Heart Disease - Ductus Dependent Fatchul Wahab; Mahrus Abdul Rahman; Teddy Ontoseno; Risa Etika; Alit Utamayasa; Taufiq Hidayat; Sarmanu Sarmanu
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.4258

Abstract

ABSTRACT Delay diagnosis of Critical Congenital Heart Disease (CHD) can be associated with sudden clinical deterioration and dangerous cardiovascular conditions. The oxygen saturation screening among newborns in the first 10 hours of life is essential for early detection of critical CHD. This study aims to prove that measuring oxygen saturation among newborns in the first 10 hours of life can detect critical CHD. This study is a diagnostic experimental with consecutive sampling subjects in the infant care unit of Dr. Soetomo Hospital, including all newborns with birth weight ≥ 1500 grams and oxygen saturation at ≥ 1 hour of age below 90%. The measurement of oxygen saturation uses fingertip pulse oximetry in the right hand and foot at the age of 10 hours. A "positive oxygen saturation" is defined as oxygen saturation ≤ 85% or different oxygen saturation ≥ 3%, while a "negative oxygen saturation" is when the oxygen saturation is 85% to 90% or different oxygen saturation is 3%. Echocardiography is performed for the gold standard. From November 2019 to January 2020, 11 newborns underwent an oxygen saturation examination. Five subjects (45.46%) in the category of positive oxygen saturation, echocardiographic showed all Critical CHD (100%). Six subjects (54.54%) with negative oxygen saturation category, echocardiographic results showed two critical CHD (33.34%) and four non-critical CHD (66.66%). Fisher's exact test p < 0.005 (α). The diagnostic oxygen saturation test among newborns at 10 hours of life shows ≤85%, all subject’s echocardiography (100%) shows detection of critical CHD, while saturation 85% to 90% has of 33.3% for detection of critical CHD. The sensitivity and specificity of oxygen saturation for early diagnosis of critical CHD are 100% and 67%, respectively. Keywords: critical congenital heart disease, oxygen saturation, fingertip pulse oximetry, diagnostic tests*Corresponding Author: wfatchul045@gmail.com

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