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Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya
Published by Universitas Muhammadiyah Surabaya
ISSN : 25412272     EISSN : 25489526     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Arjuna Subject : -
Articles 16 Documents
 1   2 
Search results for , issue "Vol 5, No 1 (2021)" : 16 Documents clear
Index and Acknowledgement Yelvi Levani
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.7361

Abstract

Index and Acknowledgement
Roflumilast: A Review of Chronic Obstructive Pulmonary Disease (COPD) Treatment Ita Octafia; Dwi Octamy Sari; Novi Wulandari; Sandra Annisa; Linda Wahyuni Wongkar; Ferdias Kurnia Bahari; Faiz Farikhah; Moh Firmansah; Erfin Midhiawati; Fauna Herawati
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.5043

Abstract

Abstract Chronic Obstructive Pulmonary Disease (COPD) is a chronic airway inflammation with resulting progressive airflow limitation that has a high incidence, morbidity, and mortality. Roflumilast is an oral phosphodiesterase-4 inhibitor as a therapy to decrease the risk of COPD exacerbations in patients with moderate-severe COPD with a history of chronic bronchitis. Roflumilast can be given orally once daily as a single or combination drug. It can be used as COPD moderate-severe but also more beneficial as COPD mild treatment. The efficacy of Roflumilast can prevent exacerbations of repetition and can fixed lung function both in terms of FEV1 and vital capacity to force. The incidence of side effects, which are diarrhea and digestive disorders. The cost-effectiveness showed that Quality of life patient with Roflumilast is better than the group without additional. This paper aimed to review systematically Roflumilast as COPD treatment for the clinical application.Keywords                   : COPD, Roflumilast, phosphodiesterase-4 inhibitorCorrespondence          : fauna@staff.ubaya.ac.id
The difference in severity and management between children and adult's cases of COVID-19 Mohammad Husin; Gina Noor Djalilah; R A Kaniraras; Afrita Amalia Laitupa
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.6229

Abstract

AbstractCOVID-19 (Coronavirus Disease 2019) has been started in Wuhan, China, and spread worldwide and resulting in many cases of death. COVID-19 attacks the respiratory tract acutely and infected both children and adults. The number of cases in children is less than in adults. By seeing from the clinical aspect, the COVID-19 case in children is milder. There are differences in immunology responses in children and adults where children have higher immunology response of COVID-19 than adults. Meanwhile, if the immunology response is slow in adults, it may cause them infected by COVID-19 with severe symptoms. There are some relations between immunization with immunology response to SARS-CoV-2 where children who already have BCG vaccination has lower infection rates of acute respiratory tract case. This study aims to know the difference between COVID-19 cases that infected adults and children seen in various aspects.Keywords                     : COVID-19,SARS-CoV-2, children, adult, severity, managementCorrespondence         : mohammad_husin@yahoo.com
In vitro Alpha Lipoic Acid supplementation in freeze-dried human sperm: the impact on DNA fragmentation index Rezia Octarina; M. P. B. Dyah Pramesti; Agustinus Agustinus
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.4374

Abstract

Freeze-drying technique is an alternative method on sperm preservation. However, this process can results in DNA damage. Adding antioxidants before freezing can reduce the detrimental effects of ROS on spermatozoa. Alpha lipoic acid (ALA) is one of the potent antioxidant that can be used to protect the sperm DNA. This study was aimed to determine the effect of ALA supplementation before freeze-drying on the DNA fragmentation index (DFI) of human spermatozoa. Nine semen samples were collected and evaluated for DFI (O1) then divided into 3 groups; freeze-drying without ALA (O2), freeze-drying with ALA 1,25 mg (O3) and freeze-drying with ALA 2,5 mg (O4).All three groups were stored at 4oC for 1 week. Sperm DFI were evaluated before and after freeze-drying. The result of this study showed a significant increase in sperm DFI in all three groups after freeze-drying (p<0,05) when compared to DFI before freeze-drying (14,67 ±3,295). However there was no significant difference between O2 (26,90 ±9,180) and O4 (29,29 ±5,524) group where the supplementation of 2,5 mg ALA did not have significant effect on protecting the DNA of freeze-dried human spermatozoa. The highest DFI was in the O3 group (44,64 ±11,717). Therefore, ALA supplementation before freeze-drying does not have a significant effect on protecting the DNA of freeze-dried human spermatozoa.
Effects of acupressure therapy period towards blood sugar level in type 2 diabetes mellitus patients at Lumajang acupressure clinic Anung Putri Illahika; Hean Safira
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.5097

Abstract

Abstract  Diabetes Mellitus is a worldwide metabolic disease and becomes a challenge for the health practitioner. Unfortunately, less than half of these diabetic individuals are aware of their conditions, and less than 1% of those receiving medical treatment achieve their therapeutic targets. Acupressure is an alternative method that is believed to be an effective way of treating diabetic patients with reducing symptoms and complications. This research aims to discover the effect of period acupressure therapy on blood sugar levels in type two diabetes mellitus patients in Lumajang Acupressure Clinic. It uses an observational analytic design with pre-test and post-test approach. It involved 36 participants who were split into two groups and contained 18 participants for each group. The first group received acupressure therapy for three weeks, while the second group received eight weeks. Both groups underwent acupressure at the San Yin Jiao (SP-6) acupoint for 20 minutes three times a week. All participants in both groups had their blood glucose checked before and after acupressure therapy. The results showed that the two groups were significantly different for the paired t-test and the independent t-test. The acupressure therapy period has an effect on decreasing blood sugar levels in type two diabetes mellitus patients at Lumajang acupressure clinic. Keywords             : Acupressure, the period of therapy, blood glucose level, type two diabetes mellitusCorrespondence   : Anungputri113@gmail.com
Role of antioxidant to protect Leydig cells induced by reactive oxygen species: a literature review Anak Agung Istri Dalem Cinthya Riris; Reny I&#039;tishom; Siti Khaerunnisa
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.4693

Abstract

The Leydig cells play crucial role in steroidogenesis and spermatogenesis. Those processes need complex communication in hormonal and testicular to maintain male reproductive function. Abnormal condition induced by reactive oxygen species reduce cell viability through lipid peroxidation and apoptotic pathway. Antioxidant ameliorate ROS elevation and prevent cell damage. Specifically, Leydig cells are vulnerable to ROS exposure and decline its function in mediating spermatogenesis. Therefore, it is needed to improve Leydig cells viability within antioxidant supplementation. This study aimed to determine the protective effect of antioxidant on Leydig cells induced by reactive oxygen species. This type of study is a literature review. Various studies have been reviewed through critical appraisal tool Olsen-Baisch Scoring for integrated review. Furthermore, this study highlighted the importance of the mechanism of antioxidant as protective agent of Leydig cells. Supplementation of antioxidant with the correct administration, dosage, and duration is potential to balance reactive oxygen species level and protect Leydig cells.    Keywords             : Leydig cell, antioxidant, reactive oxygen species, infertility
Identification of Thalassemia Carrier in Anemic Pregnant Women at Puskesmas Kertapati Palembang: Comparison of Five Erythrocyte Indices Mitayani Purwoko; Eriko Erenkwot
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.4469

Abstract

Anemia is a condition that is almost always found in pregnancy. Although a program of Fe tablets has been introduced during pregnancy, the prevalence of anemia during pregnancy is still high. This situation maybe caused by another risk factor of anemia such as Thalassemia. This study was aimed to investigate the presence of carrier Thalassemia in pregnant women at the Puskesmas Kertapati, Palembang, South Sumatera using erythrocyte indices. This was a cross-sectional study with a sample size of 68 subjects, taken by purposive sampling technique. Hemoglobin level of all subjects was measured by Easy touch GCHb and confirmed by Sysmex K21. Differences of hemoglobin between Easy Touch GCHb and Sysmex K21 were analyzed by impaired t-test used SPSS program. Other data were analyzed using descriptive statistic.The mean hemoglobin levels in subjects were 10.7 g/dl. There were 68 subjects have anemia according to Easy Touch GCHb  but only 30 subjects that confirmed positive anemia by Sysmex KX 21. T-test result gavep value <0.05 that isconsidered there was a statistically significant difference between Easy Touch GCHb and Sysmex KX 21 results(p=0.001). Calculations using the England-Fraser index, Mentzer, Sirdah, and Srivastava indicate that none of the research subjects had thalassemia carrier status.
Depression, anxiety, and stress levels in Denpasar community during the pandemic of Corona Virus Disease 2019 (COVID-19) I Gusti Ngurah Bagus Rai Mulya Hartawan; I Gede Gita Sastrawan; Rovie Hikari Parastan; Luh Seri Ani
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.5177

Abstract

The Government of Indonesia has started to implement a Large-Scale Social Limitation (PSBB) in cities and provinces in Indonesia to prevent the increasing of COVID-19 transmission. The Denpasar city as one of the cities that implemented a similar system. This study was aims to provide an overview of the levels of depression, anxiety, and stress in the Denpasar community during the COVID-19 pandemic. This study was an observational descriptive study with cross-sectional design. The data collection used Google forms that distributed online. There were 160 respondents participated in this study, dominated by women (56.9%), domiciled in South Denpasar (35.0%), living with family or relatives (85.6%), aged 18-25 years old (63.7%), had diploma or bachelor degree as their education background (55.0%), unmarried (66.3%), students (38.8%), and no income (44.4%). The results showed that respondents had 1-2 offspring (53.7%), did not experience layoffs (83.9%), and experienced a decrease in income (67.0%), dominant respondents experienced psychosocial disorders in the form of depression (51.2%) with a moderate degree (31.7%) and the anxiety (53.1%) with a mild degree (40.0%). Most respondents did not experience stress (53.1%). In conclusion, the characteristics of respondents' psychosocial disorders were moderate depression, mild anxiety, and did not stress.
Association between gestational age and persistent pulmonary hypertension of the newborn (PPHN) severity in preterm babies at Sidoarjo Regional Hospital Aisyah Faadhilah; M. Perdana Airlangga; Nurma Yuliyanasari; Gina Noor Djalilah
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.6107

Abstract

AbstractPersistent pulmonary hypertension of the newborn (PPHN) is a condition that occurs due to increased resistance to blood vessels in the lungs that occur persistently after the baby is born. This can be attributed to congenital heart disease such as right-to-left shunts through foramen ovale (PFO) or patent ductus arteriosus (PDA) due to an error transition fetal blood circulation to the neonate. Although PPHN is always associated with births in post-term babies, PPHN cases are often found in preterm babies. Chances of babies born with PPHN are quite large, at 1.9% per 1000 live births. PPHN can be fatal, causing mortality rates ranging from 4 to 33%. The incidence of preterm births in Indonesia is estimated at 7-14%, around 459,200 - 900,000 babies per year. This study aimed to prove the relationship between premature babies and persistent pulmonary hypertension of the newborn (pphn) in Sidoarjo  Regional Hospital and to know the characteristics and analyze these variables.  This research used crossed sectional studied design; the population was all preterm babies in the NICU at Sidoarjo  regional hospital. All samples are from medical records in January-December 2018. There is a significant difference between preterm babies and PPHN (p < 0.05); besides, the results from Spearman's correlation analysis obtained a correlation coefficient (ρ) = 0.485. In the cross-tabulation analysis, the result of the proportion with the highest correlation was Late Preterm babies with severe PPHN of 46.7%. It can be concluded that there is a relationship between premature babies and PPHN in Sidoarjo  regional hospital..Keywords                      : Persistent pulmonary hypertension of the newborn, PPHN, Preterm BabiesCorrespondence            : aisyahhelmadevithalib@gmail.com
Solanum betaceum Extract as a Protective on Spermatozoa Morphology of Mice Exposed to Lead Acetate Rima Wirenviona; Reny I&#039;tishom; Siti Khaerunnisa; Anak Agung Istri Dalem Cinthya Riris; Nurul Fatimah Susanti; Nurul Jannatul Wahidah; Abadiyah Zakiah Kustantina
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.4594

Abstract

Environmental pollution is one of the factors that contribute to the decline in male fertility. Lead is one of six air pollutants harmful to the reproductive system. One parameter of infertility in men is an increase in reproductive function observed with decreased morphological abnormalities of spermatozoa. The purpose is to analyze the effect of giving various dosages of Solanum betaceum extract on spermatozoa morphology of mice exposed to lead acetate. This study was true experimental using a randomized post-test only control group design. The total sample was 40 male mice Balb/ C taken by simple random sampling technique. Treatment and maintenance of experimental animals for 35 days. Statistical tests showed there were significant differences with p-value 0.005. Solanum betaceum extract can be used as a protective to improve the normal morphology spermatozoa of mice that exposed to lead acetate.

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