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ALCHEMY Jurnal Penelitian Kimia
Published by Universitas Sebelas Maret
ISSN : 14124092     EISSN : 24434183     DOI : -
Core Subject : Science, Social, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology
ALCHEMY Jurnal Penelitian Kimia is a chemistry journal published by Sebelas Maret University, Surakarta. ALCHEMY Jurnal Penelitian Kimia publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry.
Arjuna Subject : -
Articles 281 Documents
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Studi In Silico Aktivitas Senyawa Steroid Terhadap Antikanker Payudara Menggunakan Estrogen Alfa (ER-α) Nurlelasari, Nurlelasari; Widyana, Almas; Julaeha, Euis; Hardianto, Ari; Huspa, Desi Harneti Putri; Maharani, Rani; Mayanti, Tri; Darwati, Darwati; Hanafi, Muhammad; Supratman, Unang
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.62384.44-52

Abstract

Kanker payudara merupakan penyebab kedua terbanyak kematian pada wanita akibat kanker setelah kanker paru-paru di seluruh dunia. Steroid merupakan kelompok senyawa aktif yang diantaranya berhasil diisolasi dari genus Chisocheton yang dilaporkan memiliki aktivitas melawan sel kanker payudara MCF-7. Tujuan penelitian ini adalah untuk mengetahui interaksi senyawa steroid terhadap estrogen alfa (ER-α) melalui metode in silico, yaitu penambatan molekul. Pemodelan struktur tiga dimensi (3D) senyawa steroid dilakukan dengan memperhatikan keadaan terprotonasinya pada pH 7,4. Metode in silico divalidasi melalui penambatan ulang struktur kristal ER-α, hingga diperoleh nilai RMSD < 2 Å, dengan program AutoDock 4.2.6. Dengan program yang sama, senyawa-senyawa steroid ditapis dengan metode penambatan molekul. Hasil penapisan menghasilkan nilai energi bebas dari kedua senyawa steroid yaitu -10,08 kkal/mol (7α-hidroksi-β-sitosterol) dan -10,75 kkal/mol (stigmast-5-en-3β-ol), yang nilainya lebih baik dari estradiol (-9,62 kkal/mol), sebagai ligan alami ER-α. Kedua senyawa ini berpotensi untuk menginhibisi estrogen alfa, dimana senyawa stigmast-5-en-3β-ol memiliki potensi yang lebih besar karena nilai energi bebasnya lebih rendah. Hal ini menandakan bahwa modifikasi struktur senyawa mampu mengubah nilai energi ikatan dan interaksi antara ligan dan reseptor.In Silico Study of Steroid Compound Activity Against Breast Cancer Using Estrogen Alpha (ER-α). Breast cancer is the second worldwide leading cause of cancer death in women after lung cancer. Steroids are a group of active compounds isolated from the Chisocheton genus that has activity against MCF-7 breast cancer cells. This study aimed to determine the interaction activity of steroid compounds against alpha estrogen receptor (ER-α) through in silico method specifically mlecular docking. The modeling of the three-dimensional structure (3D) of steroid compounds was performed by considering their protonation states at pH 7.4. The in silico method was validated by redocking the crystal structure of ER-α until obtaining an RMSD value < 2 Å, using the AutoDock 4.2.6 program. Steroids compounds were screened with the same program namely the molecular docking method. Screening results show that the free energy values of the steroid compounds were -10.08 kcal/mol (7α-hydroxy-β-sitosterol) and -10.75 kcal/mol (stigmast-5-en-3β-ol), which are stronger than estradiol (-9.62 kcal/mol) as native ligand of ER-α. Both of these compounds can inhibit the alpha estrogen receptor, in which the stigmast-5-en-3β-ol compound has a greater potential because of its lower free energy value. This finding indicates that modification of the compound's structure could change the binding energy value and interaction between ligands and receptors.
Fermentation Effect of Cacao Beans Originate from Jember on Polyphenol-Flavonoid Content and Radical Scavenging Activity Agustriana, Eva; Valentino, Herly Angga; Rahmani, Nanik; Nuryati, Nuryati; Firmanto, Hendy; Rachmayati, Rike; Yulianti, Siti Eka; Nuryana, Isa; Yopi, Yopi; Lisdiyanti, Puspita
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.60831.23-31

Abstract

Cacao is attractive for its flavor and taste and its beneficial effects. Therefore, this commodity is promising to be developed as a functional food. Many studies reported the bioactive compounds in cacao beans and their health benefits. However, to attain desirable flavor and taste, the curing process of cacao beans is a common practice, in which fermentation is one of the processes. Despite its significance, fermentation also alters the bioactive components in cacao beans. To develop a functional food rich in bioactive compounds, measuring the bioactive contents of treated and untreated cacao beans is desired. For that reason, in this study, the analysis of total polyphenol, flavonoid, catechin, and epicatechin, as well as the radical scavenging activity of fermented cacao beans, was performed. The study revealed that fermentation negatively affected all parameters. Cacao beans fermentation up to 96 h resulted in the loss of 54% of total polyphenol, 77% of total flavonoid, and 56% of radical scavenging activity. Determination of the flavan-3-ol components, catechin, and epicatechin,  revealed that they were reduced as the fermentation occurred.
Pembuatan dan Karakterisasi Nanopartikel Perak Menggunakan Ekstrak Buah Mangrove Rhizophora stylosa Nancy Willian; Hilfi Pardi; Syukri Arief
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.59359.53-60

Abstract

Nanopartikel perak menampilkan sifat fisik dan biologis yang unik yang telah menarik minat penelitian karena aplikasi yang menjanjikan. Pada penelitian ini, proses fabrikasi nanopartikel perak(AgNPs) dilakukan dengan metode green sintesis menggunakan tanaman mangrove dengan pelarut air. Ekstrak buah mangrove Rhizophora stylosa (RS) pertama kali digunakan sebagai reduktor dan stabilizer dalam sintesis AgNPs. Karakteristik AgNPs ditentukan dengan spektrofotometer UV-Vis, FTIR, XRD dan TEM. Analisis spektrum UV-vis menunjukkan panjang gelombang pada 430 ‒ 445 nm. Studi FTIR mengungkapkan adanya senyawa fitokimia aktif yang bertindak sebagai zat penutup dan penstabil nanopartikel. TEM menunjukkan morfologi AgNPs yang ditemukan berbentuk bola dengan ukuran diamter sekitar 10 ‒ 60 nm. Pola XRD menunjukkan bahwa semua sampel AgNPs yang diperoleh memiliki struktur face-center cubic (fcc) yang menegaskan bahwa nanopartikel bersifat padatan kristalin dengan ukuran kristal 38 ‒ 77 nm. Studi ini membuktikan kemampuan biomaterial dalam sintesis AgNPs dengan mengadopsi prinsip sintesis hijau.Fabrication and Characterization of Silver Nanoparticles Using Extract of Mangrove Fruit of Rhizophora stylosa. Silver nanoparticles display unique physical and biological properties that have attracted research interest because of their promising applications. In this research, silver nanoparticle (AgNPs)  fabrication process was carried out via green synthesis methods using mangrove plants and water as a solvent. Mangrove fruit extract Rhizophora stylosa (RS) was first used as a reducing agent and stabilizer in the synthesis of AgNPs. The characteristics of AgNPs were characterized using UV-Vis, FTIR, XRD, and TEM spectrophotometers. UV-vis spectrum analysis showed a peak at 430 ‒ 445 nm. FT-IR studies revealed the presence of active phytochemical compounds which act as coating agents and stabilizers for nanoparticles. TEM showed that the morphology of AgNPs was spherical with a diameter size of 10 ‒ 60 nm. The XRD patterns showed that all of the AgNPs sample obtained had a face-center cubic (fcc) structure, indicating that the nanoparticles are crystalline solids with a crystallite size of 38 ‒ 77 nm. This study proves the ability of biomaterials in the synthesis of silver nanoparticles by adopting the principle of green synthesis.
Biosensor Elektrokimia untuk Memonitor Level Hemoglobin Terglikasi (HbA1c) pada Penyakit Diabetes Melitus Sheila Destiani; Iman Permana Maksum; Yeni Wahyuni Hartati
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.58439.94-107

Abstract

Hiperglikemia merupakan ciri diabetes melitus, sekelompok penyakit metabolik yang disebabkan oleh kelainan sekresi insulin, kerja insulin, atau keduanya. Hiperglikemia dapat menyebabkan kerusakan jangka panjang, disfungsi, dan kegagalan berbagai organ, terutama jantung, mata, saraf, pembuluh darah, dan ginjal. Oleh karena itu, diagnosis dan pemantauan rutin kadar glukosa darah sangat penting dilakukan. Hemoglobin terglikasi (HbA1c) adalah hemoglobin yang berikatan dengan glukosa dalam darah dan ditetapkan menjadi biomarker hiperglikemia yang dapat mengindikasikan diabetes atau prediabetes. Akan tetapi, pengukuran HbA1c di laboratorium klinis membutuhkan instrumen yang canggih dan mahal, tenaga ahli khusus dan waktu lama. Oleh karena itu, biosensor elektrokimia kemudian mulai dikembangkan untuk mendeteksi kadar HbA1c karena mudah digunakan, hasil cepat, dan harga yang murah. Ulasan ini membahas biosensor elektrokimia untuk mendeteksi HbA1c dan metode imobilisasi bioreseptor.Electrochemical Biosensor for Monitoring Glycated Hemoglobin (HbA1c) Levels in Diabetes Mellitus. Hyperglycemia is a hallmark of diabetes mellitus,  a group of metabolic diseases caused by defects in insulin action, insulin secretion, or both. Hyperglycemia can cause long-term damage, dysfunction, and failure of various organs, especially the heart, blood vessels, eyes, nerves, and kidneys.. Therefore, routine diagnosis and monitoring of blood glucose levels are very important. Glycated hemoglobin (HbA1c) is hemoglobin that binds to glucose in the blood and is established as a biomarker of hyperglycemia that may indicate diabetes or prediabetes. However, measurement of HbA1c in the clinical laboratory requires large and expensive instruments, specialized experts, and takes a long time. Therefore, an electrochemical biosensor began to be developed to detect HbA1c levels because it is easy to use and has fast results at lower prices. This review discusses electrochemical biosensors for detecting HbA1c and the immobilization of bioreceptors. 
GC-MS Analysis and Antibacterial Activity of Essential Oils of Five Syzygium Species Leaves Nur Amalia Choironi; Sunarto Sunarto; Esti Dyah Utami; Muhamad Salman Fareza
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.67401.61-67

Abstract

The essential oil can inhibit pathogenic bacterial activities, which can be developed to be a natural preservative for food. This research aimed to evaluate the antibacterial activity of the essential oils from five species Syzygium on Bacillus cereus, Escherichia coli, Listeria monocytogenes, Staphylococcus aureus, and Salmonella enterica sv Typhimurium. The research results show that five Syzygium sp. Essential oils have moderate antibacterial properties with a minimum inhibitory concentration (MIC) value of 250 ‒ 500 μg/mL. S. polyanthum essential oils have the highest antibacterial activity than the rest species on B. cereus at 250 μg/mL. Meanwhile, the essential oil of S. polycephalum also showed the highest antibacterial activity with a MIC value of 250 μg/mL against L. monocytogenes. The chemical component analysis using GC-MS shows the main constituents farnesol, nerolidol, and n-decanal, presenting the antibacterial effect.
Modifikasi Membran Kitosan Tertaut Silang Tripolifosfat Untuk Deteksi Ion Cu(II) Abu Masykur; Gaby Aprilia; Anggun Duwi Hapsari; Atmanto Heru Wibowo; Candra Purnawan; Sri Hastuti; Pranoto Pranoto; Tri Martini
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.56392.86-93

Abstract

Penelitian ini bertujuan untuk memodifikasi kitosan dan digunakan sebagai sensor ion logam Cu(II). Modifikasi dilakukan dengan penaut silang kitosan menggunakan tripolifosfat dan dibentuk menjadi membran. Membran yang dihasilkan dianalisis dengan spektrofotometer UV-Vis, Fourier Transform InfraRed (FTIR), dan Scanning Electron Microscope-Energy Dispersive X-Ray (SEM-EDX). Hasil analisis menunjukkan keberhasilan sintesis membran kitosan/tripolifosfat (CTS/TPP). Membran CTS/TPP dapat mendeteksi ion logam Cu(II) ditandai adanya perubahan warna membran dari bening menjadi biru. Keberhasilan deteksi ion logam Cu(II) oleh membran dikonfirmasi oleh pengujian UV-Vis, FTIR dan SEM-EDX. Pengujian spektrofotometer UV-Vis pada membran setelah dikontakkan dengan ion logam Cu(II) menunjukkan terjadinya pergeseran panjang gelombang maksimum akibat interaksi yang terjadi antara membran dengan ion logam Cu(II). Pada penentuan kondisi optimum pH, membran CTS/TPP optimum bekerja pada pH 7 dalam waktu 15 menit. Pada rentang konsentrasi ion Cu(II) 1‒10 ppm, nilai koefisien korelasi (R2) untuk membran CTS/TPP diperoleh sebesar 0,9917.Modification of Tripolyphosphate Cross-Linked Chitosan Membrane for Cu(II) Ion Sensor. This study aims to modify chitosan and use it as a sensor for Cu(II) metal ions. The modification was carried out by cross-linking chitosan using tripolyphosphate and forming it into a membrane. The resulting membranes were analyzed by UV-Vis, FTIR spectrophotometer, and SEM-EDX. The analysis results show the successful synthesis of the chitosan/tripolyphosphate (CTS/TPP) membrane. The CTS/TPP membrane can detect Cu(II) metal ions, as indicated by a change in the color of the membrane from clear to blue. The successful detection of Cu(II) metal ions by the membrane was confirmed by UV-Vis, FTIR spectrophotometer, and SEM-EDX. UV-Vis spectrophotometer testing on the membrane after contact with Cu(II) metal ions showed that the maximum wavelength was shifted due to the interaction that occurred between the membrane and Cu(II) metal ions. In the determination of the optimum pH condition, the CTS/TPP membrane optimally works at pH 7 for 15 minutes. In the Cu(II) concentration range of 1‒10 ppm, the correlation coefficient (R2) value for the CTS/TPP membrane was 0.9917.
Karbon dots (C-dots) dari Bahan Hayati untuk Deteksi Logam Berat Cut Navita Rahmi; Sri Sugiarti; Alvian Dea Yuliani
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 2 (2023): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.2.61881.234-246

Abstract

Pendeteksian logam berat pada limbah hasil industri perlu dilakukan untuk mencegah timbulnya penyakit apabila memasuki tubuh manusia. Salah satu bahan yang dapat digunakan untuk pendeteksian logam berat yaitu C-dots. C-dots yang berasal dari bahan hayati akan menghasilkan gugus fungsi yang dapat meningkatkan karakteristik optik C-dots agar lebih selektif dalam pendeteksian logam berat. Selain itu, penggunaan bahan hayati sebagai sumber C-dots akan memanfaatkan limbah sehingga mengurangi sampah. Penelitian ini bertujuan untuk mengkaji nanopartikel karbon C-dots yang berasal dari sumber hayati sebagai pendeteksian logam berat. C-dots yang berasal dari sumber hayati sudah banyak diteliti sebagai deteksi logam berat secara selektif. Gugus fungsi pada permukaan C-dots akan menentukan interaksi spesifik antara C-dots dan masing-masing logam. Reaksi pengompleksan antara C-dots dengan ion logam cenderung mengikuti aturan sebagai berikut, ion logam yang keras akan cenderung mengikat ligan yang keras dan ion logam lunak cenderung mengikat lebih banyak ligan yang lunak. C-dots tersintesis dengan metode hidrotermal cenderung menghasilkan quantum yield dan intensitas fluoresensi yang lebih tinggi yang sensitif untuk deteksi logam berat.Carbon Dots (C-Dots) from Biomass for Heavy Metal Detection. Detecting heavy metals in industrial waste is necessary to prevent the disease from entering the human body. One of the materials that can be used to detect heavy metals is carbon dots (C-dots). C-dots derived from biological materials have functional groups that can improve their optical characteristics to be more selective in detecting heavy metals. In addition, using natural materials as a source of C-dots will utilize waste, thereby reducing waste. This study aims to review carbon nanoparticles derived from natural sources for detecting heavy metals. C-dots derived from biological sources have been widely studied as selective heavy metal detection. The functional groups on the surface of the C-dots will determine the specific interactions between the C-dots and each metal. The complex reaction between C-dots and metal ions tends to follow the rules: hard metal ions tend to bind to hard ligands, and soft metal ions tend to bind more to soft ligands. C-dots synthesized via the hydrothermal method tend to produce a higher quantum yield and fluorescence intensity that are sensitive to heavy metal detection. ️
Cairan Ionik sebagai Penyerap Gas CO2 Yunita Anggraini; Inge Magdalena Sutjahja
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 2 (2023): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.2.62225.247-260

Abstract

Pemanasan global akibat emisi gas rumah kaca, terutama karbon dioksida (CO2), memiliki pengaruh yang signifikan terhadap perubahan iklim dan telah menjadi isu penting dalam beberapa tahun terakhir. Penangkapan dan pemanfaatan CO2 atau CO2 capture and utilization (CCU) adalah strategi yang efektif untuk mengurangi pemanasan global. Makalah ini bertujuan untuk memberikan gambaran singkat proses penangkapan CO2 dengan memanfaatkan cairan ionik (ionic liquid, IL). IL adalah jenis garam yang terdiri dari kation organik dan anion organik atau anorganik yang memiliki beberapa keunggulan, di antaranya volatilitas yang rendah, stabilitas termal yang cukup baik, tidak mudah korosif, laju degradasi yang rendah, dan biaya regenerasi yang rendah. Kombinasi kation-anion yang tepat membuat IL dapat digunakan sebagai pelarut untuk proses penangkapan CO2 menggantikan pelarut konvensional berbasis amina. Dalam perkembangan selanjutnya, generasi baru IL fungsional (IL berbasis basa kuat dan asam amino) dan deep eutectic solvent (DES) telah diperkenalkan sebagai larutan pengganti IL murni (IL konvensional) dengan keunggulan kapasitas penyerapan CO2 yang lebih besar, mudah terurai secara alami (biodegradable), mudah berinteraksi dengan jaringan hidup, tidak menimbulkan toksisitas (biokompatibel), dan mudah diproduksi dalam skala besar dengan biaya relatif rendah. Selain itu, dengan mempertimbangkan biokompatibilitas DES, pengembangan DES dengan mempertimbangkan aspek biologis menjadi terobosan baru yang menjanjikan sebagai bahan ramah lingkungan. Dalam hal ini DES menyerap CO2 dari gas buang dan kemudian menyediakannya sebagai sumber nutrisi bagi mikroalga.Ionic Liquid as CO2 Absorption. An increase in global warming as an impact of greenhouse gases, particularly carbon dioxide (CO2), has become an important issue in recent years. CO2 capture and utilization (CCU) are the effective strategy to mitigate global warming. This study briefly described the CO2 capture process using ionic liquid (IL). IL is a type of salt consisting of organic cations and organic or inorganic anions. IL as a solution in the CO2 capture process has several advantages, including low volatility, good thermal stability, non-corrosive, low degradation, and low regeneration costs. Using the proper cation and anion, IL acts as an effective solvent for CO2 capture, replacing amine. In subsequent developments, a new generation of functional IL (strong base and amino acid-based IL) and deep eutectic solvent (DES) has been introduced as a substitute for pure IL (conventional IL) with the advantages of more excellent CO2 absorption, biodegradable, easy to interact with live tissue, non-toxicity, biocompatible, and easy to produce on a large scale with relatively low cost. In addition, taking into account the biocompatibility of DES, the development of DES by considering the biological aspects is a promising alternative as an environmentally friendly material. In this case, DES absorbs CO2 from exhaust gases and provides it as a source of nutrition for microalgae.
Sintesis Senyawa 4-(Dimetilamino)calkon Menggunakan Microwave-Assisted Organic Synthesis (MAOS) dengan Variasi Konsentrasi NaOH dan Prediksi Profil Farmakokinetik Iin Narwanti; Aisyah Khairani Hidayati
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 2 (2023): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.2.66542.130-139

Abstract

Senyawa calkon dan turunannya mempunyai aktivitas farmakologi dengan aplikasi yang luas, karenya sintesis senyawa tersebut perlu dipelajari. Oleh karena itu, penelitian ini bertujuan untuk mensintesis 4-(dimetilamino)calkon dari dalam suasana basa dengan metode Microwave-Assisted Organic Synthesis (MAOS) dan memprediksi profil farmakokinetiknya. 4-(dimetilamino)calkon direaksikan dengan asetofenon dengan adanya basa NaOH. Sintesis 4-(dimetilamino)calkon dilakukan dengan iradiasi selama 25 detik dengan daya 140 watt. Variasi konsentrasi katalis NaOH yang digunakan adalah 40%, 50%, dan 60%. Rekristalisasi dilakukan dengan menggunakan pelarut etanol. Produk sintesis dikarakterisasi dengan penentuan titik lebur, KLT, spektrofotometri inframerah, spektrometri massa, 1H-NMR dan 13C-NMR. Selanjutnya, profil farmakokinetik 4-(dimetilamino)calkon diprediksi dengan menggunakan web server SwissADME. Hasil penelitian menunjukkan bahwa rata-rata rendemen sintesis 4-(dimetilamino)calkon dengan metode MAOS pada variasi konsentrasi katalis NaOH 40%, 50%, dan 60% berturut-turut adalah 73,4±1,72%; 90,9±0,68% dan 85,1±1,32%. Konsentrasi NaOH 50% menghasilkan rendemen produk sintesis yang paling optimal. Prediksi sifat fisikokimia dan profil farmakokinetik menggunakan SwissADME menunjukkan bahwa senyawa 4-(dimetilamino)calkon memenuhi aturan Lipinski’s Rule of Five dan mempunyai penyerapan gastrointestinal yang baik dan mampu melewati blood brain barrier (BBB).Synthesis of 4-(Dimethylamino)chalcone Compound Using Microwave-Assisted Organic Synthesis (MAOS) with Various NaOH Concentration and Pharmacokinetic Profile Prediction. Chalcones and their derivatives are widely established to have a wide application pharmacological activity; therefore, the synthesis is necessary to study. This study aimed to synthesize 4-dimethylaminochalcone in the presence of a base using Microwave-Assisted Organic Synthesis (MAOS) method and predict its pharmacokinetic profile. 4-(dimethylamino)benzaldehyde was treated with acetophenone in the presence of NaOH with various concentrations (40%, 50%, and 60%). Irradiation was conducted for 25 seconds with a power of 140 watts. Recrystallization was carried out from ethanol to give the expected product. The crude product was characterized by melting point determination, TLC, infrared spectrophotometry, mass spectrometry, 1H-NMR, and 13C-NMR. Furthermore, pharmacokinetic profiles of 4-(dimethylamino)chalcone were predicted using the SwissADME web server. The results showed that the average yield of the synthesized product using the MAOS method with catalyst NaOH 40%, 50%, and 60% was 73.4±1.72%, 90.9±0.68%, and 85.1±1.32%, respectively. The optimal yield was obtained using a 50% concentration of NaOH. The pharmacokinetic profiles of 4-(dimethylamino)chalcone analysis using the SwissADME web server showed that 4-(dimethylamino)chalcone complied with Lipinski's Rule of Five. Furthermore, it might have good gastrointestinal absorption and might be able to cross the blood-brain barrier (BBB).
Pemanfaatan Silika dari Abu Sekam Padi untuk Pembuatan Material Imprinted Ionic sebagai Adsorben Ion Logam Pb(II) Sri Hastuti; Tri Martini; Agustina Tri Utami
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 2 (2023): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.2.70373.162-169

Abstract

Sintesis material imprinted ionic Pb(II) (SiO2-TMPDT-Pb-Imp) menggunakan natrium silikat dari abu sekam padi (Na­2SiO3(ASP)) telah berhasil dilakukan pada penelitian ini dengan memanfaatkan abu sekam padi sebagai sumber silika untuk pembuatan natrium silikat (Na­2SiO3(ASP)). Modifier yang digunakan adalah N1-(3-trimethoxysilylpropyl)diethylentriamine (TMPDT) dan ion logam Pb(II) berfungsi sebagai templat. Uji kapasitas adsorpsi SiO2‒TMPDT‒Pb‒Imp terhadap ion logam Pb(II) dilakukan pada variasi pH (1 ‒ 6) dan waktu kontak (0 ‒ 120) menit dengan sistem batch. Karakterisasi material SiO2‒TMPDT‒Pb-Imp dilakukan dengan menggunakan Fourier Transform Infrared (FTIR), Scanning Electron Microscope and Energy Dispersive X-ray (SEM-EDX), dan Surface Area Analyzer (SAA).  Berdasarkan data FTIR dan SEM-EDX menunjukkan bahwa material SiO2‒TMPDT‒Pb‒Imp memiliki gugus silanol (Si‒OH); siloksan (Si‒O‒Si); alkana dan gugus amin dengan morfologi material yang halus serta terdapat unsur karbon (C) dan nitrogen (N) sebanyak 44,4% dan 8,3% secara berurutan. Hasil karakterisasi dengan SAA menunjukkan bahwa material SiO2‒TMPDT‒Pb‒Imp memiliki luas permukaan sebesar 7,418 m2/g, volume pori total sebesar 0,012 cc/g dan jari-jari pori sebesar 16,670 Å. Kondisi terbaik adsorpsi ion logam Pb(II) terjadi pada pH 5 dan waktu kontak 60 menit yang mengikuti model kinetika adsorpsi Pseudo Orde 2 dengan kapasitas adsorpsi sebesar 1,2418 mg/g.Utilization of Silica from Rice Husk Ash for Preparing Imprinted Ionic Materials as Pb(II) Metal Ion Adsorbent. Imprinted ionic Pb(II) (SiO2-TMPDT-Pb-Imp) material was synthesized using a solution of sodium silicate from rice husk ash (Na­2SiO3(RHA)) in this study using rice husk ash as a source of silica for sodium silicate (Na2SiO3(ASP)). The modifier used is N1-(3-trimethoxysilylpropyl) diethylenetriamine (TMPDT) and Pb(II) metal ion as a template. The SiO2‒TMPDT‒Pb‒Imp adsorption capacity of Pb(II) metal ion was performed on solution pH (1 ‒ 6) and contact time of (0 ‒ 120) minutes by the batch system. Material characterization was performed by Fourier Transform Infrared (FTIR), Scanning Electron Microscope and Energy Dispersive X-ray (SEM-EDX), and Surface Area Analyzer (SAA). Based on FTIR and SEM-EDX showed that SiO2‒TMPDT‒Pb‒Imp had a silanol group (Si‒OH), siloxane group (Si‒O‒Si), alkane and amine group with finer material morphology and presence of carbon (C) and nitrogen (N) element of 44.4% and 8.3% respectively. SAA characterization indicated that SiO2‒TMPDT‒Pb‒Imp had a surface area of 7.418 m2/g, total pore volume of 0.012 cc/g, and pore radius of 16.670 Å. The optimum condition of Pb(II) metal ion adsorption was obtained at pH 5 and a contact time of 60 min that followed the Pseudo Orde 2 adsorption kinetic model with an adsorption capacity of 1.2418 mg/g.

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