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ALCHEMY Jurnal Penelitian Kimia
Published by Universitas Sebelas Maret
ISSN : 14124092     EISSN : 24434183     DOI : -
Core Subject : Science, Social, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology
ALCHEMY Jurnal Penelitian Kimia is a chemistry journal published by Sebelas Maret University, Surakarta. ALCHEMY Jurnal Penelitian Kimia publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry.
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Articles 306 Documents
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Karakterisasi Nanoemulsi Minyak Tulang Ikan Sidat dengan Ekstrak Daun Salam dan Uji Aktivitas Antihiperlipidemia Fea Prihapsara; Anif Nur Artanti; Melati Sekar Hasna Hanun; Salsabila Nanda Fatiha; Fadhilla Nur Cahyani; Sholichah Rohmani
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.61169.14-22

Abstract

Pemanfaatan limbah terbuang dari pengolahan ikan sidat (Anguilla spp.) dapat diekstraksi menjadi minyak yang kaya manfaat. Kandungan asam lemak tak jenuh yang tinggi dalam minyak ikan sidat bermanfaat untuk kesehatan salah satunya sebagai antihiperlipidemia. Kombinasi dengan ekstrak bahan alam yaitu  ekstrak daun salam (Syzygium polyanthum (Wight) Walp) diharapkan memiliki efek sinergis sebagai agen antihiperlipidemia.  Formulasi kombinasi kedua bahan tersebut dibuat dalam sistem penghantaran obat berbasis lipid-based drug delivery system (LBDDS) yaitu dalam bentuk nanoemulsi dengan tujuan untuk meningkatkan kelarutan dan bioavailabilitas. Penelitian ini bertujuan untuk menganalisis kandungan minyak tulang ikan sidat, karakteristik formula nanoemulsi minyak tulang ikan sidat-ekstrak daun salam (NME) dan aktivitas antihiperlipidemia formula NME. Minyak tulang ikan sidat mengandung komposisi SAFA (Saturated Fatty Acid)  40,02%, MUFA (Mono Unsaturated Fatty Acid) 45,58% dan PUFA (Poly Unsaturated Fatty Acid) 14,40% yang termasuk asam lemak rantai sedang hingga rantai panjang. Formula NME memenuhi kriteria ukuran partikel nanoemulsi yaitu sebesar       36,45 nm dengan nilai indeks polidispersitas (PI) sebesar 0,199 serta potensial zeta -21,20 mV.  Kombinasi NME-Simvastatin paling efektif menurunkan kadar kolesterol total pada mencit (Mus musculus).Nanoemulsion Characterization of Eel Bone Oil with Bay Leaf Extracts and Antihyperlipidemic Activity Test. The utilization of waste from processing eel (Anguilla spp.) can be extracted into beneficial oil. The high content of unsaturated fatty acids in eel fish oil is beneficial for health, such as anti-hyperlipidemia. In combination with extracts of natural ingredients, bay leaf extract (Syzygium polyanthum (Wight) Walp) is expected to have a synergistic effect as an antihyperlipidemic agent. The combination formula of the two ingredients was made in a lipid-based drug delivery system (LBDDS) in the form of a nanoemulsion to increase solubility and bioavailability. This study aimed to analyze the content of eel bone oil, the characteristics of the nanoemulsion formula of bay leaf extract-eel bone oil (NME), and the antihyperlipidemic activity of the NME formula. Eel bone oil contains a composition of SAFA (Saturated Fatty Acid) of 40.02%, MUFA (Mono Unsaturated Fatty Acid) of 45.58%, and PUFA (Poly Unsaturated Fatty Acid) of 14.40%, which includes medium-to long-chain fatty acids. The NME formula has a particle size of 36.45 nm, a polydispersity index (PI) of 0.199, and a zeta potential of -21,2 mV. The combination of NME–Simvastatin is the most effective in influencing changes in lipid profiles.     
Penambatan Molekuler Senyawa Aktif Sirih Merah (Piper crocatum) pada Butirilkolinesterase sebagai Kandidat Antialzheimer Rahmadi Ganesha Putri; Mega Safithri; Husnawati Husnawati; Rini Kurniasih
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.59676.68-85

Abstract

Alzheimer adalah salah satu penyakit neurodegeneratif kronis dan menjadi penyakit yang sering dialami oleh orang lanjut usia. Perubahan yang terjadi dari penyakit Alzheimer, yakni penurunan fungsi kognitif, memori, dan perubahan perilaku secara permanen. Senyawa aktif pada daun sirih merah memiliki kesamaan kandungan dengan daun sirih hijau untuk menghambat butirilkolinesterase (BChE). Butirilkolinesterase adalah salah satu enzim yang berperan dalam penanganan penyakit Alzheimer dikaitkan dengan terbentuknya Alzheimer, yakni hipotesis kolinergik. Penelitian dilakukan menguji daya inhibisi senyawa aktif yang terkandung dalam daun sirih merah terhadap aktivitas butirilkolinesterase melalui pendekatan simulasi penambatan molekuler. Penelitian menggunakan dua metode, yakni penggabungan penapisan virtual dan penambatan molekuler sebagai tahapan awal pengembangan daun sirih merah terhadap aktivitas penghambatan butirilkolinesterase. Hasil dalam penelitian diperoleh, daya inhibisi terbaik ditemukan pada 1,2,3,4,5,6,7-heptazacycloicosane sebesar 0,4888 µM dan energi bebas pengikatan sebesar -8,6 kkal∙mol-1. Residu yang berperan dalam menghambat butirilkolinesterase, yakni pada pengikatan substrat oleh ligan uji, yakni Tyr-332 dan Trp-82. Hasil penelitian ini dapat dijadikan sebagai sumber referensi dalam menemukan alternatif pengobatan penyakit Alzheimer. Molecular Docking of the Active Compound of Red Betel (Piper crocatum) on Butyrylcholinesterase as an Antialzheimer's Candidate. Alzheimer's is a chronic neurodegenerative disease often experienced by the elderly. Changes that occur from Alzheimer's disease such as permanent decline in cognitive function, memory, and behavioral changes. The active compounds in red betel leaves have similar contents with green betel leaves to inhibit butyrylcholinesterase (BChE). Butyrylcholinesterase is an enzyme that may play an important role in the treatment of Alzheimer's disease associated with the formation of Alzheimer's, the cholinergic hypothesis. The study tested the inhibition power of the active compounds contained in red betel leaves against the activity of butyrylcholinesterase through a molecular docking simulation approach. The method in the study used the merger of virtual screening and molecular docking as the initial stage for the development of red betel leaves against the inhibitory activity of butyrylcholinesterase. The result in the study found the best inhibitiron power was found at 1,2,3,4,5,6,7-heptazacycloicosane of 0.4888 µM and binding free energy of -8.6 kkal∙mol-1. The residues that play a role in the inhibition of butyrylcholinesterase on substrate binding by test ligands were Tyr-332 and Trp-82. The research result can be used as a reference in finding alternative treatments for Alzheimer's disease. 
Sintesis Carbon Nanofoam dan Karakteristiknya Nuryah Muchlisha; Dian Maruto Widjonarko; Teguh Endah Saraswati
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.64499.108-122

Abstract

Karbon memiliki kemampuan untuk membuat jaringan ikatan hibridisasi sp, sp‒sp2, sp2, sp3, dan sp2‒sp3,sehingga karbon terdapat dalam banyak bentuk alotrop seperti grafit, diamond, graphene, nanofiber, nanofoam, dan nanotube. Carbon nanofoam (CNF) terbentuk dari atom karbon yang terikat secara sp2 dan sp3. CNF memiliki struktur sel terbuka yang saling berhubungan, densitas yang sangat rendah, stabilitas termal yang tinggi, dan porositas yang tinggi. CNF dapat diperoleh dengan menggunakan berbagai metode seperti chemical vapor depositon, laser ablsasi, arc-discharge, dan pirolisis. Sintesis dengan berbagai jenis sumber karbon dan keadaan eksperimen menghasilkan material yang memiliki berbagai ukuran, luas permukaan, dan strukturnya. Struktur CNF terdiri dari dua jenis berdasarkan pola tepi strukturnya yaitu zigzag dan armchair. Hasil karakterisasinya menunjukkan bahwa CNF lebih banyak mengandung karbon dengan hibridisasi sp2 dengan struktur yang berinterkoneksi satu sama lain dan memiliki densitas yang sangat rendah. Selain itu, material ini juga memiliki pori dalam ukuran mesopori dan luas permukaan yang tinggi. Sifat unik yang dimiliki oleh CNF berpotensi diaplikasikan dalam berbagai bidang seperti filter, superkapasitor, dan energy storage. Synthesis of Carbon Nanofoam and Its Characteristics. Carbon can create sp, sp‒sp2, sp2, sp3, and sp2‒sp3 hybridized bond networks, which make carbon in many allotropes forms such as graphite, diamond, graphene, nanofiber, nanofoam, and nanotubes. Carbon nanofoam  (CNF) is formed by sp2 and sp3 bonded carbon atoms. CNF has an interconnected open-cell structure, very low density, high thermal stability, and high porosity. CNF is obtained using several methods, such as laser ablation, arc-discharge, chemical vapor deposition, and pyrolysis. Synthesis with various types of carbon sources and experimental conditions resulted in materials having various sizes, surface areas, and structures. The structure of CNF consists of two edge pattern types, including zigzag and armchair. The characterization results show that CNF contains more interconnected carbon with sp2 hybridization and has a very low density. In addition, this material also has pores in the mesoporous size and high surface area. The unique properties of CNF provide potential applications in various fields, such as filters, supercapacitors, and energy storage.
Studi In Silico Aktivitas Senyawa Steroid Terhadap Antikanker Payudara Menggunakan Estrogen Alfa (ER-α) Nurlelasari Nurlelasari; Almas Widyana; Euis Julaeha; Ari Hardianto; Desi Harneti Putri Huspa; Rani Maharani; Tri Mayanti; Darwati Darwati; Muhammad Hanafi; Unang Supratman
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.62384.44-52

Abstract

Kanker payudara merupakan penyebab kedua terbanyak kematian pada wanita akibat kanker setelah kanker paru-paru di seluruh dunia. Steroid merupakan kelompok senyawa aktif yang diantaranya berhasil diisolasi dari genus Chisocheton yang dilaporkan memiliki aktivitas melawan sel kanker payudara MCF-7. Tujuan penelitian ini adalah untuk mengetahui interaksi senyawa steroid terhadap estrogen alfa (ER-α) melalui metode in silico, yaitu penambatan molekul. Pemodelan struktur tiga dimensi (3D) senyawa steroid dilakukan dengan memperhatikan keadaan terprotonasinya pada pH 7,4. Metode in silico divalidasi melalui penambatan ulang struktur kristal ER-α, hingga diperoleh nilai RMSD < 2 Å, dengan program AutoDock 4.2.6. Dengan program yang sama, senyawa-senyawa steroid ditapis dengan metode penambatan molekul. Hasil penapisan menghasilkan nilai energi bebas dari kedua senyawa steroid yaitu -10,08 kkal/mol (7α-hidroksi-β-sitosterol) dan -10,75 kkal/mol (stigmast-5-en-3β-ol), yang nilainya lebih baik dari estradiol (-9,62 kkal/mol), sebagai ligan alami ER-α. Kedua senyawa ini berpotensi untuk menginhibisi estrogen alfa, dimana senyawa stigmast-5-en-3β-ol memiliki potensi yang lebih besar karena nilai energi bebasnya lebih rendah. Hal ini menandakan bahwa modifikasi struktur senyawa mampu mengubah nilai energi ikatan dan interaksi antara ligan dan reseptor.In Silico Study of Steroid Compound Activity Against Breast Cancer Using Estrogen Alpha (ER-α). Breast cancer is the second worldwide leading cause of cancer death in women after lung cancer. Steroids are a group of active compounds isolated from the Chisocheton genus that has activity against MCF-7 breast cancer cells. This study aimed to determine the interaction activity of steroid compounds against alpha estrogen receptor (ER-α) through in silico method specifically mlecular docking. The modeling of the three-dimensional structure (3D) of steroid compounds was performed by considering their protonation states at pH 7.4. The in silico method was validated by redocking the crystal structure of ER-α until obtaining an RMSD value < 2 Å, using the AutoDock 4.2.6 program. Steroids compounds were screened with the same program namely the molecular docking method. Screening results show that the free energy values of the steroid compounds were -10.08 kcal/mol (7α-hydroxy-β-sitosterol) and -10.75 kcal/mol (stigmast-5-en-3β-ol), which are stronger than estradiol (-9.62 kcal/mol) as native ligand of ER-α. Both of these compounds can inhibit the alpha estrogen receptor, in which the stigmast-5-en-3β-ol compound has a greater potential because of its lower free energy value. This finding indicates that modification of the compound's structure could change the binding energy value and interaction between ligands and receptors.
Fermentation Effect of Cacao Beans Originate from Jember on Polyphenol-Flavonoid Content and Radical Scavenging Activity Eva Agustriana; Herly Angga Valentino; Nanik Rahmani; Nuryati Nuryati; Hendy Firmanto; Rike Rachmayati; Siti Eka Yulianti; Isa Nuryana; Yopi Yopi; Puspita Lisdiyanti
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.60831.23-31

Abstract

Cacao is attractive for its flavor and taste and its beneficial effects. Therefore, this commodity is promising to be developed as a functional food. Many studies reported the bioactive compounds in cacao beans and their health benefits. However, to attain desirable flavor and taste, the curing process of cacao beans is a common practice, in which fermentation is one of the processes. Despite its significance, fermentation also alters the bioactive components in cacao beans. To develop a functional food rich in bioactive compounds, measuring the bioactive contents of treated and untreated cacao beans is desired. For that reason, in this study, the analysis of total polyphenol, flavonoid, catechin, and epicatechin, as well as the radical scavenging activity of fermented cacao beans, was performed. The study revealed that fermentation negatively affected all parameters. Cacao beans fermentation up to 96 h resulted in the loss of 54% of total polyphenol, 77% of total flavonoid, and 56% of radical scavenging activity. Determination of the flavan-3-ol components, catechin, and epicatechin,  revealed that they were reduced as the fermentation occurred.
Pembuatan dan Karakterisasi Nanopartikel Perak Menggunakan Ekstrak Buah Mangrove Rhizophora stylosa Nancy Willian; Hilfi Pardi; Syukri Arief
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.59359.53-60

Abstract

Nanopartikel perak menampilkan sifat fisik dan biologis yang unik yang telah menarik minat penelitian karena aplikasi yang menjanjikan. Pada penelitian ini, proses fabrikasi nanopartikel perak(AgNPs) dilakukan dengan metode green sintesis menggunakan tanaman mangrove dengan pelarut air. Ekstrak buah mangrove Rhizophora stylosa (RS) pertama kali digunakan sebagai reduktor dan stabilizer dalam sintesis AgNPs. Karakteristik AgNPs ditentukan dengan spektrofotometer UV-Vis, FTIR, XRD dan TEM. Analisis spektrum UV-vis menunjukkan panjang gelombang pada 430 ‒ 445 nm. Studi FTIR mengungkapkan adanya senyawa fitokimia aktif yang bertindak sebagai zat penutup dan penstabil nanopartikel. TEM menunjukkan morfologi AgNPs yang ditemukan berbentuk bola dengan ukuran diamter sekitar 10 ‒ 60 nm. Pola XRD menunjukkan bahwa semua sampel AgNPs yang diperoleh memiliki struktur face-center cubic (fcc) yang menegaskan bahwa nanopartikel bersifat padatan kristalin dengan ukuran kristal 38 ‒ 77 nm. Studi ini membuktikan kemampuan biomaterial dalam sintesis AgNPs dengan mengadopsi prinsip sintesis hijau.Fabrication and Characterization of Silver Nanoparticles Using Extract of Mangrove Fruit of Rhizophora stylosa. Silver nanoparticles display unique physical and biological properties that have attracted research interest because of their promising applications. In this research, silver nanoparticle (AgNPs)  fabrication process was carried out via green synthesis methods using mangrove plants and water as a solvent. Mangrove fruit extract Rhizophora stylosa (RS) was first used as a reducing agent and stabilizer in the synthesis of AgNPs. The characteristics of AgNPs were characterized using UV-Vis, FTIR, XRD, and TEM spectrophotometers. UV-vis spectrum analysis showed a peak at 430 ‒ 445 nm. FT-IR studies revealed the presence of active phytochemical compounds which act as coating agents and stabilizers for nanoparticles. TEM showed that the morphology of AgNPs was spherical with a diameter size of 10 ‒ 60 nm. The XRD patterns showed that all of the AgNPs sample obtained had a face-center cubic (fcc) structure, indicating that the nanoparticles are crystalline solids with a crystallite size of 38 ‒ 77 nm. This study proves the ability of biomaterials in the synthesis of silver nanoparticles by adopting the principle of green synthesis.
Biosensor Elektrokimia untuk Memonitor Level Hemoglobin Terglikasi (HbA1c) pada Penyakit Diabetes Melitus Sheila Destiani; Iman Permana Maksum; Yeni Wahyuni Hartati
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.58439.94-107

Abstract

Hiperglikemia merupakan ciri diabetes melitus, sekelompok penyakit metabolik yang disebabkan oleh kelainan sekresi insulin, kerja insulin, atau keduanya. Hiperglikemia dapat menyebabkan kerusakan jangka panjang, disfungsi, dan kegagalan berbagai organ, terutama jantung, mata, saraf, pembuluh darah, dan ginjal. Oleh karena itu, diagnosis dan pemantauan rutin kadar glukosa darah sangat penting dilakukan. Hemoglobin terglikasi (HbA1c) adalah hemoglobin yang berikatan dengan glukosa dalam darah dan ditetapkan menjadi biomarker hiperglikemia yang dapat mengindikasikan diabetes atau prediabetes. Akan tetapi, pengukuran HbA1c di laboratorium klinis membutuhkan instrumen yang canggih dan mahal, tenaga ahli khusus dan waktu lama. Oleh karena itu, biosensor elektrokimia kemudian mulai dikembangkan untuk mendeteksi kadar HbA1c karena mudah digunakan, hasil cepat, dan harga yang murah. Ulasan ini membahas biosensor elektrokimia untuk mendeteksi HbA1c dan metode imobilisasi bioreseptor.Electrochemical Biosensor for Monitoring Glycated Hemoglobin (HbA1c) Levels in Diabetes Mellitus. Hyperglycemia is a hallmark of diabetes mellitus,  a group of metabolic diseases caused by defects in insulin action, insulin secretion, or both. Hyperglycemia can cause long-term damage, dysfunction, and failure of various organs, especially the heart, blood vessels, eyes, nerves, and kidneys.. Therefore, routine diagnosis and monitoring of blood glucose levels are very important. Glycated hemoglobin (HbA1c) is hemoglobin that binds to glucose in the blood and is established as a biomarker of hyperglycemia that may indicate diabetes or prediabetes. However, measurement of HbA1c in the clinical laboratory requires large and expensive instruments, specialized experts, and takes a long time. Therefore, an electrochemical biosensor began to be developed to detect HbA1c levels because it is easy to use and has fast results at lower prices. This review discusses electrochemical biosensors for detecting HbA1c and the immobilization of bioreceptors. 
GC-MS Analysis and Antibacterial Activity of Essential Oils of Five Syzygium Species Leaves Nur Amalia Choironi; Sunarto Sunarto; Esti Dyah Utami; Muhamad Salman Fareza
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.67401.61-67

Abstract

The essential oil can inhibit pathogenic bacterial activities, which can be developed to be a natural preservative for food. This research aimed to evaluate the antibacterial activity of the essential oils from five species Syzygium on Bacillus cereus, Escherichia coli, Listeria monocytogenes, Staphylococcus aureus, and Salmonella enterica sv Typhimurium. The research results show that five Syzygium sp. Essential oils have moderate antibacterial properties with a minimum inhibitory concentration (MIC) value of 250 ‒ 500 μg/mL. S. polyanthum essential oils have the highest antibacterial activity than the rest species on B. cereus at 250 μg/mL. Meanwhile, the essential oil of S. polycephalum also showed the highest antibacterial activity with a MIC value of 250 μg/mL against L. monocytogenes. The chemical component analysis using GC-MS shows the main constituents farnesol, nerolidol, and n-decanal, presenting the antibacterial effect.
Modifikasi Membran Kitosan Tertaut Silang Tripolifosfat Untuk Deteksi Ion Cu(II) Abu Masykur; Gaby Aprilia; Anggun Duwi Hapsari; Atmanto Heru Wibowo; Candra Purnawan; Sri Hastuti; Pranoto Pranoto; Tri Martini
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.56392.86-93

Abstract

Penelitian ini bertujuan untuk memodifikasi kitosan dan digunakan sebagai sensor ion logam Cu(II). Modifikasi dilakukan dengan penaut silang kitosan menggunakan tripolifosfat dan dibentuk menjadi membran. Membran yang dihasilkan dianalisis dengan spektrofotometer UV-Vis, Fourier Transform InfraRed (FTIR), dan Scanning Electron Microscope-Energy Dispersive X-Ray (SEM-EDX). Hasil analisis menunjukkan keberhasilan sintesis membran kitosan/tripolifosfat (CTS/TPP). Membran CTS/TPP dapat mendeteksi ion logam Cu(II) ditandai adanya perubahan warna membran dari bening menjadi biru. Keberhasilan deteksi ion logam Cu(II) oleh membran dikonfirmasi oleh pengujian UV-Vis, FTIR dan SEM-EDX. Pengujian spektrofotometer UV-Vis pada membran setelah dikontakkan dengan ion logam Cu(II) menunjukkan terjadinya pergeseran panjang gelombang maksimum akibat interaksi yang terjadi antara membran dengan ion logam Cu(II). Pada penentuan kondisi optimum pH, membran CTS/TPP optimum bekerja pada pH 7 dalam waktu 15 menit. Pada rentang konsentrasi ion Cu(II) 1‒10 ppm, nilai koefisien korelasi (R2) untuk membran CTS/TPP diperoleh sebesar 0,9917.Modification of Tripolyphosphate Cross-Linked Chitosan Membrane for Cu(II) Ion Sensor. This study aims to modify chitosan and use it as a sensor for Cu(II) metal ions. The modification was carried out by cross-linking chitosan using tripolyphosphate and forming it into a membrane. The resulting membranes were analyzed by UV-Vis, FTIR spectrophotometer, and SEM-EDX. The analysis results show the successful synthesis of the chitosan/tripolyphosphate (CTS/TPP) membrane. The CTS/TPP membrane can detect Cu(II) metal ions, as indicated by a change in the color of the membrane from clear to blue. The successful detection of Cu(II) metal ions by the membrane was confirmed by UV-Vis, FTIR spectrophotometer, and SEM-EDX. UV-Vis spectrophotometer testing on the membrane after contact with Cu(II) metal ions showed that the maximum wavelength was shifted due to the interaction that occurred between the membrane and Cu(II) metal ions. In the determination of the optimum pH condition, the CTS/TPP membrane optimally works at pH 7 for 15 minutes. In the Cu(II) concentration range of 1‒10 ppm, the correlation coefficient (R2) value for the CTS/TPP membrane was 0.9917.
Karbon dots (C-dots) dari Bahan Hayati untuk Deteksi Logam Berat Cut Navita Rahmi; Sri Sugiarti; Alvian Dea Yuliani
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 2 (2023): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.2.61881.234-246

Abstract

Pendeteksian logam berat pada limbah hasil industri perlu dilakukan untuk mencegah timbulnya penyakit apabila memasuki tubuh manusia. Salah satu bahan yang dapat digunakan untuk pendeteksian logam berat yaitu C-dots. C-dots yang berasal dari bahan hayati akan menghasilkan gugus fungsi yang dapat meningkatkan karakteristik optik C-dots agar lebih selektif dalam pendeteksian logam berat. Selain itu, penggunaan bahan hayati sebagai sumber C-dots akan memanfaatkan limbah sehingga mengurangi sampah. Penelitian ini bertujuan untuk mengkaji nanopartikel karbon C-dots yang berasal dari sumber hayati sebagai pendeteksian logam berat. C-dots yang berasal dari sumber hayati sudah banyak diteliti sebagai deteksi logam berat secara selektif. Gugus fungsi pada permukaan C-dots akan menentukan interaksi spesifik antara C-dots dan masing-masing logam. Reaksi pengompleksan antara C-dots dengan ion logam cenderung mengikuti aturan sebagai berikut, ion logam yang keras akan cenderung mengikat ligan yang keras dan ion logam lunak cenderung mengikat lebih banyak ligan yang lunak. C-dots tersintesis dengan metode hidrotermal cenderung menghasilkan quantum yield dan intensitas fluoresensi yang lebih tinggi yang sensitif untuk deteksi logam berat.Carbon Dots (C-Dots) from Biomass for Heavy Metal Detection. Detecting heavy metals in industrial waste is necessary to prevent the disease from entering the human body. One of the materials that can be used to detect heavy metals is carbon dots (C-dots). C-dots derived from biological materials have functional groups that can improve their optical characteristics to be more selective in detecting heavy metals. In addition, using natural materials as a source of C-dots will utilize waste, thereby reducing waste. This study aims to review carbon nanoparticles derived from natural sources for detecting heavy metals. C-dots derived from biological sources have been widely studied as selective heavy metal detection. The functional groups on the surface of the C-dots will determine the specific interactions between the C-dots and each metal. The complex reaction between C-dots and metal ions tends to follow the rules: hard metal ions tend to bind to hard ligands, and soft metal ions tend to bind more to soft ligands. C-dots synthesized via the hydrothermal method tend to produce a higher quantum yield and fluorescence intensity that are sensitive to heavy metal detection. ️

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