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JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice)
Published by Universitas Gadjah Mada
ISSN : 20888139     EISSN : 24432946     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
JMPF is the first open access journal in Indonesia specialized in both research of pharmaceutical management and pharmacy practice. Articles submitted in JMPF are peer reviewed, we accept review articles and original research articles with no submission/publication fees. JMPF receives manuscripts in both English (preferably) and Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. JMPF is also open for various fields such as pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, goverment policies related to pharmacy, and pharmaceutical care.
Arjuna Subject : -
Articles 495 Documents
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The Effectiveness of Zoledronic Acid and Ibandronic Acid in Delaying Skeletal-Related Events in Multiple Myeloma in Indonesia Nutrisia Aquariushinta Sayuti; Tri Murti Andayani; Dwi Endarti; Kartika Widayati
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 10, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.55943

Abstract

Zoledronic acid and ibandronic acid are listed in the Indonesian national formulary to prevent skeletal-related events (SRE) in patients diagnosed with bone metastasis in multiple myeloma (MM), with limited evidence to compare their effectiveness. This study aimed to investigate the effectiveness and safety of zoledronic acid and ibandronic acid in delaying SRE. The method was the retrospective, with data obtained from the multicenter study for MM patients with bone metastasis (aged over 18 years), based on medical records between January 2016 and December 2018. Patients were assigned to zoledronic acid and ibandronic acid groups. The clinical outcome was the next SRE which consists of vertebral/bone fracture, spinal cord compression leading to the need for surgery or radiation, and adverse event (AE) due to 2 years of drugs usage. Result of this research was made up of a total of seventy (70) patients with  40  in the zoledronic acid group, and 30 in ibandronic acid. At median treatment duration of 8 months (range: 2 – 24 month), SRE incident in zoledronic acid and ibandronic acid were 20.0 % and 23.3 % respectively. Furthermore, their mean SRE free survival times were 21 months [95% confidence interval (CI) 19 - 23 months], and 19 months [95% CI, 16 – 22 months], respectively. Also, their time intervals were not significantly different (p>0.05). The osteonecrosis of the jaw (ONJ) was AE which occurred more in zoledronic acid than ibandronic acid. The conclusion was zoledronic acid tends to delay SRE time compared to ibandronic acid, although more ONJ occur.
Persepsi Masyarakat terhadap Kandungan Alkohol Pada Kosmetik Nurkhasanah Nurkhasanah; Amalya Nurul; Farah Qistih Albab
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 10, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.56147

Abstract

Perception is an individual response about something that can be influenced by knowledge. Good individual knowledge of alcohol will affect their perception of alcohol-containing product.  The MUI fatwa permits the use of alcohol in cosmetics. The purpose of this study was to observe the perception of alcohol content in cosmetics. The observation was carried out using a questionnaire technique with a nonprobability sampling technique with accidental sampling. The questionnaire was conducted by Pearson correlation test, validity test, reliability test, normality test, chi-square test, and description. In this study, using 98 respondents and get an average value of knowledge about cosmetics 6,73 with SD value of 0,49; knowledge of alcohol 4,54 with SD 1,17 and behavior with SD 1,46. There is a relationship between age with the level of cosmetic knowledge with p-value <0.05. As many as 46.94% stated, the halal label's urgency on cosmetics is very important and 39.80% is important, where the religion of the individual influences the urgency level of cosmetics halal. The urgency of halal labels on cosmetics is high in line with the behavior when buying cosmetics. The 81.63% of respondents stated that halal labels on cosmetic products affect the interest in buying cosmetics. As many as 61.24% of respondents have the perception that halal cosmetics do not contain alcohol. The Pearson halal label correlation test confirms this obtained a p-value value of 0.024 that the halal label influences respondents' perceptions. Individuals were having a perception that cosmetics with halal labels do not contain alcohol, which is influenced by halal labels' knowledge.
Adverse Drug Events on the Use of Sertraline in Clinical Studies: A Review Syahrul Hidayat; Irma M. Puspitasari
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 11, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.56558

Abstract

Major depressive disorder (MDD) and anxiety are known as a widespread public health problem treated with sertraline, a class of Selective Serotonin Reuptake Inhibitor (SSRI) drugs as first-line therapy. However, clinical evidence showed that MDD and anxiety therapy with sertraline has not been optimal due to patient non-compliance associated with adverse drug events (ADE) occurring. A literature search on sertraline clinical study was conducted on the PubMed and Science Direct electronic database in April 2020. A total of 12 articles from 5.664 articles have been selected at the initial screening. A total of 6 articles used sertraline as a testing drug in MDD patients, 2 articles used sertraline as testing drug in anxiety patients, 2 articles with sertraline as a comparative drug, 1 article with sertraline as a positive control, and 1 article with sertraline as an adjuvant in MDD patients. Studies on these articles were carried out worldwide from 2010 to 2019. ADEs that occur due to the use of sertraline were: gastrointestinal disorders, nutritional and metabolic disorders, central nervous system disorders, sweating, sleep disorders, irritability, eye disorders, as well as disorders of the skin and subcutaneous tissues. Nausea is the most common ADE of sertraline. ADEs are affected by several factors such as, age, the sertraline combination therapy, and alcohol consumption.
Adverse Drug Reactions Study of Antihypertensive Drugs in Primary Care Settings Yeni Farida; Kharimah Faizathus Tsalatsatun
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 10, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.56975

Abstract

Hypertension is one of the high-prevalence diseases in primary care. Failure to achieve the target of blood pressure is affected by non-compliance due to the antihypertensive adverse reactions. This study aims to determine adverse drug reaction (ADR) of antihypertensive drugs in primary care settings. A cross sectional study was conducted in “Sibela” Primary Care in Surakarta on March 2019. Investigators interviewed patients directly and observed supporting data from medical records. Hypertension patients with antihypertensive drugs at least for a month were eligible in this study.  Then, the data were analyzed by the Liverpool algorithm that interpreted in 4 scales: unlikely, possible, probable, and definite.  A total 70 subject were dominated by female (80%). Monotherapy of antihypertensive drugs prescribed to patient in primary care were amlodipine (80%) and captopril (10%). Nine events of ADR were found in hypertension patient. None ADR were doubtful. Possible ADR of amlodipine was drowsiness (5.4%), whereas probable ADR were nausea (3.4%), diuresis (1.8%), and abdominal pain (1.8 %). Definite ADR of captopril was dry mouth (14.3%) and probable ADR was abdominal pain (14.3%). Further investigation regarding the drowsiness, ADR of amlodipine, was needed.
Hubungan Drug Related Problems (DRPs) Obat Antidiabetika terhadap Ketercapaian Kendali Glikemik pada Pasien Rawat Inap Diabetes Melitus Tipe 2 dengan Komplikasi Nyeri Neuropati Anggraini Citra Ryshang Bathari; Fita Rahmawati; Ika Puspita Sari
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 10, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.57829

Abstract

Drug Related Problems (DRPs) associated with Type-2 Diabetes Melitus is commonly caused by multi drug prescription since Type-2 Diabetes Mellitus has comorbid dan complication diseases. Neuropathic pain has 50% prevalence of Type-2 diabetes Mellitus Complication. DRPs can cause can cause inadequate therapy that might be the risk factor leads to neuropathic pain. This study was aimed to investigate the association between drug related problems of antidiabetic medication with glicemic control of hospitalized type 2 diabetes melitus with neuropathic pain patients. Cohort-study is used in this study. 50 patients were conducted in this study that underwent Hospital treatment at Rumah Sakit Akademik Universitas Gadjah Mada during the periods of 2018-2019. This study involved 50 patients who were divided into groups that experienced DRPs by 36 patients and non DRPs by 14 patients. All of the 50 has meet the inclusions criterias. Statistical analysis was using Chi-square test 95% confidence interval (p < 0.05). A number of 38 DRPs have found consists of 26,3% need more therapy, 55,2% with wrong drug therapy, 18,4% inadequate dosing. There was an association between DRPs of antidiabetics regiments and glycemic target on Type-2 Diabetes Mellitus patients with neuropathic pain complication (p=0,005). Identification of DRPs is needed to prevent the negative effect of patient therapy outcomes.
Relationship between Dose and Retention of Methadon Maintenance Therapy to Drug Dependence Patients in Primary Health Care Lili Musnelina; Jenny Pontoan; Bagus Atmana Prasetya
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 11, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.57922

Abstract

Methadon maintenance therapy is one of the substitution therapies needed as an approach to harm reduction or the reduction of the adverse effects of drug abuse. This study aims to fix the infinitive relationship doses with retention of drug dependence patients on methadon maintenance therapies program (PTRM) in Kramat Jati Primary Health Care in 2009-2018. A cross-sectional study is conducted using secondary data from medical records subsequently significance analysis. This research involves 136 patients who were included in the inclusion criteria. Results shown mean initial doses received is 27,65 mg (10-40 mg), after 2 weeks of therapy mean doses received are 51,6 mg (range 22,5 – 85 mg). Average lowest and highest maintenance dose which received is 30,9 mg (range 0,25-115 mg) dan 84,39 mg (range 7,77-126,92 mg). This research shows the retention value 1 year or more reaches 64,71%. Maintenance doses 2 weeks (P=0,005), lowest maintenance doses (P=0,000), average maintenance doses (P=0,004), and history misses doses (P=0,000) have significance with retention. The conclusion that the more optimal maintenance doses received, even more in methadone maintenance therapies. Otherwise, lower missed doses frequency better to patients retention in methadon maintenance therapies.
The Effect of Based Services Medication Therapy Management on Treatment Adherence and Quality of Life of Diabetes Mellitus Patients Rachma Malina; Nanang Munif Yasin; Chairun Wiedyaningsih
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 10, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.58052

Abstract

Diabetes mellitus is a chronic metabolic disorder that is characterized by hyperglycemia. Diabetes mellitus need appropriate therapeutic management, because it can cause complications. On of the services that can do to improve diabetes control is Medication Therapy Management (MTM). MTM is a new service that will help pharmacist to improve patient adherence and quality of life. This study aims to determine the effect of based services MTM on treatment adherence and quality of life in patients with diabetes mellitus. This study was an experimental study using a quasi-experimental with one group pretest and posttest design which was conducted in Tegalrejo, Jetis and Gedontengen Health Center Yogyakarta City. Variables measured were medication adherence using the Morisky-Green Levine Medication Adherence Scale (MGLS) questionnaire and quality of life using Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ) before and after MTM services. The effect of MTM on medication adherence was analyzed using Wilcoxon test and the effect of MTM on quality of life using Paired T-Test. The patients participate in this study were 20 people, with average score of adherences before application of MTM was 2.20±0.410 to 1.80±0.616 after the application of MTM (P=0.005) and the average of the patient's quality of life was 73.82±7.918, increased to 76.42±5,623 after MTM service (P=0.033). Statistically mean, there is a difference in adherence and quality of life before and after MTM services. Therefore, it can be concluded that MTM-based services performed by pharmacists have a significant effect on improving medication adherence and quality of life for DM patients. Moreover, it can facilitate monitoring patient therapy, and identification of problems related to the treatment.
Pengaruh Medication Therapy Management (MTM) terhadap Outcome Klinik dan Kualitas Hidup Pasien Hipertensi di Puskesmas Kota Yogyakarta Tiara Dewi Salindri Pratama; Nanang Munif Yasin; Susi Ari Kristina
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 10, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.58113

Abstract

Medication therapy management (MTM), is a service model aimed at helping general health problems by preventing morbidity and mortality. Hypertension is a non-communicable disease which is a serious health problem which requires long-term therapy.  This study aims to see the effect of MTM on clinical Outcomes and quality of life of patients in hypertensive patients. This type of research is a quasi experimental one group with a pretest-posttest design. Analysis using paired sample t-test and Wilcoxon test with a significance used P <0,05. Respondents were 70 people, 67,1% were women. The characteristics of the majority age are 55-64 years with a percentage of 51,4%, the majority of education level is high school with 42,8%, non-civil servant jobs with a percentage of 45,7%, the length of diagnosis is dominated by 1-10 years (77,1%) and comorbidities diabetes mellitus occurred the most (10,0%). The results showed that the quality of life increased from before getting MTM 54,4 ± 8,9 and after MTM intervention 60,4 ± 6,6 (P value <0,001). Clinical outcome from systolic 159,2 ± 8,9 mmHg and diastolic 103,8 ± 8,0 mmHg before MTM to 144,1 ± 14,4 mmHg for systolic and 89,7 ± 8,8 mmHg for diastolic with p value <0,001 (p <0,05) for systolic blood pressure and p value: 0,016 (p <0,05) after receiving MTM intervention. Medication Therapy Management (MTM) has a significant influence on improving the quality of life and clinical Outcomes of hypertensive patients. The higher the quality of life of patients, blood pressure becomes more controlled.
The Usage of Dosing GAMA Application to Evaluate the Appropriateness of Drug Doses in Hospitalized Patients with Renal Impairment Vidiya Gunarsih; Fita Rahmawati; Djoko Wahyono
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 10, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.58534

Abstract

An application named ‘Dosing GAMA’ has developed for drug doses adjustment in patients with renal and hepar impairment. Dosing GAMA is targeted for clinical Pharmacists to calculate and make dose recommendations for patients, based on renal and hepatic conditions. This study aims to identify the appropriateness of drug dosage adjustment by using Dosing GAMA application in hospitalized patients with renal impairment and to determine the risk factors for the drug dose inappropriateness. This study was a retrospective observational descriptive study, cross-sectional design, used a consecutive sampling technique. The source of the data was Medical Record of hospitalized patients with renal impairment (creatinine clearance ≤50 mL/min) from 2018 of February till 2020 of March in the Academic Hospital of UGM. The names and the doses of the drugs were filled to Dosing GAMA application, and it would evaluate the appropriateness of drug doses. There were 570 drugs of 73 medical records included in this study. This study revealed Dosing GAMA could assess 144 drugs (25,6%) need to adjust, and 82 drugs (56,9%) were inappropriate doses. There were significant correlations of the age characteristic (p=0,000) and the creatinine clearance value (p=0,012) to the drugs dose appropriateness. There were inappropriate doses need to adjust in the hospital. So, the use of health-based technology expected for pharmacists to improve the use of drugs rationally.
Faktor yang Berhubungan dengan Tingkat Pengetahuan Masyarakat dalam Mengelola Obat Sisa, Obat Rusak dan Obat Kedaluarsa Hananditia Rachma Pramestutie; Ratna Kurnia lllahi; Ayuk Lawuningtyas Hariadini; Tamara Gusti Ebtavanny; Tia Eka Aprilia
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 11, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.58708

Abstract

Problems that often arose as a result of improper management of unused, damaged, and expired drugs in storage and disposal, include drug abused, increased environmental damage, antibiotic resistance, and decrease effectiveness of therapy; due to the lack of public knowledge that can caused by several factors. This study aims to analyse factor associated with level knowledge in the management of unused, damaged, and expired drugs in Malang Raya. This study was an observational analytic study with a cross-sectional design. The subjects were the people of Malang Raya who were selected using a convenience sampling technique in accordance with the inclusion and exclusion criteria. The subjects were 322 respondents. The instrument used was a questionnaire to measure the level of knowledge of respondents that had been tested for validity and reliability. The results showed that, level of knowledge of respondence at Malang Raya in the management of unused, damage and expired drugs in the good (21%), sufficient (58%), and less (21%). Statistical tests used in this study were Somers'd, Kruskal-wallis, and Lambda tests to analysed factor associated with subjects’ level of knowledge in the management of unused, damaged, and expired drugs. There were a significant relationship in factors included age (p = 0.018) and income level (p = 0.003). It can be concluded that among the factors associated with  the level of knowledge in the management of unused, damaged, and expired drugs, only age and income level were statistically significant. Further study is needed to determine the factors affecting the level of knowledge the most.

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