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JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice)
Published by Universitas Gadjah Mada
ISSN : 20888139     EISSN : 24432946     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
JMPF is the first open access journal in Indonesia specialized in both research of pharmaceutical management and pharmacy practice. Articles submitted in JMPF are peer reviewed, we accept review articles and original research articles with no submission/publication fees. JMPF receives manuscripts in both English (preferably) and Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. JMPF is also open for various fields such as pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, goverment policies related to pharmacy, and pharmaceutical care.
Arjuna Subject : -
Articles 495 Documents
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General Public Knowledge on the Halalness of Herbal Syrup in Yogyakarta Province, Indonesia Utami, Nila Vidilia; Larasati, Savira Wahyu; Selalau, Waly Prakasa; Ghozali, Muhammad Thesa; Endarti, Dwi; Laksitorini, Marlyn Dian
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.95300

Abstract

Background: Recently there is an increase concern regarding the halal certification of herbal medication. This is due to the potential use of alcohol in the extraction process as well as in the formulation of herbal syrup. Mueasurement of public knowledge regarding the halal aspect of herbal syrup containing alcohol has never been reported in Indonesia.Objective: The purposes of the study is to determine the level of public knowledge regarding halal aspect of herbal syrups in Indonesia, especially in Yogyakarta Province. Alcohol has been widely used in herbal products as a solvent for extraction. Trace of alcohol has been shown to be present in herbal syrup.Methods: 300 respondents from Yogyakarta Province, Indonesia from a variety of sociodemographic backgrounds were recruited. The study employed a modified paper-based questionnaire to collect the respondents' sociodemographic details and their level of awareness regarding the halalness of herbal syrups. The study employed descriptive statistics to examine sociodemographic variables and knowledge and used Chi-Square analysis to examine the correlation between demographic characteristics and knowledge.Results: The study suggests that the public has good knowledge regarding the halalness of herbal syrups (59.0%). However, around 41% of respondents still have low knowledge regarding the topic. The were a relationship between the age of the respondent and the level of knowledge (p<0.05). Respondents who are less than 45 years old tend to have a good knowledge of the halalness of herbal syrup while in the elderly population, more than 50% of the respondents showed a lack of knowledge on the topic studied.Conclusions: There are varying levels of understanding regarding the halalness of herbal syrups in the community. While the majority of responders have a good knowledge, a significant portion still do not fully grasp this concept. To increase public knowledge of the halal components in drugs, especially among the elderly, further strategies are needed.
Clinical Outcomes for Severe COVID-19 Patients with Comorbid Type 2 DM through Dexamethasone Therapy at RSUP Dr. Sardjito Yogyakarta Dewi, Novia Ariani; Andayani, Tri Murti; Trisnawati, Ika
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.96954

Abstract

Background: Dexamethasone is a recommended therapy for severe COVID-19 patients who require hospital treatment. However, its use can affect blood glucose levels in patients, especially patients with diabetes mellitus comorbidity.Objectives: This study aims to determine the clinical outcomes for type 2 diabetes mellitus (DM) patients with Severe COVID-19 comorbidity through dexamethasone as COVID-19 therapy.Methods: This study employed the retrospective cohort an analytical observational research approach. Involving 60 patients as subjects, patients over the age of 18 received dexamethasone at RSUP Dr. Sardjito Yogyakarta between June 2021 and March 2022 and whose RT-PCR results showed severe COVID-19 with comorbidity of type 2 DM were included in the study. The blood glucose profiles derived from the patient's medical record data were the clinical outcome that already checked. The paired t-test was performed to analyze how dexamethasone affected the clinical results of the blood glucose profile.Results: The findings of the study were identified after using dexamethasone for four days, which showed that 78.30% of patients had an increased in blood glucose. Pre and post treatment of dexamethasone for four days had a significant impact on the patient’s blood glucose levels in this study, with an average change in blood glucose levels is 78.32 ± 116.77 (p<0.05).Conclusion: Dexamethasone therapy demonstrates a significant effect on blood glucose levels, resulting in a statistically difference between pre and post values for four days in patients with severe COVID-19 with type 2 DM comorbidity. Consequently, special monitoring needs to be carried out in severe COVID-19 patients with type 2 DM who receive dexamethasone to avoid worsening of the patient’s clinical condition.
Patterns of High-Alert Medicine Use in Geriatric Patients at Rumah Sakit Umum Pusat Dr. Cipto Mangunkusumo Malihi, La; Supadmi, Woro; Trisna, Yuliana; Purwanto, Barkah Djaka
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.97181

Abstract

Background: Geriatric patients are patients who are often associated with multiple diseases and decreased organ function so they are at greater risk of developing unwanted drug reactions due to drug use when compared to other adults. High Alert Medication (HAM) are drugs that have a high risk of causing significant harm to patients if used incorrectly.Objectives: This study aims to determine the pattern of HAM use among inpatient geriatric patients at Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo Jakarta.Methods: Retrospective cohort study by reviewing primary data from medical records (MR) of inpatient geriatric patients who used HAM for the period January 1 to December 31, 2023. The sample consisted of 300 geriatric patients who met the inclusion criteria using a purposive sampling technique. Descriptive data analysis includes data in the form of frequencies and percentages (%).Results: Based on gender, women with a total of 162 (54%) patients dominated. Based on age, the age range of 60 to 70 years with a total of 104 (68.87%) patients with a diagnosis of hypertension dominated compared to other ages. Based on the type of HAM used namely Insulin group HAM with 53 (20.38%) times of administration with the type of insulin in the form of novorapid flexpen 3 ml (13,532%) and anticoagulant group HAM with 49 (18,84%) times of administration with the type of anticoagulant in the form of heparin sodium 5 ml (13,181%) with the diagnosis of hypertension.Conclusion: The types of HAM that dominate the use in the therapy of hospitalized geriatric patients are novorapid flexpen 3 ml and heparin sodium 5 ml given parenterally with a diagnosis of hypertension.
Inventory Control of Medicine with Minimum-Maximum Stock Level at Ibu Fatmawati Soekarno Hospital Surakarta in 2023 Anwar, Alifia Auriel; Cahyo, Lukito Mindi; Wijayanti, Tri
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.98812

Abstract

Background: Inventory control prevents overstock and stockouts by monitoring availability, usage, while managing loss, damage, and expiration. Many hospitals struggle to manage inventory efficiently. Therefore, it is crucial to categorize drug supplies based on usage and investment values to balance supply and demand.Objectives: The study aims to categorize drug supplies based on their usage and investment values and then calculate the minimum and maximum stocks.Methods: This is a descriptive non-experimental study using cross-sectional data collected descriptively and retrospectively. Secondary data was used from drug information on SIM in 2023 and primary data from interviews. The results will be categorized using ABC categories, and inventory will be managed using the MMSL method. Additionally, the study will calculate the minimum and maximum stock as part of the investment process.Results: The ABC analysis of usage shows the percentage of drug items in groups A consists of 8.17% of items accounting for 70.06% of total usage, group B with 12.03% accounting for 20.41%, and group C with 79.80% accounting for 9.53%. Similarly, for investment value, group A accounts for 70.35%, group B for 20.16%, and group C for 9.50%. The MMSL method resulted in optimal safe, minimum, and maximum stock levels for each drug item.Conclusion: Grouping drugs into A, B, and C categories based on usage value and investment value can help to prioritize a drug, and inventory control with the MMSL method has a positive impact where there is a decrease in the number of purchases and purchase costs after the MMSL method.
A Systematic Review of Determinants Influencing Drug Availability in Community Health Centers in Indonesia Raymanus, Melani Angela Indrayani; Satibi, Satibi; Puspandari, Diah Ayu
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.100488

Abstract

Background: Drug availability in community health centers is a critical component in delivering quality health services to the community.drugSeveral factors  influence drug availability, including the procurement process, stock management, and geographic distribution of health facilities.Objectives: This study aims to  to review the factors that influence  drug availability in Indonesian community health centers.Methods: This study  conducted  a systematic review of  published articles in English that reported on factors influencing drug availability published during year 2016 to 2024. Relevant studies were located through an extensive search from four database (Scopus, PubMed, GARUDA, and Google Scholar). These keywords provide the necessary information. The quality of the included studies was assessed using Joanna Briggs Institute JBI  critical appraisal tools, including extensions tailored to various systematic review research designs.Results: Initially, 996 identified articles were screened by titles, abstracts, and full texts based on predefined inclusion and exclusion criteria, resulting in 25 eligible studies. This review identified twenty-fivestudies that focused on various regions in Indonesia, from large urban areas to remote areas. The main factors influencing drug availability include inadequacy planning and procurement processes, lack of knowledge, lack of pharmaceutical personnel, change in disease patterns and prescription patterns, the suboptimal use of the management information system and limited availability of drug at Health Office.Conclusion: Suboptimal drug availability continues to occur frequently across various regions in Indonesia. Key improvement efforts should focus on increasing knowledge of drug management, the number of pharmacies, and providing a sufficient budget for the procurement of drug.. Future research should prioritize  areas outside the main islands to develop targeted solutions to address local challenges.
Evaluation of Adverse Drug Reaction Reporting on the Badan POM Website in Yogyakarta Special Region Ernawati, Hafifah; Ikawati, Zullies; Puspitasari, Ika; Abdoellah, Siti Asfijah; Kurniawati, Fivy
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.105134

Abstract

Background: Adverse Drug Reaction (ADR) is defined as a harmful and unintended response to a drug, as a part of the pharmacovigilance system to identify drug safety-related issues. As a regulatory, the Indonesian Food and Drug Authority (BPOM) has facilitated an online reporting platform for healthcare professionals via the website www.e-meso.pom.go.id.Objectives: The objective of this study is to characterize Adverse Drug Reaction (ADR) reporting within the Special Region of Yogyakarta, serving as an early detection mechanism for potential drug safety hazards.Methods: This observational cross-sectional survey study utilized ADR reporting data obtained from the MESO website of the Indonesian Food and Drug Authority in the Special Region of Yogyakarta (DIY). The collected data were subjected to descriptive analysis. A total of 169 reports were analyzed, encompassing 255 suspected drugs and 255 ADR events.Results: The report identifies three predominant groups of patient disease characteristics: diseases of the circulatory system (15.38%), certain infectious and parasitic diseases (11.24%), and diseases of the respiratory system (9.47%). Regarding the type of ADR based on its Sub Organ Class (SOC), Skin and subcutaneous tissue disorders is most frequently involved (21.57%). The antibiotic group is the most commonly suspected type of drug (34.90%), with Levofloxacin and Ceftriaxone being the most implicated in causing ADR (11.24%). Oral administration is the most common route associated with ADR, followed by intravenous administration.Conclusion: In 2023, the monitoring of ADR in the Special Region of Yogyakarta revealed that antibiotics were the most frequently suspected drug class in relation to ADR. The dermatological organ system was also identified as the predominant organ affected by these reactions.
Systematic Review of Linezolid Population Pharmacokinetics in Pediatric: Models, Covariates, and Dosing Implication Primasari, Firdhani Satia; Hakim, Arief Rahman
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.108892

Abstract

Background: The increasing prevalence of bacterial resistance has positioned linezolid as a promising antibiotic for treating infections, including in pediatric patients. Knowledge of pharmacokinetic parameters is very useful in optimizing the dose to be used in patient therapy. However, pharmacokinetic data to guide optimized dosing in children remain limited.Objectives: This review aims to summarize population pharmacokinetic (PopPK) models of linezolid in pediatric populations and identify significant covariates influencing its pharmacokinetics.Methods: A systematic search was conducted in PubMed and ScienceDirect databases for studies published between 2014 and May 2025 using the keywords "linezolid", "population pharmacokinetics", and "pharmacokinetic model".Results: Six studies met the inclusion criteria and were analysed. The pharmacokinetic models were mainly based on blood concentration measurements and constructed using NONMEM in four studies. Most studies employed one-compartment models. Clearance values ranged from 0.068 to 5.82 L/h, and volume of distribution from 0.783 to 10.5 L. Body weight consistently emerged as a significant predictor of clearance, while body surface area was associated with volume of distribution.Conclusion: PopPK modeling highlights considerable variability in linezolid pharmacokinetics among pediatric patients, influenced primarily by weight and other covariates. Further studies are needed to compare oral versus IV formulations and to incorporate unbound (free) drug concentrations for improved dose optimization in pediatric populations.
Discrepancies in Hospital Cost and Indonesia's Case-based Groups: A Literature Review Skarayadi, Oskar; Endarti, Dwi; Satibi, Satibi; Mukti, Ali Ghufron
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.95970

Abstract

Background: Indonesia started establishing national health insurance in 2014. Implementation of Indonesian national health insurance has frequent gaps between health expenditures based on hospital tariffs and the INA-CBG tariffObjectives: This review was aimed to compare the hospital tariff of healthcare to the INA-CBGs tariff and to identify the factors contributing to the actual cost.Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology followed in this research. The keywords "Real Cost and INA CBG'S" were used in Google Scholar, and the keywords "INA CBG'S AND REAL COST" on Pubmed, ScienceDirect, and Scopus between 2014 and 2022.Results: A total of 634 records were found through database searching of Google Scholar (594), Pubmed (1), ScienceDirect (36), and Scopus (3). After the screening process, 24 articles were included in the review. It was found that 13 articles (54.16%) showed a lower hospital tariff than INA CBG's tariff, while 11 articles (45.84%) showed a higher hospital tariff than INA CBG's tariff. The main factors affecting the gaps of hospital tariff versus INA CBGs tariff mentioned in the articles were LOS, severity, and hospitality class.Conclusion: The literature of this review found hospital rates are higher with rates of INA-CBGs in many hospitals, so it requires a review of rates and an efficient strategy of hospitals.
A Cost-Effectiveness Study of Antibiotic Drug Delivery System in Chronic Suppurative Otitis Media (CSOM) Akram, Muhammad; Saud, Anshar; Arifin, Bustanul
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.97985

Abstract

Background: Chronic Suppurative Otitis Media (CSOM) is a chronic inflammatory and infectious disease of the middle ear or mastoid cavity that can result in the loss of bodily functions or even death. The higher concentration of CSOM is found in developing nations such as Indonesia, where the population cannot afford treatment. In cases of persistent otorrhea following 3 weeks of treatment with topical ear antibiotics, oral antibiotics may be considered as a second line of treatment. Topical ear antibiotics are insufficiently available at healthcare facilities because they are not included in the Indonesian National List of Essential Medicines (NLEM).Objectives: The objective of this study was to compare the cost-effectiveness of topical ear antibiotics versus oral antibiotics in the treatment of chronic suppurative otitis media (CSOM).Methods: This study was a cross-sectional study using retrospective data from medical records and cost assessments at a rural hospital in the Gowa district of South Sulawesi. The effectiveness of the treatments was evaluated based on the frequency of visits to the ENT department, with antibiotic prescriptions and positive otorrhea.Results: The findings revealed that the Average Cost-Effectiveness Ratio (ACER) for topical ear antibiotics was Rp 161,020, while the ACER for oral antibiotics was Rp 286,968. The Incremental Cost-Effectiveness Ratio (ICER) was determined to be Rp 351, and the Incremental Net Benefit (INB) was positive (Rp 99,857) at threshold Rp 434,500.Conclusion: Our study found that topical ear antibiotics were more cost-effective than oral antibiotics when considering the INB values based on INA-CBGs, along with fluctuations in cost-effectiveness using sensitivity analysis.
Adherence to Oral Chemotherapy in Breast Cancer Patients at a Gianyar General Hospital and the Influencing Factors Yuliawati, Agustina Nila; Simbolon, Ratih Elisabet; Ratnasari, Pande Made Desy
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.99518

Abstract

Background: Breast cancer patients receiving oral chemotherapy must strictly adhere to their treatment regimen for optimal therapeutic outcomes. Various factors, including demographics, environment, social dynamics, and economic circumstances may impact adherence to the recommended treatment.Objectives: This study aims to assess patient’s treatment adherence and decisively identify the factors that affect it.Methods: This cross-sectional study was conducted at a General Hospital in Gianyar, Bali, in May-June 2024, and 70 samples were purposively selected. Patients with complete medical records and consent were recruited; those with incomplete questionnaires were excluded. An adapted questionnaire and data collection sheet were used to measure adherence and gather medical information. The responses to the adherence questionnaire have been effectively processed into a final scoring format. Higher scores clearly reflect better adherence. Then, the data analysis involved univariate tests to examine respondent characteristics and adherence, as well as bivariate tests (Spearman-rho and Mann Whitney U-Test) to analyze the relationship between respondent characteristics and their adherence (with a 95% CI).Results: The majority of respondents were <60 years old (75.71%), female (100%), had completed elementary school (28.57%), were employed (64.29%), lived in rural areas (58.57%), had been diagnosed with cancer for <4 years (100%) with stage 3 cancer (47.14%), underwent oral chemotherapy ≤3 times a month (71.43%), had no comorbidities (78.57%), used national health insurance (100%), and had an average adherence score of 88.77±3.72 (moderate of adherence). None of the respondent characteristics mentioned in the results of the respondent description were related to patient adherence (p>0.005).Conclusion: The patient's adherence to oral chemotherapy is moderate. Other factors suspected to strongly influence better adherence to treatment include consistent treatment monitoring by pharmacists, family support, knowledge, health insurance, and the patient's psychological condition.

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