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Farmasains : Jurnal Ilmiah Ilmu Kefarmasian
Published by Universitas Muhammadiyah Prof. Dr. Hamka
ISSN : 20866968     EISSN : 26219816     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is an national journal published by Faculty of Pharmacy and Science University of Muhammadiyah Prof. DR. HAMKA. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is aimed at being a medium for research results dissemination and scientific paper exchanges on the pharmaceutical field among academics, practitioners, regulators, and public. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is issued two times annually, i.e., in April, and October.The Editor receives rigorous research manuscripts that have not been offered for publication elsewhere. Since its first issue published in 2010. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian has become a CrossRef Member since 2019. Therefore, all articles published by Farmasains: Jurnal Ilmiah Ilmu Kefarmasian will have unique DOI number with p-ISSN 2086-6968 dan e-ISSN 2621-9816
Arjuna Subject : -
Articles 154 Documents
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Formulasi Gel Ekstrak Etanol Daun Awar-awar dan Evaluasi Aktivitas Anti-inflamasi secara In Vitro Khansa Nur Izzati; Simanullang, Gayatri; Riri Fauziyya
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i2.17741

Abstract

Gel is a semisolid dosage form that utilises a gelling agent, such as Carbopol 940, providing ease of application and efficient skin absorption. Ethanol extract of awar-awar (Ficus septica Burm. F) leaves, which contain flavonoids and tannins, has demonstrated promising anti-inflammatory potential. This study aimed to formulate and evaluate the stability of a gel containing the ethanol extract of awar-awar leaves, as well as assess its anti-inflammatory effects. The methods comprised phytochemical screening, gel formulation and evaluation, stability testing, and an in vitro anti-inflammatory assay. Four gel formulations were created: F0 (0%), F1 (1.5%), F2 (3%), and F3 (4.5%). Evaluation results showed that F0, F1, and F3 were homogeneous, with viscosities between 5,000-50,000 mPa·s, spreadability of 5-7 cm, and adhesion time exceeding 2 seconds, meeting Indonesian National Standard (SNI) requirements. However, pH testing during the cycling tests revealed instability in formulations F1 through F3 during storage. The anti-inflammatory test, conducted using the protein denaturation inhibition method, showed all three formulations had anti-inflammatory activity, with F3 being the most effective (92.20% inhibition). Therefore, F3 is considered the most promising formulation due to its high anti-inflammatory activity and acceptable pharmaceutical characteristics for gel preparations.
Pengetahuan, Kesadaran, dan Praktik Orang Tua tentang Resistensi Antibiotik Pada Anak di Sampang, Kabupaten Cilacap Wijayanti, Pepi Nur; Kaafah, Silma; Setianingsih, Siti
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i2.18235

Abstract

Inappropriate use of antibiotics in children contributes to antibiotic resistance. Parents in Cilacap have limited knowledge and awareness of it. This study aimed to describe the knowledge, awareness, and practices of parents regarding antibiotic resistance in 0-11 years old children in Cilacap, as well as to explore the relationship of those aspects and the respondents’ characteristics. The research used a descriptive cross-sectional approach in Sampang District, Cilacap Regency, conducted in May 2024 with 96 respondents selected through cluster random sampling with inclusion criteria. The respondents were parents of 0-11 years old children, with or without antibiotic treatment history, and willing to participate by completing questionnaires. Results showed that 63.5% respondents had high knowledge, 66.7% respondents had high awareness, and 65.6% respondents had good practices. The results indicated that age and education significantly influenced knowledge, awareness, and practices, with p-values <0.05. Meanwhile, gender and occupation showed no significant effect, as evidenced by p-values >0.05. The findings indicate that parents in Sampang District generally demonstrate high knowledge and awareness, as well as good practices concerning antibiotic resistance in children. However, certain demographic factors, particularly age and education, remain influential in shaping these outcomes.
Penerapan Metode ATC/DDD dalam Analisis Penggunaan Antibiotik Pasien Rawat Inap di RSUD Chasan Boesoirie Ternate Sibadu, Muhammad Subhan A.; Siti Marita Umaternate; Ismail Rahman
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i2.18323

Abstract

The irrational use of antibiotics has the potential to increase the risk of bacterial resistance. Quantitative approaches, such as the Defined Daily Dose (DDD) method, can be utilised to evaluate the types and volumes of antibiotics consumed. The purpose of this study was to analyse the use of antibiotics at Dr H. Chasan Boesoirie (RSCB) Ternate Hospital in 2024 using the DDD approach. The research employed an observational approach using medical record data from RSCB, with a population of 1,300 during 2024. The inclusion criteria were inpatients diagnosed with bacterial infections, receiving antibiotic therapy, having clear and complete medical record data, aged over 18 years up to 65 years, and with a discharge status of “permitted” or “improved.” Study showed that the most widely used antibiotics were ceftriaxone, with a value of 45.7 DDD/100 patient-days of care, and ciprofloxacin 0.5 DDD/100 patient-days of care. The total DDD of all antibiotics was 61.7 DDD/100 patient-days of care. The 90% Drug Use (DU) segment was ceftriaxone with a value of 73.6, and the highest 10% DU was metronidazole at 9%. In conclusion, the antibiotic with the highest DDD value was ceftriaxone (45.7 DDD/100 patient-days), while the lowest was ciprofloxacin (0.1 DDD/100 patient-days).
Aktivitas Ekstrak Etanol Kulit Apel Hijau (Pyrus malus L.) Sebagai Agen Antiproliferatif Sel Kanker Payudara T47D Adhitya, Bagas Herbayu; Nisa, Devi Nisa Hidayati
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i2.18385

Abstract

Quercetin, a flavonoid compound in green apple peel (Pyrus malus L.), has shown anticancer potential in T47D cells. This study evaluated the cytotoxic effects and antiproliferative activities demonstrated by the Ethanolic Extract of Green Apple Peel (EEGAP) on T47D cells. The peel powder was extracted using 70% ethanol with ultrasonic waves. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed for the cytotoxicity test using EEGAP concentrations of 31.25, 62.5, 125, 250, 500, and 1,000 µg/mL. The IC50 value was determined using probit analysis. Based on the IC50 results, an antiproliferative assay was conducted using the doubling time technique at concentrations of ½IC50 (404.5 µg/mL) and IC50 (809 µg/mL), which were observed at 0, 24, 48, and 72 hours. EEGAP has a moderate cytotoxic effect, with an IC50 value of 809 µg/mL. EEGAP showed significant antiproliferative activity, with a doubling time of 14 hours in control samples. EEGAP at a concentration of ½ IC50 showed a replication period of 21 hours, whereas the IC50 concentration replication period was 30 hours. These results suggest that EEGAP exhibits cytotoxic and antiproliferative properties, which may have potential as a natural compound for breast cancer therapy.

Page 16 of 16 | Total Record : 154

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