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Farmasains : Jurnal Ilmiah Ilmu Kefarmasian
Published by Universitas Muhammadiyah Prof. Dr. Hamka
ISSN : 20866968     EISSN : 26219816     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is an national journal published by Faculty of Pharmacy and Science University of Muhammadiyah Prof. DR. HAMKA. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is aimed at being a medium for research results dissemination and scientific paper exchanges on the pharmaceutical field among academics, practitioners, regulators, and public. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is issued two times annually, i.e., in April, and October.The Editor receives rigorous research manuscripts that have not been offered for publication elsewhere. Since its first issue published in 2010. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian has become a CrossRef Member since 2019. Therefore, all articles published by Farmasains: Jurnal Ilmiah Ilmu Kefarmasian will have unique DOI number with p-ISSN 2086-6968 dan e-ISSN 2621-9816
Arjuna Subject : -
Articles 241 Documents
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Formulasi Gel Ekstrak Etanol Daun Awar-awar dan Evaluasi Aktivitas Anti-inflamasi secara In Vitro Khansa Nur Izzati; Simanullang, Gayatri; Riri Fauziyya
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i2.17741

Abstract

Gel is a semisolid dosage form that utilises a gelling agent, such as Carbopol 940, providing ease of application and efficient skin absorption. Ethanol extract of awar-awar (Ficus septica Burm. F) leaves, which contain flavonoids and tannins, has demonstrated promising anti-inflammatory potential. This study aimed to formulate and evaluate the stability of a gel containing the ethanol extract of awar-awar leaves, as well as assess its anti-inflammatory effects. The methods comprised phytochemical screening, gel formulation and evaluation, stability testing, and an in vitro anti-inflammatory assay. Four gel formulations were created: F0 (0%), F1 (1.5%), F2 (3%), and F3 (4.5%). Evaluation results showed that F0, F1, and F3 were homogeneous, with viscosities between 5,000-50,000 mPa·s, spreadability of 5-7 cm, and adhesion time exceeding 2 seconds, meeting Indonesian National Standard (SNI) requirements. However, pH testing during the cycling tests revealed instability in formulations F1 through F3 during storage. The anti-inflammatory test, conducted using the protein denaturation inhibition method, showed all three formulations had anti-inflammatory activity, with F3 being the most effective (92.20% inhibition). Therefore, F3 is considered the most promising formulation due to its high anti-inflammatory activity and acceptable pharmaceutical characteristics for gel preparations.
Pengetahuan, Kesadaran, dan Praktik Orang Tua tentang Resistensi Antibiotik Pada Anak di Sampang, Kabupaten Cilacap Wijayanti, Pepi Nur; Kaafah, Silma; Setianingsih, Siti
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i2.18235

Abstract

Inappropriate use of antibiotics in children contributes to antibiotic resistance. Parents in Cilacap have limited knowledge and awareness of it. This study aimed to describe the knowledge, awareness, and practices of parents regarding antibiotic resistance in 0-11 years old children in Cilacap, as well as to explore the relationship of those aspects and the respondents’ characteristics. The research used a descriptive cross-sectional approach in Sampang District, Cilacap Regency, conducted in May 2024 with 96 respondents selected through cluster random sampling with inclusion criteria. The respondents were parents of 0-11 years old children, with or without antibiotic treatment history, and willing to participate by completing questionnaires. Results showed that 63.5% respondents had high knowledge, 66.7% respondents had high awareness, and 65.6% respondents had good practices. The results indicated that age and education significantly influenced knowledge, awareness, and practices, with p-values <0.05. Meanwhile, gender and occupation showed no significant effect, as evidenced by p-values >0.05. The findings indicate that parents in Sampang District generally demonstrate high knowledge and awareness, as well as good practices concerning antibiotic resistance in children. However, certain demographic factors, particularly age and education, remain influential in shaping these outcomes.
Penerapan Metode ATC/DDD dalam Analisis Penggunaan Antibiotik Pasien Rawat Inap di RSUD Chasan Boesoirie Ternate Sibadu, Muhammad Subhan A.; Siti Marita Umaternate; Ismail Rahman
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i2.18323

Abstract

The irrational use of antibiotics has the potential to increase the risk of bacterial resistance. Quantitative approaches, such as the Defined Daily Dose (DDD) method, can be utilised to evaluate the types and volumes of antibiotics consumed. The purpose of this study was to analyse the use of antibiotics at Dr H. Chasan Boesoirie (RSCB) Ternate Hospital in 2024 using the DDD approach. The research employed an observational approach using medical record data from RSCB, with a population of 1,300 during 2024. The inclusion criteria were inpatients diagnosed with bacterial infections, receiving antibiotic therapy, having clear and complete medical record data, aged over 18 years up to 65 years, and with a discharge status of “permitted” or “improved.” Study showed that the most widely used antibiotics were ceftriaxone, with a value of 45.7 DDD/100 patient-days of care, and ciprofloxacin 0.5 DDD/100 patient-days of care. The total DDD of all antibiotics was 61.7 DDD/100 patient-days of care. The 90% Drug Use (DU) segment was ceftriaxone with a value of 73.6, and the highest 10% DU was metronidazole at 9%. In conclusion, the antibiotic with the highest DDD value was ceftriaxone (45.7 DDD/100 patient-days), while the lowest was ciprofloxacin (0.1 DDD/100 patient-days).
Aktivitas Ekstrak Etanol Kulit Apel Hijau (Pyrus malus L.) Sebagai Agen Antiproliferatif Sel Kanker Payudara T47D Adhitya, Bagas Herbayu; Nisa, Devi Nisa Hidayati
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i2.18385

Abstract

Quercetin, a flavonoid compound in green apple peel (Pyrus malus L.), has shown anticancer potential in T47D cells. This study evaluated the cytotoxic effects and antiproliferative activities demonstrated by the Ethanolic Extract of Green Apple Peel (EEGAP) on T47D cells. The peel powder was extracted using 70% ethanol with ultrasonic waves. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed for the cytotoxicity test using EEGAP concentrations of 31.25, 62.5, 125, 250, 500, and 1,000 µg/mL. The IC50 value was determined using probit analysis. Based on the IC50 results, an antiproliferative assay was conducted using the doubling time technique at concentrations of ½IC50 (404.5 µg/mL) and IC50 (809 µg/mL), which were observed at 0, 24, 48, and 72 hours. EEGAP has a moderate cytotoxic effect, with an IC50 value of 809 µg/mL. EEGAP showed significant antiproliferative activity, with a doubling time of 14 hours in control samples. EEGAP at a concentration of ½ IC50 showed a replication period of 21 hours, whereas the IC50 concentration replication period was 30 hours. These results suggest that EEGAP exhibits cytotoxic and antiproliferative properties, which may have potential as a natural compound for breast cancer therapy.
AKTIVITAS PENYEMBUHAN LUKA BAKAR FRAKSI DARI EKSTRAK ETANOL 70% DAUN PEPAYA (Carica papaya L.) PADA TIKUS BURN WOUND HEALING ACTIVITY FRACTION OF 70% ETHANOL EXTRACT OF PAPAYA LEAVES (Carica papaya L.) ON THE RATS Muthmaina, Ina
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 4 No. 2 (2017)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v4i2.91

Abstract

Papaya leaves could be used as an alternative traditional medicine by Indonesian people, such as burn wound healing. This research was aimed to find out the activity of fraction polar, semi-polar and non-polar papaya leaves (Carica papaya L.) and which fraction has better activity as healing of burn wound on rats. About 25 male rats are divided into five groups: positive control (Bioplacenton®), negative control (Gel bases) and three variations of the fraction (polar, semi-polar and non-polar) which was topically administered 2 times a day. A metal heat was pasted on the back skin of rats for 30 seconds to induce burn wound. Burn wound diameter was observed on days 3rd, 6th, 9th, 12th and 15th with 2 parameters, burn wound diameter reduction and day when the wound was shutted faster. The results showed that papaya leaf polar fraction with 2.16% dose has an activity as a burn wound healing which was begin on day 6th, while the fraction of non-polar and semi-polar fraction of papaya leaf with 0.02% dose has an activity as a burn wound healing which was begin on day 9th and 12th. Keyword : Carica papaya L., Burn Wound
AKTIVITAS PENYEMBUHAN LUKA BAKAR FRAKSI EKSTRAK ETANOL 96% DAUN COCOR BEBEK (Kalanchoe pinnata) [Lam.] Pers. Ratu Zahra, Elisia Herma; WS, sri Harsodjo; maifitrianti, maifitrianti
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 4 No. 1 (2017)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v4i1.92

Abstract

Kalanchoe pinnata leaves was used as an alternative medicine by the people of Indonesia, such as burned wound healing. This research was done to determine whether the three fractions (fraction polar, semi-polar and non-polar) has a healing activity burns on white male rats 25 male rats was divided into five groups positive control (Bioplacenton®), negative control (Base Gel) and three groups of variations of the fraction (fraction polar, semi-polar and non-polar fraction. The backs of rats induced hot metal with a temperature of 100oC and with a diameter 2x2 cm for 30 seconds. Observations diameter wound was observed on days 3,6,9,12 and 15 with the parameters of diameter reduction burns and days where faster wound shut. Polar fraction Kalanchoe pinnata with a dose of 1,29%, semi-polar fraction of 0,05% and 0,03% non-polar fractions in a gel formulation has a burned wound healing activity starting from day 12.
PENGHAMBATAN AKTIVITAS ENZIM α-GLUKOSIDASE DARI EKSTRAK AIR TANAMAN RARU (Vatica pauciflora) SECARA IN VITRO septiana, eris; winarti, wiwi; simanjuntak, partomuan
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 4 No. 1 (2017)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v4i1.96

Abstract

Diabetes mellitus is a metabolic disorder that leading the blood sugar levels become higher than normal. In Indonesia, one of the plants that traditionally used to cure hyperglycemic is raru plant (Vatica pauciflora). The objectives of this research was to investigate α-glucosidase inhibitory activity from stem bark, root, and leaf of raru plant. Extraction of stem bark, root, and leaf was conducted with reflux at 70 °C by using water as a solvent. In vitro anti-diabetic activity was tested using the method of α-glucosidase inhibition. The results show that water extracts of raru's stem bark, root, and leaf have α-glucosidase inhibitory activity. The stem bark water extract has the highest activity than leaf and root with IC50 values were 13.53, 16.96, and 41.91 ppm respectively. All extracts is categorized as active in inhibiting the activity of α-glucosidase enzyme by having IC50≤100 ppm. The results obtain in this research clearly indicate a promising potential as anti-diabetic properties of raru plant.
ANALISIS PENGGUNAAN OBAT ANTI TUBERKULOSIS PADA PASIEN TUBERKULOSIS PARU KASUS BARU RAWAT JALAN DI RUMAH SAKIT ATMA JAYA Anwar, Yelfi; Ayuni, Fitri
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Abstract

ABSTRACT Tuberculosis (TB) is a contagious infectious disease caused by Mycobacterium tuberculosis. The prevalence of pulmonary tuberculosis incident was included in the top 10 highest disease at Atma Jaya Hospital. Therefore, the study of the analysis of the use of anti-tuberculosis drugs in patients with new cases of lung rational at Atma Jaya Hospital indispensable. The purpose of this study was to determine the profile and analyze the rationality of the use of anti-tuberculosis drugs used in outpatients suffering from pulmonary tuberculosis new cases over the period July 2013 - June 2014.
EVALUASI IMPLEMENTASI PELAYANAN KONSELING OBAT DI APOTEK KOTA YOGYAKARTA baroroh, farida; darmawan, endang
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Abstract

Therefore, it is important to give counseling for patients and their family. This study is to evaluate the counseling service implementation at several pharmacy in Yogyakarta Indonesia. This study was a cross-sectional design. The result showed that the implementation counseling service at pharmacy was 59,00% of 96,00% patients who required counseling service. The several pharmacy patient were out-patient who responsible to their therapeutical management. There was 55,93% patients experienced that the room for counseling service was comfortable. So, the communication aspects of counseling service at pharmacy in Yogyakarta had been well conducted. Based on the communication technique, the pharmacist communicated with body language such as practicing how to use the drug in counseling services was 64.41%. In conlusion, the implementation counseling service at pharmacy in Yogyakarta Indonesia was 59,00% of 96,00% patients who required counseling service. A number of 94.83% of patients stated that pharmacists use an understandable language in counseling services. It can be concluded that although only 58.59% of respondents who had received counseling but the desire to get counseling services of pharmacy in Yogyakarta is very high, reaching 95.96% of respondents
GAMBARAN EFEK SAMPING ANTIPSIKOTIK PADA PASIEN SKIZOFRENIA RAWAT INAP DI RS. GRHASIA YOGYAKARTA jualeha, julaeha; ananda, vitarani; pradana, dimas
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Abstract

This study aimed to profile the use of antipsychotics, the prevalence of DRPs events, and to compare the prevalence of DRPs use of antipsychotics in patients with schizophrenia in Grhasia hospital. This study is an observational study with cross sectional descriptive. Patients who were included in this study were patients with schizophrenia in the period 2007-2009 Grhasia Hospital who met the inclusion criteria, number of patients who were taken in this research are as many as 300 patients with a stratified sampling method. Data collection was performed retrospectively through medical records included patient characteristics, drug use data, and side effect event. From the data were collected regarding the percentage of use of antipsychotics. The results showed that administration of combination klorpromazin and haloperidol, an antipsychotic of the most widely used for the treatment of schizophrenia with a percentage over the period 2007, 2008, and 2009 are 60%, 70%, and 47%. Percentage side effect event over the period 2007, 2008, and 2009 are 31%, 28 % dan 14 %.

Page 16 of 25 | Total Record : 241

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