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Farmasains : Jurnal Ilmiah Ilmu Kefarmasian
Published by Universitas Muhammadiyah Prof. Dr. Hamka
ISSN : 20866968     EISSN : 26219816     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is an national journal published by Faculty of Pharmacy and Science University of Muhammadiyah Prof. DR. HAMKA. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is aimed at being a medium for research results dissemination and scientific paper exchanges on the pharmaceutical field among academics, practitioners, regulators, and public. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is issued two times annually, i.e., in April, and October.The Editor receives rigorous research manuscripts that have not been offered for publication elsewhere. Since its first issue published in 2010. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian has become a CrossRef Member since 2019. Therefore, all articles published by Farmasains: Jurnal Ilmiah Ilmu Kefarmasian will have unique DOI number with p-ISSN 2086-6968 dan e-ISSN 2621-9816
Arjuna Subject : -
Articles 154 Documents
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REVIEW: ISOLASI α-SELULOSA DARI BAHAN ALAM DENGAN BERBAGAI METODE Lestari, Yulianita Pratiwi Indah
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 11 No. 2 (2024)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v11i2.11919

Abstract

Salah satu sumber daya alam Indonesia yang paling melimpah adalah selulosa (C6H10O5)n,  senyawa ini merupakan komponen utama dari sebagian besar sel tumbuhan. Selulosa merupakan monomer glukosa dengan rantai polimer yang panjang. Karena menyusun sebagian besar dinding sel tumbuhan, selulosa adalah zat yang relatif umum terdapat di alam. Sebagian besar selulosa masih berkombinasi dengan lignin dan hemiselulosa yang terdapat pada sel tumbuhan berkayu, sedangkan sebagian lagi terdapat dalam bentuk murni, seperti pada biji kapas dan tanaman lainnya. Beberapa prosedur untuk mendapatkan selulosa telah dilakukan, termasuk perlakuan dasar alkalinasi dengan proses bleaching, steam exposion, iradiasi, ekstruksi, biodelignifikasi, serta enzimatik, yang tahapan ini dapat digunakan untuk mengisolasi selulosa. Jenis zat yang digunakan sebagai alkali, zat pemutih, penambahan enzim, dan penggunaan peralatan semuanya berdampak pada seberapa efektivitas proses isolasi selulosa. Penelitian ini dilakukan berdasarkan studi literatur mengenai metode-metode yang dapat digunakan dalam proses isolasi selulosa, diakses dengan membandingkan berbagai prosedur yang tepat akan menghasilkan kadar selulosa yang maksimal. Penelitian ini bertujuan untuk mengetahui berbagai macam metode yang dapat dilakukan untuk mendapatkan atau mengisolasi α-selulosa dari bahan alam. Berdasarkan hasil studi literatur yang dilakukan, didapatkan hasil bahwa isolasi selulosa dapat melalui beberapa cara, antara lain: cara kimia, cara fisika, cara biologi dan cara tradisional lainnya.
ANALISIS UTILITAS BIAYA KOMBINASI ANTIHIPERGLIKEMIA ORAL PADA PASIEN DIABETES MELLITUS TIPE II DI RSUD DR. SOERATNO GEMOLONG Anggriani, Indah Putri; Dewi, Lucia Vita Inandha; Pradesthya, Karinda Wirandani; Hanifah, Inaratul Rizkhy
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 11 No. 2 (2024)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v11i2.12418

Abstract

Diabetes Melitus (DM) tipe II sebagai suatu kondisi kronismemerlukan biaya dan waktu perawatan yang cukup besar dengan kualitas hidup sebagai salah satu parameter keberhasilan terapi. Kombinasi metformin-gliclazid dan metformin-pioglitazon merupakan kombinasi obat yang terbanyak digunakan di RSUD Dr. Soeratno Gemolong. Penelitian ini bertujuan untuk menentukan obat mana yang lebih cost-utility lebih besar. Penelitian ini merupakan penelitian observasional dengan metode farmakoekonomi Cost Utility Analysis (CUA). Penelitian yang dilakukan pada bulan Januari-Februari 2023 ini melibatkan 71 responden yang memenuhi kriteria inklusi, 38 responden menggunakan kombinasi metformin-gliklazid dan 33 lainnya menggunakan kombinasi metformin-pioglitazon. Pengambilan data menggunakan kuisoner Diabetes Quality of Life (DQoL). Rata-rata total biaya untuk kombinasi metformin-gliklazid sebesar Rp 8.634.959 dengan Quality-Adjusted Life Years (QALY) mencapai 2,33, sedangkan kombinasi metformin-pioglitazon membutuhkan total biaya rata-rata Rp 10.030.517 dengan QALY sebesar 1,99. Nilai Average Cost Effectiveness Ratio (ACER) kombinasi metformin-gliklazid dan kombinasi metformin-pioglitazon sebesar Rp 3.705.991 dan Rp 5.040.461, dengan nilai ICER –Rp 4.104.582, sehingga dapat disimpulkan bahwa kombinasi metformin-gliklazid lebih cost-utility. Berdasarkan analisis sensitivitas menunjukkan biaya obat lain memiliki rentang yang paling panjang, sehingga memiliki dampak paling signifikan terhadap biaya pengobatan.
UJI AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK ETANOL DAUN KELOR (Moringa oleifera Lam.) DAN BIJI PEPAYA (Carica papaya L.) TERHADAP BAKTERI Escherichia coli Raharjo, Rahmat Budhi; Rahayu, Titi Pudji; Kiromah, Naelaz Zukhruf Wakhidatul
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 11 No. 2 (2024)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v11i2.14146

Abstract

Penyakit infeksi  disebabkan oleh beberapa mikroorganisme seperti bakteri, virus, parasit, dan kapang. Daun kelor (Moringa oleifera Lam.) dan biji pepaya (Carica papaya L.) dapat digunakan sebagai obat alami karena mengandung zat aktif yang berperan sebagai antibakteri. Tujuan penelitian ini adalah mengetahui aktivitas antibakteri kombinasi ekstrak daun kelor dan biji pepaya terhadap bakteri Escherichia coli. Penelitian ini menggunakan ekstrak etanol 96% dengan metode maserasi. Uji antibakteri dilakukan menggunakan metode difusi dengan konsentrasi ekstrak 10% dan 20%. Hasil menunjukan bahwa kombinasi ekstrak daun kelor dan biji pepaya memiliki aktivitas lebih baik dibandingkan dengan ekstrak tunggal baik daun kelor maupun biji pepaya. Diameter zona hambat paling besar ditemukan pada konsentrasi 10% dan 20 % dengan perbandingan 2:1. Namun aktivitas yang paling baik terhadap bakteri E. coli adalah kombinasi 20% dengan perbandingan 2:1 dengan hasil diameter zona hambat 13,92±0,65 mm dan memiliki aktivitas paling baik dalam menghambat bakteri E. coli pada kategori kuat.
An KRIM ANTIJERAWAT EKSTRAK ETANOL DAUN KESUM (Polygonum minus Huds) Saepudin, Syumillah; Hartono, Kusdi; Wasih, Efriliya Andila
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 11 No. 2 (2024)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v11i2.14707

Abstract

Kesum (Polygonum minus Huds) memiliki potensi sebagai antibakteri dan dapat dikembangkan menjadi sediaan krim untuk pengobatan jerawat. Salah satu eksipien krim, asam stearat, merupakan emulgator yang dapat mempengaruhi sifat fisik sediaan. Tujuan penelitian ini untuk melihat pengaruh konsentrasi asam stearat 6% (F1), 12% (F2), dan 18% (F3) terhadap sifat fisik sediaan krim. Ekstraksi daun kesum dilakukan menggunakan metode maserasi dengan pelarut etanol 70%. Konsentrasi ekstrak daun kesum yang diformulasikan menjadi krim adalah 5%. Evaluasi sifat fisik sediaan krim meliputi pengamatan organoleptik, uji nilai pH, homogenitas, dan daya sebar. Aktivitas antibakteri dari tiap formula dilakukan terhadap bakteri Propionibacterium acnes. Hasil menujukkan krim ekstrak daun kesum terdistribusi secara homogen, kisaran pH krim yang diperoleh adalah 4­6, kemampuan penyebaran krim adalah 5,2­6,2 cm. Hasil uji antibakteri formula krim F1, F2, dan F3 memiliki aktivitas yang kuat dalam menghambat pertumbuhan bakteri P. acnes. Sediaan krim ekstrak daun kesum dengan variasi konsentrasi asam stearat 6%,12%, dan 18% memiliki sifat fisik yang meliputi bentuk, warna dan bau yang stabil, sediaan yang homogen, nilai pH dan daya sebar yang telah memenuhi syarat evaluasi fisik sediaan krim.
FORMULASI SERUM MINYAK ATSIRI TIMI DAN CENGKEH SERTA UJI AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH Liem, Marcella; Monica, Eva; Yanuar, Michael Resta
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i1.16087

Abstract

Essential oils from thyme (Thymus vulgaris) and clove (Syzygium aromaticum) are natural antioxidants with significant potential to neutralize free radicals. This study aims to evaluate the antioxidant properties of a serum containing a blend of these essential oils using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. It also aims to determine which serum formulation meets the required physical quality standards. The assessment includes organoleptic analysis, pH measurement, viscosity, homogeneity, spreadability, adhesiveness, globule size distribution, stability, emulsion type, hedonic evaluation, and antioxidant activity. The results indicate that the serum is in liquid form, with a pH between 5.149±0.227 and 5.447±0.109, viscosity ranging from 817.1±3.8 to 2083±0.00 cPs, adhesiveness lasting 5.45±0.26 to 11.210±0.09 minutes, and spreadability between 2.32±0.016 and 2.71±0.053 cm. Hedonic testing revealed that F1 was the most preferred formulation. Antioxidant activity analysis showed moderate to very weak effects, with IC50 values of 145.628 ppm (F1), 413.658 ppm (F2), and 536.529 ppm (F3).  F1, which contains 4.5% clove essential oil and 1.5% thyme essential oil, demonstrated the best balance of physical properties and antioxidant activity among the tested formulations.
Ekstrak Daun Kersen (Muntingia calabura L.) Meningkatkan Konsentrasi GLUT 4 pada Tikus Jantan yang Diinduksi Streptozotosin-Nikotinamida Ramadhiani, Aninditha Rachmah; Tari, Mayang; Pratiwi, Galih; Janadia, Putri Eka; Pratiwi, Jessica Wahyu
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i1.16948

Abstract

Diabetes Mellitus (DM) is a group of metabolic diseases characterised by hyperglycaemia, resulting from abnormalities in insulin secretion, insulin action, or both. Kersen (Muntingia calabura L.) leaves contain bioactive compounds, namely flavonoids, tannins, terpenoids, saponins, and polyphenols, which exhibit antioxidants and anti-diabetics. Glucose transporter (GLUT) 4 is an insulin-responsive glucose transporter in muscle and adipose tissue. This study aimed to examine the effect of Kersen leaves extract on GLUT 4 concentration in male rats induced by Streptozotocin-Nicotinamide. Diabetic rats were induced by Streptozotocin 45 mg/kg BW-Nicotinamide 110 mg/kg BW intraperitoneally, and the extract was administered orally for 14 days. Blood glucose level was measured using the Glucose Oxidase-Phenol 4-Aminoantipyrine (GOD-PAP) method, and GLUT 4 activity was assessed using the ELISA method. Statistical results showed significant differences (p<0.05) at 200, 400, and 600 mg/kg BW doses on the glucose and GLUT 4 levels. The 600 mg/kg BW group dose showed the best result with a blood glucose level of 88.22±2.31 mg/dL and a GLUT 4 level of 37.21±0.81 ng/mL. These findings demonstrate that Kersen leaves ethanol extract effectively lowers blood glucose levels and enhances GLUT 4 activity, with the most effective dose being 600 mg/kg BW.
Optimasi Formula Facial Wash Gell Antipolutan Ekstrak Bunga Rosella Ungu (Hibiscuss sabdariffa L. Var. Roselindo2) Anisa Fitri, Hidayah; Falahdin, Fadita Iza; Astuti, Ika Yuni
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i1.17127

Abstract

Exposure to Particulate Matter (PM) and other airborne pollutants can lead to various skin issues. The anthocyanin compounds in purple roselle flower extract exhibit antipollution activity, making the extract a promising candidate for the development of a facial wash gel formulation, optimised with carbopol 940 and triethanolamine (TEA). These two ingredients were selected due to their influence on the physical properties of the formulation, which is expected to help maintain the physicochemical stability of anthocyanins. This study aimed to determine the optimal concentrations of these components as gel base-forming agents, such as viscosity, pH, and spreadability. The optimum formula was designed using Design Expert 13 software with a Simple Lattice Design (SLD) model, while statistical analyses were conducted using one-way ANOVA and T-test to verify the predicted and actual optimum formula. The physical evaluation results confirmed that the optimum formula met the required viscosity (3826±28.67 cPs), dispersibility (6.07±0.45 cm), and exhibited an acidic pH (6.53±0.07) suitable for a facial cleansing gel. Based on the conducted tests and analyses, the optimum formula contained 2% carbopol 940 and 2% TEA, with a desirability value of 0.993. Verification testing indicated no significant differences between the predicted and actual optimum formula.
Asam mefenamat Efek Rekristalisasi Konvensional dan Dengan Bantuan Ultrasonik terhadap Karakteristik Kristal Asam Mefenamat Rasydy, La Ode Akbar; Damayanti, Hilda; Femalda, Adefia; Yuniarto, Ari; Arrahman, Ikhsan Nazar; Wahid, Rifki Saldi A.
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i1.17164

Abstract

Mefenamic acid is classified as a Biopharmaceutical Classification System (BCS) Class II drug. Crystallisation techniques can significantly influence the critical properties of mefenamic acid crystals, an essential consideration in the pharmaceutical industry. This study investigates the effect of recrystallisation on the morphology and particle size of mefenamic acid crystals using ethyl acetate as the solvent.  Recrystallisation was conducted using both conventional and ultrasonic-assisted methods. The yield was calculated, and characterization was performed to determine the crystal properties, shape, and particle size using polarized microscopy, X-ray Diffraction (XRD), and Fourier Transform Infrared Spectroscopy (FTIR). The results showed that conventional recrystallisation yielded 25.078%, while ultrasonic-assisted recrystallisation at 50 W, 60 W, 70 W, and 80 W yielded 43.47%, 47.71%, 51.90%, and 50.20%, respectively. Skewness and kurtosis values for the average crystal length and width indicated a normal distribution. XRD analysis revealed that the diffraction peak intensity of conventionally recrystallised crystals became narrow. In contrast, the diffraction peak intensity of ultrasonically assisted crystals broadened. FTIR results demonstrated that the recrystallisation process did not alter the fundamental chemical structure of mefenamic acid. Recrystallisation methods influence crystal shape and size, with ultrasonic-assisted techniques producing crystals of smaller average size than those obtained through conventional methods.
Pengujian Sifat Anti-Inflamasi Ekstrak Bunga Chamomile dalam Nanopartikel Kristal Cair Lyotropik Secara In Vitro Widyan Muchzadi Akbar; Muhammad Dzakwan; Fransiska Leviana
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i1.17402

Abstract

Chamomile is renowned for its anti-inflammatory properties. Lyotropic Liquid Crystal Nanoparticle (LLCN) offers better enhancement of the bioavailability and efficacy of natural products. This study evaluated the LLCN system’s effectiveness in improving chamomile extract’s anti-inflammatory activity and compliance with nanoparticle standards. Chamomile 70% ethanol extract was prepared, and the total phenolic and flavonoid content was measured. The extract was formulated into LLCN, and the particle size, polydispersity index, zeta potential, stability, and entrapment efficiency were evaluated. Anti-inflammatory activity was tested in vitro using the protein denaturation inhibition method. The extract showed high phenolic and flavonoid content. The characterisation results demonstrated that the LLCN system met the required specifications, exhibiting particle size values of 230.366±3.412 nm, polydispersity index of 0.217±0.034, a zeta potential of -23.763±0.756 mV, and an entrapment efficiency of 84.060%±0.100. Stability testing indicated that storage at 4°C was more effective than room temperature, preserving a smaller particle size and improving overall stability. The LLCN system significantly enhanced the extract’s anti-inflammatory activity, as demonstrated by a lower IC50 value than the viscous extract. In conclusion, the LLCN system enhances the therapeutic potential of chamomile extract and represents a promising strategy for developing phytochemical-based anti-inflammatory formulations.
Aktivitas Antibakteri Sabun Padat dari Ekstrak Air Rimpang Kunyit (Curcuma domestica) terhadap Staphylococcus aureus Mukarromah, Milda Lailatul; Wuryandari, Wahyu; Andini, Dinda Ayu; Wulandari, Tri Dewi Indah
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i2.16120

Abstract

Turmeric (Curcuma domestica) contains flavonoids and curcumin, which exhibit antibacterial properties, making it a suitable active ingredient for solid soap production. Solid soap must pass physical, chemical, and antibacterial activity assessments to ensure quality. This study evaluates the physical, chemical, and antibacterial properties of turmeric rhizome water extract-based solid soap against Staphylococcus aureus. The research was conducted experimentally, using turmeric rhizome water extract obtained through the maceration method. Antibacterial activity was assessed using the well diffusion method. The solid soap was formulated through saponification, incorporating thick extract (F1) and liquid extract (F2) of turmeric rhizome as active ingredients. Findings indicate that soap F1 has a solid texture, odourless, brown, and homogeneous, with a foam height of 13.63 cm±0.35, a moisture content of 7.52%±0.37, a pH of 10.03±0.05, a free alkali of 0.094%±0.008, and an inhibition zone diameter of 22.38 mm±0.58, classified as very strong antibacterial. Soap formulated F2 demonstrated comparable characteristics, with an 18.60 mm±0.96 inhibition zone, categorised as strong antibacterial. The soap F1 complies with pharmaceutical standards and effectively inhibits Staphylococcus aureus growth.

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