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Majalah Farmaseutik

majalahfarmaseutik
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Published by Universitas Gadjah Mada

ISSN : 1410590x EISSN : 26140063 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Majalah Farmaseutic accepts submission concerning in particular fields such as pharmaceutics, pharmaceutical biology, pharmaceutical chemistry, pharmacology, and social pharmacy.

Arjuna Subject : -

Articles 488 Documents

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TANGGAPAN PASIEN RAWAT INAP KELAS I, II DAN III TERHADAP PELAYANAN OBAT DI BANGSAL PENYAKIT DALAM RSUD KABUPATEN BREBES Indri Dwi Rahasasti; Abdul Karim Zulkarnain
Majalah Farmaseutik Vol 9, No 1 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Pelayanan obat merupakan bagian dari pelayanan kesehatan umumnya pasien menuntut kualitas pelayanan yang bermutu. Keadaan sosial-ekonomi dan pendidikan masyarakat yang semakin tinggi menjadikan masyarakat lebih kritis dalam menilai kualitas rumah sakit. Penelitian ini bertujuan mengetahui ada tidaknya pengaruh yang signifikan dari kualitas pelayanan obat ditinjau dari dimensi berwujud, keandalan, daya tanggap, kepastian dan empati terhadap tanggapan pasien, mengetahui tingkat tanggapan pasien sebagai pengguna layanan rawat inap, dan mengetahui perbandingan tingkat tanggapan pasien rawat inap antar kelas terhadap pelayanan obat. Penelitian dilakukan dengan metode deskriptif non eksperimental dan data diperoleh dari penyebaran kuesioner dan pengambilan sampel dilakukan dengan cara purposive sampling sebanyak 60 responden yang diambil pada bulan Februari-Maret 2007. Data dianalisis dengan uji kruskal-wallis dan korelasi bivariate (T Kendall) dengan bantuan program SPSS for window ver.12.0. Hasil penelitian menunjukan bahwa ada pengaruh signifikan antara kualitas pelayanan obat ditinjau dari dimensi keandalan terhadap tanggapan pasien, sedangkan pengaruh dimensi daya tanggap, kepastian, empati, dan berwujud tidak signifikan. Penilaian responden terhadap pelayanan obat di bangsal penyakit dalam RSUD Kabupaten Brebes masuk dalam kategori cukup baik untuk dimensi daya tanggap, sedangkan dimensi keandalan, dan empati masuk dalam kategori tidak baik, dan dimensi kepastian, berwujud, serta tanggapan pasien secara keseluruhan terkait dengan kelima dimensi adalah masuk dalam kategori cukup baik. Ada perbedaan tingkat tanggapan antara pasien kelas I, II, dan III.

SWAMEDIKASI PADA PASIEN GERIATRI DI APOTEK AFINA DAN FARMARIN KOTA YOGYAKARTA PERIODE MEI-JULI 2014 Dwi Hastuti; Dyah Aryani Perwitasari; Wahyu Widyaningsih
Majalah Farmaseutik Vol 11, No 2 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Apotek merupakan salah satu tempat pelayanan kesehatan yang menyediakan kebutuhan pasien, salah satunya obat-obatan. Tujuan penelitian ini adalah untuk mengetahui pengaruh perbedaan pemberian konseling terhadap kepatuhan dan kesembuhan pasien geriatri yang melakukan pengobatan sendiri di Apotek Afina (AF) dan Apotek Farmarin (FARM). Penelitian ini merupakan penelitian eksperimental dengan membandingkan kelompok pasien geriatri di Apotek AF dengan kelompok pasien geriatri di Apotek FARM. Pasien di Apotek AF akan diberi konseling oleh Apoteker, sedangkan di Apotek FARM diberikan informasi obat. Data yang diperoleh meliputi data demografi responden, riwayat penyakit, obat yang digunakan, kepatuhan penggunan obat, dan kesembuhan pasien yang dianalisis secara deskriptif untuk memperoleh gambaran pasien geriatri yang melakukan pengobatan sendiri di Apotek AF dan FARM. Analisis chi square dilakukan untuk melihat pengaruh konseling terhadap kepatuhan dan konseling terhadap kesembuhan. Hasil analisis chi square antara pemberian konseling terhadap kepatuhan maupun kesembuhan didapatkan p

The Analysis of Nutmeg Mace Essential Oil Compound Using GC-MS and Antibacterial Activity Test Toward Ecschericia coli and Staphylococcus aureus Nur ‘Aini Hidayah; Hery Muhamad Ansory; Prietta Khania Kusuma Putri; Anita Nilawati
Majalah Farmaseutik Vol 13, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Isolation of essential oil from nutmeg mace by using water distillation method had been done. The content analysis of the nutmeg mace essential oil compound was done by using GC-MS. The analysis result shows that there are 4 dominant compounds they are α-pinene, sabinene, 2-β-pinen, and myristicin. The quality of nutmeg mace essential oil is seen from the ratio of oil resulted from isolation with the SNI standard. Nutmeg mace essential oil does not fulfill the SNI standard in term of specific weight. However, it contains a relatively high among of myristicin which is 30.82%. According to Agusta (2000), essential oil is a good antibacterial. The antibacterial activity test was done by using the dilution and diffusion method. The result of the dilution test could not conclude the value of KHM and KBM. The diffusion test result shows that nutmeg mace essential oil with 7.5% concentration is able to inhibit the growth of Stapylococus aureus with the average inhibition zone diameter of 9.25 mm. While on the Ecschericia coli bacteria, it has the average inhibition zone diameter of 7.375 mm.

Nanoparticle Preparation of Pentagamavunon-0 Using Medium Viscous Chitosan Matrix Cross Linked by Sodium Tripolyphosphate Through Ionic Gelation Mechanism as Anti-Inflammatory Candidate Adhyatmika Adhyatmika; Ronny Martien; Hilda Ismail
Majalah Farmaseutik Vol 13, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Pentagamavunon-0 (PGV-0, abbreviated), a curcumin analogue with chemical structure as 2,5-bis(4’-hydroxy-3’-methoxybenzilidin)cyclopentanone, has proven to have anti-inflammatory activity and non-ulcerogenic. However, orally PGV-0 has low bioavailability because of its low solubility. One of the strategy to improve PGV-0 solubility in order to increase bioavailability is using nanoparticle carrier. The aim of the study is to formulate chitosan-PGV-0 nanoparticles through ionic gelation mechanism cross-linked by tripolyphosphate. PGV-0 nanoparticle produced was then characterized for its particle size, morphology, zeta potential, entrapment efficiency, and stability against artificial gastric and intestinal fluids (AGF and AIF). PGV-0 nanoparticle was tested for its anti-inflammatory activity by carrageenan induced inflammatory method, and its enzymatic affinity against enzyme cyclooxygenase (COX)-1 and COX-2. Chitosan-PGV-0 nanoparticles were formulated in the combination of 0,05% PGV-0, 0,05% medium-viscous chitosan and 0,002% TPP. The nanoparticles were 144,37 + 17,41 nm amorphous particles. Amount of PGV-0 entrapped was 99,40 + 0,08 % with +3,8 + 0,27 mV in zeta potential. Stability study in AGF and AIF was shown that 99,64-99,74 % (AGF) and 99,54-99,69 % (AIF) of PGV-0 remains in nanoparticles. Chitosan-PGV-0 nanoparticles at 5 mg/kg body weight was obtain 35,47 % anti-inflammatory activity and has found to have self-affinity against COX enzyme, relatively selective to COX-2.

Comparative Evaluation of Some Commercial Clopidogrel Tablets Available in Yemen Bassam Abduh Ali; Mohammed Gameel Al-haddad; Abdullah Ahmed Areqi
Majalah Farmaseutik Vol 13, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Clopidogrel is a medication to reduce the risk of heart disease and taken orally. Quality of drug characterizes the production process and every phamaceutical company strives for it but often it is very difficult to achieve. This study was to investigate quality control parameters of some marketed Clopidogrel tablets. To assess the quality, eight different marketed brands of Clopidogrel 75 mg tablets available in Yemeni market collected from different pharmacies in Hodeida city. Different quality parameters like weight variation, hardness, thickness and friability were determined according to established protocols. Then the in-vitro dissolution test, potency, disintegration time were also carried out. UV-spectrophotometer was used to determine the percentage released and assay at 218 nm. All the brands comply the requirements of Pharmacopoeia as they showed acceptable weight variation range. Friability of all brands was less than 1% and no significant differences in disintegration times as they disintegrated within 15 minutes. In case of dissolution profile, all brands except C6 showed acceptable dissolution time as they released more than 60% of drug in 45 minute. The hardness of only two brands was within the range. All brands also meet the potency specifications. This study suggested that most commercially Clopidogrel tablets in Yemen maintain the quality and comply with the pharmacopeia specifications.

Comparison of Methanol, Ethyl Acetates and Chloroform Extracts of Zingiber zerumbet (L) Smith in Larvisidal Activities on Aedes aegypti (Diptera: Culicidee) Larvae Tri Murini; Mae Sri Hartati Wahyuningsih; Tri Baskoro T.Satoto
Majalah Farmaseutik Vol 13, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The resistance of mosquito larvae to conventional larvicides has been increased in the recent years. Therefore, it is necessary to develop new larvacides from natural materials. Previous studies showed that Zingiber zerumbet (L.) Smith has a potential ability as a larvicide in Artemia salina Leach and Anopheles nunestovary. Nevertheless, the use of different solvents to observe the best larvicidal activity has not been known. This study aims to assess the larvicidal activity of methanol extract, ethyl acetate, and chloroform in Aedes aegypti larvae. This is an exploratory laboratory study with the posttest-only control group. The extraction solvents used were methanol, ethyl acetate, and chloroform. Twenty-five instar larvae (III-IV) of Ae.aegypti were treated with seven different concentrations of the three Z. rhizome extracts. The mortality rate of the larvae was calculated and analyzed using probit analysis regression to obtain LC50 and LC90 values. The LC50 of the methanol, ethyl acetate, and chloroform extracts are 153.57, 185.80, 3542.03 ppm; while the LC90 are 226.59, 274.70, and 5567.24 ppm, respectively. The study suggested that the methanol extract of Z. zerumbet rhizome has the most robust larvicidal activity against third-fourth instar larvae of Ae. aegypti among other extracts.

Computational Peniclilin Derivative That is Resistant to Acid and Beta Laktamase Enzyme Hari Purnomo; Intan Setyorini K
Majalah Farmaseutik Vol 13, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Penicillin is an antibiotic that is still widely used to treat infections. Some penicillin derivatives are known to have acid resistance properties such as penicillin V, ampicillin, amoxicillin and methicillin. Other penicillin derivatives have resistance to beta lactamase enzymes such as methicillin, nafsilin and cloxacillin. Computational chemistry can explain why this can occur. Groups responsible for the hydrolysis process by acids and decomposition by enzymes can be calculated elektron density, so it can be understood why derivatives that are acid resistant and others are resistant to the beta lactamase enzyme. The study was conducted by optimizing each molecule using the PM3 semi-empirical method, with a gradient of 0.01 and calculating the elektron density in the carbonyl. From the results of the study it can be concluded that the acid-resistant penicillin, elektron density of the O carbonyl amide at -0.335 in penicillin V, -0.333 in methicillin, -0.316 in ampicillin, -0.315 in amoxicillin, the four less nucleophiles than the elektron density of the O amide at Benzyl penicillin which is not acid resistant is -0,347. For penicillin which is resistant to beta laktamase, it can be concluded that the elektron density of C carbonyl lactam in nafsilin + 0.272, cloxacillin + 0.270, methicillin + 0.269 is less electrophile than penicillin which is not resistant to the beta laktamase enzyme +0.280.

Formulation of Betel Leaf (Piper Betle L.) Essential Oil Patch Buccal with Variation CMC-Na and Carbopol as Mucoadhesive Polimers Amitia Nice Tiensi; Tri Ratna S.; T. N. Saifullah Sulaiman
Majalah Farmaseutik Vol 14, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Betel leaf (Piper betle L.) contains essential oils that have antibacterial activity. The research aimed to determine the effect of CMC-Na and carbopol concentration as mucoadhesive polymers on the physical properties of bucal patches of betel leaf essential oil and inhibition activity of bacterial Streptococcus mutans. The essential oil was extracted by distillation on steam-water method, detection of compounds by GC-MS. Patches are made by the solvent casting method, with varying levels of polymer CMC-Na and carbopol, namely: formula I (80%: 20%), formula II (60%: 40%), formula III (50%: 50%), formula IV (40%: 60%), formula V (20%: 80%). The patchs were tested on their physical properties and antibacterial assay against streptococcus mutans. The results showed that the five formulas had uniform weight, thickness, folding endurance, good swelling index, and neutral pH. Higher levels of CMC-Na could increase the weight, thickness, folding endurance, swelling index, and antibacterial activity. Formula I provides higher antibacterial activity than other formulas.

Formula Optimization and Activity Test In Vitro Lotion O/W Ethanolic Extract of Mangga Temperature (Curcuma Mangga Val. and Van Zijp) as Solar Tables Mercy Arizona; A. Karim Zulkarnain
Majalah Farmaseutik Vol 14, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Intersection mango extract (Curcuma mango Val.) Has activity as a sunscreen by spectrophotometry. This study aims to determine the optimum formula lotion o/w, properties and physical stability of the optimum formula lotion o/w, and the activities of the optimum formula sunscreen lotion o/w Intersection mango extract (Curcuma mango Val.) by spectrophotometry. The optimum formula was obtained by the method Simplex Lattice Design (SLD). Responses are used to determine the optimum formula is the bonding strength and viscosity. Physical stability lotion o/w at room temperature include tests dispersive power, adhesion, and viscosity, as well as freeze thaw cycling test. Activities sunscreen lotion o/w determined by spectrophotometry to determine the Sun Protecting Factor (SPF),% transmission erythema, and% transmission pigmentation. Data were analyzed by One Way ANOVA and t test. The results showed that the optimum formula lotion o/w on a combination of 5% triethanolamine (TEA) -stearat and 5% cetyl alcohol. Lotion o/w intersection mango extracts have had the scatter 63.21 ± 2.69 cm2, the stickiness of 2.32 ± 0.15 seconds, and the viscosity of 133.5±8.05 dPas. Results of statistical analysis showed that the lotion o/w has good stability. Lotion o/w has activity as a sunscreen lotion at concentrations o/w 12.5% are indicated with an SPF value of 12.82 ± 0.16 and ineffective in the protection against erythema and pigmentation.

Potential of Anticoagulan Garlic Estract (Allium sativum) Using Lee-White Method and Blood Destruction Rahmawati Rahmawati; Muammar Fawwas; Rais Razak; Utami Islamiati
Majalah Farmaseutik Vol 14, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Garlic (Allium sativum L.) contains essential oils, allicin compounds, alliin and other organosulfur compounds such as ajoene which play a role in anticoagulants. This study aimed to examine the anticoagulant activity of garlic extract using the Lee-White method and blood smear. Anticoagulant activity testing was carried out by looking at the time it took for the blood to freeze after adding garlic juice, 96% ethanol (negative control) and EDTA (positive control) and looking at the red blood cell profile under a microscope (blood smear). From the test results showed that garlic extract had anticoagulant activity in which the Lee-White method, blood control freezing for three consecutive probes occurred at 4 minutes, 3 minutes 30 seconds and 3 minutes 30 seconds; addition of 96% ethanol occurred at 4 minutes 30 seconds, 2 minutes 30 seconds and 2 minutes 30 seconds and the addition of EDTA and garlic extract did not experience blood clots. Then in the blood smear method, the red blood cells added with garlic juice look round and not in groups.

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