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Majalah Farmaseutik

majalahfarmaseutik
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Published by Universitas Gadjah Mada

ISSN : 1410590x EISSN : 26140063 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Majalah Farmaseutic accepts submission concerning in particular fields such as pharmaceutics, pharmaceutical biology, pharmaceutical chemistry, pharmacology, and social pharmacy.

Arjuna Subject : -

Articles 488 Documents

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PIPER BETLE EXTRACT PATCH (Piper betle L): THE INFLUENCE IN ADDING REALESE ENHANCER SUBSTANCES TOWARDS PHYSIOCHEMICAL AND ANTIBACTERIAL ACTIVITY Mufrod Mufrod; Suwaldi Suwaldi; Subagus Wahyuono
Majalah Farmaseutik Vol 12, No 2 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Piper betle extract has an antibactery activity with eugenol as a major active substance its sparingly soluble in water. Piper betle extract mucoadhesive patch was a suitable form used in oral cavity for inhibiting Streptococcus mutans a bactery that caused plaque. Physicochemical properties and the release of active substance affect the acceptability of patch as well as antibacterial activity. Glycerin, propilen glycol and tween 80 are the substances(release enhancer substances/RES) that affect the flexibilty and release the active substance from patc. The aim of the research was to investigate the influance of the concentration of extract and addition of RES to the physicochemical and antibacterial activity of the patchs. Extract obtained by infusion method. Extract piper betle made based on variation concentration of extract 0,5%, 1%,2%,3% ,4% and adding release enhancer subtances glycerin, propilen glycol and tween 80. Patches produced tested for physicochemical properties including uniformity of weight, surface pH, folding endurance, swelling index and antibactery activity. Data obtained were descriptiv and statisticaly analize. The result showed that release enhancer substances affect the physicochemical properties and antibactery activity of the patches. The adding release enhancer substances increasing the value of folding endurance and swelling index and antibactery activity of patch.

OPTIMIZING FORMULA OF FAST DISINTEGRATING TABLET NATRIUM DICLOFENAC β-CYCLODEXTRIN INCLUSION COMPLEX WITH CROSPOVIDONE AS THE SUPERDISINTEGRANT AND MICROCRYSTALLINE CELLULOSE PH 102 AS THE FILLER BINDER Wahyu Irawan; T.N. Saifullah Sulaiman
Majalah Farmaseutik Vol 12, No 2 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Natrium diclofenac (Na-DCF) is one of non-steroidal anti-inflammatory drug (NSAID) that have a bitter taste. The inclusion complex of NaDCF with β-cyclodextrin (BSD) can be made to mask the unpleasant taste. The inclusion complex of natrium diclofenac-β-cyclodextrin (NaDCFBSD) was prepared by spray drying method in 1:1 molar ratio. NaDCF, BSD, and NaDCF-BSD inclution complex was characterized by Fourier Transform Infrared Spectroscopy (FTIR). NaDCF-BSD complex was formulated into Fast Disintegrating Tablet (FDT) by optimizing crospovidone as superdisintegrant and microcrystalline cellulose (MCC) PH 102 as filler binder. FDTs were made by direct compression method. A respond test of taste was conducted on the FDT of optimum formula. The optimum physical properties of FDTs were produced by formulating 5,79% crospovidone and 39,21% MCC PH 102. The respond test of taste results showed that FDT with NaDCF in inclution complex have a better taste than FDT with NaDCF without inclusion complex.

Effect of Andrographis paniculata (Burm.f) Ness Herbs and Gynura Procumbens (Merr) Leaves Extracts Combination in Free-Radical Scavenging Activity Kurnia Rahayu Purnomo Sari; Nofran Putra Pratama; Margaretha Kurniasari
Majalah Farmaseutik Vol 15 No 1, (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Development of medical plants as an alternative treatment needs support in terms of scientific evidence to increase public confidence in its efficacy and to ensure the safety of its use. Recent research on Andrographis paniculata (Burm.f) Ness dan Gynura procumbens (Lour.) Merr show that the combination of these two extracts has a potential to be developed into antihyperglycemic agent, through the mechanism of action as an antioxidant. The aim of this study was to evaluate the antioxidant effect of these two extracts combination. Extraction was done by maceration method. Testing of free radical capture activity was carried out by the DPPH method. The results of the antioxidant activity test showed that the combination of soluble ethanol extract of A. paniculata herbs and G. procumbens leaves 50:50 had the best IC50 value of 91.418 µg/mL, the combination of soluble ethanol extract 75:25 had IC50 value 117,059 µg/mL, and the combination combination of soluble ethanol extract 25:75 had the weakest IC50 of 142,277 µg/mL. The three comparisons of the combination were weaker in antioxidant activity compared to the standard vitamin C which had IC50 3,546 µg/mL. Statistical analysis using one-way ANOVA obtained significant differences in antioxidant activity of the three comparison groups.

Effect of Forms of Pharmaceutical Preparations on Antibacterial Activity of Red Betel Oil (Piper crocatum Ruiz & Pav.) Marchaban Marchaban; Anisa Ragil Handayani; Elsa Putri Kartika; Sudarsono Sudarsono
Majalah Farmaseutik Vol 15 No 1, (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The Red Sirih Essential Oil (RSEO) which be obtained from red betel leaf (Piper crocatum Ruiz & Pav.) by water and vapour distillation has potential as antibacterial activity. Formulation of an active pharmaceutical ingredient to become a pharmaceutical dosage form can generally modify their activity. The aim of the study is to proof the influence of dosage forms to the activity of RSEO. The study was done by formulating the RSEO to become emulsion, microemulsion and solubilisation dosage forms, and then, their antibacterial activity againt Escherichia coli ATCC 25922 by microdilution method of 1.25% using ELISA reader at 570 nm. The results showed that formulation reduced antibacterial activity. The raw RSEO had a Bacterial Growth Inhibition (BGI) of 66.59%, whereas microemulsion had 49.58%, emulsion had 17.45%, and solubilisation had 0% of BGI, that mean lost its antibacterial activity.

Antifungal Cream Preparation of Galangal Rhizome Extract (Alpinia galanga L.) Rety Setyawaty; Feriadi Feriadi; Dewanto Dewanto
Majalah Farmaseutik Vol 15 No 1, (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Cream is a semi-solid emulsion dosage form of both water-in-oil (W/O) or oil in water (O/W) type containing one or more dissolved or dispersed ingredients in the corresponding base material (containing no less than 60% water). Cream is usually used as emollient or containing active pharmaceutical ingredients on the skin (Ansel, 2008). The advantage of cream are the application practicallity, water washeability, and the easiness to spread evenly. In this research, we formulated cream containing rhizome Galangal rhizome. According to Darmono (2008), Galangal rhizome has various properties such as antifungal and antibacterial activities. Galangal rhizome contains 1-asetoksikhavikol asetat (ACA). ACA is an antifungal. ACA has good solubility in 70% ethanol. We maserated Galangal rhizome (Alpinia galangal L.) to extract ACA from the simplicia. As for the cream base, we use hidrophilic base containing emulgators stearic acid and triethanolamine, with glycerin as humectant. During the optimization, we chose three formulas, formula 1 (10% stearic acid , 2% triethanolamin, 5% glycerin, and 0.01% vitamin E), formula 2 (15% stearic acid , 3% triethanolamin, 10% glycerin, and 0.05% vitamin E), and formula 3 (20% stearic acid, 4% triethanolamin, 7.5% glycerin, and 0.09% vitamin E). We used the bases to contain 10% of the extract. The results show that formula 1, formula 2, and formula 3 had typical smell of Galangal rhizome, brown color, and thick consistency. All formulas are homogenous. Formula 1 the best stability. We conclude that Galangal rhizome (Alpinia galanga L.) can be formulated in cream form with our formula 1 had the best stability among others.

Evaluation of Peptic Ulcer Medication Use in Patients with Peptic Ulcer at Inpatient Installation RSUD Sultan Syarif Mohamad Alkadrie Novi Yana Santika; Rise Desnita; Muhammad Akib Yuswar
Majalah Farmaseutik Vol 15 No 1, (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Peptic ulcer is an upper gastrointestinal tract disease caused by hypersecretion of acids and pepsin of gastric mucosa. Peptic ulcer disease can be caused by several factors such as smoking, fast food, alcoholic beverages, NSAIDs and Helycobacter pylori. The purpose of this research was to obtain the distribution of antiulcer and itsrationality on peptic ulcer inpatients at the RSUD Sultan Syarif Mohamad Alkadrie Pontianak. This study is a descriptive observational study with cross sectional design. Data from medical record collected retrospectively. This research using medical record peptic ulcer inpatients from January to December in 2017. The samples used were 34 of 44 patients who met the inclusion criteria. Based on results, the distribution of anti ulcer were omeprazole (2.94%), pantoprazole (73.53%), lansoprazole (26.47%), ranitidine 5.89%, 58.82% antacids and 85.29% sucralfat. The result of rationality evaluation on criteriaof appropriate indication (100%);appropriate drug (55.88%); appropriate patient (97.06%); and appropriate (61.76%). Overall,the rationality of treatment that meets all four rational treatment criterias was 78.68%.

Formulation of Orally Disintegrating Tablet from Nifedipin-β-siklodekstrin Inclusion Complex using Kneading Method Nur Aini Purnamasari; Pratama Anggi Saputra
Majalah Farmaseutik Vol 15 No 1, (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Nifedipine is widely used for managing hypertension. The challenges of developing nifedipine oral preparation are its low solubility and unpleasant taste. The purpose of developing the Oral Disintegrating Tablet (ODT) dosage form from the Nifedipine-β-cyclodextrin inclusion complex is to increase the solubility of nifedipine and mask the unpleasant taste of the drug. Specific target: use of a superdisintegrant combination to increase the solubility of nifedipine and mask the bitter taste. The method used in the formation of Nifedipine inclusion complex with β-cyclodextrin was kneading method. Making ODT was done by direct pressing method. Characterization of nifedipine-β-cyclodextrin inclusion complex was analyzed by FTIR and DSC. ODT was tested for the physical properties of the tablet and its solution. Test results for ODT physical properties were analyzed and compared with the literature. Data obtained from the dissolution test results calculated the concentration of the active substance dissolved at 20 minutes (Q20). The results showed that the formation of the Nifedipine-β-cyclodextrin inclusion complex increased solubility and masked the bitter taste. The combination of superdisintegrant Ac-Di-Sol-Crosspovidon accelerated the disintegration and dissolution time and improve the taste of Nifedipine ODT.

Pembuatan Sediaan Tabir Surya Ekstrak Etanol Buah Mahkota Dewa (Phaleria macrocarpa), Aktivitas Inhibisi Fotodegradasi Tirosin dan Kandungan Fenolik Totalnya Tatang Irianti; T. N. Syaifullah Sulaiman; Nanang Fakhrudin; Siluh Astuti; Nita Testikawati; Sofa Farida; Sari Rosiati Nur Khasanah
Majalah Farmaseutik Vol 15, No 2 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Senyawa fenolik mempunyai potensi sebagai fotoprotektor, sehingga mampu melindungi kulit dari kerusakan oksidatif terutama menyerap Ultra Violet dari pancaran sinar matahari. Ekstrak etanolik buah masak mahkota dewa [Phaleria macrocarpa (Scheff) Boerl.] mengandung senyawa fenolik dan memiliki peranan sebagai fotoprotektor. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak etanolik buah mahkota dewa sebagai fotoprotektor dalam sediaan tabir surya dan oksibenson sebagai pembanding. Aktivitas fotoprotektor ditentukan dari tingkat fotodegradasi tirosin dan kadar fenolik totalnya, kemudian penelitian ini dilakukan dengan 8 formula; formula 1 sebagai kontrol negatif (basis); formula 2 sebagai kontrol positif (basis dan oksibenson); formula 3, formula 4, dan formula 5 mengandung ekstrak etanolik buah mahkota dewa dengan berbagai konsentrasi; formula 6, formula 7, dan formula 8 mengandung oksibenson dan ekstrak etanolik buah mahkota dewa dengan berbagai konsentrasi. Penentuan kemampuan fotoproteksi berdasarkan persen transmisi eritema dan persen transmisi pigmentasi. Uji inhibisi fotodegradasi dilakukan dengan menggunakan enam kelompok komposisi tirosin dan Rhetoflam. Uji penentuan kadar fenolik total dilakukan menggunakan metode Follin-Ciocalteu. Hasil pengukuran diintrapolasikan ke dalam kurva baku asam galat. Ekstrak etanolik buah mahkota dewa dalam sediaan tabir surya memberikan nilai Te sebesar 17,86-37,01 % dan nilai Tp sebesar 12,07-22,64 %. Efektivitas fotoproteksi ekstrak etanolik buah mahkota dewa lebih kecil dibandingkan oksibenson yang memiliki nilai Te sebesar 1,15.10-5 % dan Tp sebesar 0,67 %. Kombinasi ekstrak etanolik buah mahkota dewa dan oksibenson memberikan nilai Te sebesar 0,17-0,52 % dan nilai Tp sebesar 2,10-4,48 %. Sedangkan kandungan fenolik total ekstrak buah mahkota dewa adalah sebesar 8,29 ± 0,27 % dengan aktivitas penghambatan fotodegradasi tirosin 1,58 kali lebih besar dibandingkan dengan vitamin C pada kadar yang sama, yaitu 0,15%. Hal ini menunjukkan bahwa ekstrak etanolik buah mahkota dewa dapat dimanfaatkan sebagai bahan 4aktif fotoprotektor dalam sediaan kosmetik.

Desain Sistem Pelayanan Resep Rawat Jalan RSUD Blambangan Melalui Pendekatan User Centered Hariaty Octavia; Susi Ari Kristina; Eko Nugroho
Majalah Farmaseutik Vol 15, No 2 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Pelayanan resep rawat jalan meliputi kegiatan administratif dan kegiatan pelayanan farmasi klinik. Kebutuhan pengguna dalam pelayanan resep rawat belum sepenuhnya didukung oleh Hospital Pharmacy Information System (HPIS), sehingga perlu dilakukan desain sistem pelayanan resep rawat jalan di RSUD Blambangan menggunakan pendekatan user centered. Penelitian ini bertujuan membuat desain sistem pelayanan resep rawat jalan di RSUD Blambangan melalui pendekatan user centered yaitu berdasarkan kebutuhan pengguna di instalasi farmasi. Penelitian ini merupakan rancangan deskriptif yaitu analisis kebutuhan pengguna menggunakan metode focus group discussion (FGD) dan telaah dokumen. Subyek penelitian ini berjumlah 24 otang yang terdiri dari 9 orang apoteker, 13 orang tenaga teknis kefarmasian (TTK), dan 2 orang tenaga administrasi. Kebutuhan data dalam pelayanan resep rawat jalan meliputi data pasien, data obat, data admisi, data pemeriksaan fisik, data pemeriksaan klinis, data pemeriksaan laboratorium, dan data pelayanan resep yang selanjutnya dikelompokkan dalam kebutuhan data skrining resep, labeling, dan penyerahan obat. Desain sistem pelayanan resep rawat jalan yang dibuat merupakan desain dalam bentuk data flow diagram (DFD). Kesimpulan penelitian ini adalah perlu dibuat desain model lanjutan pelayanan resep rawat jalan yaitu entity relationship diagram (ERD), data dictionary, dan system flowchart.

Pengukuran Kualitas Hidup Pasien Program Pengelolaan Penyakit Kronis (Prolanis) di Puskesmas Menggunakan Instrumen EQ-5D-5L Nur Hamida; Mursyida Ulfa; Restu Nur Hasanah Haris; Dwi Endarti; Chairun Wiedyaningsih
Majalah Farmaseutik Vol 15, No 2 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Prevalensi penyakit diabetes melitus (DM) dan hipertensi di Indonesia semakin tahun semakin meningkat. Pemerintah melalui Badan Penyelenggara Jaminan Sosial (BPJS) mencanangkan Program Pengelolaan Penyakit Kronis (Prolanis) untuk mencapai kesehatan yang optimal dan kualitas hidup yang baik pada penyakit DM dan hipertensi. Studi ini bertujuan untuk mengukur kualitas hidup pasien prolanis di puskesmas menggunakan instrumen EQ-5D-5L. Studi dilakukan pada 200 pasien prolanis yang terdiri dari 100 pasien diabetes melitus dan 100 pasien hipertensi. Lokasi pengambilan sampel berada di puskesmas Kota Palu Provinsi Sulawesi Tengah untuk pasien DM dan Kabupaten Aceh Barat Provinsi Nangroe Aceh Darussalam untuk pasien hipertensi yang dilakukan dalam kurun waktu 3 bulan (September-November 2018). Penelitian menggunakan rancangan cross-sectional study dengan metode convenience/accidental sampling. Kualitas hidup diukur menggunakan instrumen European Quality of Life-5 Dimension-5 Level (EQ-5D-5L) dan konversi health utility (utility) dengan value set Indonesia. Analisis data menggunakan uji independent t-test untuk melihat perbedaan kualitas hidup pada tiap kelompok karakteristik pasien DM dan hipertensi. Hasil penelitian menunjukkan domain rasa sakit/tidak nyaman merupakan domain yang paling banyak dilaporkan terjadi masalah pada pasien DM maupun Hipertensi. Nilai utility pasien DM sebesar 0,843±0,081, sedangkan hipertensi sebesar 0,767±0,154. Terdapat perbedaan signifikan nilai utility berdasarkan karakteristik umur (p=0,001), riwayat penyakit keluarga (p=0,006), lama menderita penyakit (p=0,000) dan frekuensi kontrol (p=0,000) pada pasien hipertensi, sedangkan pada pasien DM hanya pada karakteristik memiliki penyakit lain (p=0,026).

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