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INDONESIA
Indonesian Journal of Obstetrics & Gynecology Science
Published by Universitas Padjadjaran
ISSN : 2615496X     EISSN : 2615496X     DOI : -
Core Subject : Health,
Health Professions Public Health
OBGYNIA (Indonesian Journal of Obstetrics & Gynecology Science ) adalah jurnal dalam bidang ilmu Obstetri & Ginekologi yang diterbitkan resmi oleh Departemen Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran. OBGYNIA menerbitkan artikel penelitian tentang kemajuan ilmiah, manajemen klinis pasien, teknik bedah, kemajuan pengobatan dan evaluasi pelayanan, manajemen serta pengobatan dalam bidang obstetri & ginekologi.
Arjuna Subject : -
Articles 394 Documents
 18   19   20   21   22 
Correlation of Leucine-Rich-α-2-Glycoprotein- 1 (LRG-1) Level in Urine with Cervical Cancer Stage, Histology Type and Histology Grading Prilly Astari; Syahrul Rauf; Elizabet C. Jusuf; St. Maisuri T Chalid; Sharvianty Arifuddin; Retno B Farid
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.489

Abstract

Objective: To determine if the level of LRG-1 in urine correlates with cervical cancer stage, histology type and histology gradingMethod: This cross-sectional study using ELISA to test urinary LRG-1 of 59 cervical cancer patients. Data were analyzed using Kruskal-Wallis test.Results: From the total of 59 samples, LRG-1 in urine ranged from 0.48 ng/mL to 170.43 ng/mL, with median value 58.42 ng/mL. A median value of 21.42±52.29 ng/mL was found in the urine at early stage and 115.32±59.36 ng/mL at advanced stage. Most patients had cervical cancer at advanced stage (69.4%), squamous cell carcinoma (66.1%), and grade cannot be assessed (45.8%). Median LRG-1 levels were highest in squamous cell carcinoma (66.42±60.89 ng/mL) and poorly differentiated (127.74 ±54.13 ng/mL). LRG-1 levels were significantly correlated with cervical cancer stage (p-value=0.045) but not histological type (p-value=0.940) or histopathological grade (p-value=0.488).Conclusion: The more advanced the cervical cancer stage, the more elevated urinary LRG-1 levels. LRG-1 contributes to angiogenesis and antiapoptotic processes in cancer. Further studies are required to identify and evaluate LRG-1 in urine as an important biomarker for making clinical decisions and developing potential treatments.Hubungan Kadar Protein Leucine-Rich-α-2-Glycoprotein-1 (LRG-1) Urine dengan Stadium, Tipe Histologis, dan Derajat Diferensiasi Kanker ServiksAbstrakTujuan: Untuk mengetahui hubungan kadar LRG-1 dalam urine dengan stadium, tipe histologis, dan derajat diferensiasi kanker serviks.Metode: Studi ini menggunakan desain penelitian cross-sectional pada 59 perempuan yang telah didiagnosis kanker serviks, kemudian diperiksa kadar protein LRG-1 dalam urine dengan metode ELISA. Uji statistik menggunakan Kruskal Wallis. Hasil: Dari total 59 sampel didapatkan kadar LRG-1 dalam urine terendah 0,48 ng/mL dan tertinggi 170,43 ng/mL, nilai median 58,42 ng/mL. Nilai median pada stadium awal 21,42±52,29 ng/mL dan stadium lanjut 115,32±59,36 ng/mL. Lebih banyak penderita mengalami kanker serviks pada stadium lanjut (69,4%), tipe histopatologis Squamous Cell Carcinoma (66,1%), derajat diferensiasi tidak dapat ditentukan (45,8%). Median tertinggi kadar LRG-1 pada tipe Squamous Cell Carcinoma (66,42±60,89 ng/mL), dan derajat diferensiasi yang buruk (127,74±54,13 ng/mL). Terdapat hubungan yang signifikan antara kadar LRG-1 dan stadium kanker serviks (nilai p = 0,045), tetapi tidak dengan tipe histologis (nilai p=0,940) dan derajat diferensiasi (nilai p=0,488).Kesimpulan: Semakin tinggi stadium maka semakin tinggi kadar protein LRG-1 dalam urine. LRG-1 berperan dalam proses angiogenesis dan antiapoptosis pada kanker. Diperlukan penelitian lebih lanjut agar identifikasi dan evaluasi biomarker LRG-1 urine dapat menjadi penanda penting yang membantu dalam pengambilan keputusan klinis, serta pengembangan terapi.Kata Kunci: Derajat diferensiasi, Kanker serviks, LRG-1, Stadium, Tipe histologis
COVID-19 Infection in Pregnancy Increases Length of Hospitalization and Need for Postpartum Intermediate Care Slamet Susanto; Zulvayanti Zulvayanti; Windi Nurdiawan; Djamhoer Martaadisoebrata; Hadi Susiarno
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.528

Abstract

Objective: To find the prevalence and the outcomes of pregnant women with COVID-19 infection. Method: This was a cross-sectional study. The subjects were selected by total sampling. All pregnant women with COVID-19 infection and without COVID-19 infection who gave birth at Harapan Mulia Hospital from June 1, 2020 to August 31, 2021 with complete medical record data were recruited.Results: The average age of the patients with COVID-19 was 29.10 ± 7.325 years and the average age of the patients without COVID-19 was 29.24 ± 7.021 years. The average gestational age of pregnant women with COVID-19 was 37.52 ± 1.978 weeks and without COVID-19 was 38.14 ± 1.718 weeks. From the results of the statistical test of maternal outcomes, it was obtained that the P value for the length of hospitalization and type of treatment room after delivery was < 0.05, while the other variables were >0.05. For perinatal outcome analysis, from the results of statistical tests, it was obtained that P values for all variables were >0.05. Conclusion: There are differences in maternal outcomes and no differences in perinatal outcomes between pregnant women with COVID-19 and pregnant women without COVID-19 infection.Infeksi COVID-19 pada Kehamilan Meningkatkan Lama Rawat Inap dan Kebutuhan Ruang Intermediate Pasca PersalinanAbstrakTujuan: Mengetahui besarnya prevalensi dari ibu hamil dengan infeksi COVID-19 serta luarannya di RS Harapan Mulia BekasiMetode: analitik cross-sectionalHasil: Perbandingan demografi kelompok Ibu hamil dengan COVID-19, rata-rata usia pasien adalah 29,10 ± 7,325 tahun dan non COVID-19 29,24 ± 7,021 tahun. Rata-rata usia kehamilan ibu hamil dengan COVID-19 adalah 37,52 ± 1,978 minggu dan non COVID-19 adalah 38,14 ± 1,718 minggu. Dari hasil uji statistik luaran maternal, diperoleh nilai P pada lama perawatan dan jenis perawatan setelah persalinan lebih kecil dari 0,05 (nilai p < 0,05), sementara variabel lainnya lebih besar dari 0,05 (nilai p>0,05). Untuk analisis luaran perinatal, dari hasil uji statistik diperoleh nilai P pada semua variabel lebih besar dari 0,05 (nilai  >0,05). Kesimpulan: Terdapat perbedaan luaran maternal dan tidak didapatkan perbedaan luaran perinatal antara kelompok ibu hamil dengan COVID-19 dan non COVID-19.Kata kunci: infeksi COVID-19, luaran maternal, luaran perinatal
Hubungan antara Kisspeptin-10 dan Preeklamsia Berat Dwi Arry Wibowo; Nusratuddin Abdullah; Isharyah Sunarno; Andi Nursanty Padjalangi; Upik A. Miskad
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.487

Abstract

Tujuan: Menganalisis perbandingan ekspresi KISSPEPTIN-10 antara pasien tidak preeklamsia, preeklamsia berat, dan preeklamsia berat dengan komplikasi.Metode: Penelitian ini menggunakan desain kontrol kasus yang dilakukan pada ibu hamil preeklamsia berat dengan dan tanpa komplikasi sebagai kelompok kasus dan ibu hamil tidak preeklamsia berat sebagai kontrol di RSUP dr. Wahidin Sudirohusodo dan rumah sakit jejaring Fakultas Kedokteran Universitas Hasanuddin. Pengambilan sampel dilakukan dengan consecutive sampling. Kriteria inklusi yaitu ibu hamil dengan preeklamsia berat dan preeklamsia berat dengan komplikasi. Kriteria eksklusi yaitu pasien dengan hipertensi kronik, penyakit tiroid, dan penyakit ginjal sebelum kehamilan dan plasenta previa. Ekspresi KISSPEPTIN-10 diukur secara imunohistokimia dari plasenta saat melahirkan. Data dianalisis dengan uji chi square dan uji Kruskal Wallis. Data dianalisis dengan program SPSS.Hasil: Hasil ini diperoleh 88 subyek penelitian yang terdiri atas 30 pasien kelompok tidak preeklamsia, 30 pasien kelompok preeklamsia berat dan 28 pasien kelompok preeklamsia berat dengan komplikasi. Ekspresi KISSPEPTIN-10 berbeda signifikan antara kelompok tidak preeklamsia berat, preeklamsia berat, dan preeklamsia berat dengan komplikasi (p<0,05).Kesimpulan: Semakin tinggi ekspresi KISSPEPTIN-10 sejalan dengan semakin beratnya derajat preeklamsia berat. Relationship between Kisspeptin-10 and Severe PreeclampsiaAbstractObjective: To analyze the comparison of KISSPEPTIN-10 expression between severe preeclampsia and severe preeclampsia with complications.Method: This study used a case control design which was carried out in pregnant women with severe preeclampsia with and without complications as the case group and pregnant women without severe preeclampsia as a control at Dr. Wahidin Sudirohusodo and the Hasanuddin University Faculty of Medicine network hospital. Sampling was done by consecutive sampling. The inclusion criteria were pregnant women with severe preeclampsia and severe preeclampsia with complications. Exclusion criteria were patients with chronic hypertension, thyroid disease and kidney disease before pregnancy and placenta previa. KISSPEPTIN-10 expression was measured immunohistochemically from the placenta at delivery. Data were analyzed with the chi square test and the Kruskal Wallis test. Data were analyzed with the SPSS program.Results: This result founded 88 subjects consisting of 30 patients in the non-preeclampsia group, 30 patients in the severe preeclampsia group and 28 patients in the severe preeclampsia group with complications. KISSPEPTIN-10 expression differed significantly between groups without severe preeclampsia, severe preeclampsia and severe preeclampsia with complications (p<0.05). Conclusion: The higher the KISSPEPTIN-10 expression is in line with the more severe the degree of preeclampsia. Key words: Complications, KISSPEPTIN, Severe Preeclampsia
Karakteristik Karsinoma Ovarium Pra-Menopause dengan Kadar CA 125 ≤200 U/mL di RSUP Dr. Hasan Sadikin Bandung dari Tahun 2019–2021 Yudi Mulyana Hidayat; Eunike Febe Febriani; Ali Budi Harsono; Gatot N. A. Winarno; Andi Kurniadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.491

Abstract

Tujuan: Mendeskripsikan karakteristik karsinoma ovarium pra-menopause dengan kadar CA 125 ≤ 200 U/mL di RSUP Dr. Hasan Sadikin Bandung dari tahun 2019 sampai 2021.Metode: Penelitian deskriptif ini menggunakan metode total sampling dari data sekunder pasien kanker ovarium yang memenuhi kriteria inklusi dan memiliki variabel lengkap.Hasil: Penelitian yang melibatkan 32 sampel ini, menunjukkan nilai rata-rata CA 125 sebesar 82,63 U/mL dengan interval 3,3–194,8 U/mL. Mayoritas pasien berada pada rentang usia 40–49 tahun (40,6%), sudah menikah (87,5%), berprofesi sebagai ibu rumah tangga (81,3%), dan tinggal di Kawasan Pembangunan Bandung Raya (34,4%). Sebanyak 37,5% pasien adalah nullipara dan memiliki tipe histopatologis tumor epitel mucinous. Stadium tumor terbanyak adalah stadium I (56,3%). Kebanyakan pasien menjalani surgical staging komplit sebagai terapi penyakitnya (46,8%). Kesimpulan: Sebagian besar pasien karsinoma ovarium pra-menopause dengan kadar CA 125 ≤ 200 U/mL pada tahun 2019–2021 berada pada rentang usia 40–49 tahun, sudah menikah, bekerja sebagai ibu rumah tangga, dan berdomisili di Kawasan Pengembangan Bandung Raya. Kebanyakan pasien berstatus nullipara, memiliki tumor dengan tipe histopatologis epitel mucinous, dan terdiagnosis pada stadium I. Tipe pengobatan yang paling umum ditemui adalah surgical staging komplit.Characteristics of Pre-Menopausal Ovarian Carcinoma with CA 125 Level ≤ 200 U/mL in Dr. Hasan Sadikin General Hospital Bandung From 2019–2021Abstract Objective: To describe the characteristics of pre-menopausal ovarian carcinoma patients with CA 125 Level ≤ 200 U/mL in Dr. Hasan Sadikin General Hospital Bandung from 2019 until 2021.Method: This descriptive study used the total sampling method of secondary data on ovarian cancer patients that have met the inclusion criterias and have complete variables.Results: This study involving 32 samples showed the average level of CA 125 was 82,63 U/mL with the interval of 3,3 – 194,8 U/mL. Majority of the patients were in the age range of 40 – 49 years old (40,6%), has been married (87,5%), were housewifes (81,3%), and lived in Development Area of Bandung Raya (34,4%). About 37,5% patients were nullipara and had mucinous epithelial histopatology type of tumor. The most abundant tumor stage were stage I (56,3%). Most patients had undergoing complete surgical staging for their therapy (46,8%). Conclusion: Most of pre-menopausal ovarian carcinoma patients with CA 125 level ≤ 200 U/mL  in 2019–2021 were in the age range of 40 – 49 years old, has been married, had profession as housewifes, and domiciled in Development Area of Bandung Raya. Majority of patients were nullipara, had tumor with mucinous epithelial histopatology type, and were diagnosed at the stage I. The most found therapy were complete surgical staging.Key words: ovarian cancer, CA 125, cancer antigen 125, characteristic
Achondroplasia Berulang pada Orangtua dengan Perawakan Normal: Laporan Kasus Fatima Zahra; Adhi Pribadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.479

Abstract

Achondroplasia adalah penyebab paling umum dari perawakan pendek yang tidak proporsional. Individu yang terkena memiliki pemendekan rhizomelia pada anggota badan, makrosefali, dan fitur wajah yang khas. Diagnosis achondroplasia dapat ditegakkan dengan temuan klinis dan radiografi yang khas pada sebagian besar individu yang terkena. Identifikasi varian patogen heterozigot pada FGFR3 dapat membantu menegakkan diagnosis. Kejadian rekurensi achondroplasia pada orangtua dengan perawakan normal sangat jarang terjadi. Pada presentasi kasus ini, kami melaporkan achondroplasia berulang pada orangtua dengan perawakan normal, dengan ditemukan mutasi pada gen FGFR3.Recurrent Achondroplasia in Average Stature Parents : A Case ReportAbstractAchondroplasia is the most common cause of disproportionate short stature. Affected individuals have rhizomelic shortening of the limbs, macrocephaly, and characteristic facial features. Achondroplasia can be diagnosed by characteristic clinical and radiographic findings in most affected individuals. Identification of a heterozygous pathogenic variant in FGFR3 can establish the diagnosis. Recurrent achondroplasia in average stature parents is a very rare case. In this case presentation, we report recurrent achondroplasia in average stature parents with proven mutation of FGFR3 gene mutation.Keyword: recurrent achondroplasia, FGFR3 mutation
Faktor-Faktor Risiko dan Status Kecemasan Ibu dengan Kehamilan Tidak Diinginkan Hairunnisa, Hairunnisa; Tahir, Andi Mardiah; Lisal, Lenny M.; Sunarno, Isharyah; Chalid, St. Maisuri T.; Leonardy, Rudy B.
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.540

Abstract

Tujuan: Untuk mengetahui hubungan faktor-faktor risiko dan status kecemasan pada ibu dengan kehamilan tidak diinginkan.Metode: Metode  kasus kontrol terhadap 62 sampel perempuan dengan kehamilan tidak diinginkan di RSUP Dr. Wahidin Sudirohusodo, RSKDIA Fatimah, RSIA Sitti Khadijah 1, RSKDIA Pertiwi, RS Syekh Yusuf dan RSUD Lapalaloi periode Januari 2022–Juni 2022. Data diperoleh menggunakan kuesioner dan status kecemasan dihitung berdasarkan Hamilton  Anxiety Rating Scale.Hasil: Kehamilan tidak diinginkan dihubungkan dengan paritas (16.500; CI 95%=3.675–74.081; p=0,001), penghasilan (OR 3.818; CI 95% = 1.398–10.429; p=0.012), unmet needs (OR 4.444; CI 95% = 2.087–9.464; p=0.001) dan penggunaan kontrasepsi (OR 2.722; CI 95%=1.309–5.659; p=0.011).Kesimpulan: Faktor risiko multiparitas, penghasilan, status unmet need, dan penggunaan kontrasepsi berhubungan dengan tingkat kecemasan pada ibu dengan kehamilan tidak diinginkan.Risk Factors and Anxiety Status in Women with Unwanted PregnancyAbstract Objective: To determine the relationship between risk factors and anxiety status in women with unwanted pregnancies.Method: Case control method of 62 samples of women with unwanted pregnancies at Dr. Wahidin Sudirohusodo, RSKDIA Fatimah, RSIA Sitti Khadijah 1, RSKDIA Pertiwi, Syekh Yusuf Hospital and Lapalaloi Hospital for the period January 2022 - June 2022. Data were obtained using a questionnaire and anxiety status was calculated based on the Hamilton Anxiety Rating Scale.Results: Unwanted pregnancy was associated with parity (16,500; 95% CI = 3,675–74,081; p=0.001), income (OR 3,818; 95% CI = 1,398–10,429; p=0,012), unmet needs (OR 4,444; 95% CI = 2.087–9.464; p=0.001) and contraceptive use (OR 2.722; 95% CI=1.309–5.659; p=0.011).Conclusion: Multiparity risk factors, income, unmet need status and contraceptive use are associated with the level of anxiety in mothers with unwanted pregnancies.Key words: Unwanted Pregnancy, Anxiety, Risk Factors, Hamilton Anxiety Rating Scale
Leiomioma Uteri Besar pada Wanita dengan Grande Multipara dan Pasca-Menopause di Rumah Sakit Umum Daerah Ciamis : Sebuah Laporan Kasus Azhari, Fiqhul; Rasas, Budi Ahmad; Wibowo, Nanang
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.633

Abstract

Pendahuluan: Leiomyoma uteri, merupakan neoplasma jinak yang berasal dari otot rahim. Leiomyoma uteri biasanya tumbuh selama usia 30 - 50 tahun, dan kemudian stabil atau menurun setelah menopause. Namun, terdapat beberapa laporan mengenai sejumlah besar pasien yang telah menjalani operasi leiomyoma uteri selama periode pasca-menopause.Presentasi Kasus: Kami melaporkan kasus wanita dengan grande multipara berusia 58 tahun dan pasca-menopause dengan keluhan utama perut terasa membesar sejak 1 tahun. Pasien termasuk kedalam kategori obesitas tipe 2 dengan pemeriksaan tanda vital dalam batas normal dan Pemeriksaan abdomen di dapatkan massa yang mobile dengan ukuran uterus sebesar usia kehamilan 8 bulan yang terbentang di garis tengah tubuh area abdomen. Pada pemeriksaan USG di temukan adanya massa hipoekoik pada uterus. Dilakukan tatalaksana operatif pada pasien dengan giant leiomyoma uteri dengan berat 5 kg tanpa keluhan kompresi yaitu potongan beku, dan total abdominal histerektomi dengan bilateral salpingo-oophorectomy. Hasil pemeriksaan patologi anatomi yaitu tumor jinak leiomyoma uteri intramural.Kesimpulan: Leiomioma sangat umum dan diasumsikan akan hilang seiring dengan di mulainya menopause. Penyebab terjadinya leiomyoma uteri di sebabkan karena interaksi berbagai variasi faktor risiko di antaranya usia, paritas, obesitas, merokok, hipertensi, diet, stress, riwayat kontrasepsi oral yang dapat menstimulasi peningkatan hormon estrogen dan progesterone yang meningkatkan pertumbuhan leiomyoma uteri secara definitif masih belum dapat di simpulkan.Giant Uterine Leiomyoma in Grand Multiparity and Post Menopause Woman at Ciamis Regional General Hospital : A Case ReportAbstractIntroduction: Leiomyoma Uterine, are benign neoplasms originating from the uterus. Uterine leiomyomas typically grow during the age 30 to 50 years of age, and then stabilize or regress after menopause. However, there have been several reports of a considerable number of patients who have undergone surgery for uterine leiomyomas during the postmenpause period. Case Presentation: We report the case of 58 year old female grand multiparity and post menopause with chief complaining of a fast expanding lump in her belly over the past year. Patient categorized a type two obesity, her vital sign was normal and during the abdominal examination a moveable mass that could have been an 8 month pregnancy was felt in the midline of the abdominal area. On ultrasound examination, it was found that there was a hypoechoic mass in uterine. A frozen section, a bilateral salpingo-oophorectomy, and total abdominal hysterectomy were performed for giant uterine leiomyoma weighing 5 kg without compression symptoms. The results of the histology suggested a benign intramural uterine leiomyoma. Conclusion: Leiomyomas are very common and the assumption that they will resolve with the onset of the menopause. The occurrence of uterine leiomyomas was the result of mutual interaction among various factors including age, parity, obesity, smoking, blood pressure, diet, stress, oral contraceptive but whether some of the risk factors can promote estrogen and progesterone to induce uterine leiomyomas has no definitive conclusion.Key words: Giant Leiomyoma; Post Menopause 
Front Cover, Editorial Team, Table of Contents, and Back Cover Jurnal, Obgynia
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 2 Juli 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i2.736

Abstract

Front Cover, Editorial Team, Table of Contents, and Back Cover Jurnal, Obgynia
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.601

Abstract

Providing Antioxidants to Reduce Symptoms of Endometriosis Related Pain: Systematic Review Nurwany, Raissa; Alfarobi, Muhammad Farhan; Alkaf, Syifa
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 2 Juli 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i2.626

Abstract

Introduction: Approximately 10 - 15% of women in their reproductive age experience endometriosis. Endometriosis is defined by chronic discomfort and pain, specifically dysmenorrhea, dyspareunia, and dyschezia. A recent study has provided insight into the involvement of oxidative stress in the progression of endometriosis. Oxidative stress refers to an imbalance between reactive oxygen species (ROS) and antioxidants, resulting in inflammation within the peritoneal cavity. This comprehensive analysis examined the efficacy of antioxidant administration and its impact on pain symptoms associated with endometriosis. Method: This study reviewed literature by searching the PubMed, ScienceDirect, and Cochran Library databases. The search query included “endometriosis” and “antioxidant.” The study was reviewed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards. The scope of analysis was restricted to clinical trials conducted exclusively from 2012 to 2023. Result: A total of 10 studies were incorporated, encompassing the utilisation of vitamin C and vitamin E, N-acetylcysteine, alpha-lipoic acid, bromelain, zinc, melatonin, and combination oral contraception. After administering antioxidants, the analysis of different groups consistently revealed a greater degree of improvement in dysmenorrhoea, dyspareunia, and chronic pelvic pain. Vitamin C, vitamin E, and N-acetylcysteine act as antioxidants and effectively decrease oxidative stress and the development of endometriosis discomfort. Conclusion: using antioxidants, including vitamin C and vitamin E, or N-acetylcysteine, has a beneficial effect in decreasing pain sensations associated with endometriosis.Pemberian Antioksidan untuk Mengurangi Gejala Nyeri Endometriosis: Sistematik ReviewAbstrakPendahuluan: Diperkirakan 10 - 15%wanita usia produktif di dunia mengalami endometriosis. Endometriosis ditandai dengan rasa tidak nyaman dan nyeri yang terus-menerus, meliputi dismenore, dyspareunia, dan disychezia serta menjadi salah satu penyebab infertilitas. Studi terbaru menjelaskan adanya peran stres oksidatif pada patofisiologi endometriosis yang didefinisikan sebagai ketidakseimbangan antara Reactive Oxygen Species (ROS) dan antioksidan yang menyebabkan respons inflamasi di rongga peritoneum. Systematic review ini membahas mengenai efektivitas pemberian antioksidan dan pengaruhnya terhadap gejala nyeri endometriosis. Metode: Pencarian literatur dilakukan pada database PubMed dan ScienceDirect, dan Cochrane Library Pencarian dilakukan menggunakan istilah “endometriosis” DAN “antioksidan”. Penulisan systematic review disesuaikan dengan pedoman professed reporting for systematic review and meta-analysis (PRISMA). Semua studi yang diinklusi merupakan clinical trials pada periode tahun 2012-2023. Hasil: Terdapat 10 penelitian yang disertakan, meliputi penelitian menggunakan vitamin C dan vitamin E, N-asetilsistein, asam alfa lipoat, bromelain, zinc, melatonin dan kontrasepsi oral kombinasi. Perbandingan antar kelompok secara umum menunjukkan perbaikan nyeri dismenorea, dispareunia, dan nyeri panggul kronis yang lebih baik setelah suplementasi antioksidan. Hal ini berkaitan dengan peran vitamin C, vitamin E, N-asetilsistein sebagai antioksidan yang dapat mengurangi stress okisdatif sebagai pathogenesis terjadinya nyeri endometriosis. Kesimpulan: Pemberian antioksidan secara umum terutama vitamin C, vitamin E, dan N-asetilsistein berkaitan dengan berkurangnya gejala nyeri pada endometriosis.kata kunci: Endometriosis; antioksidan; dismenorea; dispareunia; nyeri pelvik kronis

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