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All Journal The Indonesian Biomedical Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Sunarno, Isharyah
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Faktor-Faktor Risiko dan Status Kecemasan Ibu dengan Kehamilan Tidak Diinginkan Hairunnisa, Hairunnisa; Tahir, Andi Mardiah; Lisal, Lenny M.; Sunarno, Isharyah; Chalid, St. Maisuri T.; Leonardy, Rudy B.
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.540

Abstract

Tujuan: Untuk mengetahui hubungan faktor-faktor risiko dan status kecemasan pada ibu dengan kehamilan tidak diinginkan.Metode: Metode  kasus kontrol terhadap 62 sampel perempuan dengan kehamilan tidak diinginkan di RSUP Dr. Wahidin Sudirohusodo, RSKDIA Fatimah, RSIA Sitti Khadijah 1, RSKDIA Pertiwi, RS Syekh Yusuf dan RSUD Lapalaloi periode Januari 2022–Juni 2022. Data diperoleh menggunakan kuesioner dan status kecemasan dihitung berdasarkan Hamilton  Anxiety Rating Scale.Hasil: Kehamilan tidak diinginkan dihubungkan dengan paritas (16.500; CI 95%=3.675–74.081; p=0,001), penghasilan (OR 3.818; CI 95% = 1.398–10.429; p=0.012), unmet needs (OR 4.444; CI 95% = 2.087–9.464; p=0.001) dan penggunaan kontrasepsi (OR 2.722; CI 95%=1.309–5.659; p=0.011).Kesimpulan: Faktor risiko multiparitas, penghasilan, status unmet need, dan penggunaan kontrasepsi berhubungan dengan tingkat kecemasan pada ibu dengan kehamilan tidak diinginkan.Risk Factors and Anxiety Status in Women with Unwanted PregnancyAbstract Objective: To determine the relationship between risk factors and anxiety status in women with unwanted pregnancies.Method: Case control method of 62 samples of women with unwanted pregnancies at Dr. Wahidin Sudirohusodo, RSKDIA Fatimah, RSIA Sitti Khadijah 1, RSKDIA Pertiwi, Syekh Yusuf Hospital and Lapalaloi Hospital for the period January 2022 - June 2022. Data were obtained using a questionnaire and anxiety status was calculated based on the Hamilton Anxiety Rating Scale.Results: Unwanted pregnancy was associated with parity (16,500; 95% CI = 3,675–74,081; p=0.001), income (OR 3,818; 95% CI = 1,398–10,429; p=0,012), unmet needs (OR 4,444; 95% CI = 2.087–9.464; p=0.001) and contraceptive use (OR 2.722; 95% CI=1.309–5.659; p=0.011).Conclusion: Multiparity risk factors, income, unmet need status and contraceptive use are associated with the level of anxiety in mothers with unwanted pregnancies.Key words: Unwanted Pregnancy, Anxiety, Risk Factors, Hamilton Anxiety Rating Scale
Hubungan antara Kadar Hepsidin dan Kadar Hemoglobin pada Kehamilan dengan Obesitas Ratnaningsih, Andi Sri; Sunarno, Isharyah; Madya, Fatmawati; Hamid, Firdaus; Irianta, Trika; Susiawaty, Susiawaty
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.583

Abstract

Tujuan: Untuk menilai kadar Hepsidin dan kadar hemoglobin menggunakan sampel darah dan selanjutnya dianalisis dengan metode ELISA.Metode: Penelitian ini merupakan kohort prospektif pada perempuan hamil dengan obesitas dan pembanding non-obesitas pada trimester pertama dan kedua di RSUP Dr. Wahidin Sudirohusodo dan Rumah Sakit Pendidikan Jejaring pada periode Januari - Agustus 2022.Hasil: Penelitian dilakukan terhadap 44 sampel yang terdiri atas 22 sampel kelompok ibu hamil dengan obesitas dan 22 sampel ibu hamil dengan IMT normal. Pada pasien obesitas tidak didapatkan korelasi antara kadar Hepsidin dan kadar hemoglobin di trimester pertama dengan nilai p=0.097 sedangkan pada trimester kedua terdapat korelasi dengan nilai p=0.028. Pada pasien non obesitas tidak didapatkan korelasi antara kadar Hepsidin dengan kadar hemoglobin nilai p=0.489 di trimester pertama dan nilai p=0.906 di trimester kedua.Kesimpulan: Peningkatan kadar Hepsidin dan anemia dapat ditemukan pada wanita obese yang sedang hamil, terutama pada trimester kedua.The Relationship Between Hepcidin Levels And Hemoglobin Levels In Pregnancy With ObesityAbstract Objective: To compare hepcidin levels and hemoglobin levels using blood samples and further analyzed with ELISA method.Method: This study is a prospective cohort of obese pregnant women and a non-obese comparator in the first and second trimesters at RSUP Dr. Wahidin Sudirohusodo Hospital and Networking Teaching Hospitals in the period January - August 2022.Results: The study was conducted on 44 samples consisting of 22 samples of obese pregnant women and 22 samples of pregnant women with normal BMI. In obese sample, there was no correlation between hepcidin levels and hemoglobin levels in the first trimester with a value of p=0.097 while in the second trimester there was a correlation with a value of p=0.028. In non-obese patients, there was no correlation between hepcidin levels and hemoglobin levels, p = 0.489 in the first trimester and p= 0.906 in the second trimester.Conclusion: Increased hepcidin levels and anemia can be found in obese women in the second trimester of pregnancy.Key words: Hepcidin, Obesity, Hemoglobin
Hubungan Antara Neutrophil Gelatinase Associated Lipocaline (NGAL) dan Kejadian Preeklamsia: Penelitian Potong-Lintang Koesuma, Edward Chandra; Lukas, Efendi; Tahir, Mardiah; Sunarno, Isharyah; Jusuf, Elizabet C; Abidin, Nuraini
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.567

Abstract

Tujuan: Untuk mengetahui hubungan antara kadar Neutrophil Gelatinase Associated Lipocaline (NGAL) pada kehamilan normal, Preeklamsia Berat (PEB) tanpa Komplikasi, dan PEB dengan Komplikasi.Metode:Desain penelitian cross sectional dilakukan pada ibu hamil dengan usia kehamilan lebih dari 20 minggu di RSUP Dr. Wahidin Sudirohusodo dan rumah sakit jejaring pendidikan lainnya sejak bulan Januari hingga Juni tahun 2022. Data dikumpulkan menggunakan sampel darah dan diperiksa lebih lanjut dengan metode ELISA. Uji Chi-Square digunakan untuk menganalisis hubungan antara kadar NGAL dan derajat keparahan PEB.Hasil: Pada penelitian ini mencakup 156 sampel, yang terdiri atas wanita hamil normal (n=53), wanita hamil dengan PEB tanpa komplikasi (n=50), dan wanita hamil dengan PEB dan komplikasi (n=53). Penelitian ini menemukan bahwa semakin  berat derajat preeklamsia, maka  semakin rendah kadar NGAL-nya yaitu kadar NGAL diamati pada 58% wanita PEB dengan komplikasi dan 32,1% wanita PEB tanpa komplikasi dan 9,8% pada kehamilan normal (p <0,05). Hasil penelitian ini  tidak sesuai dengan teori yang menemukan peningkatan kadar NGAL pada pasien PEB. Penurunan kadar NGAL ini mungkin dapat disebabkan oleh prevalensi obesitas yang banyak pada kelompok PEB dengan dan tanpa komplikasi. Obesitas merupakan  kondisi inflamasi sistemik dan NGAL dapat bertindak sebagai regulator negatif terhadap aktivitas inflamasi yang dimediasi oleh disfungsi adiposit. Pada kelompok PEB juga didapatkan pemberian MgSO4, yang  memiliki peran untuk menghambat kadar IL-6 sehingga dapat menurunkan kadar NGALKesimpulan: Penurunan kadar NGAL berpotensi untuk menjadi biomarker dalam menilai derajat keparahan preeklamsia.Correlation Between Neutrophil Gelatinase Associated Lipocaline (NGAL) and Preeclampsia: A Cross-sectional StudyAbstract    Objective: to observe the correlation between level of Neutrophil Gelatinase Associated Lipocaline (NGAL) on normal pregnancy, severe preeclampsia (SPE) without complication, & SPE with complication. Method: Cross-sectional Study Design method is performed on pregnant women with gestational age of more than 20 weeks at Dr. Wahidin Sudirohusodo hospital & the other educational networking hospitals from January to June 2022. Data were collected using blood samples & further examined with ELISA method. Chi-Square test   is used to analyze the correlation between NGAL level & degree of severity of the severe preeclampsia.Results: this study includes 156 samples consisting of normal pregnant women (n=53), pregnant women with SPE without complication (n= 50), & pregnant women with SPE with complication (n= 53), we found out that the more severe the degree of preeclampsia, the lower the level of NGAL where the level of NGAL is observed on 58% of pregnant women with complication & 32.1% pregnant women without complication, & 9.8% on women with normal pregnancy (p<0.05). This study result is irrelevant with the theory which  found the rising level of NGAL on patients with SPE, this decreasing level of NGAL might be caused by obesity prevalence mostly found on pregnant with & without complication since obesity is a systemic  inflammatory condition & NGAL can act as negative regulator against inflammatory activity mediated by adipocyte disfunction. On SPE group there is also MgSO4 administration functioning as a hindrance for IL6 level thus may lessen the NGAL level.Conclusion: the decreasing level of NGAL  is potential to become a biomarker in evaluating the severity of preeclampsia.Key words: degree of severity, Neutrophil Gelatinase Associated Lipocaline, preeclampsia
An internal iliac artery ligation technique for bleeding control in the placenta accreta spectrum disorder Riu, Deviana Soraya; Sunarno, Isharyah; Pelupessy, Nugraha; Bakri, Syarif; Muchtar, Faisal; Andi Adil; Muhiddin, Rachmawati
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 4 October 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i4.2134

Abstract

Objective: To assess the contribution of internal iliac artery ligation to bleeding control during surgery. Methods: This retrospective study used secondary data from medical records. All patients diagnosed with PASD from January 2019 – to December 2022 were included in this study. Participants were grouped based on operation technique, and the blood loss and operative duration were evaluated. The tests used were the Kruskal-Wallis and the Mann-Whitney U tests. Results: 108 PAS patients were discovered. The most age group was between 20-35 years with parity of more than or equal to 4, history of Cesarean section once, gestational age at termination 34-36 weeks, and maternal death in 7 out of 101 cases. There were 49 resections, 13 resections with internal iliac artery ligation, 34 hysterectomies, and 12 hysterectomies with internal iliac artery ligation. There was no difference in bleeding and operative duration between resection vs. resection with internal iliac artery ligation (p: 0.113; p: 0.639), hysterectomy vs. a hysterectomy with internal iliac artery ligation ((p:0.052; P:0.723), and resection with ligation vs hystetectomy with the internal iliac artery ligation (p:0.052; p:0.723). Bleeding and operative duration differed significantly between resection vs. hysterectomy (p:0.002; p:0.013). All patients underwent tourniquet placement. Conclusion An Internal iliac artery ligation was not shown to reduce bleeding in treating PASD. Keywords: accreta, internal iliac artery, placenta .
MCM6 rs4988235 Allele G, AGT rs699 Allele C, ACE rs4343 Allele A, FADS1 rs174547 Allele C, DCHR7 rs12785878 Allele G, and GC rs7041 Allele T: Candidate Genes for Preeclampsia Prevention Riu, Deviana Soraya; Sunarno, Isharyah; Lukas, Efendi
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3422

Abstract

BACKGROUND: Preeclampsia is the primary cause of maternal and neonatal morbidity and mortality; however, currently there is no definitive method exists to prevent preeclampsia. Recent findings indicate a possible genetic influence on preeclampsia. Therefore, this study was conducted to assess nutrigenomic patterns in preeclampsia as a potential mechanism for identifying appropriate preventive strategies through a nutrigenomic approach.METHODS: This descriptive study focused on 15 primiparous pregnant women diagnosed with preeclampsia. The nutrigenomic test was performed using DNA microarray method to examine variant genes associated with food response and nutrient metabolites. The genetic tendencies were categorized as "low," "average," and "high." The frequencies of alleles and probabilities were assessed for gene variants expressing "high" and "low" genotypic tendencies.RESULTS: The identified genetic variations were MCM6 rs4988235 allele G that indicated lactose intolerance (allele frequency 100%), AGT rs699 allele C and ACE rs4343 allele A that were associated with sodium metabolism (allele frequency 82% and 90%, respectively), as well as FADS1 rs174547 allele C that was pertained to omega metabolism (allele frequency 85%). Likewise, DCHR7 rs12785878 allele G and GC rs7041 allele T were relevant for vitamin D (allele frequencies 82% and 77%, respectively). However, MCM6 rs4988235 allele G, FADS1 rs174547 allele C, DCHR7 rs12785878 allele G, and GC rs7041 allele T had not been explicitly linked to preeclampsia.CONCLUSION: MCM6 rs4988235 allele G, AGT rs699 allele C, ACE rs4343 allele A, FADS1 rs174547 allele C, DCHR7 rs12785878 allele G, and GC rs7041 allele T are the dominant variant genes observed. The associations between preeclampsia and AGT rs699 allele C and ACE rs4343 allele A are consistent with other study.KEYWORDS: preeclampsia, nutrigenomics, nutrition metabolism
Co-Authors Abidin, Nuraini Andi Adil Andi Mardiah Tahir Efendi Lukas Hairunnisa Hairunnisa Hamid, Firdaus Jusuf, Elizabet C Koesuma, Edward Chandra Leonardy, Rudy B. Lisal, Lenny M. Madya, Fatmawati Muchtar, Faisal Muhiddin, Rachmawati Pelupessy, Nugraha Ratnaningsih, Andi Sri Riu, Deviana Soraya St. Maisuri T. Chalid Susiawaty, Susiawaty Syarif Bakri, Syarif Tahir, Mardiah Trika Irianta