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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Published by Perkumpulan Obstetri dan Ginekologi Indonesia
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 1,760 Documents
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Electroacustimulation is as Effective as B6 for Reducing Nausea and Vomiting in the First Trimester of Pregnancy Pamungkas, Novan S.
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To determine the benefit of electroacustimulation in reducing nausea and vomiting in the first trimester of pregnancy. Methods: This study is an experimental study. The subject were 40 pregnant women divided into 2 groups randomly. The control group was given vitamin B6 3x30 mg per day and the case given the electroacustimulation device. The degree of severity of nausea and vomiting of patients assessed before and 3 days after treatment using Pregnancy Unique Quantification of Emesis and Nausea (PUQE) questionnaire. Result: There were no differences between groups in gestational age at entry and PUQE score pre-treatment. After 3 days therapy, there were significant decrease in PUQE score in group receiving B6 (p=0.004) and also in electroacustimulation group (p=0.000). However, the change in PUQE score was not significantly different between the two groups (p=0.286). Conclusion: From the results of this study concluded that electroacustimulation is effective for reducing nausea and vomiting in the first trimester of pregnancy. There is no difference in effectiveness between electroacustimulation and vitamin B6 to treat nausea and vomiting in the first trimester of pregnancy. [Indones J Obstet Gynecol 2013; 37-2: 71-6] Keywords: electroacustimulation, nausea and vomiting in pregnancy, P6 or neiguan point, pregnancy unique quantification of emesis and nausea (PUQE)
Distribution of Regulatory T-Cell (Cd4+, Cd25+) in the Peritoneal Fluid of Endometriosis Patients Rusdi, Gazali
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 1, January 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objectives: To observe the distribution of Regulatory T-cell (CD4+, CD25+) in the peritoneal fluid of endometriosis patients, as related to the local immune system of the peritoneum. Method: A cross-sectional descriptive research Perioneal fluid was taken from endometriosis patients and non-endometriosis patients who underwent laparoscopic or laparotomy surgery at Raden Saleh Reproductive Health Clinic and Central Operating Theatre between June 2008 to March 2009. Total leukocyte and its differential count was counted manually. Regulatory T-cell was labelled with monoclonal antibodies for CD45 (PerCP-347464), CD4 (SIPC- 340133) dan CD25 (PE-341009) and counted by Flowcytometry (Facscalibur) using cellquest pro software. Data were collected and analyzed with SPSS ver 11 software. Result: Thirty-three patients were participated in this study, 12 non-endometriosis and 21 endometriosis patients were analyzed. 10 endometriosis patients were classified as minimal-mild, while 11 others were in moderate-severe stage. Higher median level of Regulatory T-cells were found in endometriosis patients (0.52%) compared to non-endometriosis cases (0.12%), even it was not significantly different (p 0.403). The median level of Regulatory T-cell in minimal-mild endometriosis (0.46%) was not significantly different with moderate severe endometriosis (0.52%) (p 0.981). Conclusion: The percentage and total number of Regulatory Tcell in the peritoneal fluid did not show significant difference between endometriosis and non-endometriosis patients. Endometriosis patients shows tendency of higher percentage and total number of Regulatory T-cell than non-endometriosis group. The stage of endometriosis apparently does not show any significant difference in terms of Regulatory T-cell in peritoneal fluid. [Indones J Obstet Gynecol 2010; 34-1:19-23] Keywords: Regulatory T-cells, CD4 CD 25, peritoneal fluid, endometriosis
Correlation between level of serum estrogen, c-telopeptide, and interleukin-6 in determining bone density in perimenopausal women Suparman, Eddy
Indonesian Journal of Obstetrics and Gynecology Volume. 34. No. 2, April 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To evaluate the role of estrogen as a menopausal biochemical marker to c-telopeptide (CTx) and IL-6 as a biochemical marker of mineral bone density in perimenopausal women. Method: This is an observational, cross-sectional study in perimenopausal women between 45 - 51 years old, who matched the inclusion and exclusion criteria such as no contraception was taken before, no specific disease that could affect the laboratory findings. Samples were taken from outpatients clinic of Prof Dr. R.D. Kandou hospital. The patients were gathered for blood samples collection. Blood samples were tested in laboratory. All data were collected and being processed statistically using Pearson correlation coefficient (SPSS version 16). Result: From 60 perimenopausal women (45 - 51 years old) sample, mean age was 47.98 ± 2.26 SD. Estrogen (estradiol) level: < 10 pg/ml, maximum 358 pg/ml, and mean 77.11 ± 86.2 SD. IL-6 level: minimum is 1.645 pg/ml, maximum 7.771 pg/ml, and mean 4.317 ± 2.112 SD. We found significant correlation between age and estrogen level (correlation level < 0.05) and CTx level (in level < 0.01). From regression curve, age has no significant correlation with IL-6 concentration. However, we found significant correlation between estradiol and CTx and IL-6 with respective correlation coefficient value of < 0.01. Likewise the correlation between CTx and IL- 6 showed significant statistically with the value of the correlation coefficient < 0,01. Conclusion: There is a significant correlation between estrogen, Il-6 and CTx. These variables play an important role in the occurrence of the physiological changes in the perimenopausal women. This study also showed the occurrence of a bone reabsorption process that was marked by the increase of CTx level in accordance with the increase in the age and the increase in the level of CTx together with the decline in the level of oestrogen. Therefore, prevention therapy of osteoporosis should begin in earlier age, before the further bone reabsorption take place. [Indones J Obstet Gynecol 2010; 34-2: 84-8] Keywords: c-telopeptide, bone mineral density, estrogen, interleukin- 6, perimenopause women
Tes Pap, Tes HPV dan Servikografi sebagai Pemeriksaan Triase untuk Tes IVA Positif: Upaya Tindak Lanjut Deteksi Dini Kanker Serviks pada Fasilitas Kesehatan dengan Sumber Daya Terbatas beserta Analisis Sederhana Efektivitas Biayanya OCVIYANTI, D.
Indonesian Journal of Obstetrics and Gynecology Volume. 31, No. 4, October 2007
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Tujuan: Memperoleh informasi tentang efektivitas pemeriksaan dalam bentuk Nilai Prediksi Positif dan Analisis Efektivitas Biaya tes Pap, tes HPV, servikografi dan gabungan dari dua atau tiga pemeriksaan tersebut sebagai pemeriksaan triase untuk tes IVA positif dalam upaya mendeteksi lesi prakanker serviks. Tempat: Poliklinik Obstetri dan Ginekologi Rumah Sakit dr. Cipto Mangunkusumo Jakarta. Rancangan/rumusan data: Selama kurun waktu penelitian yaitu antara bulan Januari 2005 hingga Januari 2006 poliklinik Obstetri dan Ginekologi Rumah Sakit dr. Cipto Mangunkusumo Jakarta menerima 130 orang perempuan dengan hasil tes IVA positif dan 1 orang dengan dugaan kanker serviks yang dirujuk dari 8 Puskesmas dan Klinik Bersalin di Jakarta Pusat dan Jakarta Timur. Empat belas orang bidan dari Puskesmas dan Klinik selama kurun waktu tersebut telah melakukan pemeriksaan terhadap 1250 perempuan sesuai kriteria inklusi yaitu berusia antara 25 hingga 45 tahun. Terhadap seluruh kasus yang dirujuk peneliti melakukan berturut-turut pengambilan sampel tes Pap, sampel tes HPV untuk pemeriksaan dengan metode Hybrid Capture 2, pemeriksaan servikografi dan dilanjutkan dengan kolposkopi. Bila didapatkan lesi epitel putih dilakukan biopsi-histopatologi. Data hasil pemeriksaan dianalisis untuk uji diagnostik dengan komputer menggunakan program Stata 7.0. Analisis efektivitas biaya dilakukan dengan menggunakan program Treeage@. Hasil: Pada penelitian ini didapatkan hasil tes IVA positif pada 130 perempuan (10,4%) dari 1250 perempuan usia 25-45 tahun yang diperiksa. Hasil pemeriksaan histopatologi menunjukkan hasil positif lesi prakanker pada 67 perempuan (persentasenya sekaligus menggambarkan Nilai Prediksi Positif dari pemeriksaan kolposkopi + biopsi pada kasus dengan tes IVA positif, yaitu: 51,5%). Prevalensi lesi prakanker serviks pada penelitian ini adalah 5,4% dengan prevalensi lesi derajat tinggi 0,2% yaitu sekitar 2% dari seluruh kasus IVA positif yang dirujuk. Satu kasus yang dirujuk dengan kanker serviks ternyata memang positif menderita kanker serviks stadium 3B. Seluruh kasus lesi derajat tinggi (3 kasus) adalah NIS2. Hasil Nilai Prediksi Positif yang sekaligus menggambarkan efektivitas masing-masing pemeriksaan sebagai triase pada tes tes IVA positif: tes Pap 82% (CI 95% 75%; 88%), tes HPV 58% (CI 95% 49%; 66%), servikografi 94% (CI 95% 90%; 98%), tes Pap+HPV 73% (CI 95% 64%; 79%), tes Pap+servikografi 86% (CI 95% 81%; 90%), tes HPV+servikografi 78% (CI 95% 72%; 84%), tes Pap+HPV+servikografi 77% (CI 95% 72%; 82%). Pemeriksaan triase yang lebih efektif biaya dibandingkan rujukan langsung tes IVA positif untuk kolposkopi apabila diasumsikan bahwa pasien dari dalam kota adalah servikografi, tes Pap dan gabungan tes Pap+servikografi, sedangkan bila diasumsikan pasien dari luar kota maka seluruh pemeriksaan triase yang diteliti terbukti lebih efektif biaya. Kesimpulan: Pemeriksaan triase dengan tes Pap, tes HPV dan servikografi maupun gabungannya dapat meningkatkan efektivitas pemeriksaan dan efektivitas biaya tes IVA dalam mendeteksi lesi prakanker serviks. [Maj Obstet Ginekol Indones 2007; 31-4: 201-11] Kata kunci: tes IVA, tes Pap, tes HPV, servikografi, pemeriksaan triase, analisis efektivitas biaya
Complication on Teenage Pregnancy and Related Factors Roesman, Nanda I.S.
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To evaluate related factors, which contribute to complication of teenage pregnancy. Method: A cross-sectional research by consecutive sampling method was held upon teenager who was having her first pregnancy or had just been having her first child. This research took place at dr. Zainoel Abidin Public Hospital, Banda Aceh, in period of June until November 2012. Result: By demographic characteristic, we obtained that the majority of complication of teenage pregnancy occur in the age range of 17-19 years old and most are within Sex maturation Rate grade 5. The most common complications are caesarean section, premature rupture of membranes and cephalo-pelvic disproportion. There is a significant relation between antenatal visit conducted in accordance with WHO criteria and economic level with the incidence of complication. Conclusion: We found significant relation between antenatal visit conducted in accordance with WHO criteria and economic level with the incidence of complication. [Indones J Obstet Gynecol 2014; 2-1: 10-12] Keywords: complications, teenage pregnancy.
A Real-time Optoelectronic Device in Screening of Precancerous Cervical Lesion Rahmadhany, Rizky; Indarti, Junita
Indonesian Journal of Obstetrics and Gynecology Volume. 3, no. 2, April 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (108.381 KB) | DOI: 10.32771/inajog.v3i2.38

Abstract

Objective: To obtain the diagnostic values of optoelectronic device for screening of precancerous cervical lesions. Method: We performed a diagnostic study with cross sectional design. Subjects were recruited from Dr. Cipto Mangunkusumo Hospital, from February until December 2013. Subjects were enrolled based on consecutive sampling until the minimum sample was achieved (60 samples). Result: During the study period, 60 patients were enrolled. Sensitivity, specificity, positive predictive value, and negative predictive value of the optoelectronic device were 76%, 95%, 96%, and 64%, respectively. We also investigated diagnostic values of other screening methods, namely citology and colposcopy. Sensitivity and specificity of liquid based cytology were 83% and 63% respectively. The combination of optoelectronic device and liquid based cytology increased the sensitivity to 92.8%. Meanwhile, sensitivity and specificity of colposcopy were 88% and 58%, respectively. Based on Altman criteria, kappa value for optoelectronic device with cytology was 0.35 (fair) and optoelectronic device with colposcopy was 0.45 (moderate). Conclusion: A real-time optoelectronic device might be used as an alternative method in early detection of precancerous cervical lesions, either as a single method or combined with liquid based cytology. Keywords: diagnostic values, optoelectronic device, precancerous cervical lesions
Chronic Pelvic Pain and Associated Clinical Characteristics among Women in a Tertiary Care Center in Indonesia Sumapradja, Kanadi; Chayadi, Thomas
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 3, July 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (107.895 KB) | DOI: 10.32771/inajog.v5i3.543

Abstract

Objective: To determine the prevalence and various aspects associated with female chronic pelvic pain. Methods: During the period of January to March 2016, a crosssectional study was conducted at the Women’s Health Clinic of Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Subjects were female who complained of pelvic pain for more than 6 months. We performed history taking, physical examination, and laboratory investigations including hs-CRP serum examination. We calculate the prevalence and describe the clinical characteristics and diagnosis of the patient. Quality of life and levels of hs-CRP were compared between the group of mild and severe pain. Results: In this study, the prevalence of CPP was 9.78%. We found 96.9% of gynecological disorders, 1% of urological disorders, and 2.1% of musculo-skeletal disorders. The most common diagnosis is endometriosis. The Clinical characteristics of patients were found 62.9% suffer for 6 months - 1 year with the intensity of pain (VAS) 7-10 as much as 51.5%. Levels of hs-CRP serum was around 1.99 (0.00 - 404, 53). We found a decreased in the quality of life of the patient. The physical domain score was 56 (38-81); the psychology domain score was 56 (31-100); the domain of social relationships was 59 (25-75); and the environmental domain score was 56 (31-94). Conclusion: Endometriosis is the most common diagnosis in female chronic pelvic pain of reproductive age. The pain causes a decreased in quality of life who suffer from it. [Indones J Obstet Gynecol 2017; 5-3: 154-159] Keywords: chronic pelvic pain, hs- CRP, intensity of pain, quality of life
Removing the uterus and both ovaries: pros and cons of hysterectomy and bilateral oophorectomy Baziad, Ali
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 3, July 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Removing the uterus and both ovaries, due to many reasons, are still performed at perimenopausal age and due to many reasons, uterus and ovaries removal are still performed at reproductive age. Hysterectomy with or without salphingooophorectomy is still the most common procedure performed not only in developing countries but also in developed countries. Among of all reasons the most frequent one is to improve the quality of life and prevent future malignancies if the uterus and both ovaries are not removed. Malignancies might probably occur although the incidence rate is very low. When both of the ovaries are removed, estrogen will decrease significantly, this will cause short and long term medical problems and decrease the quality of life. The incidence of coronary heart disease and fractures increases as estrogen decreases. A study performed by Parker et al with some of 10.000 women who underwent total hysterectomy and bilateral salphingooophorectomy at the age of 50 - 54 years old and did not receive HRT, shows that 838 died due to heart disease.1 Other studies reported cognitive disturbances among women who underwent bilateral salphingooophorectomy.2 Further more, the incidence of depression, anxiety and sexual disturbances is higher in women whose ovaries were removed compared to those who underwent natural menopausal state. If both ovaries were removed and then medical problems occured, the next question would be whether the clinician is willing to give HRT or whether the patient is willing to have HRT? In Indonesia, clinicians are afraid of giving HRT and patients are not willing to have HRT. Then what will happen to the patient? Symptomatic medication is then given. One of the reasons of removing both ovaries is to prevent the occurence malignancies of ovary and breast. HRT will increase the incidence of breast cancer. If it is so, then the patient is at the point of no return. If the uterus is removed, will medical problems happen? Yes, there are papillary thyroid cancer found in women whose uterus were removed.3 It shows that uterus also plays important role in controlling thyroid glands. Levi et al. reported an increased risk of epithelial thyroid cancer in women with artificial menopause (OR 6.3%, 95% CI: 1.7 - 23.2).4 Several studies in Europe and USA concluded that hysterectomy will increase the risk of thyroid cancer.5,6 Estrogen indirectly takes part in controlling the release of HRT, if there is no estrogen then HRT release will increase and trigger the growth of thyroid tumor.3 Myometrium and endometrium also have the ability to produce thyroid hormone. The level of iodothyronine deodinase enzyme is high in myometrium and endometrium, especially during pregnancy.7,8 There are 2 types of deodinase enzyme, type 2 and type 3. D2 enzyme transforms T4 to active T3, while D3 transforms T4 to inactive T3.7,8 If uterus is removed, the T3 will decrease and HRT release will be uncontrolled. Estrogen only (+ progesterone) will increase D2 enzyme activity while estrogen + progesterone will increase D3 activity.9 It shows that estrogen plays more important role in increasing D2 enzyme activity. If there is no uterus, then there is no D2 enzyme available. Uterus also has the ability to syntezise prostacycline. Prostacycline has vasodilatation effect, increasing the blood flow to the heart. Women without uterus will have an increased risk of heart disease. Removing the uterus has to be considered carefully. The incidence of malignancies as a consequence of conserving the uterus is lower compared to the adverse effect due to hysterectomy and bilateral salphingooophorectomy. Further study is needed in Indonesia to evaluate the consequences of hysterectomy and bilateral salphingooophorectomy towards thyroid cancer and quality of life in the future.
Prognostic value of p53 gene in ovarian cancer RAUF, S.; MASADAH, R.
Indonesian Journal of Obstetrics and Gynecology Volume. 32, No. 3, July 2008
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (70.159 KB)

Abstract

Tujuan: Mengetahui peranan gen p53 dan mengidentifikasi nilai prognostik ekspresi protein p53 mutan terhadap kanker ovarium. Rancangan/rumusan data: Penelitian survei analitik dengan desain cross sectional pada rumah sakit pendidikan di Makassar. Bahan dan cara kerja: Pasien dinyatakan kanker ovarium berdasarkan hasil pemeriksaan histopatologi, dianalisis ekspresi protein p53- nya dengan teknik imunohistokimia. Hasil: Derajat ekspresi protein p53 ditemukan lebih tinggi pada kanker ovarium stadium lanjut. Follow-up penderita antara 6 bulan sampai 2 tahun setelah operasi menunjukkan bahwa penderita yang mempunyai ekspresi protein p53 mutan yang tinggi mempunyai angka kematian yang tinggi. Kesimpulan: Analisis p53 dapat dipakai sebagai indikator prognostik terhadap kanker ovarium. [Maj Obstet Ginekol Indones 2008; 32-3: 172-6] Kata kunci: p53, kanker ovarium, prognosis.
Difference of Maternal Serum Interleukin-8 in Preterm Labor and Full Term Labor Budiartha, Komang W
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 4, October 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (98.989 KB) | DOI: 10.32771/inajog.v2i4.404

Abstract

Objective: To determine the difference of maternal interleukin-8 (IL-8) in preterm labor and full term labor. Method: This is a cross sectional study with 68 samples, 29 subjects with preterm labor and 39 subjects with full term labor. IL-8 concentration was obtained from blood samples of the subjects, which were examined at Prodia Laboratory Denpasar. Data was analyzed using t-test for independent samples with =0.05. Result: The mean IL-8 level for the preterm labor group was 23.56 10.69 pg/ml and 12.19 5.79 pg/ml for the full term labor group. Statistical analysis using independent samples t-test showed that the average IL-8 level of both groups were significantly different (p=0.001). Conclusion: We concluded from this study that serum IL-8 concentration in women who had preterm labor is significantly higher in comparison to women who had full term labor. [Indones J Obstet Gynecol 2014; 4: 185-187] Keywords: full term labor, interleukin-8, preterm labor

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