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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Published by Perkumpulan Obstetri dan Ginekologi Indonesia
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 1,760 Documents
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Curcumin Administration on Proliferation and Apoptosis Index in Complete Hydatidiform Mole CellCulture Nurseta, Tatit; Irwanto, Yahya; Imelda, Imelda
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 1, January 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (221.128 KB) | DOI: 10.32771/inajog.v4i1.70

Abstract

Objective: To investigate that curcumin can decreasing proliferation index and increasing apoptosis index. Method: This is an experimental non-blinded study with post test control group design, at Cell/Tissue Culture Laboratory at Medical Faculty of Brawijaya University. This study using CHM trophoblastic cell culture from CHM curettage patient, exposed by several doses of curcumin, 0, 50, 100, 200, 400 and 800 μM, then examined by the method of MTT proliferation index and apoptosis index by the method of labeling DNA fragmentation TUNEL system. Data analyzed by one-way ANOVA. Result: In this study, the mean values obtained decrease in proliferation index with increasing doses of curcumin. Giving a dose of 200 μM curcumin, 400 μM and 800 μM proved highly significant (p = 0.001) reduced proliferation index compared with the control and curcumin dose of 50 μM and 100 μM. From this research shows that there are significant differences in the increase of apoptosis index (p = 0.001) between the control group with curcumin dose group 200 μM, 400 μM and 800 μM. But there was no significant difference in the mean of apoptosis index among the three dose groups. Conclusion: Giving curcumin dose of 200 μM can decreasing the proliferation index and increasing the apoptosis index increases in CHM trophoblastic cell culture. [Indones J Obstet Gynecol 2016; 1: 37-41] Keywords: apoptosis index, curcumin, proliferation index
The Effect of Cyclophosphamide Chemotherapy on Ovarian AntiMüllerian Hormone Levels in Breast Cancer Patients Liga, Elisabeth G.K.; Abdullah, Nusratuddin; Tiro, Eddy; T. Chalid, St. Maisuri
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 1. January 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.105 KB) | DOI: 10.32771/inajog.v6i1.761

Abstract

Objective: To evaluate cyclophosphamide effects on Anti-Müllerian hormone (AMH) levels in breast cancer patientstreated with cyclophosphamide chemotherapy.Methods: This cohort prospective study was conducted inDr. Wahidin Sudirohusodo Hospital in the Department of Obstetricsand Gynecology in collaboration with Department of Surgery,Faculty of Medicice, Universitas Hasanuddin between September2015 and June 2016. Serum levels of AMH from forty breast cancerpatients received three series of cyclophosphamide chemotherapydetermined by Enzyme Linked Immuno Sorbent Assay (ELISA).Results: Serum AMH levels decreased significant in the first series(from 2.092.04 g/ml to o.651.06 g/ml; p<0.05) through thethird series (from 1.531.34 g/ml to 0.50.65 g/ml; p<0.05) ofcyclophosphamide chemotherapy.Conclusion: AMH levels decreased significant after cyclophosphamideindicated that cyclosphosphamide decrease ovarianreserve.[Indones J Obstet Gynecol 2018; 6-1: 64-67]Keywords: anti-müllerian hormone, breast cancer, cyclophosphamide,ovarian reserveObjective: To evaluate cyclophosphamide effects on Anti-Müllerian hormone (AMH) levels in breast cancer patientstreated with cyclophosphamide chemotherapy.Methods: This cohort prospective study was conducted inDr. Wahidin Sudirohusodo Hospital in the Department of Obstetricsand Gynecology in collaboration with Department of Surgery,Faculty of Medicice, Universitas Hasanuddin between September2015 and June 2016. Serum levels of AMH from forty breast cancerpatients received three series of cyclophosphamide chemotherapydetermined by Enzyme Linked Immuno Sorbent Assay (ELISA).Results: Serum AMH levels decreased significant in the first series(from 2.092.04 g/ml to o.651.06 g/ml; p<0.05) through thethird series (from 1.531.34 g/ml to 0.50.65 g/ml; p<0.05) ofcyclophosphamide chemotherapy.Conclusion: AMH levels decreased significant after cyclophosphamideindicated that cyclosphosphamide decrease ovarianreserve.Keywords: anti-müllerian hormone, breast cancer, cyclophosphamide,ovarian reserve
High Expression of Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) is Highly Correlated with Eclampsia Lukas, Efendi
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objectives: To understand the expression of placental vascular endothelial growth factor receptor (VEGFR-1) in severe preeclampsia with complication (eclampsia and HELLP syndrome). Methods: The study was an observational study with cross sectional design, performed at several hospitals of Department of Obstetrics and Gynecology Medical Faculty of University of Hasanuddin, Makassar. Subjects met to inclusion criteria were taken as samples. Placental tissue samples were taken from cord insertion site and fixated with formalin buffer solution. Immunohistochemical examination was performed at Center of Research University of Hasanuddin. Antibody used were primary antibody of Mouse monoclonal anti VEGFR-1 antibody (Santa Cruz) dissolved to 1:100 and link antibody (secondary antibody labeled with biotin) (Dakopatt). Placental tissues were examined in Streptavidin biotin peroxides and interpreted according to the intensity of trophoblast cytoplasmic dye. Results: High VEGFR-1 expression was found in 100% of the placenta from patients with eclampsia , 42.9&% in patients with HELLP syndrome and 37.8% in patients with severe preeclampsia. High VEGFR-1 expression was correlated to incidence of eclampsia (p=.000) and not correlated to severe preeclampsia and HELLP syndrome (p=0.734). Conclusion: High VEGFR-1 expression was correlated to eclampsia and not correlate to severe preeclampsia and HELLP syndrome. [Indones J Obstet Gynecol 2012; 36-3:116-20] Keywords: eclampsia, HELLP syndrome, severe preeclampsia, VEGFR-1 expression
Classic Antiphospholipid and Antiphosphatidylserine Antibody Profile in Suspected Antiphospholipid Antibody Syndrome Patient Suryadi, Angga J; Sumapradja, Kanadi
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (92.577 KB) | DOI: 10.32771/inajog.v4i3.435

Abstract

Objective: To compare the classic examination results of antiphospholipid (aPS) and antiphospatidylserine (aPL) antibody profile to establish the diagnosis from suspected antiphospholipid antibody syndrome (APS) patient in order to state the subsequent treatment strategies. Method: This descriptive cross-sectional study design was conducted at outpatient clinics of Dr. Cipto Mangunkusumo Hospital (RSCM) from January to December 2015. The laboratory test was held in Clinical Pathology Laboratory RSCM/Faculty of Medicine Universitas Indonesia (FKUI) and in corporation with Prodia laboratory. Result: All of normal patients did not have positive result in any laboratory examination (Lupus Anti-coagulant (LA), anticardiolipin (aCL), anti-?2 glycoprotein I (anti-?2GPI), and aPS). In patient suspected APS, 11 (37.1%) patients had positive aCL, 7 (25.9%) patients had positive anti-?2GPI, and 11 (37.1%) patients had positive aPS. The most positive cross laboratory examination was between aCL and aPS (25.9%). In this study, we found the most positive test result was aCL and aPS (62.9%). From this study, suspected APS patient who had negative result in classic laboratory examination, but showing the positive result in aPS was in 5 (18.5%) patients. Conclusion: All normal pregnant patients do not have any positive classic examination and aPS. Meanwhile, in patients with suspected APS, less than 20% patients show positive result of aPS with negative result in classic laboratory examination. Keywords: antiphospatidylserine, antiphospolipid syndrome
Measurement of Vitamin A Level in Patients with Malignant and Benign Ovarian Tumors ANDRIJONO, ANDRIJONO; DJAENUDIN, A.; MUHILAL, M.
Indonesian Journal of Obstetrics and Gynecology Volume. 30, No. 2, April 2006
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Pendahuluan: Tumor ovarium ganas adalah salah satu tumor ganas ginekologi yang mempunyai angka kematian tertinggi. Beberapa penelitian telah dilakukan untuk mengetahui etiologi atau faktor risiko tumor ovarium ganas. Beberapa penelitian dilakukan seperti faktor genetik, kontaminasi kimiawi, penggunaan kontrasepsi. Penelitian faktor predisposisi sangat penting dalam upaya untuk mencegah terjadinya tumor ganas ovarium. Vitamin A adalah vitamin yang bekerja mengatur proliferasi sel dan diferensiasi sel. Defisiensi vitamin A diduga menyebabkan gangguan metabolisme p53 sehingga proliferasi tidak dapat dikendalikan atau dikontrol. Tujuan: Membandingkan kadar vitamin A pada pasien tumor ganas ovarium dengan tumor ovarium jinak. Tempat: Departemen Obstetri dan Ginekologi Fakultas Kedokteran Universitas Indonesia. Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo, Jakarta. Bahan dan cara kerja: Penelitian potong lintang pada kasus tumor ganas ovarium dan tumor ovarium jinak yang memenuhi kriteria penerimaan. Contoh darah diambil dari kedua kelompok dan dilakukan pemeriksaan kadar vitamin A. Kadar vitamin A diperiksa dengan HPLC (high performanced liquid chromatography). Dengan proporsi pengaruh tumor ovarium jinak 0,1 dan risiko relatif 3, dibutuhkan sampel 39 kasus setiap grup. Dilakukan analisis statistik secara Anova untuk menilai adakah perbedaan kadar vitamin A pada kedua kelompok. Hasil: Sejumlah 71 kasus yang masuk dalam penelitian untuk dianalisis. Faktor paritas tampak adanya peningkatan risiko sebesar 2,1 kali pada paritas yang meningkat setelah paritas tiga. Faktor keluarga yang menderita tumor ganas ovarium terdapat hanya pada kelompok tumor ovarium ganas. Kadar vitamin A pada tumor ganas ovarium sebesar 28,2 μg/100 ml dengan standar deviasi 7,3 μg/100 ml, sedangkan kadar vitamin A rata-rata pada kelompok tumor ovarium jinak 33,5 μg dengan standar deviasi 8 μg/100 ml. Perbedaan ini secara statistik bermakna. Kesimpulan Terdapat perbedaan bermakna, kadar vitamin A ratarata dari penderita tumor ovarium ganas pada penelitian ini, yaitu 28,3 μg/100 ml dibandingkan dengan 33,5 μg/100 ml kadar rata-rata tumor ovarium jinak. [Maj Obstet Ginekol Indones 2006; 30-2: 124-7] Kata kunci: tumor ovarium, vitamin A.
Secretory Leukocyte Protease Inhibitor in Preterm Labor and Pregnancy Sutiono, Ferriyanto; Kaeng, Juneke J; Loho, Maria FT
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 July 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (117.639 KB) | DOI: 10.32771/inajog.v6i3.778

Abstract

  Objective: To investigate the levels of secretory leukocyteprotease inhibitor (SLPI) in women with preterm labor andpregnancy.   Methods: SLPI level examination conducted to 32 samples ofpregnant women who meet the inclusion and exclusion criteria,consists of 16 preterm labor and 16 preterm pregnancy.Sample analysis carried out in Prodia Laboratory Jakarta. SLPIlevel examination used ELISA method. The obtained dataprocessed by SPSS software version 20.0 and discussed withexisting literature theory.   Results: Mean plasma SLPI level in patients with preterm laboris 30.319 ng/ml and median: 29.950 ng/ml with p value: 0.652,while the mean on preterm pregnancy is 45.975 ng/ml andmedian: 41.600 ng/ml with p value: 0.005.   Conclusion: There are significant differences of SLPI level betweenpreterm labor and preterm pregnancy. Keywords: preterm labor, preterm pregnancy, SLPI
Higher Cortisol Level Would Increase the Risk of Spontaneous Abortion Sastra, Christian
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 1, January 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To understand the correlation between cortisol level and spontaneous abortion in normal pregnancy with gestational age less than 20 weeks. Method: The study design was a correlative analytic prospective study with cross sectional observational approach. This study started from June 2012 until the number of participant sufficiently from Prof. Dr. R.D. Kandou General Hospital. The data then processed SPSS version 2.0, ROC and logistic regression equation model (chance model). Result: The study included 50 cases consisted of 25 spontaneous abortion cases and 25 normal pregnancies with gestational age less than 20 weeks, and got result if cortisol level for 18.52 μg/dl so spontaneously abortion chance for 35.7% and if cortisol level for 24.0 μg/dl would chance for spontaneous abortion for 99.3%. Conclusion: In this study, there was a significant difference in cortisol level in women with spontaneous abortion and < 20 weeks normal pregnancy. Higher cortisol level would increase spontaneous abortion risk. The mean cortisol level in spontaneous abortion was 27.28892 μg/dl. While the mean cortisol level in women with normal pregnancy was 11.7660 μg/dl. Analysis of the correlation between cortisol level and spontaneous abortion gave a cut off point for cortisol level of 19.1 μg/dl with sensitivity of 92% and specificity of 92%. [Indones J Obstet Gynecol 2013; 37-1: 17-20] Keywords: cortisol level, normal pregnancy, spontaneous abortion
Comparison of Fibrinogen Level Changes between Pregnancy with History of Abortion and Normal Pregnancy Wicaksono, Robbi A.
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 2, April 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (36.395 KB)

Abstract

Objective: To know the change of fibrinogen level in pregnancy with history of abortion and normal pregnancy on 6 - 8 weeks pregnancy and 10 - 12 weeks pregnancy. Method: This is a comparative study analytic comparative with cross sectional method on both groups, pregnancy with history of abortion and normal pregnancy. Observe the changes of fibrinogen level on 6 - 8 weeks pregnancy and then on 10 - 12 weeks pregnancy in pregnancy with history of abortion and normal pregnancy. Result: Comparison of mean fibrinogen level between 6 - 8 weeks pregnancy and 10 - 12 weeks pregnancy, on both group showed that the fibrinogen level in the group with history of abortion increased 9.6% and in the group of normal pregnancy increased 11.4%. The raise on both group was not significant stastistically (p = 0.810). The raise fibrinogen level on normal pregnancy was significant (p < 0.001), while on pregnancy with history of abortion is not significant (p = 0.255). All patterns of raise and fall on fibrinogen level on both groups were not stastistically significant (p > 0.005). Conclusion: Fibrinogen level on 10 - 12 weeks pregnancy was not lower than on 6 - 8 weeks pregnancy in pregnancy with history of abortion. There was no significant raise changes in fibrinogen level on both groups. [Indones J Obstet Gynecol 2011; 35-2: 53-6] Keywords: abortion, fibrinogen, haemostasis, history of abortion, normal pregnancy
Not only embryo quality but also Endometrial Thickness Contributes to IVF outcome: a retrospective study of all IVF cycles in Yasmin Clinic, Jakarta, Indonesia Wiweko, Budi
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 1, January 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (35.141 KB)

Abstract

Objective: To study the endometrial thickness and embryo quality during In Vitro Fertilization (IVF) cycles in predicting IVF outcome. Methods: This retrospective study involved 206 infertile patients undergoing 218 IVF cycles in Yasmin Clinic, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia. All IVF cycles were performed from January 2005 until May 2009. The outcome of this study is the clinical pregnancy following IVF cycles. The endometrial thickness was measured on the day of human chorionic gonadotrophin (hCG) administration. The number of embryos that developed ≥ 8 cells on cleavage II represented as the embryo quality. Results: There were 51 among 218 cycles (23.4%) resulted in pregnancy. The endometrial thickness on day of hCG administration was significantly higher in pregnant group compared to non-pregnant group (11.49±1.97 mm versus 10.13±1.93mm; p
Upaya Menurunkan Angka Kesakitan dan Angka Kematian Ibu pada Penderita Preeklampsia dan Eklampsia ROESHADI, R. H.
Indonesian Journal of Obstetrics and Gynecology Volume. 31, No. 3, July 2007
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (227.379 KB)

Abstract

N/A

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