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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Published by Perkumpulan Obstetri dan Ginekologi Indonesia
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 1,760 Documents
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Basal Temperature, Cervical Mucous, and Both Combination as Diagnostic Tools to Detect Ovulation Gunardi, Eka R; Mukti, Alexander; Situmorang,  Herbert
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 July 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (95.654 KB) | DOI: 10.32771/inajog.v6i3.781

Abstract

    Objective: To make basal body temperature examination andcervical mucus as an alternative examination in detectingovulation, especially in health facilities that do not have ultrasound.   Methods: This cross-sectional study was conducted at the outpatientclinic of RSUPN Dr. Cipto Mangunkusumo in the year2016-2017. A total of 49 infertile female patients who had normalmenstrual cycles were asked to participate and performedbasal body temperature measurements, cervical mucussampling and transvaginal ultrasound examination, the dataare subsequently grouped into 3 Days Estimated Ovulation(DEO); DEO-2 days, DEO and DEO+ 2 days. Diagnostic testswere performed and accurate comparison between basal bodytemperature, cervical mucus and a combination of both werelater assessed.   Results: The best accuracy was found on cervical mucus andcombination of both with 65% in detecting ovulation, whilstthe lowest was basal body temperature (59%) with sensitivity46.7%, and specificity 78.9%. Cervical mucus in diagnosingovulation has a sensitivity of 70% and specificity 57.8%. Thecombination of temperature-cervical mucus in diagnosing ovulationhas sensitivity of 46.67% and specificity of 94.73%.   Conclusion: Cervical mucus examination has better accuracy comparedwith basal body temperature examination in detecting ovulation.Further research for validating these diagnostic tools to thewider community and not only in patients with infertility is needed.   Keywords: basal body temperature, cervical mucus, infertility, ovulationdetection, ultrasound
Expression of Fas Ligand is Higher in Early Stage Cervical Cancer with Lymph Nodes Metastasis Irwanto, Yahya
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (239.225 KB)

Abstract

Objective: To know whether the expression of Fas Ligand has correlation with incidene of metastasis of pelvic lymph node and lymph-vascular stromal invasion (LVSI). Methods: All patients diagnosed of cervical cancer stage IB or IIA who underwent radical hysterectomy in Dr. Cipto Mangunkusumo Central General Hospital from January 2008 until December 2009 were included in analytic cross sectional study. We tested expression of Fas Ligand in cervical cancer specimen by immunohystochemistry with monoclonal antibody. The expression of Fas Ligand was compared between the group of patients with a positive and negative pelvic lymph node and between LVSI positive and negative. The difference of expression in both group were statistically analized with Chi-square test and the correlation Spearman test. Result: Ninety one patients underwent radical hysterectomy for two years and 43 patients were included in these study. The expression of Fas Ligand in 7 patients (16.3%) were negative and the others were positive, with weak, moderate and strong expression were 4 (9.3%), 27 (62.8%), and 5 (11.6%) respectively. The expression of Fas Ligand was significantly higher in the group of patients with positive pelvic lymph node compared to the group of the patients with negative pelvic lymph node (p=0.007) but there was no significant difference between group of the patients with LVSI positive and negative. With Spearman test, we found that the expression of Fas Ligand had a strong correlation with pelvic lymph nodes metastasis (coeff. correlation=0.519 and p=0.00) and have no correlation with LVSI (coef. corellation=0.112 and p=0.474). Conclusion: These finding suggested that expression of Fas Ligand in cervical cancer patients has a strong correlation with the incidence of pelvic lymph node metastasis and none with LVSI. [Indones J Obstet Gynecol 2012; 36-4: 194-9] Keywords: cervical cancer, fas ligand, immunohystochemistry, LVSI, pelvic lymph node metastasis
Effects of Peritoneal Fluid on Sperm Motility and Viability in Endometriosis Tasya, Marissa
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 1, January 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (28.879 KB)

Abstract

Objective: To know the effects of peritoneal fluid on sperm motility and viability in patients with endometriosis. Design/data identification: This was a laboratory experimental study to peritoneal fluid from endometriosis and non-endometriosis patients who underwent surgery in Dr. Hasan Sadikin Hospital and around with endoscopy facility which fulfill inclusion and exclusion criterias. Experiments was performed in ASTER Fertility Clinic, Dr. Hasan Sadikin Hospital. Method: Semen samples were normozoospermic of which has been prepared using swim up method with sperm count 3 x 106/ml. The sperm were exposed to peritoneal fluid from endometriosis and non-endometriosis patients and analyzed at h 0, 1, 3, 6, and 24 to see the difference of sperm motility and viability postincubation with endometriosis peritoneal fluid. The sperm viability was detected using trypan blue 0.4%. Result: Exposure of sperm to peritoneal fluid reduced sperm motility significantly from the h 6 observation (Zw = 2.17; p = 0.03) and the h 24 (Zw = 2.35; p = 0.01). The sperm viability which incubated with endometriosis peritoneal fluid reduced significantly from h 6 observation (Zw = 1.99; p = 0.04) and the h 24 (Zw = 2.55; p = 0.01). Conclusion: The endometriosis peritoneal fluid reduced the motility and viability of the sperm began from the h 6 postincubation. This indicate the possibility of involvement of endometriosis peritoneal fluid to infertility. [Indones J Obstet Gynecol 2011; 35-1: 18-20] Keywords: sperm motility, sperm viability, endometriosis
Accuracy of Preoperative Endometrial Sampling for the Detection of Endometrial Pathology: a Retrospective Study Tali, Keven P M; Cole, Lilli M T
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 1, January 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (102.142 KB) | DOI: 10.32771/inajog.v5i1.461

Abstract

Objective: To investigate the accuracy of endometrial sampling in the diagnosis of endometrial pathology and the need of intraoperative frozen section. Methods: One hundred forty women who underwent endometrial sampling followed by hysterectomy between 2011 and 2014 were included in this study. Data were retrieved from patient files and pathology archives in Department of Obstetrics and Gynecology, Jose R. Reyes Memorial Medical Center, Manila, Philippines. Results: There were 25 patients with malignancy but endometrial sampling detected only 22 of them. The endometrial sampling sensitivity and specificity for detecting cancer were 88% and 100%, respectively with negative and positive predictive values of 97.5% and 100%, respectively. In 3 patients, the endometrial sampling failed to detect malignancy; 1 patient had a preoperative diagnosis of complex hyperplasia with atypia, 1 patient had complex hyperplasia without atypia and 1 patient had adenofibroma. A total of eighty patients had benign findings. There were fifty-three cases with finding of proliferative endometrium and twenty-seven were secretory. Twenty-three (55.0%) and 11 (39.0%) cases were confirmed by the hysterectomy specimen, respectively. The sensitivity of endometrial sampling in detecting benign samples was 76.0% and the specificity reached up to 83.0%. The histopathology result of the other fourteen cases were reported of having atrophy, twelve cases were reported of having endometrial hyperplasia, four with basal endometrium, four with endometrial polyp and one with adenomyosis. Conclusion: Outpatient endometrial biopsy has a high overall accuracy in diagnosing endometrial cancer when the specimen obtained is sufficient. A positive test result is more accurate for ruling in disease than a negative test result is for ruling it out. However, the diagnosis should be confirmed by frozen section in patients with complex hyperplasia and adenofibroma. [Indones J Obstet Gynecol 2017; 5-1: 23-29] Keywords: abnormal uterine bleeding, endometrial hyperplasia, endometrial sampling, frozen section, pipelle
Karakteristik Pasien Endometriosis di Rumah Sakit Dr. Cipto Mangunkusumo Selama Periode 1 Januari 2000 - 31 Desember 2005 PUSPASARI, B.; BAZIAD, A.; HESTIANTORO, A.
Indonesian Journal of Obstetrics and Gynecology Volume. 31, No. 2, April 2007
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.575 KB)

Abstract

Tujuan: Mengetahui karakteristik pasien endometriosis yang berobat ke RSCM. Rancangan/rumusan data: Studi deskriptif. Karakteristik pasien endometriosis di RSCM. Tempat: Poliklinik Imunoendokrinologi Reproduksi Departemen Obstetri dan Ginekologi FKUI/RSCM Jakarta. Bahan dan cara kerja: Dilakukan pendataan dari catatan medik tentang karakteristik faktor risiko semua pasien endometriosis baru yang didiagnosis pertama pada tanggal 1 Januari 2000 sampai dengan 31 Desember 2005 dengan hasil histopatologi (+) endometriosis. Hasil: Didapatkan 111 sampel yang sesuai dengan kriteria penerimaan dan penolakan. Rerata usia pasien adalah 33,39 ± 6,40 tahun, di mana yang terbanyak adalah kelompok usia 30 - 34 tahun (29,72%). Sebagian besar pasien (68,47%) datang atas keinginan sendiri, dan hanya 1 pasien (0,9%) rujukan dari bidan. Sisanya rujukan dokter umum dan SpOG. Lebih dari separuh (63,96%) pasien mengalami dismenorea, tetapi pasien yang datang dengan keluhan utama dismenorea hanya 29,73%. Pasien lain datang dengan keluhan nyeri perut (27,3%), benjolan di perut (22,52%), gangguan haid (10,81%), ingin anak (7,21%) dan gangguan berkemih (2,71%). Sebagian besar subjek sudah menikah (77,48%), dan hampir separuhnya (48,84%) mengalami infertilitas, baik primer maupun sekunder. Rerata usia menars adalah 13,19 ± 1,87 tahun. Usia menars terbanyak adalah 12 tahun, sebanyak 36 pasien (32,43%). Sebagian besar pasien (85,59%) memiliki siklus haid normal (antara 21 - 35 hari), dengan banyaknya haid yang juga normal (2 - 5 pembalut/ hari). Untuk lama haid, ternyata cukup banyak pasien yang mengalami haid lebih lama dari lama haid normal, yaitu sebanyak 48,65%. Hampir seluruh subjek tidak menggunakan kontrasepsi oral (91%). Berdasarkan diagnosis preoperatif, sebanyak 35,13% pasien terdiagnosis sebagai endometriosis. Sebanyak 26,13% pasien mempunyai diagnosis preoperatif selain endometriosis atau adenomiosis. Intra operatif dilakuan penilaian stadium endometriosis menurut (revised) American Fertility Society (AFS 1 - 4), di mana sebagian besar pasien menderita endometriosis stadium 3 dan 4 (sedang - berat), yaitu sebanyak 44,14% dan 46,35%. Pada penelitian ini didapatkan keluhan dismenorea lebih banyak ditemukan pada stadium 4, yaitu sebanyak 49,30%, walaupun terdapat 2 pasien (2,81%) pasien dengan dismenorea berada pada stadium 1 (minimal). [Maj Obstet Ginekol Indones 2007; 31-2: 73-8] Kata kunci: endometriosis, karakteristik, faktor risiko
Caspase-3 can not be Used to Predict the Response to Neoadjuvant Chemotherapy Regiment PVB in Cervical Cancer Stage IB-IIA Ambari, Ediwibowo
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (101.064 KB)

Abstract

Objectives: To determine the factors that may be used as the prognostic parameter for the therapeutic efficacy of neoadjuvant chemotherapy, which can be used to revising the management of early stage cervical cancer patients with large lesions. Methods: This was a retrospective cohort study. The study was conducted in the Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia. The subjects were 15 cervical cancer stage IB2 and IIA patients with lesions’ size of > 4 cm, who would be treated with neoadjuvant chemotherapy, consisted of cisplatin 50 mg/m2, vincristine 2 mg/m2 and bleomycin 15 mg regiment. The patients’ response would be evaluated after completing 3 series of chemotherapy. Data was retrieved from medical records and cervical biopsy paraffin blocks and examined histopathologically using IHC staining to see expression of caspase-3 with histoscore assessment score. Data was analyzed by univariate, bivariate analysis. Results: Response to PVB neoadjuvant chemotherapy was found in 5 out of 15 patients. None of the clinicopathology variables can be used to predict response to therapy. Expression of caspase-3 as a marker of apoptosis, can not predict the response of the therapy before administrating neoadjuvant chemotherapy either. There is a significant difference between the levels of caspase-3 in epidermoid carcinoma with adenocarcinoma, with p value of 0.02 (RR 6;95% CI 1.69-21.26). Conclusion: Clinicopathologic factors and the expression of caspase-3 before getting chemotherapy neoadjuvant can not predict the succeed of the therapy. [Indones J Obstet Gynecol 2013; 1-3: 156-60] Keywords: caspase -3, clinicopathologic, early-stage cervical cancer lession in large, neoadjuvant chemotherapy response to therapy
Serum Vascular Endothelial Growth Factor (VEGF) in DMPA Acceptors: Influence on Bleeding Occurrence Pratiwi, Ratih; Amran, Rizani; Said, Usman; Saleh, Irsan
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 1, January 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (146.512 KB) | DOI: 10.32771/inajog.v3i1.22

Abstract

Objective: To analyze the relationship between levels of serum vascular endothelial growth factor (VEGF) and bleeding occurrence in depo medroxyprogesterone acetate (DMPA) acceptors. Method: We employed a cross‐sectional study on 70 DMPA acceptors with DMPA use of 3 to 6 months who presented for midwifery service in Palembang. Blood samples were obtained in order to assess levels of serum VEGF using ELISA (enzyme‐linked immunoabsorbent assay) method. Laboratory assessments were carried out in PRODIA laboratory in Jakarta. Result: We recruited 70 subjects into our study. After 3 to 6 months of using DMPA, as much as 26 subjects (37.1%) reported complaints of bleeding and 44 subjects (62.9%) reported no bleeding. The mean level of serum VEGF in DMPA acceptors with bleeding was 355 K 170 pg/ml, and 323 K 202 pg/ml in acceptors with no bleeding. We identified a significant association between duration of use and bleeding occurrence (p0.05). Conclusion: In our sample, we found an association between duration of DMPA use and presence of bleeding but VEGF levels was not found to be different in women experiencing abnormal uterine bleeding and those who did not. Keywords: bleeding, DMPA acceptor, serum VEGF
Endothelin1 Levels in Pregnant Women with Severe Preeclampsia and Normal Pregnant Women Wijaya, Yosiana; Wantania, John JE; Laihad, Bismarck J
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (101.959 KB) | DOI: 10.32771/inajog.v5i2.523

Abstract

Objective: To determine the ratio of serum endothelin-1 levels between severe preeclampsia and normotensive pregnancy. Methods: Observational analytic study using cross-sectional. Sixteen woman with normal pregnancy and sixteen others with severe preeclampsia who met the inclusion and exclusion criteria, were tested for ET-1. The serum was analyzed at Prodia Laboratory, Manado. The ET-1 level was examined using ELISA (R&D Systems, Inc., Minneapolis, MN 55413, USA). The data obtained was analyzed using SPSS software version 20.0.and discussions were held using the existing literature theory. Results: The mean and median levels of endothelin-1 plasma in patients with severe preeclampsia is 2:46 ± 1:44 pg/ml, 1:09 ±  0:26 pg/ml, whereas in normotensive pregnancy is 1:03 ±  0:26 pg/ml, 1.95 ± 1:44 pg/ml with p < 0:05 (0000). Conclusion: There was a significant difference between endothelin- 1 level in severe preeclampsia and normotensive pregnancies. [Indones J Obstet Gynecol 2017; 5-2: 77-82] Keywords: endothelin-1, normotensive, preeclampsia
Levonorgestrel Concentration in a Single Rod Implant Users for Six Months Gunardi, Eka R.
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 3, July 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (65.728 KB)

Abstract

Objective: This research was conducted to measure levonorgestrel serum concentration Monoplant® after six months of usage. Method: Thirty healthy women, 20 - 40 years old, and after been proven for fertility, had implants on their body. Levonorgestrel serum levels were measured monthly from the first month to the sixth month. Result: Levonorgestrel serum concentration was still above 200 pg/ml until the sixth month. First month and second month serum concentration was not recorded while data for the following months were 338.9 pg/ml, 424.8 pg/ml, 320.3 pg/ml, and 337.5 pg/ml. Conclusion: Levonorgestrel serum concentration in Monoplant® users was still above contraceptive level until six months. [Indones J Obstet Gynecol 2011; 35-3: 122-7] Keywords: single rod implant Monoplant®, levonorgestrel serum concentration
Penatalaksanaan Kehamilan Ektopik dengan Kajian Hasil Laparoskopi Operatif HADISAPUTRA, W.
Indonesian Journal of Obstetrics and Gynecology Volume. 32, No. 2, April 2008
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (40.859 KB)

Abstract

Tujuan: Membahas tatalaksana Kehamilan Ektopik (KE) secara dini dengan pendekatan medisinal dan operatif, serta mengkaji karakteristik pasien dan keberhasilan kehamilan pascatatalaksana laparoskopi operatif. Tempat: Pusat pelatihan nasional endoskopi Klinik Raden Saleh Departemen Obstetri Ginekologi FKUI/ RSCM dan Rumah Sakit Bersalin Yayasan Pemeliharaan Kesehatan (YPK) Jakarta Pusat. Bahan dan cara kerja: Tulisan ini merupakan rangkuman pustaka terkini mengenai tatalaksana KE secara medisinal dan operatif, serta menganalisis hasil (luaran) protokol tatalaksana KE dengan laparoskopi operatif. Hasil: Sebagian besar kasus yang mengalami KE ada pada usia reproduksi. Lama waktu yang dibutuhkan untuk hamil ialah 0 - 6 bulan (50%) dan keberhasilan hamil 48%. Kesimpulan: Pilihan terapi medisinal adalah Methotrexate (MTX), laparoskopi operatif merupakan pilihan akses pertama untuk KE yang akan menjalani operasi serta angka keberhasilan kehamilan pascaoperasi adalah 48%. [Maj Obstet Ginekol Indones 2008; 32-2: 72-6] Kata kunci: kehamilan ektopik (KE), Methotrexate (MTX), salpingostomi linear, laparoskopi operatif

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