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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
  • Website
Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 429 Documents
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Future Application of Oncolytic Viruses for Cancer Treatment Lesmana, Jevon Aaron; Jo, Juandy
Medicinus Vol 12, No 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7037

Abstract

Cancer treatments have developed over the years. A particular improvement is the utilization of oncolytic viruses to treat cancers. Oncolytic viruses are one of the immunotherapeutic tools that potentially could provide good results and benefits to the patients. Oncolytic viruses could mediate antitumor effects. Indeed, the connection between viral infections and cancer treatment have been reported historically. It is known that oncolytic viruses prefer to infect cancer cells rather than normal cells, resulting in the presentation of tumor-associated antigens to the immune system, boosting immunological activity in the tumor microenvironment, as well as assisting in the expression of inflammatory and immunomodulatory cytokines. Oncolytic viruses are a novel regimen in the cancer therapy, in which knowledge and technology of utilizing oncolytic viruses to treat cancer are still evolving. Importantly, clinical trials demonstrated that the viruses were well tolerated by cancer patients. Considering its potency and prospect, oncolytic viral treatments could be a useful additional tool for cancer therapy.
The Appropriate Acquisition Time Interval Following Injection of 99mTc-Sestam ibi with Water Protocol in Single Photon Emission Computed Tomography Myocardial Perfusion Imaging: First Experience in Indonesia Prasetyo, Nora Anggun; Soeriadi, Erwin Affandi; Budiawan, Hendra; Kartamihardja, Achmad Hussein Sundawa
Medicinus Vol 12, No 1 (2022): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.7016

Abstract

Introduction: According to EANM/ESC guideline, image acquisitions in stress test should be begun at 30-60 minutes after tracer administration. Our center is a referral hospital for nuclear medicine imaging with many patients but limited number of gamma camera. The shorter time between injection of radiopharmaceutical and imaging acquisition will add to the number of examinations that can be performed. The aim of this study was to evaluate the appropriate acquisition time interval with water protocol in 99mTc-Sestamibi SPECT myocardial perfusion imaging.Methods: Patients who were referred to undergo stress MPI between October 2020 to December 2020 were included in this study. Cardiac stress procedure was performed using treadmill with modified Bruce Protocol. Subjects drank a total of 330 mL water following 99mTc-Sestamibi injection. Image acquisitions were performed 10 and 30 minutes afterwards. Quantitative assessment was done by calculating target background ratio (TBR). Statistical analysis was performed using student t-test with Microsoft Excel version 2019. P-value < 0.05 was considered to be statistically significant.Result: Thirty out of 35 subjects were included in this study. Sixteen of them are male and 14 are female with a mean age of 48.7 years old (28 – 80). Mean target background uptake ratio (TBR) in 10- and 30-minutes images were 0.67 (0.44 – 1.11) and 0.76 (0.43 – 1.18) respectively (p-value = 0.15).Conclusion: There was no significant difference of target to background ratio between 10- and 30-minutes acquisition time interval following injection of 99mTc- Sestamibi with water protocol in myocardial perfusion imaging.
The Difference of Low Density Lipoprotein Cholesterol Levels on Different Severity of Coronary Artery Disease Patients in Siloam Hospital Lippo Village Tanaka, Michael; Santoso, Wilbert; Anggraini, Novita
Medicinus Vol 12, No 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7033

Abstract

Background: Coronary artery disease (CAD) is one of the highest causes of death in the world. Hypercholesterolemia, especially low-density lipoprotein (LDL) levels, is a major risk factor, because it is the main precursor of atherosclerosis. Previous studies showed the relationship between LDL level and the number of vessel disease is still inconsistent, therefore it needs to be observed further. The objective of this study was to know the effect of LDL levels on the number of vessel disease in CAD patients who underwent coronary angiography.Methods: It was a cross-sectional and retrospective study, where data were taken from medical records of CAD patients who underwent coronary angiography at Siloam Hospital Lippo Village between January to June 2018. Patients with at least one vessel disease were included. The number of vessel disease was categorized into 3 groups: one-vessel, two-vessels, and multi-vessel. The relationship between LDL levels and the number of vessel disease was analyzed using one way ANOVA.Result: The data includes 90 patients; 70 (77.8%) were male with average age of 56±9 years. There were 32 (35.6%) patients in one-vessel group; 27 (30%) in two-vessel group; and 31 (34.4%) in multi-vessel group with an average LDL levels of 106.43±40.51 mg/dl; 111.15±39.43 mg/dl; and 114.52±32.55 mg/dl respectively. Although it seemed that the increase in LDL cholesterol levels was in line with the number of vessel disease, there was no statistically significant relationship between the two variables (p=0.694).Conclusions: LDL cholesterol level does not affect the number of vessel disease in CAD patients.
Postoperative Pain Comparison Between Open Hemorrhoidectomy and Stapled Hemorrhoidopexy on Internal Hemorrhoid at Siloam Hospitals Lippo Village Sudirman, Taufik; Wiguna, Alvin Leonard
Medicinus Vol 12, No 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7038

Abstract

Background: Hemorrhoids have a prevalence of 4,4%. Surgery is one of the modalities for treating hemorrrhoids. The method accepted as the "golden standard" is open hemorrhoidectomy. Although considered effective, open hemorrhoidectomy is still often associated with a significant rate of morbidity and pain symptoms that are a complaint of most patients. Therefore, another method is an alternative, namely, stapled hemorrhoidopexy. Some studies showed that stapled hemorrhoidopexy has a lower occurrence of postoperative pain, and others offer the opposite.Methods: This study was conducted at Siloam Hospitals Lippo Village between February and March 2019. Samples were taken as many as 70 patients by taking secondary data from medical records. Patients diagnosed with third or fourth degree hemorrhoids and undergoing open hemorrhoidectomy or stapled hemorrhoidopexy will be taken the pain score from the visual analogue scale. Data is then tabulated using Microsoft Excel and analysed using SPSS.Result: the occurrence of postoperative pain in the stapled hemorrhoidopexy and open hemorrhoidectomy group, respectively, are 80% and 97%, with a p-value of 0,055. The average visual analogue scale score for open hemorrhoidectomy and stapled hemorrhoidopexy was 3±1,39 and 2±1,39, respectively, with a p-value of 0.003.Conclusions: the result showed that the occurrence of postoperative pain was not statistically significant. And the average visual analogue scale score was lower in the stapled hemorrhoidopexy group.
Comparison of Post-Operative Pain Score Between Open Appendectomy and Laparoscopic Appendectomy on Acute Appendicitis Patient in Siloam Hospital Lippo Village Elsa, Mary Christina; Sudirman, Taufik
Medicinus Vol 12, No 3 (2023): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i1.7362

Abstract

Background: Appendicitis is inflammation of vermiform appendix which can be caused by luminal obstruction. Appendicitis is one of the most common causes of emergency abdominal surgery, with 11 cases per 10.000 person per year. Until today, open appendectomy is still the gold standard for appendicitis treatment although laparoscopic appendectomy has significantly lower post-operative pain.Methods: This study uses cross-sectional study design with post-open appendectomy and laparoscopic appendectomy patients in Siloam Hospital Lippo Village as the sample population. The Visual Analogue Scale (VAS) is taken from patient’s medical record and processed using Mann-U-Whitney test.Result: From 70 acute appendicitis patients, 36 underwent open appendectomy and 34 underwent laparoscopic appendectomy. The result showed the median score of VAS 1 day post open appendectomy surgery (median = 3, min/max = 2/6 [95% CI = 2,55 – 3,14]) is higher than post laparoscopic appendectomy (median = 2,25, min/max = 0/4, [95% CI = 1,97 – 2,59]), with adjusted p value against age and surgery duration is 0,024. In pediatric patients, median score of VAS 1 day post open appendectomy surgery is the same with laparoscopic appendectomy (median = 3, p value = 0,863). Multivariate analysis showed that surgery duration affects VAS 1 day post appendectomy surgery in pediatric patients (p value = 0,042).Conclusions: This study shows that the median score of VAS 1 day post open appendectomy surgery is higher than laparoscopic appendectomy. This result is statistically significant. However, in pediatric patients the median score of VAS 1 day post open appendectomy surgery and laparoscopic appendectomy is the same. VAS 1 day post appendectomy surgery in pediatric patients is affected by surgery duration.
Concomitant Chylothorax and Chyloperitoneum with Newly Diagnosed: B-Cell Lymphoma: A Case Report Siahaan, Sylvia Sagita; Prasetya, Ignatius Bima; Pradhana, Cindy Meidy Leony
Medicinus Vol 12, No 3 (2023): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i1.7367

Abstract

Chylothorax and Chyloperitoneum are an infrequent condition, characterized by the accumulation of chyle in the pleural and peritoneum cavity. We report an uncommon presentation of concomitant chylothorax and chyloperitoneum caused by diffuse B- cell Lymphoma. A 60-year woman was admitted with progressive shortness of breath, abdominal fullness, cough when lying down on one week duration. She also complains progressive non painful neck lump, night sweats, and weight loss. Chest radiograph showed right pleural effusion. CT scan abdomen with contrast revealed ascites with lobulated mass and multiple lymphadenopathy. Thoracocentesis and paracentesis were performed, revealed exudative with yellow and milky appearance and elevated triglyceride. Histopathologic confirmed diffuse large B-cell lymphoma. Chylothorax concomitant with chylous ascites is rarely encountered. Serous effusion occur often in malignant lymphomas. Management of chylothorax and chyloperitoneum is conservative measures and treat the aetiology. Effusion often becomes a chronic problem that persist although the lymphoma has been treated.
Ultrasound-guided Genicular Nerve Ablation with Alcohol Solution for Knee Osteoarthritis: A Case Series Butarbutar, John; Phandu, Mirna; Lee, Kevin; Tasya, Earlene; Sulaeman, Wendell Sebastian
Medicinus Vol 13, No 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i2.7531

Abstract

Genicular nerve ablation using radiofrequency (RF) is a common minimally invasive procedure for painful osteoarthritic knees. However, the high cost and unavailability of equipment in many healthcare centers made this inconvenient for some patients. Some case reports tried the cheaper and newer method, using an alcohol solution to ablate the genicular nerves, showing considerable improvement in the patient's pain, functional knee score, and quality of life. We have attempted the ultrasound-guided genicular nerve ablation using alcohol solution in 6 patients with knee osteoarthritis to complement the body of evidence. We found that the genicular nerve ablation using alcohol solution is an excellent method for relieving symptoms of knee osteoarthritis if knee pain is the main symptom.
Factors Associated With Atopic Dermatitis In Elementary School Children In Suburban Area In Indonesia: Original Research Gunawan, Catherine; Satriajaya, Anthony; Vatvani, Akhil Deepak; Waren, Kalis; Angela, Angela; Broto, Resza; Kalumpiu, Jane Florida; Tan, Sylvia
Medicinus Vol 12, No 3 (2023): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i1.7363

Abstract

Background: There was limited data of Atopic Dermatitis (AD) prevalence and its associated factors in Indonesia. Therefore, the aim of this study was to identify and evaluate the AD prevalence and factors associated with AD in elementary school children in suburban area in Banten.Methods: A cross-sectional study was conducted in 3 elementary schools children age 6–7 years old who were randomly selected. Information was obtained through an Indonesian version of the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC).Results: From 304 school children in semi-urban area, AD was reported as ever had an itchy rash which was reccurent for at least 6 months in 17.4% of the children, 19.5%  of the children had this itchy rash at any time in the past 12 months, and 11.4 % reported doctor-diagnosed AD. The factors found to be associated with an increased risk of AD were allergic rhinitis (OR 2.151 CI: 1.086-4.261), history of premature birth (<37 weeks) (OR 5.306, CI:1.577-17.858), exclusive breastfeeding (OR 3.126 CI:1.314-7.439), and food allergy (OR 2.912 CI:1.386-6.119).Conclusion: The results of this study showed that allergic rhinitis, history of premature birth (<37 weeks), exclusive breastfeeding, and food allergy were factors associated with AD in Indonesian schoolchildren. 
Role of Light Physical Activity Towards Stress in the Elderly in Nursing Homes Nesia, Waynhena Sarawa; Atmodjo, Wahyuni Lukita; Moningkey, Shirley Ivonne
Medicinus Vol 13, No 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i2.7526

Abstract

Introduction: It was reported that one in five adults and four out of five adolescents around the world did not do enough physical activity, especially the elderly tend not to do physical activity that is classified as active. Less physical activity can inhibit the release of ACTH and decrease cortisol secretion so that it can cause stress. Although it has been reported about the relationship between physical activity and stress levels at the age of 23-54 years, there has not been much research on the relationship in the elderly. Many elderly people aged over 60 years, especially those living in nursing homes experience stress due to lack of physical activity. Thus, further research is needed regarding the relationship between light physical activity and stress levels in the elderly at the Nursing Home.Methods: It was an unpaired categorical comparative analytic study. Elderly respondents at the Nursing Home aged 60-74 years will fill out the PASE questionnaire to assess physical activity and the PSS-10 to assess stress levels. The data obtained will be processed using Microsoft Excel and analyzed with the Pearson Chi-Square test using the SPSS-25 program.Result: Of the 40 respondents, 30 did light physical activity and 10 did heavy physical activity. It was also found that 14 experienced mild stress and 26 experienced severe stress. The results from Pearson ChiSquare show p-value <0.001 and OR = 16.000.Conclusions: The results of this study states that there is a significant relationship between light physical activity and stress levels in the elderly aged 60-74 years who live in nursing homes.
Strangulated Left Lateral Inguinal Hernia in a 54-Year-Old Woman: A Case Report Sudirman, Taufik; Surya, Clarissa; Marina, Sinta
Medicinus Vol 13, No 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i2.7532

Abstract

Introduction: Around 20 millions of hernia repairs were done annually with women presenting least cases. The occurrence of inguinal hernia in female patients is 3-6%, which is lower than men (27-43%). Inguinal hernia itself may present as a bulge in the groin in which the definitive treatment is through surgery. Although many research were done for hernia repair in men, guidelines for women are still currently observed with less favourable outcomes.Case illustration: A 54-year-old woman came to the ED complaining of pain of protruding bulge in the groin area for two hours. The patient has had a history of bulging for three years, which was previously reducible. Examination of the inguinal region revealed a lump with a diameter of +/- 4 cm and painful when palpated. Abdominal USG showed a left inguinal hernia consisting intestinal tissues. Open herniotomy with mesh grafting was performed and the patient got discharged after 4 days of hospitalisation.Conclusion: Lifetime risk for development of inguinal hernia is higher in men compared to women, but the rate of emergency procedures in women is 3 to 4-fold higher than in men. Guidelines for hernia repair in women show less favourable results than in men. Therefore, special steps must be taken in the repair of inguinal hernia in women.

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