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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
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Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 429 Documents
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Characteristics of High-Risk Behaviours Related to Alcohol and Illicit Drug Use and their Associated Factors among Adolescents in Middle and High School Widjaja, Melanie; Latief, Abdul; Sekartini, Rini
Medicinus Vol 13, No 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8883

Abstract

Background: Use of narcotics, psychotropic and addictive substances (NPA) in adolescents has become one of the major social problems we are facing in society and it gives a negative impact. This study was done to determine the characteristics and factors that influence high-risk behaviour of NPA use in adolescents in middle and high school, also introducing CRAFFT questionnaire as an early screening tool for alcohol an illicit drugs use.Methods: Quantitative study (validated questionnaire) was conducted among 514 subjects aged 12-18 years old. CRAFFT questionnaire was used to detect a high-risk behavior of alcohol and illicit drugs use and self-reported questionnaire used to determine the risk factors of NPA.Result: Most participants (19,6%) were involved in high-risk behaviour of alcohol and illicit drugs, with the majority was males (12,4%). This study showed smoking behaviour (23,8%), drinking alcohol (15,8%) and illicit drugs use (13,6%). The type of drugs being used were cannabis (52,7%), tramadol (15,2%), dextromethorphan (10,7%) and methamphetamine (6,3%). CRAFFT questionnaire has a good internal consistency with Cronbach’s α 0,73. Education level, authoritarian parenting style, unharmonious parents, peer pressure or threat, and extracurricular activities were factors that influenced high-risk behavior of alcohol and illicit drug useConclusions: Early detection, comprehensive treatment, and intervention of risk factors of NPA use are needed. CRAFFT can be use as one of the screening tools for detection of alcohol and illicit drugs use in adolescents.
Uncommon Presentation of Perianal Condyloma Acuminata in a Young Male: A Case Report Christina, Natalia Maria; Prasetyo, Patricia Diana; Cendikiawan, Albert; Wijaya, Jeremiah Hilkiah
Medicinus Vol 13, No 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8888

Abstract

Background: Perianal warts, also known as anogenital warts or condyloma acuminata, represent a significant health concern in the young male population. Here, we present a unique case of a large perianal wart in a 26-year-old male patient.Case Description: The patient came to the surgical clinic with complaints of an anal lump for 7 months ago. The lump first appeared in February 2019 as big as a green bean, it increased in size, bled easily and painful to be touched. The patient had a history of anal intercourse 1 month before the lump appeared. The lump size was about 8 x 5 cm and resembled “cauliflower”. Diagnosis of suspected anal papilloma was made.  In July 2019, an incisional biopsy was performed, and the result showed papilloma squamosa with condyloma acuminata as a differential diagnosis. In September 2019, perianal soft tissue tumor excision with advancement flap was performed and the result showed condyloma acuminata. Discussions: The case highlights the importance of careful evaluation and diagnosis in such clinical scenarios, as the initial diagnosis of anal papilloma was later refined to condyloma acuminata based on the biopsy and surgical findings. Early detection and appropriate management are crucial in cases like this to ensure the best possible patient outcomes.
Comparison of 2009 and 2011 WHO Guidelines, and Scoring Models for Adult Hospitalized Dengue Infection: A Single Observation in Tangerang, Indonesia Wiwing, Veronica; Japutri, Josephine; Suryadinata, Neneng
Medicinus Vol 13, No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.8104

Abstract

Background: World Health Organization (WHO) published a dengue guideline in 2009 and in 2011 by WHO-SEARO. However, many of dengue cases in early phase do not meet all the criteria by WHO classification. Because of this condition there is a scoring model that was published in 2015, that might help in primary health care. Therefore, a study to compare those diagnostic tools especially in adult dengue patients in Banten is needed.Aims: This study is to know the comparison between 2009 version and 2011 version of dengue diagnostic guidelines by WHO and scoring model version.Methods and Material: This study used a descriptive method with a cross-sectional design at 60 adult dengue patients. Each patient is grouped according to diagnostic tools’ classification and will be analyzed using Chi-square.Results: Results are grouped according to the WHO diagnosis from 2009 and 2011, presumptive model and probable models where there are 46 (77%), 48 (78%), 31(52%), and 15 (25%) of patients diagnosed with dengue infection. Overall, the diagnosis made by the 2009 WHO and the probable models has the most superior sensitivity and specificity values of 84,6% and 25%, and 82,4% and 97,7% respectively compared to other diagnostic tools. However, from the results of positive predictive values, probable models have a higher percentage than the 2009 WHO diagnosis.Conclusions: The probable model is more sensitive and specific than other diagnostic results. These conclude that probable model is best tool for dengue infection screening in early phase of infection.
A Systematic Review of Efficacy and Safety of Difelikefalin in Treating Pruritus in Hemodialysis Patients with Chronic Kidney Disease Enggalhardjo, Muljani; Tumiwa, Gabriella Hilary; Khosasih, Yeshiza
Medicinus Vol 13, No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.8109

Abstract

Background: Chronic Kidney Disease (CKD) is a type of kidney disease that gradual loss of kidney function over a period of months or years, usually more than 3 months. Uremic pruritus or chronic kidney disease-associated with CKD (CKD-aP) is a common complication that experienced by CKD patients especially for patients undergoing haemodialysis and it will negatively impact quality of life, for example depression, poor sleep quality, and miss dialysis sessions.Methods: Three online databases were used for the literature search: Science Direct, Embase, and PubMed. obtaining the information in January 2024. Using specific keywords, a comprehensive analysis of research articles was carried out. We examined the safety and effectiveness of difelikefalin in the management of pruritus in patients receiving hemodialysis who have chronic kidney disease.Result: Six studies were evaluated that met the criteria for inclusion. The efficacy of difelikefalin in all studies was examined by using WI-NRS as assessment tools for the primary outcome, and for the secondary outcome, skindex-10 or skindex-16 scoring, the 5-D itch scale, and the itch MOS (Medical Outcome Study) sleep disturbance scale were used. From all studies, difelikefalin in various dosages and routes (oral and intravenous) improved pruritus reduction in hemodialysis patients with CKD over placebo. However, in the majority of cases, difelikefalin caused a higher chance of experiencing adverse events than in the placebo group.Conclusions: All studies show a greater pruritus reduction in hemodialysis patients receiving therapy over placebo, with the optimal benefit-risk at 0.5 μg/kg of difelikefalin, despite unclear efficacy-dosage connections.
Relationship Between Breast Milk Feeding and COVID-19 Incidence in Children Aged 0-2 Years at Siloam Hospital Kelapa Dua During The Pandemic Setiawan, Jovanicha P.; Rivami, Dwi Savitri
Medicinus Vol 13, No 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8884

Abstract

Background: The COVID-19 pandemic has claimed more than 6 million lives worldwide, and children are not spared from its danger. Breast milk is known to protect babies from various kinds of infections. Until now there are few data regarding the relationship between breastfeeding and the incidence of COVID-19 in children aged 0-2 years in Indonesia. This study aims to further examine the relationship between breastfeeding and the incidence of COVID-19 in children aged 0-2 years. Siloam Hospitals Kelapa Dua (SHKD) was chosen as a location because it was one of the referral hospitals for treating COVID-19 for pediatric patients in Tangerang that can be accessed by the researcher.Methods: This study was conducted using a cross-sectional study method on a sample of children aged 0-2 years from the medical record database of Siloam Hospitals Kelapa Dua for the period 2020 to 2022.Result: Upon calculation, it was found that the p-value is 0,154 (p>0,05). From 61 sample, 37,7% of the samples were breastfed and 44,3% was COVID-19 positive.Conclusions: No significant relationship was found between breastfeeding and COVID-19 infection among children aged 0-2 years old in SHKD.
Age, Onset, and Tumor Size Differences in Newly Diagnosed Breast Cancer Patients Before and During the SARS-CoV-2 Pandemic at Siloam Hospital Lippo Village (April 2019 – December 2020) Halim, Freda Susana
Medicinus Vol 13, No 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8889

Abstract

Background: The current pandemic condition has caused delays in cancer treatment therefore surveillance should be increased.Methods: By total sampling, this retrospective cross-sectional study enrolled 108 samples, who were newly diagnosed breast cancer patients at the outpatient department of Siloam Hospital Lippo Village (April 2019 - December 2020). Data obtained from medical records and interviews from December 2020 – February 2021.Result: From the total of 108 samples which consisted of 54 samples before the pandemic (April 2019 – February 2020) and 54 samples during the pandemic (March 2020 – December 2020), accompanied by an increasing trend. The age during pandemic was younger than before pandemic (51,167 years old ± 11,255 vs 47,537 years old ± 9,824, p value=0,038), the tumor size during pandemic was bigger than before pandemic (3,403 cm ± 3,024 vs 4,262cm ± 4,212, p value=0,046) but the onset of patient during pandemic was not longer than before pandemic (281,69 days ± 401,387 vs 178,09 days ± 292,563, p value=0,036).Conclusions: Newly diagnosed patients have younger age and larger tumor size during pandemic when we compare to before pandemic period, but no difference in onset term. Surveillance to society is needed to ensure older people with smaller tumor size to seek medical attention.
Difference Disease Knowledge Level in Type 2 Diabetes Mellitus Patients at Siloam Lippo Village General Hospital Moningkey, Shirley Ivonne; Aprilyanri, Iegreat; Atmodjo, Wahyuni Lukita
Medicinus Vol 13, No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.8105

Abstract

Background: In Indonesia, Diabetes Mellitus (DM) with complications is the third leading cause of death. Risk of complication increases tremendously in uncontrolled diabetes. The level of knowledge is one of the factors affect glycaemic control. However, little study has been done regarding the difference in disease knowledge level in type 2 DM patients. This study aims to find out the difference between the level of DM knowledge and glycaemic control in type 2 diabetes mellitus patients at Siloam Lippo Village General Hospital.Methods: Analytical observational with a cross-sectional study was conducted. 46 type 2 diabetes mellitus patients qualified for the inclusion criteria and were given the self-administered Michigan Diabetes Knowledge Test (MDKT) for General Knowledge Part (GKP) questionnaire and HbA1c test results taken in the past six months to evaluate glycaemic control. Purposive sampling method was used in this study for data collection. Student T-test was done to measure the difference with 95% significancy.Result: In 46 samples were shown that 60.90% women, a majority in the 50-59 age group, and 65.20% with more than 5 years of DM history. Among 46 samples, 26 have uncontrolled glycaemic with a mean score of 6.65 ± 1.83 in knowledge, and 20 have controlled glycaemic with a mean score 7.80 ± 1.61. Student T-test showed significant difference in level of knowledge between controlled and uncontrolled glycaemic levels with p = 0.032.Conclusions: It is concluded that there is a difference in disease knowledge level in type 2 DM patients at Siloam Lippo Village General Hospital. 
RNAi-Based Therapy: Prospect as Cancer Treatment Soentoro, Samuel E; Timothy, Michael; Jo, Juandy
Medicinus Vol 13, No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.8110

Abstract

Cancer is one of the deadliest form of diseases in humans, with the annual deaths ranging in the millions. Conventional treatments including chemotherapy, radiotherapy, or surgery has their limitations, including common off-target and non-specific effects. Ribonucleic acid interference (RNAi) offers a new strategy for treating cancer by silencing specific genes to prevent gene expression. This review highlights the application of RNAi-based approach in targeting cancer, discusses its potential advantages and limitations, summarizes the existing clinical trials and provides a greater understanding of RNAi-based therapy in cancer.
Anemia and Erythropoietin Use Among Hemodialysis Chronic Kidney Disease Patients at Rumah Sakit Umum Siloam Tjiang, Margaret Merlyn; Caroline, Elliscia; Siregar, Jeremia Immanuel
Medicinus Vol 13, No 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8885

Abstract

Background: Chronic kidney disease (CKD) affects an estimated 8-16% of the population and is increasing in prevalence. Anemia, a common and significant complication of CKD, is primarily caused by reduced erythropoietin production, which is essential for red blood cell production. Erythropoietin, a kidney-produced hormone, stimulates bone marrow to produce red blood cells. This study examines trends in the use of erythropoiesis-stimulating agents (ESAs) and the management of anemia in dialysis CKD patients before and after the implementation of ESA reimbursemen.Methods: This cohort study was conducted at Rumah Sakit Umum Siloam, Tangerang, Indonesia, from February to July 2017. Patients who received blood transfusions or iron supplements during the study were excluded. Data collected included age, gender, dry weight, history of diabetes mellitus, hypertension, hemodialysis adequacy, and nutritional status. Statistical analysis with a 95% confidence interval (CI) was used to assess the association between hemoglobin levels (Hb) and erythropoietin use.Results: Sixty patients completed the study. The proportion of anemic patients (Hb <10 g/dL) increased from 22 (36.7%) to 28 (46.7%) after erythropoietin administration. A mean dose of 6000 IU/week (CI: 4679 to 7321 IU/week) was effective in achieving target hemoglobin levels, while a dose of 4131 IU/week (CI: 3479 to 4782 IU/week) was sufficient to maintain them. Additionally, a dosage of 103.31 IU/kg/week increased hemoglobin by 1 g/dL in anemic patients.Conclusions: Erythropoietin use should be optimized given the increasing prevalence of anemia. A dosage of 103.31 IU/kg/week is recommended to achieve target hemoglobin levels, while 4131 IU/week is suggested for maintaining hemoglobin within the target range. 
Intracranial Solitary Fibrous Tumor in a 25-Year-Old Woman Prasetyo, Patricia Diana; Marisca, Stephanie; Wahjoepramono, Eka J.
Medicinus Vol 13, No 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8890

Abstract

Introduction: Intracranial solitary fibrous tumors (ISFTs) are extremely rare spindle cell tumors originating from dendritic mesenchymal cells expressing CD34 antigens that are usually benign, although malignant transformation had been reported. The knowledge of natural course and prognostic factors of ISFTs is still limited and the tumor is easily misdiagnosed.Case Presentation: An intra-cranial extra-axial tumor tissue resection from a 25-year-old woman was evaluated in the Surgical Pathology Laboratory. Histologic findings (cellular spindle cell tumor with ‘patternless’ pattern, staghorn blood vessels and <5 mitoses per 10 hpf) and immunophenotype (positive for CD34, weakly and focally positive for STAT6) suggested a diagnosis of intracranial solitary fibrous tumor WHO Grade II.Discussion: ISFTs have very low incidence in the CNS and are difficult to distinguish radiologically from meningiomas, thus post operative pathological examination and immunohistochemistry markers evaluations are the mainstay for diagnosis. ISFT is associated with NAB2-STAT6 gene fusion and may exhibits a wide spectrum of histological features. STAT6 immunohistochemistry is considered as one of the most sensitive diagnostic methods, while the evaluation of CD34 expression can be used as alternative diagnostic method despite having lower sensitivity.

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