cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Julius July
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota tangerang,
Banten
INDONESIA
Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
  • Website
Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 429 Documents
 16   17   18   19   20 
Lactate Dehydrogenase A as a Target of Cancer Therapy Neolaka, Gladies Mercya Grameinie
Medicinus Vol 12, No 3 (2023): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i1.7364

Abstract

Lactate dehydrogenase (LDH) is an enzyme that catalyzes the conversion of pyruvate to lactate and on the contrary lactate to pyruvate. LDH is a tetramer consisting of two types of subunits M (LDHA) and H (LDHB). LDHA catalyzes the conversion of pyruvate to lactate, while LDHB converts lactate to pyruvate. LDHA increases its expression in cancer cells and is associated with cancer aggressiveness. Lactate that continues to increase gives the effect of an acidic microenvironment so that there is sufficient availability of oxygen for metabolism, which increases anaerobic glycolysis and decreases oxidative phosphorylation. Inhibition of LDHA can provide hope in cancer therapy because many studies have shown that inhibition of LDHA reduces cancer growth. This review will describe several cancer treatment approaches using LDH as a cancer therapy target until now.
Association Between Body Mass Index and Low Back Pain Among Students at the Faculty of Medicine, Pelita Harapan University Thiono, Jeskry; Suryadinata, Neneng
Medicinus Vol 13, No 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i2.7527

Abstract

Background: Low back pain (LBP) is the most common musculoskeletal complaint and the largest contributor to the burden of disability in the world. One of the risk factors for LBP is having a higher body mass index (BMI). Although the relationship between BMI and LBP in the age group susceptible to LBP has been widely studied, the relationship in the young adult age group is still under-researched. Meanwhile, several studies report that lifestyle changes that occur during the COVID-19 pandemic might lead to an increasing number of overweight obese sufferers, including in the young adult age group. Given the context, this research aims to determine the relationship between BMI and LBP in UPH Medical Faculty (FK UPH) students during the COVID-19 pandemic.Method: A cross-sectional method of unpaired categorical comparative analytical study design was conducted with a population of 414 medical students. Data were collected by an online survey of BMI measurement and the Nordic Musculoskeletal Questionnaire. Statistical analysis was done using SPSS Statistics with Chi-squared or Fischer's exact method.Result: The study involved a sample of 372 people with 188 people (50.5%) being LBP sufferers. Most of the sample belongs to the category of BMI < 23 kg/m2, which is 215 people (57.8%).Conclusion: The result from this research concludes that there is no significant relationship between BMI and LBP in FK UPH students during the COVID-19 pandemic (P = 0.420); significant relationships were found between LBP with gender (P = <0.001) and smoking habit (P = 0.022).  
Intramedullary Spinal Cord Cavernoma: A Case Report and Literature Review Widjaya, Ingrid A; Yunus, Yesaya; Wahjoepramono, Eka Julianta; July, Julius
Medicinus Vol 13, No 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i2.7533

Abstract

Background: Spinal cord intramedullary cavernous malformation (SICM) is kind of rare vascular disease, and the therapeutic strategy is still under debate. Cavernous malformation (CM) can be found throughout the central nervous system (CNS) but only rarely occur within the spinal cord. The purpose of this article is to describe natural history, clinical presentation and outcome of SICM case which treated surgicallyCase Presentation: A 70-year-old healthy woman presented with lower extremity weakness. A posterior laminectomy was performed, and a diagnosis of intramedullary spinal cord cavernous malformation was established. Neurological improvement was seen in one month after surgeryConclusion: Intramedullary CM is a rare disease but one with significant consequences if not managed appropriately. whenever safely feasible, gross total resection is suggested, to prevent rebleeding and further worsened of neurological deficit.
Relationship Between Clinical Factors of Lymphoma DLBCL GCB and Non-GCB Subtype with Ki-67 Proliferation Index in Siloam Karawaci Hospital 2014 - 2018 Kristiani, Erna; Marisca, Stephanie; Qurro, Tri Ulfatul; Kweeswara, Natasya; Chandra, Amos Immanuel
Medicinus Vol 12, No 3 (2023): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i1.7365

Abstract

Background: Non-Hodgkin large cell B-lymphoma (DLBCL: Diffuse Large B-cell Lymphoma) were classified into two subtypes of Germinal Center B-Cell Like (GCB) and non-Germinal Center B-Cell Like (non-GCB), which GCB has a better prognosis. The Ki-67 antigen is one of the most reliable markers of cell proliferation. This research aims to establish the relationship between proliferation index Ki-67 with DLBCL subtypes and to evaluate the utility of Ki-67 proliferative index as a predictive marker for predicting stages of lymphoma.Methods: We obtained 60 cases of patient samples DLBCL in Siloam Hospital Lippo Karawaci in 2014-2018. Clinical and pathological data were obtained from medical records. Chi-square methods were used to analyze data.Result: There were more ≤60 years compared to >60 years. In this study, there were more male patients than female patients. lymphoma provided in extranodal were higher than lymphoma in nodal form.Conclusions: There is a relationship between Ki-67 proliferation index with lymphoma GCB and non-GCB subtypes and stage of lymphoma, which can be used as a predictive factor in predicting the stage of lymphoma.
The Role of Classical Music Therapy on Dysmenorrhea Pain and Anxiety in Pelita Harapan University Medical Students Godjali, Handriani Almira; Haryanto, Hori; Sungono, Veli
Medicinus Vol 13, No 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i2.7529

Abstract

Introduction: Dysmenorrhea is menstrual pain that often occurs in young women. The pain felt in every women can be different from one another. Anxiety experienced by each women can also worsen the menstrual pain. Efforts to treat dysmenorrhea can be in the form of non-pharmacological therapy, one of which is music therapy.Aim: This study uses an experimental method with random allocation to divide 122 respondents who are medical students of Pelita Harapan University into a control group and an intervention group.Methodology: The intervention group has been given anexperiment of random allocationin the form of classical music therapy for 20 minutes on the first day of the respondent getting menstruation. As for the control group given 40Hz sound for 20 minutes. The data analyzed using chi-square and wilcoxon test.Results: The results of the study found that the average menstrual pain in the control group before the intervention was 6.11 and after the intervention was 6.07. Meanwhile, in the intervention group, the average menstrual pain before being given classical music therapy was 6.46 and after the intervention was 3.39.Conclusion: So that classical music therapy is effective for reducing anxiety by 0.77 and the menstrual pain scale is 3.07 in the group given classical music therapy with P value <0.001.
Association between Anemia and Severe Pneumonia among Children 6-59 Months Old in RSUD Wangaya, Denpasar: A Cross Sectional Study Sukarno, Theodora; Suryawan, I Wayan Bikin; Sucipta, Anak Agung Made
Medicinus Vol 12, No 3 (2023): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i1.7361

Abstract

Background: Severe pneumonia dan anemia happened to many children under five years old. Anemia leads to hypercapnia and slowing down red blood cell maturation and facilitate ischaemic syndrome. In the other side, pneumonia may increase hepcidin that suppressed erythropoiesis, hence anemia could worsen pneumonia. The aim of this research is to find association of hemoglobin level and severe pneumonia under five years old.Methods: Cross sectional study was done in medical record RSUD Wangaya Denpasar starting from May-August 2022. Data was taken from subject with severe and mild and moderate pneumonia age 6-59 months old that admitted to PICU and Kaswari ward from January 2020-June 2022. Variables processed in this study are gender, pneumonia severity, hemoglobin level, and length of stayResult: This study admits 56 subjects that fulfilled inclusion and exclusion criteria. Boy and girls subjects are found equally (28 subjects equally in both groups). Severe pneumonia found in 18 (32.1%) subjects and 25 subjects (44.6%) has anemia. Length of stay for severe pneumonia is 4.83 ± 1.54 days. Hemoglobin level in severe pneumonia is 10.93±1,96 mg/dL and subjects with mild and moderate pneumonia is 11.69 ±1.41 mg/dL. The result of chi-square test between haemoglobin level and severe pneumonia is p= 0.26Conclusions: This study shows that there is no correlation between hemoglobin level and severe pneumonia. Further study is needed since the correlation between them is still controversial.
A Case Report: Combined Sciatic Nerve and Lumbar Plexus Nerve Block in A Patient with Acute Decompensated Heart Failure Undergoing Lower Extremity Surgical Debridement Tantri, Irma Lusiana; Saroso, Natalia Frederika Darmawan Adji; Domini, Marielle Ancilla; Wiwing, Veronica
Medicinus Vol 12, No 3 (2023): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i1.7366

Abstract

Background: Peripheral nerve block for lower extremity surgeries requires a minimum of two block injections. Although the combination of the lumbar plexus block and the sciatica block is a procedure that requires large doses of local anesthetic, which may induce cardiotoxicity, a recent study suggests that change in the hemodynamic system is not clinically significant.Case Description: We report a case of a 53-year-old male presenting with a worsened shortness of breath two days before hospital admission. He also experienced a sudden high fever and pain on his right thigh. The patient had a history of Heart Failure (EF 28%) and Congestive liver disease and was diagnosed with right femur cellulitis with right phlegmon. Surgical debridement was planned to treat sepsis. Right lumbar plexus block and right sciatica block were performed as surgical anesthesia. The surgery duration was one hour, and the patient was transferred to the PACU. The patient was treated in ICU before being admitted to the general ward and was discharged on day three post-surgery.Conclusion: The combination of Sciatic nerve and lumbar plexus nerve block is an effective anesthesia and analgesia technique for lower limb surgery in individuals with a severe heart condition. 
WNT-Activated Medulloblastoma in A 6-Year-Old Boy Prasetyo, Patricia Diana; Wahjoepramono, Eka Julianta
Medicinus Vol 13, No 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i2.7530

Abstract

Background: Medulloblastoma is the most common malignant brain tumor of childhood. Prognosis is mostly favorable, but may be affected by histological and molecular subtypes. Long-term therapy-related morbidity also remains a significant concern.Case Presentation: A 6-year-old boy with brainstem/midline cerebellum tumor. Histopathology found area of necrosis, sheets of malignant undifferentiated round cells with hyperchromatic nuclei and scanty cytoplasm, no nodule and no anaplasia. Immunohistochemistry found p53 wild-type staining pattern along with b-catenin diffuse cytoplasmic and focal nuclear staining. This indicated a diagnosis of WNT-activated medulloblastoma, World Health Organization (WHO) grade IV, with classic histological features.Discussion: WNT-activated medulloblastomas with classic histological features and no anaplasia were reported to have the most favorable prognosis. The current patient showed negative staining for GFAP, Olig2, EMA, H3K27M, EZHIP, and LIN28A, with retained staining for INI1 and BRG1, thus excluding several differential diagnosis such as atypical teratoid/rhabdoid tumor, embryonal tumor with multilayered rosettes, small cell glioblastoma, Ewing sarcoma, high-grade neuroepithelial tumor with BCOR alteration or diffuse midline glioma. Histopathology in combination with immunohistochemical and molecular subtyping of medulloblastoma can help to refine diagnosis, exclude differential diagnosis, and improve counseling in regards to overall prognosis.
Sudden Onset of Diabetic Ketoacidosis in a Patient with Discordant HbA1C: A Unique Case of Fulminant Type 1 Diabetes Mellitus (FT1DM) in a Middle-aged Man Nadine, I Gusti Ayu; Siregar, Jeremia Immanuel; Prasetya, Yonesha Rahmania
Medicinus Vol 13, No 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8887

Abstract

Introduction: Diabetic Ketoacidosis (DKA) is an acute complication of diabetes mellitus (DM) which present as the first manifestation in fulminant type 1 diabetes mellitus (FT1DM) without significant elevation of HbA1C. We present a unique case of a 52-years-old male with DKA without previous history of DM and HbA1c of 6.6.Case Illustration: A 52-years-old male was brought to hospital due to persistent vomiting. He experienced polyuria and unexplained weight loss but denied previous history of DM. He was diagnosed with DKA due to his blood glucose of 1107 mg/dL along with elevated blood ketone and metabolic acidosis. However, his HbA1c was a mere 6.6. His serum lipase was increased, consistent with pancreatic damage. He was then discharged with basal-bolus insulin.  Discussion: Although the symptoms of this patient was consistent with hyperglycemic crisis, the presentation of DKA is usually associated with elevated HbA1c, approximately 10.4 - 16.9%. This unusual HbA1c points to the diagnosis of FT1DM. It is caused by sudden beta-cell destruction triggered by viral infections, alongside genetic disposition, leading to sudden depletion of insulin occurred less than a week and presents with ketoacidosis. It is characterized by low HbA1c (< 8.7%) yet extremely high blood glucose (≥ 288 mg/dl) and elevated pancreatic enzymes (depicting pancreatic damage). A diagnosis of FT1DM can be ascertained in this patient as his presentations matches its characteristics.Conclusion: FT1DM is a sub-type of T1DM which can suddenly occur in patients and associated with discordant HbA1c. It is important to recognize and treat it accordingly to avoid fatal outcomes.
Isolated Abducens Nerve Palsy: A Case Report of Cerebral Pseudocyst of Dorello’s Canal Puspitasari, Vivien; Japutri, Josephine; Solansa, Tracy; Cenweikiawan, Anderson
Medicinus Vol 13, No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.8108

Abstract

Background: Abducens nerve is the second longest intracranial path out of all of the cranial nerves. Abducens nerve pasly had a prevalence 11.3/100.000 and mostly seen in adults. Isolated abducens nerve palsy due to neoplastic lesion are rare and mostly related to skull base tumor.Case Presentation: We present a case of 57 years old woman with complaints of red right eye and worsening headache associates with diplopia on the right lateral gaze for three days prior admission. She was later diagnosed with isolated abducens nerve palsy associated to neoplasm cause in Dorello’s canal. Patient was then discharged with symptomatic therapy and educated for head posturing and avoid triggers.Conclusions: Abducens nerve palsy is the most common isolated ocular nerve palsy. The incidence of mass formation such as neoplastic lesion or cyst are rare.

Page 18 of 43 | Total Record : 429

 16   17   18   19   20 

Filter by Year

2015 2026


Reset
Filter By Issues
All Issue Vol. 15 No. 2 (2026): February Vol. 15 No. 1 (2025): October Vol. 14 No. 3 (2025): June Vol. 14 No. 2 (2025): February Vol. 14 No. 1 (2024): October Vol. 13 No. 3 (2024): June Vol 13, No 3 (2024): June Vol 13, No 2 (2024): February Vol. 13 No. 2 (2024): February Vol. 13 No. 1 (2023): October Vol 13, No 1 (2023): October Vol. 12 No. 3 (2023): June Vol 12, No 3 (2023): June Vol. 12 No. 2 (2023): February Vol 12, No 2 (2023): February Vol 10, No 3 (2022): October 2022 - January 2023 Vol 10, No 2 (2022): June 2022 - September 2022 Vol 10, No 1 (2022): February 2022 - May 2022 Vol 9, No 3 (2021): October 2021-January 2022 Vol. 12 No. 1 (2022): October Vol 12, No 1 (2022): October Vol. 11 No. 3 (2022): June Vol 11, No 3 (2022): June Vol. 11 No. 2 (2022): February Vol 11, No 2 (2022): February Vol 10, No 3 (2021): June 2021 Vol. 10 No. 3 (2021): June 2021 Vol. 10 No. 2 (2021): February : 2021 Vol 10, No 2 (2021): February : 2021 Vol. 11 No. 1 (2021): October Vol 11, No 1 (2021): October Vol 7, No 3 (2018): June 2018 - September 2018 Vol 10, No 1 (2020): October:2020 Vol. 10 No. 1 (2020): October:2020 Vol 9, No 3 (2020): June 2020 Vol. 9 No. 3 (2020): June 2020 Vol. 9 No. 2 (2020): February : 2020 Vol 9, No 2 (2020): February : 2020 Vol 7, No 2 (2018): February 2018 - May 2018 Vol 7, No 1 (2017): October 2017 - January 2018 Vol 9, No 1 (2019): October:2019 Vol. 9 No. 1 (2019): October:2019 Vol. 8 No. 3 (2019): June 2019 Vol 8, No 3 (2019): June 2019 Vol. 8 No. 2 (2019): February : 2019 Vol 8, No 2 (2019): February : 2019 Vol. 7 No. 3 (2018): June 2018 - September 2018 Vol. 7 No. 2 (2018): February 2018 - May 2018 Vol 6, No 3 (2017): June 2017 - September 2017 Vol 6, No 2 (2017): February 2017 - May 2017 Vol 6, No 1 (2016): October 2016 - January 2017 Vol 5, No 3 (2016): June 2016 - September 2016 Vol 5, No 2 (2016): February 2016 - May 2016 Vol 5, No 1 (2015): October 2015 - January 2016 Vol 4, No 9 (2015): June 2015 - September 2015 Vol 4, No 8 (2015): February 2015 - May 2015 Vol 8, No 1 (2018): oktober 2018 Vol. 8 No. 1 (2018): oktober 2018 Vol. 7 No. 1 (2017): October 2017 - January 2018 Vol. 6 No. 3 (2017): June 2017 - September 2017 Vol. 6 No. 2 (2017): February 2017 - May 2017 Vol. 6 No. 1 (2016): October 2016 - January 2017 Vol. 5 No. 3 (2016): June 2016 - September 2016 Vol. 5 No. 2 (2016): February 2016 - May 2016 Vol. 5 No. 1 (2015): October 2015 - January 2016 Vol. 4 No. 9 (2015): June 2015 - September 2015 Vol. 4 No. 8 (2015): February 2015 - May 2015 More Issue