Pharmacology and Clinical Pharmacy Research
Pharmacology and Clinical Pharmacy Research (PCPR) is an international, peer-reviewed journal, publishing original research, review, case reports, and commentaries on all aspects of pharmacology and clinical pharmacy. The journal aims to contribute to the scientific committee by publishing the high quality articles. It is published 3 times a year to provide a forum for pharmacologists, pharmacists, and other healthcare professionals to share best practice, encouraging networking, and a more collaborative approach in pharmacology and clinical pharmacy.
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<![CDATA[Antioxidant Activity of Ethanol Extract of Polygonum pulchrum Blume ]]>
<![CDATA[Sadino, Asman]]>;
<![CDATA[Sahidin, Idin]]>;
<![CDATA[Wahyuni, Wahyuni]]>
<![CDATA[ Pharmacology and Clinical Pharmacy Research Vol 1, No 2 ]]>
Publisher : <![CDATA[Universitas Padjadjaran, Indonesia ]]>
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DOI: 10.15416/pcpr.v1i2.15201
<![CDATA[The use of antioxidants from natural resources has attracted increasing interest. One of theplant that was empirically used as an antioxidant dietary supplement was Polygonum pulchrumBlume (P. pulchrum Blume). This study aimed to investigate antioxidant activityof roots, stems, leaves and flowers ethanol extract of P. pulchrum Blume. The extract wasobtained by maceration method using ethanol solvent. Antioxidant activity was determinedwith 1,1-diphenyl-picrylhydrazyl (DPPH) method. We found that ethanol extracts of P. pulchrumBlume roots and stems had strong antioxidant activity with IC50 values of 25.2 mg/land 43.26 mg/l, respectively. Ethanol extract of flowers had the weakest antioxidant activitywith IC50 value of 202.96 mg/l. Vitamin C had very strong antioxidant activity with IC50value of 3.97 mg/l. In conclusion, our study revealed that ethanol extract of Polygonumpulchrum Blume roots and stems had strong antioxidant activity. Therefore, P. pulchrumBlume might be potential as an excellent source for natural antioxidant agents for medicalapplication.Keywords: Polygonum pulchrum Blume, DPPH, antioxidant, maceration, ethanol]]>
<![CDATA[Effect of Aerobic Exercise on Selenium Level in Plasma ]]>
<![CDATA[Kanakarajah, Sarmmila]]>;
<![CDATA[Soetedjo, Nanny N. N. M.]]>;
<![CDATA[Lesmana, Ronny]]>
<![CDATA[ Pharmacology and Clinical Pharmacy Research Vol 1, No 2 ]]>
Publisher : <![CDATA[Universitas Padjadjaran, Indonesia ]]>
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DOI: 10.15416/pcpr.v1i2.15204
<![CDATA[Moderate and high aerobic exercises are the activities that can induce high oxidant. Demandof endogen and exogen antioxidant for neutralizing oxidant induced by exercise will playimportant role in maintaining body performance. Microtrace elements, such as selenium,may able to balance high oxidant formation. However, limited research and data have beencollected with regards to the exercise and selenium. Therefore, this research was conductedto investigate the effect of aerobic exercise on selenium level in plasma. An analytic studywith experimental method of data collection was performed from October -November 2016.17 male students with the age between 19-25 years old and without medically compromiseddisease from Universitas Padjadjaran, Jatinangor, were selected as subjects. Blood sampleswere taken pre- and post-aerobic exercise, i.e., brisk walking with the intensity of 4.5 mi/h.Selenium level in plasma was then examined by enzyme linked immunosorbent assay (ELISA)kit as selenium binding protein (SELENBP1). This study found that 11 (65%) subjectshad a decrease in their selenium plasma after exercise (3.1 ± 2.58 ng/ml), 5 (29%) subjectshad an increase in their selenium plasma after exercise (2.08 ± 2.8 ng/ml) and 1 (6%) subjecthad unchanged selenium (SELENBP1) plasma (1.4 ± 1.4 ng/ml) level. Effect of aerobicexercise on selenium level in plasma varied among individuals.Keywords: aerobic exercise, selenium, young adult]]>
<![CDATA[Antibacterial Activity of Pluchea indica and Piper betle Ethanol Extract on Staphylococcus epidermidis and Pseudomonas aeruginosa ]]>
<![CDATA[Simanjuntak, Nela]]>;
<![CDATA[Yuniarni, Umi]]>;
<![CDATA[Prayugo, Diki]]>
<![CDATA[ Pharmacology and Clinical Pharmacy Research Vol 1, No 2 ]]>
Publisher : <![CDATA[Universitas Padjadjaran, Indonesia ]]>
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DOI: 10.15416/pcpr.v1i2.15202
<![CDATA[Medicinal plants are widely used for the treatment of different infectious diseases. This study was aimed to investigate antibacterial activity of Pluchea indica (P. indica) and Piper betle (P.betle) ethanol extract on Staphylococcus epidermidis (S. epidermidis) and Pseudomonasaeruginosa (P. aeruginosa) using agar disk diffusion method. Ethanol extract of Piper betle showed more potent antibacterial activity than P. indica against S. Epidermidis with the highest inhibiton zone at 30.71 mm and 21.73 mm from 1 mg/ml concentration, respectively. In contrast, against P. aeruginosa, the ethanol extract of P. indica was more potent than P. betle with 21.44 mm and 20.12 mm of inhibition zone on 1 mg/ml concentration, respectively. There was no increased effect from the combination of these two extracts against these bacteria. When comparing the antibacterial activity of these extract with tetracycline asthe standard, we found that antibacterial activity of P. indica at the concentration of 0.9 mg/ ml was comparable with that of tetracycline at concentration of 12.52 μg/ml, while P. betle needed 0.3 mg/ml concentration to had similar activity with 10.51 μg/ml of tetracycline. In conlusion, the antibacterial activity of ethanol extracts of P. indica and P. betle indicated that these extract had sufficient potential to warrant further examination and development as a new antibacterial agent.Keywords: Pluchea indica, Piper betle, antibacterial, agar disk diffusion]]>
<![CDATA[Antimitotic Activity of Cayratia trifolia Ethanol Extract on Zygote Cells of Tripneustes gratilla ]]>
<![CDATA[Feriadi, Eva]]>;
<![CDATA[Wahyuni, Wahyuni]]>;
<![CDATA[Yusuf, Muhammad I.]]>
<![CDATA[ Pharmacology and Clinical Pharmacy Research Vol 1, No 2 ]]>
Publisher : <![CDATA[Universitas Padjadjaran, Indonesia ]]>
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DOI: 10.15416/pcpr.v1i2.15205
<![CDATA[Cancer is a devastating disease characterized by abnormal cell growth. Due to several safety issues associated with current cancer treatment, identification of new strategies for cancer therapy is considered necessary. Natural substances in plants m and fruits have the potentials to be developed as anticancer drugs. One of them is Cayratia trifolia (C. trifolia). This study was aimed to determine the cytotoxic activity of stem and leaf ethanol extract of C. trifolia against zygote cells of sea urchin or Tripneustes gratilla (T. gratilla). Extraction of stem and leaf of C. trifolia was conducted using maceration method in ethanol solvent. Thin layer chromatography was performed to screen phytochemicals contained in the extract. Zygoteof T. gratilla was used to conduct antimitotic activity test. We found that stem and leaf ethanol extract had IC50 of 169.82 μg/ml and 208.92 μg/ml, respectively. In comparison with positivecontrol of vincristine which had IC50 value of 3.23x10-3 μg/ml (very strong category), this extract showed moderate antimitotic activity. In conclusion, C. trifolia is potential to be developed as anticancer treatment.Keywords: cancer, Cayratia trifolia, antimitotic]]>
<![CDATA[Antioxidant Activity of Ethanol Extract of Polygonum pulchrum Blume ]]>
<![CDATA[Asman Sadino]]>;
<![CDATA[Idin Sahidin]]>;
<![CDATA[Wahyuni Wahyuni]]>
<![CDATA[ Pharmacology and Clinical Pharmacy Research Vol 1, No 2 ]]>
Publisher : <![CDATA[Universitas Padjadjaran, Indonesia ]]>
Show Abstract
|
Download Original
|
Original Source
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Check in Google Scholar
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Full PDF (377.767 KB)
|
DOI: 10.15416/pcpr.v1i2.15201
<![CDATA[The use of antioxidants from natural resources has attracted increasing interest. One of theplant that was empirically used as an antioxidant dietary supplement was Polygonum pulchrumBlume (P. pulchrum Blume). This study aimed to investigate antioxidant activityof roots, stems, leaves and flowers ethanol extract of P. pulchrum Blume. The extract wasobtained by maceration method using ethanol solvent. Antioxidant activity was determinedwith 1,1-diphenyl-picrylhydrazyl (DPPH) method. We found that ethanol extracts of P. pulchrumBlume roots and stems had strong antioxidant activity with IC50 values of 25.2 mg/land 43.26 mg/l, respectively. Ethanol extract of flowers had the weakest antioxidant activitywith IC50 value of 202.96 mg/l. Vitamin C had very strong antioxidant activity with IC50value of 3.97 mg/l. In conclusion, our study revealed that ethanol extract of Polygonumpulchrum Blume roots and stems had strong antioxidant activity. Therefore, P. pulchrumBlume might be potential as an excellent source for natural antioxidant agents for medicalapplication.Keywords: Polygonum pulchrum Blume, DPPH, antioxidant, maceration, ethanol]]>
<![CDATA[Effect of Aerobic Exercise on Selenium Level in Plasma ]]>
<![CDATA[Sarmmila Kanakarajah]]>;
<![CDATA[Nanny N. N. M. Soetedjo]]>;
<![CDATA[Ronny Lesmana]]>
<![CDATA[ Pharmacology and Clinical Pharmacy Research Vol 1, No 2 ]]>
Publisher : <![CDATA[Universitas Padjadjaran, Indonesia ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
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Full PDF (267.275 KB)
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DOI: 10.15416/pcpr.v1i2.15204
<![CDATA[Moderate and high aerobic exercises are the activities that can induce high oxidant. Demandof endogen and exogen antioxidant for neutralizing oxidant induced by exercise will playimportant role in maintaining body performance. Microtrace elements, such as selenium,may able to balance high oxidant formation. However, limited research and data have beencollected with regards to the exercise and selenium. Therefore, this research was conductedto investigate the effect of aerobic exercise on selenium level in plasma. An analytic studywith experimental method of data collection was performed from October -November 2016.17 male students with the age between 19-25 years old and without medically compromiseddisease from Universitas Padjadjaran, Jatinangor, were selected as subjects. Blood sampleswere taken pre- and post-aerobic exercise, i.e., brisk walking with the intensity of 4.5 mi/h.Selenium level in plasma was then examined by enzyme linked immunosorbent assay (ELISA)kit as selenium binding protein (SELENBP1). This study found that 11 (65%) subjectshad a decrease in their selenium plasma after exercise (3.1 ± 2.58 ng/ml), 5 (29%) subjectshad an increase in their selenium plasma after exercise (2.08 ± 2.8 ng/ml) and 1 (6%) subjecthad unchanged selenium (SELENBP1) plasma (1.4 ± 1.4 ng/ml) level. Effect of aerobicexercise on selenium level in plasma varied among individuals.Keywords: aerobic exercise, selenium, young adult]]>
<![CDATA[Antibacterial Activity of Pluchea indica and Piper betle Ethanol Extract on Staphylococcus epidermidis and Pseudomonas aeruginosa ]]>
<![CDATA[Nela Simanjuntak]]>;
<![CDATA[Umi Yuniarni]]>;
<![CDATA[Diki Prayugo]]>
<![CDATA[ Pharmacology and Clinical Pharmacy Research Vol 1, No 2 ]]>
Publisher : <![CDATA[Universitas Padjadjaran, Indonesia ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (299.448 KB)
|
DOI: 10.15416/pcpr.v1i2.15202
<![CDATA[Medicinal plants are widely used for the treatment of different infectious diseases. This study was aimed to investigate antibacterial activity of Pluchea indica (P. indica) and Piper betle (P.betle) ethanol extract on Staphylococcus epidermidis (S. epidermidis) and Pseudomonasaeruginosa (P. aeruginosa) using agar disk diffusion method. Ethanol extract of Piper betle showed more potent antibacterial activity than P. indica against S. Epidermidis with the highest inhibiton zone at 30.71 mm and 21.73 mm from 1 mg/ml concentration, respectively. In contrast, against P. aeruginosa, the ethanol extract of P. indica was more potent than P. betle with 21.44 mm and 20.12 mm of inhibition zone on 1 mg/ml concentration, respectively. There was no increased effect from the combination of these two extracts against these bacteria. When comparing the antibacterial activity of these extract with tetracycline asthe standard, we found that antibacterial activity of P. indica at the concentration of 0.9 mg/ ml was comparable with that of tetracycline at concentration of 12.52 μg/ml, while P. betle needed 0.3 mg/ml concentration to had similar activity with 10.51 μg/ml of tetracycline. In conlusion, the antibacterial activity of ethanol extracts of P. indica and P. betle indicated that these extract had sufficient potential to warrant further examination and development as a new antibacterial agent.Keywords: Pluchea indica, Piper betle, antibacterial, agar disk diffusion]]>
<![CDATA[Antimitotic Activity of Cayratia trifolia Ethanol Extract on Zygote Cells of Tripneustes gratilla ]]>
<![CDATA[Eva Feriadi]]>;
<![CDATA[Wahyuni Wahyuni]]>;
<![CDATA[Muhammad I. Yusuf]]>
<![CDATA[ Pharmacology and Clinical Pharmacy Research Vol 1, No 2 ]]>
Publisher : <![CDATA[Universitas Padjadjaran, Indonesia ]]>
Show Abstract
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Download Original
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Original Source
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Check in Google Scholar
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DOI: 10.15416/pcpr.v1i2.15205
<![CDATA[Cancer is a devastating disease characterized by abnormal cell growth. Due to several safety issues associated with current cancer treatment, identification of new strategies for cancer therapy is considered necessary. Natural substances in plants m and fruits have the potentials to be developed as anticancer drugs. One of them is Cayratia trifolia (C. trifolia). This study was aimed to determine the cytotoxic activity of stem and leaf ethanol extract of C. trifolia against zygote cells of sea urchin or Tripneustes gratilla (T. gratilla). Extraction of stem and leaf of C. trifolia was conducted using maceration method in ethanol solvent. Thin layer chromatography was performed to screen phytochemicals contained in the extract. Zygoteof T. gratilla was used to conduct antimitotic activity test. We found that stem and leaf ethanol extract had IC50 of 169.82 μg/ml and 208.92 μg/ml, respectively. In comparison with positivecontrol of vincristine which had IC50 value of 3.23x10-3 μg/ml (very strong category), this extract showed moderate antimitotic activity. In conclusion, C. trifolia is potential to be developed as anticancer treatment.Keywords: cancer, Cayratia trifolia, antimitotic]]>
<![CDATA[Drug Related Problems of Diabetic Nephropathy Patients in a Tertiary Hospital in Malaysia ]]>
<![CDATA[Dika P. Destiani]]>;
<![CDATA[Athirah Ghazali]]>
<![CDATA[ Pharmacology and Clinical Pharmacy Research Vol 1, No 2 ]]>
Publisher : <![CDATA[Universitas Padjadjaran, Indonesia ]]>
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DOI: 10.15416/pcpr.v1i2.15207
<![CDATA[Patients with diabetic nephropathy (DN) are particularly vulnerable to drug related problems (DRPs) due to complex medication regimen and renal dysfunction. However, there was limited information regarding prevalence of DRPs among patients with DN in Malaysia. This research was conducted to determine the prevalence of DRPs among hospitalized patients with DN at tertiary hospital in Malaysia during June 2014-May 2015. This was a retrospective observational descriptive study that used patients medical records as data source. There were 104 subjects included in this study. The prevalence of DRPs among the included subjects was 74%. Most DRPs observed were from two categories, namely non-compliance to medication and adverse drug reactions (20.93% for both categories). These categories were followed by the category of unnecessary drugs (16.28%), too low dose (15.81%), inappropriate drugs (11.16%), untreated indication (10.23%) and too high dose (4.65%). Pharmacists are encouraged to perform comprehensive medication review to improve health outcomes and enhance patients safety.Keywords: Drug related problems, diabetic nephropathy, T2DM]]>
