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Pharmacology and Clinical Pharmacy Research

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Published by Universitas Padjadjaran

ISSN : 25277332 EISSN : 26140020 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Pharmacology and Clinical Pharmacy Research (PCPR) is an international, peer-reviewed journal, publishing original research, review, case reports, and commentaries on all aspects of pharmacology and clinical pharmacy. The journal aims to contribute to the scientific committee by publishing the high quality articles. It is published 3 times a year to provide a forum for pharmacologists, pharmacists, and other healthcare professionals to share best practice, encouraging networking, and a more collaborative approach in pharmacology and clinical pharmacy.

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Articles 207 Documents

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Secondary Metabolites and Antioxidant Activity of Methanol Extract of Castanopsis costata Leaves Alkandahri, Maulana Y.; Nisrihadi, Leo; Salim, Emil
Pharmacology and Clinical Pharmacy Research Vol 1, No 3
Publisher : Universitas Padjadjaran, Indonesia

Castanopsis costata (C.costata) leaves were empirically used by people in North Sumatera, Indonesia, as an antioxidant dietary supplement. However, its pharmacological effect has not been scientifically explored. The purpose of this study was to identify the secondary metabolites and antioxidant activity of C. costata. The leaves were cold extracted with methanol. The secondary metabolites were determined using thin layer chromatography. Its antioxidant activity was investigated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The results showed that methanol extract of C. costata leaves consisted of alkaloids, flavonoids, glycosides, anthraquinone glycosides, tannins and triterpenoids. The methanol extract of C. costata leaves showed comparable antioxidant activity with vitamin C, IC50 35.56 Î¼g/ml and 14.17 Î¼g/ml, respectively.Keywords: Castanopsis costata leaves, methanol extract, antioxidant, DPPH, vitamin C.

Performance Evaluation of Four Activated Partial Thromboplastin Time Reagents Yuzaqi, Peppi Z.; Halimah, Eli; Noviani, Tatat
Pharmacology and Clinical Pharmacy Research Vol 3, No 2 (2018)
Publisher : Universitas Padjadjaran, Indonesia

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Activated Partial Thromboplastin Time (APTT) is a hematological examination to identify hemostatic abnormalities. This study aimed to compare the performance evaluation of four APTT reagents, i.e., CK Prest, Pathromtin SL, Actin SL, and Cephascreen. The methods used were photo optical, percent detection, and viscosity-based detection system (VDS). The analysis was performed on blood specimen of 43 subjects. The results indicated that the accuracy and precision in normal plasma control using C. K. Prest reagent in Coag-A-MateÂ® MTX II were d% -0.605 and CV% 2.252%, Pathromtin SL reagent in CA 560Â® (SysmexÂ®) were d% 6.9345 and CV%1.687, Actin FSL reagent in CA 560Â® (SysmexÂ®) were d% -1.51 and CV% 1.74, and Cephascreeen reagent in STA CompactÂ® were d% 10.81 and CV% 1.60. The accuracy and precision in pathological plasma control using Pathromtin SL reagent in CA 560Â® (SysmexÂ®) were d% -1,11 and CV% 8.82, Cephascreen reagent in STA CompactÂ® were d% 4.64 and CV% 2.72. The coefficient of correlation between C. K. Prest reagent and Pathromtin SL reagent was 0.880 with the regresion equation y=2.31xâ33.70. The coefficient of correlation between C. K. Prest reagent and Actin FSL reagent was 0.986 with the regretion equation y=0.78x+2.93. The coefficient of correlation between C. K. Prest reagent and Cephascreen reagent was 0.987 with the regretion equation y=1.70xâ3.97. In conclusion, the best precision was obtained from Cephascreen reagents in STA compactÂ®devices for both normal and pathologic control plasma, with eligible accuracy.Keywords : Activated Partial Thromboplastin Time (APTT), Photo-optical, Viscosity-based Detection System (VDS)

Predictor of Diabetes: Correlation between Leucine Concentration and Insulin Resistance Wijaya, Chyntia R.; Sukmana, Indriyanti R.; Levita, Jutti
Pharmacology and Clinical Pharmacy Research Vol 2, No 3
Publisher : Universitas Padjadjaran, Indonesia

Leucine catabolism changes among people with central obesity. This condition can lead to metabolic pathway disorder and increased mTORC-1 activation. Downstream signal of mTORC-1 is p70S6K1, which causes phosphorylation of insulin-1 receptor substrate (IRC-1). This study was performed to evaluate correlation between leucine concentration and insulin resistance (IR). This study was a prospective cross-sectional study, involving two groups; control and obese group. General characteristics and blood sample were taken from each subject. Leucin and Homeostasis Model Assesment (HOMA)-IR, as the marker of insulin resistance, were evaluated. The result indicated a significant positive correlation between leucine concentration and insulin resistance value (R=0.351; P=0.006) in central obese men. The higher leucine concentration, the higher the risk of insulin resistance occurrance. Therefore, leucine can be used as a biomarker for early detection of insulin resistance.Keywords: amino acids, mTORC-1, insulin-1 receptor substrate

Binding Modes of Doxorubicin Compared to Estratetrol and Tamoxifen Ghozaly, Muchammad R.; Febrina, Ellin; Zaenudin, Achmad
Pharmacology and Clinical Pharmacy Research Vol 2, No 1
Publisher : Universitas Padjadjaran, Indonesia

Doxorubicin, a compound isolated from Streptomyces peucetius var Caesius, is commonlyused in the treatment of breast cancer. This drug works by interacting on human nucleicacids. This work was aimed to study the binding modes of doxorubicin with estrogen receptoralpha (ERÎ±). Estratetrol and tamoxifen were used as natural ligand and standard drug,respectively. Molecular docking simulations was performed by AutoDock v.3.05 using minimumcoordinates -34, -6, -15 (x, y, z) and the maximum coordinates -13, 13, 3 (x, y, z).Tamoxifen formed one hydrogen bond with Glu353 (Ki=3.78 Î¼M); estratetrol binds to Glu-353, Arg394, Gly521, and His524 (Ki=0.01 Î¼M). Doxorubicin only formed one hydrogenbond with Ser317 (Ki=N/A). In conclusion, doxorubicin could not interact appropriatelywith ERÎ± due to its voluminioues structure which hinder its entrance to binding pocket ofthe macromolecule.Keywords: doxorubicin, estrogen receptor alpha.

Efficacy and Side Effects of Deferasirox and Deferiprone for Thalasemia Major in Children Rindarwati, Asti Y.; Diantini, Ajeng; Lestari, Keri
Pharmacology and Clinical Pharmacy Research Vol 1, No 3
Publisher : Universitas Padjadjaran, Indonesia

Thalassemia major (TM) is an inherited disease caused by defective or absent of hemoglobin chain synthesis. Regular chelation therapy is necessary to reduce excess iron in several organs of TM patients. The most commonly used chelating agents are deferasirox and deferiprone. However, information regarding their effectiveness and side effects in Indonesian children population with TM were limited. This study was conducted to assess the effectiveness and side effects of deferasirox and deferiprone in pediatric patients with TM. This was an observational study with prospective analysis which was conducted during April-August 2015. We included pediatric patients with TM who visited a hospital in Bandung, Indonesia, using consecutive sampling method. Thirty two subjects were divided into two groups, i.e., deferasirox and deferiprone group. Review of medical records and interview were performed for each participants. Effectiveness was defined as reduction in ferritin level. Side effects were assessed using Naranjo scale. Data were analyzed using Mann-Whitney test, Wiloxon test and Chi square test. P value < 0.05 defined statistical significance. We found that deferasirox was more effective than deferiprone for the treatment of TM in pediatric patiens, with less side effects. The use of deferasirox as iron chelating agent is recommended for patients with TM.Keywords: deferasirox, deferiprone, ferritin, thalassemia major

Assessment of Plasma Selenium Level based on Dietary Intake among Geriatric Patients Silviana, Ika M.; Yasmin, Nuraini; Lesmana, Ronny
Pharmacology and Clinical Pharmacy Research Vol 1, No 1
Publisher : Universitas Padjadjaran, Indonesia

Low plasma selenium level was associated with the increasing risk of death in geriatric patients, particularly those with multiple comorbidities. The sufficient level of selenium intake as an antioxidant is necessary for this population. This study aimed to investigate the plasma selenium level based on dietary intake in geriatric clinic population at Dr. Hasan Sadikin General Hospital Bandung.This study was a descriptive study using cross-sectional method. Fourteen geriatric patients were selected by consecutive sampling technique. Semiquantitative food frequency questionnaire (SQ-FFQ) was used as a tool to assess dietary intake. Plasma selenium level was measured as selenium binding protein 1 (SELENBP1) using enzyme-linked immunosorbent assay kit. Overall, mean of plasma selenium level of the subjects was 2,68 Âµg/L and mean of selenium intake was 62,85 Âµg/day. Selenium level of the subjects with sufficient selenium intake (85,7%) was 2,62 Âµg/L and selenium level of the subjects with deficient selenium intake (14,3%) was 3,05 Âµg/L. In conclusion, plasma selenium level among geriatric patients was varied and not dependent on dietary intake.Keywords: antioxidant, dietary intake, geriatric, plasma selenium level

Comparison of Effectiveness between Combination of Beta-Lactam with Azyhtromycin or Levofloxacin for Adult Pneumonia Patients Arifah, Gina; Halimah, Eli; Abdulah, Rizky
Pharmacology and Clinical Pharmacy Research Vol 3, No 1
Publisher : Universitas Padjadjaran, Indonesia

Treatment for pneumonia has always been a challenge due to the difficulties in diagnosis and the growing incidence of antibiotic resistance. Beta-lactam antibiotics are the first line treatment for pneumonia. The combination of beta-lactam with other antibiotics are preferred than single antibiotic therapy. However, there was limited information regarding the effectiveness of combination between beta-lactam with either macrolides or fluoroquinolone for the treatment of pneumonia.The purpose of this study was to determine the most effective combination of antibiotics for hospitalized adults pneumonia patients. This was a cross-sectional study with prospective data collection. The data source was the medical record of the subjects. We included adult pneumonia patients hospitalized at Dr. Hasan Sadikin General Hospital during June-August 2015. We found that mean reduction of body temperature in group who received combination of a beta-lactam antibiotic and azithromycin was 1.53 0C, while in levofloxacin group, the reduction was 1.22 0C (p=0.210). Reduction in leukocytes and respiratory rate were 7800 and 2.29 times/minute, respectively, in the former group, while in the latter group the reduction of leukocytes and respiratory rate were 2600 and 5 times/minute. The differences were not statistically significant in both parameters (p=0.036 and 0.149, respectively). In conclusion, better clinical outcomes were observed in patients treated with combination of beta-lactam and azithromycin compared to combination of beta-lactam and levofloxacin, although the difference was not statistically significant.Keywords: pneumonia, pneumonia therapy, combination therapy for pneumonia

Assessment of Plasma Selenium-Binding Protein-1 Level in Geriatric Population Dewi, Annisa F.; Dwipa, Lazuardhi; Lesmana, Ronny
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Geriatric physiologically undergoes aging process that can cause decreasing cell functionand increasing risk of degenerative diseases caused by the accumulation of reactive oxygenspecies (ROS) in the body. Selenium (Se) is an antioxidant, which is needed for maintainingthe balance of ROS. The aim of this study was to observe the selenium-binding protein(SELENBP1) level in relation with the geriatric patients charcateristics including sex, age,body mass index (BMI), activity of daily living (ADL), instrumental activity of daily living(IADL), cognitive function, nutrition, depression, and insomnia status. The study usedcross-sectional quantitative descriptive study design on 14 geriatric patients in Geriatric OutpatientsClinics, at a hospital in Bandung. The data was obtained by interviewing the patientsand then blood samples were taken. The analysis of SELENBP1 was done using ELISA kit.The average level (SD) of SELENBP1 from all of the characteristics group was 2.68 (0.69)ng/ml. The highest SELENBP1 level was identified in female geriatric patients and followedby male and pre-obese groups. The lowest SELENBP1 level was identified in geriatric patientsaged 70-79 years.Keywords: elderly, SELENBP1, selenium.

Potential Nephrotoxicity of Lisinopril and Valsartan on Patients with Congestive Heart Failure Pani, Sarini; Barliana, Melisa I.; Halimah, Eli; Chaeriadi, Venice; Sholih, Mally G.
Pharmacology and Clinical Pharmacy Research Vol 2, No 1
Publisher : Universitas Padjadjaran, Indonesia

Lisinopril (angiotensin converting enzyme inhibitor) and valsartan (angiotensin II receptorblocker) are the first-line treatment for patients with congestive heart failure (CHF). Thesetwo drugs potentially cause side effects on renal functions. However, limited informationwas available regarding the comparison of potential nephrotoxicity of these drugs in IndonesianCHF patients. This research was aimed to compare the potential nephrotoxicitybetween lisinopril and valsartan in outpatients with CHF at a hospital in Palu, Indonesia.This was an observational study conducted during April-May 2015. Potential nephrotoxicitywere assessed by measuring serum creatinin (SCr) and blood urea nitrogen (BUN). Datawere obtained from Cardiology Unit from a hospital in Palu, Indonesia. Statistical analysiswas conducted using T-test and Mann-Whitney test. The increasing trend of SCr and BUNwere observed in lisinopril-treated patients with the mean of increase were 21% and 59%,respectively. Relatively higher increase was observed in valsartan treatment group with 47%and 51% in SCr and BUN, respectively. The analysis showed that there were significant differencesin SCr level between lisinopril and valsartan groups (p=0.001), but the oppositeresults observed in BUN parameter (p=0.697). Therefore, valsartan was potentially morenephrotoxic than lisinopril based on the increase of SCr parameter. Thus, lisinopril is recommendedfor CHF patients who are particularly at high risks of having renal impairment.Keywords: lisinopril, valsartan, nephrotoxicity, congestive heart failure

Synthesis of Silver Nanoparticles from Cucumis melo L. and Assessment of Its Antimicrobial Properties Yuli Haryani; Iswatun Nabella; Yuharmen Yuharmen; Ganis F. Kartika
Pharmacology and Clinical Pharmacy Research Vol 3, No 2
Publisher : Universitas Padjadjaran, Indonesia

Over the past decade, the use of biological agents such as plants, cyanobacteria, bacteria, and fungi for synthesis of metal nanoparticles has been developed. The aim of this study was to investigate antibacterial activity of Cucumis melo L. peel extract and its nanoparticles formulation against Eschericia coli. The nanoparticles were made using silver nitrate with the ratio between C. melo L. extract and silver nitrate aqueous solution (1 mM) were 1:10 and 1:15. The formation of silver nanoparticles was observed after microwaved for 30, 60, 90, 120, 150, and 180 seconds by visible spectrophotometry analysis. Phytochemical screening revealed the presence of flavonoid and terpenoid within the extract. However, the characteristic of surface plasmon resonance band, which occurs in the range of 410-500 nm were not found in the nanoparticle extract, even though the reaction time was extended to 330s. Antibacterial activity against E. coli of the extract and its nanoparticle formulations was determined using Resazurin microtiter assay and compared to Amoxsan® as positive control. The highest E. coli inhibition was exhibited by the nanoparticles (79.8739±0.3859), followed by the extract (65.2821±0.9949). The nanoparticles and the extract have potent antibacterial activity compared to positive control (84.5519 ± 0.2544). In conclusion, the antibacterial activity of the C. melo L. silver nanoparticles formulation was better than its extract.Keywords: Cucumis melo, silver nanoparticles, UV-Vis spectra

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Home Page

OAI Link

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Contact Name Widya Norma Insani, M.Sc., Apt.

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Journal Mail Official pcpreditorialteam@gmail.com

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Location Kota bandung, Jawa barat INDONESIA

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Contact Name
Widya Norma Insani, M.Sc., Apt.

Contact Email
Widya Norma Insani, M.Sc., Apt.

Phone
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Journal Mail Official
pcpreditorialteam@gmail.com

Editorial Address
-

Location
Kota bandung,

Jawa barat

INDONESIA