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INDONESIA
Indonesian Journal of Medicine
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
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Articles 8 Documents
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Search results for , issue " Vol 1, No 2 (2016)" : 8 Documents clear
Antimicrobial Activity of Cladosporiumoxysporum Endophytic Fungus Extract Isolated From Aglaiaodorata Lour Sugijanto, Noor Erma; Dorra, Bella Lexmita
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Endophytic fungi have econo­mi­c potential as enzymes, medicines and biological control agents. Cladosporiumoxysporum endophytic fungi can be isolated from a plant named Aglaia­o­dorata Lour (Indonesian: Paca rCina). This plant can be found inPurwodadi Botanical Garden, Pasu­ruan, East Java. This study aimed to assess the antimicrobial activity from the ethyl ace­tate extract of the Cladosporiumoxysporum endophytic fungi against Escherichia coli, Staphylo­coc­cu­saureus, and Candida albicans.Subjects and Method: This was a descriptive study. C. oxysporum was cultivated, extracted, and fractionated. The fractions then were applied to antimicrobial activity assay. Disc diffusion method was used in this project with 2 mg/disc concentration extracts.Results: Some fractions of ethyl acetate extracts C. oxysporum showed anti­mi­cro­bial activity against all microbials tested. 6 of 13 fractions exhibited inhibition zone against S. aureusATCC 6538, E. coli ATCC 8739, and C. albicansATCC 10231. The seventh fraction exhibited the highest inhibition zone against S. aureusATCC 6538, and C.albicans ATCC 10231.The tenth fraction exhibit  ed the highest zone against E. coli ATCC 8739.Conclusion: Cladosporiumo­xysporum from Aglaiaodorata could be a good source of anti­microbial substance.It produces bioactiveagent that can be developed into a new drug at a larger commercial scale.Keywords: endophytic fungi, cladosporiumn oxysporum, aglaiaodorata lour, antimicrobial activityCorrespondence: Noor Erma Sugijanto, Bella Lexmita Dorra. Faculty of Pharmacy, Airlangga University.Indonesian Journal of Medicine (2016), 1(2): 108-115https://doi.org/10.26911/theijmed.2016.01.02.04
Effect of Purple Sweet Potato (Ipomoea Batatas L.) Extract on Glutathione Peroxidase (GPx) Activities in Hepatic House Mice (Mus musculus) After Maximum Physical Exercise Elvana, Ayu; Rusmarilin, Herla; Silaban, Ramlan; Sinaga, Rika Nailuvar
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Physical exercise can improve antioxidant defense system of organis. But long and heavy exercise can disrupt the balance of oxidant-antioxidant. Low glutathione peroxidase is associated with free radicals. Plant purple sweet potatoes (Ipomoea batatas L.) contain anthocyanins high enough that act as antioxidants. This stu­dy aimed to determine the effect of extracts of tubers of purple sweet potato (Ipomoea Batatas L.) on the activity of glutathione peroxidase (GPx) liver of mice (Mus Musculus) treated with maximal physical exercise.Subjects and Method: This was a true experimental study. This conducted with the design of the control group post-test only in vivo on 24 white male mice (Mus musculus), DD Webster strain. Da­ta analysis was using SPSS software 19. Statistical testing decision taken 5% significance level (p=0.05). Results: The results showed that the average enzyme activity of GPx in the P5 is the highest enzyme activity GPx (mean=19:39 ± SD=7:06, p=0.024), which means there are significant differ­rences in the enzyme activity of GPx values between groups.Conclusion: This study showed that the extract could increase the activity of GPx hepatic enzyme­es mice significantly.Keywords: physical exercise maximum, free radicals, purple sweet potato, anthocyanin, GPxCorrespondence: Ayu Elvana. School of Health Sciences (STIKes) Siti Hajar, Medan, Indonesia.Indonesian Journal of Medicine (2016), 1(2): 116-120https://doi.org/10.26911/theijmed.2016.01.02.05
Comparison of Soluble fms-Like Tyrosine Kinase-1 (SFLT-1) between Normal and Severe Pre-eclampsia in Pregnant Women, Medan, Indonesia Lamtiar, Rebecca Rumesty; Mutiara, Erna; Raja, Sarma N Lumban
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The pathogenesis of pre-eclampsia as a primary cause of mortality among pregnant women remains unclear. It was suggested that angiogenic factors such as Soluble fms-Like Tyrosine Kinase-1 (SFLT-1) play an important role in the causal mechanism of pre-eclampsia/ eclampsia. This study aimed to compare the SFLT-1 level in pre-eclampsia/eclampsia in pregnant women with that in normotensive pregnant women.Subjects and Method: This was an analytic observational conducted at three hospitals: Haji Adam Malik, Pirngadi, and Sundari Hospitals, Medan, Indonesia, from September to December 2014. A total sample of 60 pregnant women of the third trimester, including those with severe pre-eclampsia/eclampsia and normotensive women, was selected for this study. The level of serum SFLT-1 was measured by ELISA method. The difference in mean of serum SFLT-1 levels between the two groups was tested by Mann-Whitney.Results: The mean of serum SFLT-1 level in women with preeclampsia was higher (mean=1692.69pg/ml; SD=540.64) than that in normotensive women (mean=1348.52pg/ml; SD=649.83). This difference was statistically significant (p=0.040).Conclusion: Level of serum SFLT-1 in women with severe pre-eclampsia/eclampsia is significantly higher than that of normotensive women.Keywords: serum SFLT-1, pre-eclampsia, pregnant womenCorrespondence: Rebecca Rumesty Lamtiar. Department of Physiology, Faculty of Medicine, HKBP Nommensen University, Medan.Indonesian Journal of Medicine (2016), 1(2): 84-89https://doi.org/10.26911/theijmed.2016.01.02.01
The Effect of Depression on the Quality 0f Life of Patient with Cervical Cancer at Dr. Moewardi Hospital in Surakarta Adriani, Rita Benya; -, Martono; Sulistyowati, Endang Caturini
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The share of cervical cancer of all types of cancer was  37.65% (9.113 cervical cases of the total 24,204 cancer cases) in Central Java in 2009. Cancer deteriorates physical, psychological, social, and spiritual states of the persons affected, especially in patients of terminal stage. Depression may interfere the quality of life of the affected. This study aimed to determine the effect depression on the quality life of patients with cervical cancer.Subjects and Method: This was an analytic observational study with cross sectional design. This study was conducted at Dr. Moewardi Hospital, Surakarta, from May to August 2014. A total of 36 patients with cervical cancer at Dr. Moewardi Hospital were selected for this study. The independent variables were age, education, employment status, duration of illness, and depression. The dependent variable was quality of life. The depression was measured by Beck Depression Inventory (BDI). The quality of life was measured by European Organization for Research and Treatment of Cancer (EORTC) QOQ-C30 and EORTC QOQ-CX24. The data were analyzed by logistic regression analysis.Results: After controlling for age, education, employment status, and duration of illness, depression showed strong effect (OR= 14.83; p= 0.005) on the quality of life of patients with cervical cancer. Patients with severe depression were 14.83 times more likely to have poor quality of life than those with moderate or mild depression.Conclusion: Depression affects the quality of life in patients with cervical cancer. Patients with severe depression were more likely to have poor quality of life than those with moderate or mild depression.Keywords: depression, quality of life, cervical cancerCorrespondence: Rita Benya Adriani. School of Health Polytechnics, Poltekkes Surakarta. Email: benyaadriani@gmail.com. Mobile: 08122617033Indonesian Journal of Medicine (2016), 1(2): 121-128https://doi.org/10.26911/theijmed.2016.01.02.06
Path Analysis on the Effects of Bio-psychosocial Factors and Calorie Intake in Blood Glucose Control in Patients with Type 2 Diabetes Mellitus -, Isfaizah; Murti, Bhisma; Indarto, Dono
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Diabetes mellitus (DM) is a serious chronic disease with its tendency to deteriorate. The DM cases worldwide in 2015 was 415 million people and it is estimated to increase as many as 642 million cases in 2040. Indonesia ranked 7 in the world with 10 million cases of DM in 2015, about 90% of which were Type 2 Diabetes Mellitus. This study aimed to determine the effect of biopsychosocial factors and calorie intake on the blood glucose control in patients with Type 2 DM.Subjects and Method: This was an analytic and observational study with case control design. This study was carried out at Internal Medicine Polyclinic, Department of Endocrinology, Dr. Moewardi Hospital, Surakarta, Central Java, from October to November 2016. A total sample of 135 cases of Type 2 DM were selected for this study by fixed disease sampling. As many as 106 of these study subjects at  HbA1c ≥6.5% and 29 cases of Type 2 DM had HbA1c <6.5%. The dependent variable was HbA1c level. The independent variables were educational level, family income, psychological stress, calorie intake, and Body Mass Index (BMI). The data were collected by a set of questionnaire. HbA1c was measured by High Performance Liquid Chromatography (HPLC), which was recorded in the medical record. Calorie intake was measured by 24 hour food recall. Psychological stress was measured by International Physical Activity Questionnaire (IPAQ). The data was analyzed by path analysis on STATA 13.Results: Psychological stress (b=0.99, 95%CI=0.07 to 1.92, p=0.034), calorie intake (b= 1.84, 95%CI= -0.24 to 3.92, p=0.083), and BMI (b= 1.15, 95%CI= 0.22 to 2.08, p=0.016), had positive and statistically significant effect on HbA1c. Calorie intake increased BMI (b= 2.35, 95%CI=0.31 to 4.39, p=0.024), education decreased calorie intake (b=-2.26, 95%CI= -3.38 to -1.14, p<0.001), and family income increased calorie intake (b= 1.23, 95%CI= 0.26 to 2.21, p= 0.013).Conclusion: Calorie intake, BMI, psychologi stress, and family income are associated with increase in HbA1c level. Education decreases HbA1c level via decreased calorie intake. Type 2 DM patients need to pay attention to these biopsychosocial factors and calorie intake in order to control blood sugar.Keywords: biopsychosocial factors, calorie intake, HbA1cCorrespondence: Isfaizah. Ngudi WaluyoUniversity, Ungaran, Central Java. Email: is.faizah84@yahoo.com. Mobile: +6281228570003.Indonesian Journal of Medicine (2016), 1(2): 90-99https://doi.org/10.26911/theijmed.2016.01.02.02
Path Analysis of Factors which Correlated with Dysmenorrhea Ertiana, Dwi; Akhyar, Muhammad; Budihastuti, Uki Retno
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: All women menstruate every month. There are some disorders suffered by women associated with menstruation, dysmenorrhea is among them. It interferes the women activities, even often requires the sufferers to take a rest and leave classes. The research was purposed to analyze the factors associated with dysmenorrhea.Subjects and Method: This research is an analytical research with cross-sectional approach. The research was conducted on February 23 to March 23, 2016 at Senior High School of Pare, Kediri district. The population study were 452 senior high school students in the Pare who had dysmenorrhea. The samples of research were 198 students by using proportional random sampling technique. The technique for collecting the data was questionnaires. The data were analyzed using path analysis of IBM SPSS AMOS 22.Results: The results showed that the fit model with CMIN = 0.77 (p= 0258); GFI= 0.99; NFI= 0.95; CFI= 0.99; RMSEA= 0.038. The five variables were associated by dysmenorrhea obtained three variables associated indirectly with dysmenorrheal, i.e. physical activity/exercise, BMI and family support and two variables associated with dysmenorrheal directly, i.e. psychological stress (b= 0:36; p <0.001) and the coping mechanisms (b= -0.39; p= 0.002). Obtained of relationships, i.e; family support with coping mechanisms (b= 0:31; p= 0.008); coping mechanisms with psychological stress (b= - 0:13; p= 0.007); BMI with psychological stress (b= -0.43; p= 0.025).Conclusion: Dysmenorrhea is directly related to coping mechanisms and psychological stress. Physical activity / exercise, BMI and family support are related indirectly. It is expected to improve the coping mechanisms and family support so that the sufferers can avoid the stress that can reduce the occurrence of dysmenorrhea. It is expected to improve the coping mechanisms and family support so the sufferers can avoid the stress that can reduce the occurrence of dysmenorrhea.Keywords: path analysis, dysmenorrhea, coping mechanisms, psychological stressCorrespondence: Dwi Ertiana. Masters Program in Public Health, Sebelas Maret University, Surakarta.Journal of Medicine (2016), 1 (2): 136-145https://doi.org/10.26911/theijmed.2016.01.02.08
Anthrax Seroprevalence in Central Java, Indonesia Redhono, Dhani; Dirgahayu, Paramasari
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Anthrax is a zoonotic disease that is caused by Bacillus Anthracis is transmitted to humans through infected animal. The transmission to humans occurs when there is a contact to animals or animal products contracting anthrax. Clinical skin manifestations and anthrax serum Ig G antibody can be used to diagnose infected anthrax animals. This study aimed to determine the prevalence of anthrax based on ELISA serum Ig G antibody and clinical skin manifestations occurring in patients with anthrax.Subjects and Method: This was a descriptive study with cross sectional design conducted in Sragen district, Central, Indonesia, in 2015. A sample of 101 patients infected with anthrax was examined based on clinical skin manifestations and anthrax serum Ig G antibody.Results: 39.6% of the sample was 21 to 40 years of age. 57.4% of the sample was female. 74% of the sample completed primary school. 21% worked as farmers. 30.5% of the sample who cooked and consumed meat showed positive Ig G. Test results showed serum Ig G antibody negative 50%, 15.8% and 33.7% borderline positive. Clinical manifestations in the skin as much as 11.9%, which is the eschar on all respondents and 92.8% showed positive Ig  G. While 88.1% did not show any clinical signs of anthrax.Conclusion: The increase in serum antibody titer Ig G anthrax is not all respondents were exposed, in an area that otherwise outbreak of anthrax, which is only a third of all respondents, and when it comes up eschar will be followed by an increase in Ig G antibody titer.Keywords: cutaneous anthrax, Ig G antibody ELISA, escharCorrespondence: Dhani Redhon. Sub Division Tropical Medicine and Infectious Disease, Internal Medicine.Indonesian Journal of Medicine (2016), 1(2): 129-135https://doi.org/10.26911/theijmed.2016.01.02.07
The Relationship Between Maternal Education, Family Income, Parenting Style, and Language Development in Children Aged 3-4 Years in Boyolali, Central Java -, Muryanti; Dharmawan, Ruben; Murti, Bhisma
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Early childhood is a unique period where development proccess such as language development occurs rapidly.  Speech and language disorders are two among the most common problems in children. The first years of life form critical period in children’s life. Maximum brain plasticity occurs during the initial years of life and continues to develop for a few years with slower pace. Sensorik experience, stimulation, and language exposure during this period determine the synaptogenesis, myelinisation, and synaptic relation. National Center for Health Statistics (NCHS) reported that speech disorder ocurred approximately 0.9% in children under five, and 1.94% in children aged 5-14 years old. The purpose of this study was to determine the relationship between maternal education, family income, parenting style, and language development in children aged 3-4 years.Subjects and Method: This was an analytic observational study with cross sectional design. This study was conducted at Kindergarten Nogosari Sub-district, Boyolali, Central Java. A sample of children aged 3-4 years old were selected for this study. The dependent variable was language development. The independent variables were maternal education, family income, and parenting style. The data were analyzed by multiple logistic regression. Results: Maternal education ≥ high school (OR= 25.74; 95% CI= 1.80 to 367.62; p= 0.017), family income ≥ minimum regional wage (OR= 32.98; 95% CI= 2.93 to 370.52; p= 0.005), and democratic parenting style (OR= 20.19; 95% CI= 1.83 to 222.82; p= 0.014), had positive and statistically significant relationships with language development in children aged 3-4 years old.Conclusion: Maternal education ≥ high school, family income ≥ minimum regional wage, and democratic parenting style, have positive and statistically significant relationships with language development in children aged 3-4 years old.Keywords: maternal education, family income, parenting style, child language developmentCorrespondence: Muryanti. School of Health Polytechnics, Poltekkes Surakarta. Email: muryanti.tw@gmail.comIndonesian Journal of Medicine (2016), 1(2): 100-107https://doi.org/10.26911/theijmed.2016.01.02.03

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