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JSFK (Jurnal Sains Farmasi & Klinis)

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Published by Universitas Andalas

ISSN : 24077062 EISSN : 24425435 DOI : 10.25077

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.

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Articles 509 Documents

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ARTIKEL DITARIK: [Pengaruh Konseling Farmasis Terhadap Pengetahuan dan Kepatuhan Pasien HIV/AIDS di Poliklinik VCT RSUP Dr. M. Djamil Padang] Jelly Permatasari; Dedy Almasdy; Raveinal Raveinal
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.3.2.178-185.2017

Adherence to antiretroviral therapy is key to sustained HIV suppression, reduced risk of drug resistance, improved quality of life, and survival of HIV/AIDS patients. A pharmacist is in charge in optimizing the result of the therapy by providing counseling to increase the patients’ knowledge which finally increases the quality of life. The objective of this study was to explore the impact of pharmacist counseling toward knowledge and adherence of patients with HIV/AIDS. The study was conducted in quasi-experiment with a design of one group pretest-posttest. The setting of this study was conducted in VCT RSUP DR. M. Djamil Padang. Data were collected through questionnaires and medical records. Patients’ knowledge and adherence were scored by using knowledge aspect questionnaire and MMAS-8 questionnaire. All questionnaires had been tested for validity and reliability. The data were analyzed by Wilcoxon test and paired t-test. A number of 124 patients completed all follow-ups of study. The result of this study showed that there was a significant increase of patients’ knowledge (p=0,00) and adherence (p=0,00) after the counseling. The study concluded that pharmacist counseling could increase patients’ knowledge and adherence to the therapy.

Pengembangan dan Validasi Metode KLT-Densitometri untuk Analisis secara simultan Parasetamol, Asam Mefenamat dan Ibuprofen dalam Jamu “Pegel Linu” Hayun Hayun; Mulia Ade Karina
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

Jamu is a traditional or herbal medicine that is widely used by Indonesian people for prevention, maintenance and treatment of diseases. Traditional medicines contain plants or extracted plant material, or combinations thereof. The adulteration practice violates the laws. However, the presence of undeclare synthetic chemical drugs in the herbal products are still often found, among others, analgesic and anti-inflammatory drugs. The purpose of this study is to obtain a validated, simpler and lower operational cost of TLC-densitometric method to analyze paracetamol, mefenamic acid and ibuprofen in herbal medicines in “pegel linu” herbal medicines. The samples were extracted with ethanol, then separated over silica gel GF254 TLC plate with mixture of chloroform-ethanol (8:1) as mobile phase and analyzed using TLC-densitometry. The method has a satisfactorily specificity and linearity, and met the precision and accuracy criteria at the concentration of 1500 ng/spot for paracetamol, 1250 ng/spot for mefenamic acid, and 2000 ng/spot for ibuprofen. The results of the determination of eight samples showed that four of them were positive containing paracetamol with the concentration of 337.12 - 505.55 mg/single dosage.

Kajian Efek Analgetik dan Toksisitas Subakut Dari Ekstrak Etanol Daun Kitolod (Isotoma longiflora L.) Pada Mencit Putih Jantan Helmi Arifin; Tesa Inmerka Alwi; Octy Aisyahharma; Dian Ayu Juwita
Jurnal Sains Farmasi & Klinis Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018
Publisher : Fakultas Farmasi Universitas Andalas

Penelitian tentang pengaruh ekstrak etanol daun kitolod (Isotoma longiflora L. Presl.) terhadap aktivitas analgetik dan uji toksisitas pada mencit putih jantan telah dilakukan.. Hewan percobaan terdiri dari 30 ekor yang dibagi menjadi 6 kelompok yaitu kelompok kontrol negatif, kontrol positif, pembanding (Asam mefenamat 65 mg/kg BB), dan ekstrak etanol daun kitolod dengan dosis 1; 2 dan 4 g/kg BB. Asam mefenamat dan ekstrak etanol daun kitolod diberikan secara oral selama 15 hari. Aktivitas stimulansia diuji pada hari ke-1, ke-5, ke-10, dan ke-15. Parameter yang diamati yaitu jumlah geliat hewan dengan metode writhing test. Pada pengujian aktivitas SGPT dan kadar kreatinin serum, hewan percobaan dibagi menjadi 4 kelompok (15 ekor/kelompok) yaitu kelompok kontrol yang diberikan Na CMC dan kelompok ekstrak etanol daun kitolod dengan dosis 1, 2, 4 g/Kg BB. Sediaan diberikan selama 15 hari secara oral. Aktivitas SGPT dan kadar kreatinin serum diukur dari serum pada hari ke-5, ke-10, dan ke-15 dengan menggunakan spektrofotometer microplate. Hasil penelitian menunjukkan bahwa ekstrak etanol daun kitolod dosis 1; 2; 4 g/kgBB dan lama pemberian mempengaruhi aktivitas analgetik (Sig < 0,05), dimana aktivitas terbesar ditunjukkan oleh ekstrak etanol daun kitolod dosis 4 g/kg BB. Ekstrak etanol daun kitolod terbukti tidak memberikan pengaruh terhadap aktivitas SGPT dan kadar kreatinin serum. Hal ini dilihat dari tidak adanya perbedaan yang signifikan aktivitas SGPT dan kadar kreatinin serum kelompok uji dibandingkan dengan kelompok control (Sig > 0,05).

Kajian Ketepatan Indikasi Penggunaan Alprazolam pada Pasien Stroke di Bangsal Rawat Inap Neurologi Rumah Sakit Stroke Nasional Bukittinggi Rika Sepriani; Fatma Sri Wahyuni; Almahdy Almahdy; Khairil Armal
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

Cerebrovascular disease such as stroke remains one of diseases that causes disability and death in the world. Having sufficient quality and quantity of good sleep is one important part of the healing process. Sleep disorders also increase the patient’s risk of developing recurrent stroke. The objective of this study was to analyze the accuracy of the indications for alprazolam in patients with stroke in neurology ward of National Stroke Hospital Bukittinggi, Indonesia. The study was conducted on November 2011 to February 2012 with the prospective method through observations on the condition of the patients, medical records, drug instruction cards, and the nursing care records of stroke patients who use alprazolam. Data were analyzed descriptively based on the treatment standards related to inaccuracy: alprazolam use without medical indications and indications which were not treated. The study showed that of 35 patients taking alprazolam, 1 of them was without medical indication 1 (3.45%) and another 1 was categorized as untreated indication (3.45%) of 29 incidences of drug related problems (DRP).

Hubungan Depresi Terhadap Tingkat Kepatuhan dan Kualitas Hidup Pasien Sindrom Dispepsia di RSUP Dr. M. Djamil Padang Bobbi Hemriyantton; Helmi Arifin; Arina Widya Murni
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

The objective of this study was to examine the correlation of depression, adherence, and quality of life in dyspepsia patient. Cross-sectional data were collected from 61 outpatient with dyspepsia at a special clinic in M. Djamil Hospital Padang. Patients were interviewed based on BDI II (Back Depression Inventory II) to assess depression, Morisky scale to assess adherence. Patient with BDI scores more than 12 was consulted to a special clinic of psychosomatic to diagnose for depression. Correlation between depression, adherence, and quality of life was analyzed with Spearman correlation. Coefficient correlation of depression and adherence was 0.272, while the correlation between depression and quality of life was 0.655. This finding demonstrates that there is a high correlation between depression and quality of life, while there is a low correlation between depression and adherence. Keywords: Depression, adherence, quality of life, dyspepsia.

Evaluasi Penggunaan Obat Antidiabetik Pada Pasien Diabetes Melitus Tipe-2 di Suatu Rumah Sakit Pemerintah Kota Padang – Sumatera Barat Dedy Almasdy; Dita Permata Sari; Suhatri Suhatri; Deswinar Darwin; Nina Kurniasih
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

The appropriateness of antidiabetic usege on a public hospital in Padang - West Sumatra has been studied. This study was a descriptive study, which used patient’s medical record as data resources. The appropriateness of antidiabetic usage based on criterion which was established earlier, such as the appropriateness of indication, the appropriateness of patient, the appropriateness of regiment, and the appropriateness of drug administration. Evaluation also has been done to the potential of drug interaction. The results showed that antidiabetic usage on that hospital were 100% appropriate in term of indication and drug administration. While evaluation to appropriateness of patient and drug regiment were 95.59% and 40.82% respectively.

Evaluasi Penggunaan Obat Antitiroid Pada Pasien Hipertiroid di RSUP Dr. M. Djamil Padang, Indonesia Dian Ayu Juwita; Suhatri Suhatri; Risa Hestia
Jurnal Sains Farmasi & Klinis Vol 5, No 1 (2018): J Sains Farm Klin 5(1), April 2018
Publisher : Fakultas Farmasi Universitas Andalas

Hyperthyroidism is the second largest hormonal disease in Indonesia after diabetes mellitus. The most common cause of hyperthyroidism is Graves’ disease. Untreated in hyperthyroid patients will causes decreased patient quality of life, atrial fibrillation and osteoporosis. Therefore need a therapy to control thyroid hormone levels in the normal range, one of them with antithyroid drugs. This study aims to determine the patterns of antithyroid use and evaluate the appropriateness use of antithyroid drugs in patients hyperthyroidism include precise indications, precise medications, precise patients and appropriate doses. This study is a descriptive study that retrospective data collection using patient medical records during the period January-December 2015 in Polyclinic Dr. M. Djamil hospital Padang. The number of patients who fulfills the inclusion criteria are 175 patients. Antithyroid drugs used in patients with hyperthyroidism are PTU (82,75%) and thyrozol (17,25%). The results showed that inappropriate indication and inappropriate drug was not found, while there were 13 patients (7,43%) with an inappropriate dosage regimen and 1 patients (0,57 %) with inappropriate patient.

Kajian Regimen Dosis Penggunaan Obat Asma pada Pasien Pediatri Rawat Inap di Bangsal Anak RSUP. Dr. M. Djamil Padang Rahmi Yosmar; Meri Andani; Helmi Arifin
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

A study on dosage regimens of asthma medications in pediatric patients hospitalized at the pediatrics ward DR. M. Djamil Padang hospital has been carried out. The purpose of this study was to determine and compare the suitability of dosage regimen given to pediatric patients in the pediatrics ward of Dr. M. Djamil Padang hospital with the literature. This study was conducted retrospectively with consecutive sampling technique. Samples were obtained from medical records during 2013. The results showed that the appropriate dosage administration of asthma medication for the prednisone, Combivent® and ambroxol were 100%, salbutamol 75%, and theophylline 0%. On the other hand, the entire medications showed 100% suitability concerning the route of administration. While for the interval of administration, the study showed that dexamethasone, prednisone, salbutamol, theophylline and ambroxol were 100% appropriate, but Combivent® was lower at 95.24%. The study concludes that the dose and interval of administration are not in accordance with the literature, while the route of administration is considered to be in accordance with the literature.

Identifikasi Gen E7 Isolat Human Papillomavirus Tipe 18 (HPV18) dari Penderita Kanker Serviks Arfiandi Arfiandi; Densi Selpia Sopianti; Dewi Gulyla Hari; Marlina Marlina; Yufri Aldi; Andani Eka Putra; Akmal Djamaan; Rustini Rustini
Jurnal Sains Farmasi & Klinis Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016
Publisher : Fakultas Farmasi Universitas Andalas

Gen E7 HPV18 merupakan salah satu onkoprotein yang selalu diekspresikan oleh HPV pada sel yang terinfeksi. Infeksi persisten oleh Human papillomavirus (HPV) beresiko tinggi adalah faktor etiologi utama untuk kanker serviks dan ekspresi Onkoprotein HPV E7 disarankan untuk menjadi penanda potensial untuk perkembangan tumor. E7 akan mempengaruhi aktivitas pRB supresor tumor serta mengikat dan mengaktifkan kompleks cyclin sehingga dapat menimbulkan kanker serviks. Dalam penelitian ini akan dilakukan identifikasi terhadap Gen E7 isolat HPV18 dari penderita kanker serviks yang berasal dari RSUP M. Jamil Padang, Sumatera Barat dan RSUD Arifin Ahmad, Pekan Baru, Riau. Proses identifikasi dilakukan dengan metode Polymerase Chain Reaction (PCR) menggunakan primer spesifik untuk gen E7 HPV18. Dari lima belas isolat HPV18 yang diamplifikasi dengan primer spesifik gen E7 HPV18, didapatkan sepuluh sampel positif teridentifikasi gen E7 (66,6%) sedangkan lima sampel lainnya tidak teridentifikasi. Infeksi kanker pada penderita kanker serviks yang berasal dari RSUP. M. Jamil, Padang dan RSUD. Arifin Ahmad, Pekan Baru, Riau sebagian besar disebabkan oleh gen E7 HPV18 sehingga hal ini bisa dijadikan penanda potensial untuk perkembangan tumor bagi penderita kanker serviks di Sumatera Barat dan Riau pada khususnya serta di Indonesia pada umumnya.

Perbandingan Metode SYBR Green dan Hydrolysis Probe dalam Analisis DNA Gelatin Sapi dan Gelatin Babi Menggunakan Real Time Polymerase Chain Reaction Zilhadia Zilhadia; Afifah Nurul Izzah; Ofa Suzanti Betha
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

Gelatin has a large application in the food, pharmaceutical and cosmetics industries. Gelatin is mostly derived from the skin or bone of porcine and bovine. Porcine gelatin is forbidden for Muslim and Jews. For this reason, analytical methods to detect gelatin are needed to make sure the source of gelatin. One of the analytical techniques that can differentiate bovine and porcine gelatin is Real Time Polymerase Chain Reaction (PCR). There are two popular methods of fluorescence dye, namely SYBR green and hydrolysis probe. This study was conducted to compare SYBR green and hydrolysis probe method in analyzing porcine and bovine gelatin DNA using Real Time PCR. The DNA was isolated by commercial kit. The obtained porcine and bovine gelatin DNA were 19.38 ng/μl and 13.63 ng/μl with purity were 1,566 and 1,573, respectively. Then, isolated DNA was analyzed by SYBR green and hydrolysis methods. SYBR green methods was done by annealing temperature of 65 oC for bovine primer and 60 oC for porcine primer. Therefore, hydrolysis probe methods were analyzed by annealing temperature of 60 oC for both porcine primer and bovine primer. The result showed that the hydrolysis probe was higher specificity to identify of porcine and bovine gelatin DNA than SYBR green method.

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Home Page

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Contact Name Yori Yuliandra

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Location Kota padang, Sumatera barat INDONESIA

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Contact Name
Yori Yuliandra

Contact Email
yoriyuliandra@gmail.com

Phone
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Journal Mail Official
jsfkonline@gmail.com

Editorial Address
-

Location
Kota padang,

Sumatera barat

INDONESIA