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JSFK (Jurnal Sains Farmasi & Klinis)

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Published by Universitas Andalas

ISSN : 24077062 EISSN : 24425435 DOI : 10.25077

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.

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Articles 509 Documents

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Analisis α-Mangostin dalam Minuman Herbal Kulit Buah Manggis (Garcinia mangostana L.) dengan Metode Kromatografi Lapis Tipis-Densitometri Regina Andayani; Friardi Ismed
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

Some herbal formulation containing α-mangostin as a marker compound in the pericarp of the mangosteen (Garcinia mangostana L.) are marketed now in Indonesia. The determination of the component of preparation both qualitatively and quantitatively is essential to ensure quality of the product. This research is aimed to develop a TLC (Thin Layer Chromatography)-densitometry method to analyze α-mangostin in the herbal drinks of mangosteen rind. The analysis was performed with TLC Scanner using Camag TLC Scanner 4 with Wincats software. Silica gel 60 F254 (Merck) plates (20x20 cm: 200 μm thickness) were used as stationary phase and mixture of chloroform and ethyl acetate (9:1,v/v) as a mobile phase. The developed chromatogram was scanned at 316 nm, the wavelength of maximum absorption for α-mangostin. At this condition, the Rf value of α-mangostin is 0.48. Regression analysis of the calibration data showed an excellent linear relationship between peak-area vs drug concentration. Linearity was found to be in the range of 50-400 µg/mL. The suitability of developed TLC densitometry method for estimation of α-mangostin was established by validating it as per the ICH guidelines. The limits of detection (LOD) and quantification (LOQ) for α-mangostin were found to be 54.38 μg/mL and 181.28 μg/mL. The developed method was found to be linear (r=0,99415), precise (RSD <1.28 % and < 2.39 % for intra-day and inter-day precision) and accurate (mean recovery of 90.04%). Results of the samples analysis showed that sample A does not contain α-mangostin, whereas sample B and C contain α-mangostin. The average concentrations obtained for samples B and C were 0.040% w/v and 0.118% w/v, respectively. The developed method has been successfully applied for the determination of α-mangostin in the herbal drinks of mangosteen rind.

Waktu Kultivasi Optimal dan Aktivitas Antibakteri dari Ekstrak Etil Asetat Jamur Simbion Aspergillus unguis (WR8) dengan Haliclona fascigera Agnes Rendowaty; Akmal Djamaan; Dian Handayani
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

The optimal cultivation time of symbiont fungi Aspergillus unguis (WR8) with marine sponge Haliclona fascigera and antibacterial activity assay from the ethyl acetate extracts symbiont fungi A. unguis (WR8) have been determined. The fungi was cultivated on Sabaoraud Dextrose Broth medium in both static condition and using shaker incubator at 120 RPM at 25-28oC. Optimal cultivation time was determined by the amount of dry biomass mycelium fungi per unit of time. Liquid medium was extracted with ethyl acetate and used for antibacterial activity assay using agar diffusion method against Staphylococcus aureus. The study showed that the optimal cultivation time of symbiont fungi A. unguis (WR8) in static condition was achieved on day 21 while the extract (5 % w/v) inhibited bacterial growth of S. aureus with an inhibition zone of 21 mm. Meanwhile, The optimal cultivation time in the shaker was achieved on day 14 and the inhibition zone of the extract was 11 mm. The study concludes that the optimal cultivation time for production of antibacterial compounds by symbiont fungi A. unguis (WR8) was obtained at 21 days in static condition.

Formulasi Sediaan Nano Herbal Tempuyung (Sonchus arvensis L.) dalam Bentuk Self Nano-Emulsifying Drug Delivery System (SNEDDS) Budy Wijiyanto; Primadara Damayanti; Mira Amaliasari Sitorus; Ratih Dyah Listianingrum; Arifa Caryn Dea; Yandi Syukri
Jurnal Sains Farmasi & Klinis Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016
Publisher : Fakultas Farmasi Universitas Andalas

Tempuyung (Sonchus arvensis L.) is a plant native to Indonesia with a diuretic and antioxidant effect. To obtain the optimal therapeutic effect need innovation to make it the nano herbs preparations. This research aims to preparation and characterization of nano herbal tempuyung in the form of Nano Self-emulsifying Drug Delivery System (SNEDDS). The active substance of tempuyung was extracted with ethanol and the solvent evaporated to obtain a viscous extract. Extracts were standardized following the Indonesian Pharmacopeia Herbal. Next, the SNEDDS of tempuyung were made using Capryol-90 as oils, tween 20 as surfactants and PEG 400 as co-surfactant. SNEDDS was characterized include particle size and zeta potential. The viscous extract obtained from extraction was 77.52 g. This result has been eligible if compared with Indonesian Pharmacopoeia Herbal that mentions the acquisition of thick leaf extract tempuyung yield is not less than 7.5%. Tempuyung formulation in dosage forms SNEDDS obtained a clear nanoemulsion with a particle size of 16.2 ± 1.06 nm and zeta potential value of -37.48 ± 0.74 mV. It can be concluded that the tempuyung extract can produce a nano herbs in SNEDDS preparation.

Senyawa Antibiotik dari Bacillus sp1 (HA1) yang Bersimbiosis pada Spon Laut Haliclona fascigera Wiza Leila Puspita Sari; Deddi Prima Putra; Dian Handayani
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

Bakteri simbion merupakan bakteri yang hidup dalam jaringan suatu host dan tidak merugikan host tersebut. Bakteri ini dapat menghasilkan berbagai senyawa bioaktif seperti antibakteri. Penelitian ini bertujuan untuk mengisolasi senyawa antibiotik dari ekstrak etil asetat bakteri Bacillus sp1 (HA1) yang bersimbiosis dengan spon laut Haliclona fascigera. Metoda yang digunakan yaitu kultivasi bakteri pada media Nutrient Broth menggunakan Incubator Shaker dengan kecepatan 150 RPM pada suhu 37ºC selama 24 jam. Isolasi senyawa antibakteri dilakukan dengan metoda kromatografi kolom dan pengujian aktivitas antibakteri dengan metode difusi agar. Dari penelitian yang telah dilakukan diperoleh 2 senyawa antibakteri W1 dan W2. Senyawa W1 (10,8 mg) larut dalam pelarut etil asetat dan metanol, tapi sukar larut dalam n-heksana. Senyawa ini dapat menghambat pertumbuhan bakteri patogen Staphylococcus aureus ATCC 25923 dengan Konsentrasi Hambat Minimum (KHM) 1%. Sedangkan senyawa W2 (2,3 mg) larut dalam diklorometana dan metanol, namun sukar larut dalam n-heksana. Senyawa W2 tidak dapat menghambat pertumbuhan Staphylococcus aureus ATCC 25923.

Potensi Antihiperlipidemia Ekstrak Etanolik Daun Bayam Merah (Amaranthus tricolor L.) Terstandar secara in Vivo Berdasarkan Parameter LDL (Low Density Lipoprotein) Dimas Adhi Pradana; Faras Sophia Rahmah; Tri Ratna Setyaningrum
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

This study aims to determine the potential for curative therapy ethanolic extract of red spinach leaves (Amaranthus tricolor L.) standardized to decrease LDL levels in vivo. Animal model used in this study were 30 male Wistar rats aged 2-3 months were randomly divided into 6 groups include normal control, negative control, positive control and three doses ratings eksktrak. Induction of hyperlipidemia using poloxamer on day 1st and propylthiouracil on day 5th to day 18th. The positive control groups were given by simvastatin and the treatment group were given three doses of the extract variations on each - each group ie 200 mg / kg, 400 mg / kg, and 800 mg / kg rat. Ethanolic extract of red spinach leaves that are used have been through a standardized test based on specific parameters and non-specific. Determination of plasma LDL levels was done 3 times, day 0 (baseline), day 4th (after induction process) and day 19th (after treatment). The results obtained show the ethanolic extract of red amaranth (Amaranthus tricolor L.) standardized at a dose of 800 mg / kg body weight can lower LDL levels statistically significant (p <0.05) compared with normal and negative group. It can be concluded that the ethanolic extract red spinach leaves standardized has activity as a curative therapy for hyperlipidemia.

Effect of Eleutherine americana Merr. bulb extract on blood pressure and heart rate in anesthetized hypertensive rats Yori Yuliandra; Rizki Oktarini; Armenia Armenia
Jurnal Sains Farmasi & Klinis Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018
Publisher : Fakultas Farmasi Universitas Andalas

The effect of ethanolic extract of Eleutherine americana Merr. on the blood pressure and heart rate has been investigated. A number of 25 Sprague-Dawley male rats were induced with prednisone 1.5 mg/kg in combination with saline solution 2.5% for 14 days to obtain hypertension model. The rats were anesthetized and prepared for the recording of blood pressure and heart rate. The rats were divided into five groups receiving 100, 200, and 400 mg/kg of the extract, vehicle control, and captopril 30 mg/kg as the reference. The treatment was administered three times with 30 minutes interval. The systolic (SBP), diastolic (DBP), mean arterial pressure (MAP), and heart rate (HR) were recorded. The data were analyzed with two-way analysis of variance (ANOVA) followed by Duncan’s MRT (95% confidence interval). The study revealed that the extract exhibited a blood pressure lowering effect. The best antihypertensive activity of the extract was shown by the dose of 100 mg/kg. Meanwhile, HR was also affected inversely by the treatment, in which the lowest dose caused the highest increase. The study suggests that the extract of Eleutherine americana exhibits antihypertensive activity that may be potential for future development of drugs.

Formulasi Mikrokapsul Ranitidin HCl Menggunakan Rancangan Faktorial dengan Penyalut Etil Selulosa Lili Fitriani; Ulfi Rahmi; Elfi Sahlan Ben
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

Ranitidine HCl is a histamine H2-antagonist which is used in the treatment of benign gastric and duodenal ulceration. In order to improve its bioavailability and half life time, microcapsule is prepared to extend the dose regiment. The aim of this study was to formulate and optimize ranitidine HCl containing microcapsule to prepare a suitable sustained release delivery system using factorial design. Microspheres were prepared using ethylcellulose by solvent evaporation method. The effect of different formulation variables, including stabilizer concentration (1-2 %) and drug/polymer ratio (2:2-1:2) on appearance, and entrapment efficiency was investigated. Data analysis showed that microspheres with optimum entrapment efficiency could be prepared using 2 % span 80, and 1:2 drug/polymer ratio. The results showed spherical shaped microcapsules, and porous, with realeasing time up to 10,55 hours.

Kajian Drug Related Problems Pasien Otitis Media Supuratif Kronis di Bangsal THT RSUP. Dr. M. Djamil Padang Suhatri Suhatri; Popy Handayani; Harisman Harisman
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

A study of drug related problems in patients with chronic suppurative otitis media has been done in the ENT ward of Dr. M. Djamil Hospital Padang. The study was conducted retrospectively and prospectively by tracking the patient’s condition, medical record, Drug Instruction Card (KIO) and nursing care records in patients with chronic suppurative otitis media. The data obtained is then analyzed descriptively. The results showed that the most prevalent DRPs category was drug interactions. There were 10 cases of drug interactions of 11 DRPs incidents from retrospective data and 5 cases of drug interaction of 10 DRPs incidents from prospective data in chronic suppurative otitis media in the ENT ward of Dr. M. Djamil Hospital Padang. The other DRPs categories were from dose retrospective data of less than 1 case (3.84%) and from prospective data of adverse drug reactions of 5 cases (45.45%). From the results of this study, it can be concluded that the category of drug related problems found in patients suppurative chronic otitis media in the ENT ward of Dr. M. Djamil Hospital Padang is drug interaction, less dosage, and adverse drug reactions.

Tingkat Kepatuhan Penggunaan Obat pada Pasien Tuberkulosis di Rumah Sakit Mayjen H. A Thalib Kabupaten Kerinci. Puspa Pameswari; Auzal Halim; Lisa Yustika
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

Kepatuhan pasien dalam mengkonsumsi obat secara teratur sampai tuntas merupakan salah satu faktor yang menentukan keberhasilan dalam pengobatan tuberkulosis paru. Penelitian ini bertujuan untuk mengetahui Tingkat Kepatuhan Pemakaian Obat pada Pasien Penderita TB paru di Rumah Sakit Mayjen H.A Thalib Kabupaten Kerinci, pada bulan April–Juni 2015. Penelitian ini termasuk penelitian observasional (non eksperimental). Pengambilan data menggunakan kuisioner yang dibuat berdasarkan MMAS (Morisky Medication Adherence Scale) dan CSA (Continous Single-Interval Medication Avaibility). Hasil penelitian menunjukkan sebanyak 55,56% responden patuh; 33,33% responden cukup patuh dan 11,11% responden tidak patuh dalam pengunaan obat.

Dispersi Padat Asam Usnat dengan Teknik Freeze Drying menggunakan Poloxamer 188 sebagai Polimer Deni Noviza; Lili Fitriani; Riana Zikra Fauzi
Jurnal Sains Farmasi & Klinis Vol 5, No 1 (2018): J Sains Farm Klin 5(1), April 2018
Publisher : Fakultas Farmasi Universitas Andalas

This study aimed to improve the solution of usnic acid, a poorly soluble drug using solid dispersions (SDs). The SDs were prepared by a freeze-drying technique with poloxamer 188 as a polymer. The physicochemical properties of the SDs were characterized using X-ray diffractometry (XRD) and Fourier transform-infrared (FT-IR) spectroscopy, Scanning Electron Microscopy (SEM),. In addition, drug content, solution test and dissolution profile was evaluated by using usnic acid (pure drug) and physical mixture as a reference. The results from XRD and SEM showed that usnic acid was molecularly dispersed in the SDs as an amorphous form. The FT-IR results suggested that intermolecular hydrogen bonding had formed between usnic acid and its carriers. The result of solubility test showed that solubility of solid dispersions 1:1; 1:2; 2:1 (5.80 µg/ml; 6.94 µg/ml ; 4.88 µg/ml) were higher than the physical mixture 1:1 ( 0.39 µg/mL) and pure asam usnat have the lowest solubility (0.34 µg/mL). In conclusion, SDs prepared by a freeze-drying technique used poloxamer as a polymer can be used to enhance solubility of usnic acid

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Home Page

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Contact Name
Yori Yuliandra

Contact Email
yoriyuliandra@gmail.com

Phone
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Journal Mail Official
jsfkonline@gmail.com

Editorial Address
-

Location
Kota padang,

Sumatera barat

INDONESIA