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SRIWIJAYA JOURNAL OF MEDICINE
Published by Universitas Sriwijaya
ISSN : -     EISSN : 26223589     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Sriwijaya Journal of Medicine (SJM) is a scientific journal managed by Faculty of Medicine Universitas Sriwijaya, Indonesia. It publishes original research articles and reviews in Biomedical Sciences, Medicine (Neurology, Cardiovascular, Respiratory, Gastrointestinal, Urogenital, Endocrine and Metabolism, Integument, Mental Health, Obstetry and Gynecology, Ophtalmology, ENT, Musculosceletal) and Public Health Medicine. Sriwijaya Journal of Medicine (SMJ) published three times a year (January, April, October).
Arjuna Subject : Kedokteran - Anatomi
Articles 325 Documents
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Penta Herbs Forte: The Effect of PHF Extract on Superoxide Dismutase Activity in Hypoxic Sprague Dawley Rat’s Heart Jessie Farica Gunardi; Noer Saelan Tadjudin; Frans Ferdinal; David Limanan; Eny Yulianti
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.382

Abstract

Hypoxia is a condition in which tissues receive insufficient oxygen, leading to increased production of reactive oxygen species (ROS) and triggering oxidative stress that can cause heart damage. Penta Herbs Forte (PHF), a combination of Blumea balsamifera, Curcuma xanthorrhiza, Zingiber officinale var. rubrum, Phyllanthus niruri, and Andrographis paniculata, contains bioactive compounds with antioxidant properties that may help strengthen the body’s defense against oxidative injury. This study aimed to evaluate the effect of PHF extract on the activity of the antioxidant enzyme Superoxide Dismutase (SOD) in the hearts of hypoxia-induced Sprague Dawley rats. The research included in vitro assessments (total phenolic content, BSLT toxicity, and FRAP assays) and in vivo experiments involving eight groups of rats receiving PHF extract with different hypoxia exposure durations (0, 1, 7, and 14 days). Heart tissues were processed into homogenates, and SOD activity was measure by spectrophotometry, followed by statistical analysis using the Mann-Whitney and Kruskal-Wallis tests. Although PHF groups showed higher SOD activity, significant differences between control and treated groups were observed only at 1-day hypoxia. These findings suggest that PHF may help protect the heart from hypoxia-related oxidative stress by enhancing antioxidant enzyme activity.
The Difference in Mean Blood Pressure Before and After Dark Chocolate Administration in the Elderly Sabrina Kezia Yohannes; Alfianto Martin
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.383

Abstract

Hypertension is particularly prevalent among the elderly and requires careful therapy to minimize cardiovascular consequences.  Flavanol chemicals found in dark chocolate are thought to enhance endothelial function by increasing the availability of nitric oxide, which may lower blood pressure.  This study assessed the acute effect of dark chocolate consumption on systolic and diastolic blood pressure in older persons.  A quasi-experimental pre–post design was undertaken among 65 elderly people of Panti Werdha Wisma Mulia and Panti Santa Anna who met the inclusion criteria and given informed consent.  A digital sphygmomanometer was used to assess each participant's blood pressure prior to consumption and at 15, 30, and 60 minutes after consuming 30 grammes of 72% dark chocolate. Data normality was assessed using the Kolmogorov–Smirnov test, and paired t-test or Wilcoxon analysis. Systolic blood pressure at 30 minutes (126.14 ± 16.17 mmHg; p = 0.015) and 60 minutes (122.57 ± 16.36 mmHg; p = 0.000) was significantly lower than baseline (130.51 ± 17.54 mmHg). Diastolic blood pressure revealed a significant drop only at 60 minutes (74.26 ± 9.98 mmHg; p = 0.005) from baseline (77.89 ± 14.24 mmHg). Although early post-consumption measures indicated no statistically significant changes, the overall results indicate that dark chocolate produces a considerable short-term hypotensive impact in the elderly. These data imply that dark chocolate may serve as a complementary non-pharmacological strategy to blood pressure management in older populations.
Relationship between Knowledge and Attitudes Regarding Preventive Behaviors for Sexually Transmitted Infections Among Prisoners in Ambon City’s Women's Correctional Institution Zahra Hansuri; Fauzan Tuankotta; Fathiyatul Khair; Alessandra Flowrence Saija; Amanda Gracia Manuputty
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.385

Abstract

Sexually transmitted infections (STIs) are diseases that are transmitted through sexual intercourse, whether vaginal, anal, or oral. STIs cases specifically target key groups such as FSWs (female sex workers), MSM (men who have sex with men), WSW (women who have sex with women), injecting drug users and prisoners in correctional institutions who are closely related to risky sexual behavior. Risky sexual behavior in these groups is often caused by low knowledge about the dangers and impacts of STIs. Preventing the transmission of STIs is very important to control their spread. Good knowledge and attitudes about STIs can improve effective preventive behaviors. This research aims to determine the relationship between knowledge and attitude towards STIs prevention behavior in Ambon City’s Class III Women's Correctional Institution. This research used a cross-sectional design with a total sampling technique, involving 68 female inmates. Data were collected through a questionnaire containing questions about knowledge, attitudes, and STIs prevention behavior. The results showed that 44 respondents (64.7%) had good knowledge of STIs, 50 respondents (73.5%) had a supportive attitude towards STIs, and 58 respondents (85.3%) had good STIs prevention behavior. The results of bivariate analysis using the Fisher exact test showed a significant relationship between knowledge and prevention behavior (p=0.003) and between attitude and STIs prevention behavior (p=0.017). Good knowledge and attitudes towards STIs correlate with better prevention behaviors. Therefore, it is important to improve knowledge and attitudes that support STIs prevention in prisons.
Quantitative Analysis of Borax in Cilok from Selected School-area Vendors in Seberang Ulu II, Palembang Using UV–Vis Spectrophotometry Muhammad Fachri Falahi; Yanti Rosita; Putri Erlyn; Yuni Fitrianti
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.395

Abstract

Cilok is one of the most popular traditional street foods in Indonesia because of its chewy consistency, low price, and unique flavor. Despite its popularity, concerns regarding food safety remain, especially related to the misuse of hazardous additives such as borax. Based on the Regulation of the Indonesian Ministry of Health issued in 2012, the use of borax in food products is prohibited due to its harmful effects on human health. However, several studies have reported the continued presence of borax in traditional foods and snacks sold in the community. Therefore, this study was conducted to evaluate the physical characteristics of cilok suspected of containing borax and to measure borax concentrations quantitatively. Samples were obtained from selected vendors in the Seberang Ulu II district through purposive sampling with enrichment criteria. Borax analysis was performed using a curcumin-based UV–Vis spectrophotometric method. All collected samples showed diverse physical characteristics and were confirmed positive for borax contamination, with concentrations ranging from 2.84 to 56.28 mg/kg. These results demonstrate that borax is still being used in cilok sold by certain vendors in Seberang Ulu II, Palembang City. This condition suggests that food safety supervision by authorities, including the National Agency of Drug and Food Control and local Health Offices, has not yet achieved optimal effectiveness. Greater efforts are needed to strengthen policy implementation, improve routine monitoring, and increase educational campaigns for the public, particularly parents and school communities, in order to enhance the safety of street food products and safeguard public health.  
COPD in a Construction Worker with Heavy Smoking History: Application of the PERDOKI Seven-Step Work-Relatedness Assessment Noer Triyanto Rusli; Ardi Artanto
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.401

Abstract

Chronic obstructive pulmonary disease (COPD) is a multifactorial disease in which tobacco smoking remains the dominant risk factor, while occupational exposure to vapours, gases, dusts, and fumes may contribute to disease development and progression. This case report describes a 65-year-old male construction labourer with a 48-pack-year smoking history and more than 30 years of unprotected occupational exposure to cement dust, sand, road dust, and probable respirable crystalline silica. He presented with worsening dyspnea and a productive cough consistent with an acute exacerbation of COPD. Spirometry showed airflow obstruction with FEV1/FVC of 59% and FEV1 of 60% predicted, corresponding to GOLD 2 airflow obstruction if confirmed by post-bronchodilator spirometry. Chest radiography demonstrated emphysematous changes, including bilateral hyperinflation, flattened diaphragms, attenuated vascular markings, and a vertical cardiac silhouette. Using the seven-step work-relatedness assessment of the Indonesian Association of Occupational Medicine Specialists (PERDOKI), occupational exposure was interpreted as a possible contributing factor rather than a definitive or sole cause, given the patient’s substantial smoking history and the absence of quantitative exposure monitoring. Management combined guideline-based COPD pharmacotherapy, smoking abstinence, workplace exposure reduction, respiratory protection, work modification, pulmonary rehabilitation referral, and periodic occupational health surveillance. This case highlights the importance of systematic occupational history taking in COPD patients, especially among construction workers with dual exposure to smoking and mineral dust.

Page 33 of 33 | Total Record : 325

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