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SRIWIJAYA JOURNAL OF MEDICINE
Published by Universitas Sriwijaya
ISSN : -     EISSN : 26223589     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Sriwijaya Journal of Medicine (SJM) is a scientific journal managed by Faculty of Medicine Universitas Sriwijaya, Indonesia. It publishes original research articles and reviews in Biomedical Sciences, Medicine (Neurology, Cardiovascular, Respiratory, Gastrointestinal, Urogenital, Endocrine and Metabolism, Integument, Mental Health, Obstetry and Gynecology, Ophtalmology, ENT, Musculosceletal) and Public Health Medicine. Sriwijaya Journal of Medicine (SMJ) published three times a year (January, April, October).
Arjuna Subject : Kedokteran - Anatomi
Articles 335 Documents
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Penta Herbs Forte: The Effect of PHF Extract on Superoxide Dismutase Activity in Hypoxic Sprague Dawley Rat’s Heart Jessie Farica Gunardi; Noer Saelan Tadjudin; Frans Ferdinal; David Limanan; Eny Yulianti
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.382

Abstract

Hypoxia is a condition in which tissues receive insufficient oxygen, leading to increased production of reactive oxygen species (ROS) and triggering oxidative stress that can cause heart damage. Penta Herbs Forte (PHF), a combination of Blumea balsamifera, Curcuma xanthorrhiza, Zingiber officinale var. rubrum, Phyllanthus niruri, and Andrographis paniculata, contains bioactive compounds with antioxidant properties that may help strengthen the body’s defense against oxidative injury. This study aimed to evaluate the effect of PHF extract on the activity of the antioxidant enzyme Superoxide Dismutase (SOD) in the hearts of hypoxia-induced Sprague Dawley rats. The research included in vitro assessments (total phenolic content, BSLT toxicity, and FRAP assays) and in vivo experiments involving eight groups of rats receiving PHF extract with different hypoxia exposure durations (0, 1, 7, and 14 days). Heart tissues were processed into homogenates, and SOD activity was measure by spectrophotometry, followed by statistical analysis using the Mann-Whitney and Kruskal-Wallis tests. Although PHF groups showed higher SOD activity, significant differences between control and treated groups were observed only at 1-day hypoxia. These findings suggest that PHF may help protect the heart from hypoxia-related oxidative stress by enhancing antioxidant enzyme activity.
The Difference in Mean Blood Pressure Before and After Dark Chocolate Administration in the Elderly Sabrina Kezia Yohannes; Alfianto Martin
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.383

Abstract

Hypertension is particularly prevalent among the elderly and requires careful therapy to minimize cardiovascular consequences.  Flavanol chemicals found in dark chocolate are thought to enhance endothelial function by increasing the availability of nitric oxide, which may lower blood pressure.  This study assessed the acute effect of dark chocolate consumption on systolic and diastolic blood pressure in older persons.  A quasi-experimental pre–post design was undertaken among 65 elderly people of Panti Werdha Wisma Mulia and Panti Santa Anna who met the inclusion criteria and given informed consent.  A digital sphygmomanometer was used to assess each participant's blood pressure prior to consumption and at 15, 30, and 60 minutes after consuming 30 grammes of 72% dark chocolate. Data normality was assessed using the Kolmogorov–Smirnov test, and paired t-test or Wilcoxon analysis. Systolic blood pressure at 30 minutes (126.14 ± 16.17 mmHg; p = 0.015) and 60 minutes (122.57 ± 16.36 mmHg; p = 0.000) was significantly lower than baseline (130.51 ± 17.54 mmHg). Diastolic blood pressure revealed a significant drop only at 60 minutes (74.26 ± 9.98 mmHg; p = 0.005) from baseline (77.89 ± 14.24 mmHg). Although early post-consumption measures indicated no statistically significant changes, the overall results indicate that dark chocolate produces a considerable short-term hypotensive impact in the elderly. These data imply that dark chocolate may serve as a complementary non-pharmacological strategy to blood pressure management in older populations.
Relationship between Knowledge and Attitudes Regarding Preventive Behaviors for Sexually Transmitted Infections Among Prisoners in Ambon City’s Women's Correctional Institution Zahra Hansuri; Fauzan Tuankotta; Fathiyatul Khair; Alessandra Flowrence Saija; Amanda Gracia Manuputty
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.385

Abstract

Sexually transmitted infections (STIs) are diseases that are transmitted through sexual intercourse, whether vaginal, anal, or oral. STIs cases specifically target key groups such as FSWs (female sex workers), MSM (men who have sex with men), WSW (women who have sex with women), injecting drug users and prisoners in correctional institutions who are closely related to risky sexual behavior. Risky sexual behavior in these groups is often caused by low knowledge about the dangers and impacts of STIs. Preventing the transmission of STIs is very important to control their spread. Good knowledge and attitudes about STIs can improve effective preventive behaviors. This research aims to determine the relationship between knowledge and attitude towards STIs prevention behavior in Ambon City’s Class III Women's Correctional Institution. This research used a cross-sectional design with a total sampling technique, involving 68 female inmates. Data were collected through a questionnaire containing questions about knowledge, attitudes, and STIs prevention behavior. The results showed that 44 respondents (64.7%) had good knowledge of STIs, 50 respondents (73.5%) had a supportive attitude towards STIs, and 58 respondents (85.3%) had good STIs prevention behavior. The results of bivariate analysis using the Fisher exact test showed a significant relationship between knowledge and prevention behavior (p=0.003) and between attitude and STIs prevention behavior (p=0.017). Good knowledge and attitudes towards STIs correlate with better prevention behaviors. Therefore, it is important to improve knowledge and attitudes that support STIs prevention in prisons.
Quantitative Analysis of Borax in Cilok from Selected School-area Vendors in Seberang Ulu II, Palembang Using UV–Vis Spectrophotometry Muhammad Fachri Falahi; Yanti Rosita; Putri Erlyn; Yuni Fitrianti
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.395

Abstract

Cilok is one of the most popular traditional street foods in Indonesia because of its chewy consistency, low price, and unique flavor. Despite its popularity, concerns regarding food safety remain, especially related to the misuse of hazardous additives such as borax. Based on the Regulation of the Indonesian Ministry of Health issued in 2012, the use of borax in food products is prohibited due to its harmful effects on human health. However, several studies have reported the continued presence of borax in traditional foods and snacks sold in the community. Therefore, this study was conducted to evaluate the physical characteristics of cilok suspected of containing borax and to measure borax concentrations quantitatively. Samples were obtained from selected vendors in the Seberang Ulu II district through purposive sampling with enrichment criteria. Borax analysis was performed using a curcumin-based UV–Vis spectrophotometric method. All collected samples showed diverse physical characteristics and were confirmed positive for borax contamination, with concentrations ranging from 2.84 to 56.28 mg/kg. These results demonstrate that borax is still being used in cilok sold by certain vendors in Seberang Ulu II, Palembang City. This condition suggests that food safety supervision by authorities, including the National Agency of Drug and Food Control and local Health Offices, has not yet achieved optimal effectiveness. Greater efforts are needed to strengthen policy implementation, improve routine monitoring, and increase educational campaigns for the public, particularly parents and school communities, in order to enhance the safety of street food products and safeguard public health.  
COPD in a Construction Worker with Heavy Smoking History: Application of the PERDOKI Seven-Step Work-Relatedness Assessment Noer Triyanto Rusli; Ardi Artanto
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.401

Abstract

Chronic obstructive pulmonary disease (COPD) is a multifactorial disease in which tobacco smoking remains the dominant risk factor, while occupational exposure to vapours, gases, dusts, and fumes may contribute to disease development and progression. This case report describes a 65-year-old male construction labourer with a 48-pack-year smoking history and more than 30 years of unprotected occupational exposure to cement dust, sand, road dust, and probable respirable crystalline silica. He presented with worsening dyspnea and a productive cough consistent with an acute exacerbation of COPD. Spirometry showed airflow obstruction with FEV1/FVC of 59% and FEV1 of 60% predicted, corresponding to GOLD 2 airflow obstruction if confirmed by post-bronchodilator spirometry. Chest radiography demonstrated emphysematous changes, including bilateral hyperinflation, flattened diaphragms, attenuated vascular markings, and a vertical cardiac silhouette. Using the seven-step work-relatedness assessment of the Indonesian Association of Occupational Medicine Specialists (PERDOKI), occupational exposure was interpreted as a possible contributing factor rather than a definitive or sole cause, given the patient’s substantial smoking history and the absence of quantitative exposure monitoring. Management combined guideline-based COPD pharmacotherapy, smoking abstinence, workplace exposure reduction, respiratory protection, work modification, pulmonary rehabilitation referral, and periodic occupational health surveillance. This case highlights the importance of systematic occupational history taking in COPD patients, especially among construction workers with dual exposure to smoking and mineral dust.
Laparoscopic Management of a Translocated Intrauterine Device in a Postmenopausal Woman: A Case Report Venny Sari; Adnan Abadi
Sriwijaya Journal of Medicine Vol. 9 No. 2 (2026): Vol 9, No 2, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i2.371

Abstract

Intrauterine device perforation is rare, yet remains one of the most serious complications of long-term IUD (Intrauterine Device) use. Although extrauterine migration has been reported in multiple pelvic and abdominal structures, chronic migration in postmenopausal women with very long retention periods is uncommon. We present a distinctive case involving a 60-year-old female patient who has retained a copper-T intrauterine device for a duration of 19 years without any subsequent medical follow-up and has been in a postmenopausal state for the past 17 years. She presented with a one-month history of abdominal pain. Ultrasonography and abdominal radiography demonstrated the absence of the device within the uterine cavity. Diagnostic laparoscopy elucidated the presence of the intrauterine device penetrating the posterior uterine wall and exhibiting a strong adherence to the right fallopian tube, extending towards the fimbriae, accompanied by substantial adhesions associated with copper. The device was successfully removed via laparoscopic adhesiolysis. This case highlights an unusual presentation of extrauterine IUD migration in which the strings remained visible at the external cervical os despite perforation and adnexal adhesion. Postmenopausal uterine atrophy, myometrial thinning, and the chronic inflammatory response induced by copper likely contributed to progressive erosion and adhesion formation. Current WHO and ACOG recommendations advise the removal of all migrated IUDs regardless of symptoms to prevent complications. The present case demonstrates that ongoing surveillance after IUD insertion and removal of the device following menopause is essential to prevent delayed perforation, chronic migration, and complex surgical retrieval.
Comparison of The Efficacy of Single Antibiotic Ear Tampon Versus Combination Antibiotic–Steroid Ear Tampon in Patients with Acute Diffuse Otitis Externa Sugianto; Abla Ghanie; Ahmad Hifni; Erial Bahar
Sriwijaya Journal of Medicine Vol. 9 No. 2 (2026): Vol 9, No 2, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i2.392

Abstract

Acute diffuse otitis externa is an acute inflammatory condition of the external auditory canal commonly associated with otalgia and ear canal oedema. Standard management includes aural toilet, pain control, and topical antimicrobial therapy, which may be administered using ear tampons with or without corticosteroids. This study aimed to compare the effectiveness of single-antibiotic ear tampons versus antibiotic–steroid combination ear tampons in reducing pain and ear canal oedema in patients with acute diffuse otitis externa. This double-blind randomized controlled clinical trial analyzed 40 patients with acute diffuse otitis externa who completed follow-up and were assigned to receive either single-antibiotic ear tampons or antibiotic–steroid combination ear tampons. Pain intensity was assessed using the Visual Analog Scale, and ear canal oedema was evaluated using the Brighton scale at baseline and on days 1, 3, and 5 after tampon insertion. Longitudinal analysis was performed using repeated-measures models.  Both treatment groups demonstrated significant improvement in pain and oedema over time. However, longitudinal analysis showed that the antibiotic–steroid combination group experienced a significantly faster reduction in pain than the single-antibiotic group, whereas the trajectory of oedema improvement did not differ significantly between groups. Multivariable longitudinal analysis confirmed that treatment type and baseline pain severity were associated with pain outcome, while baseline oedema severity was strongly associated with oedema outcome. Both treatment regimens were effective over time, but antibiotic–steroid ear tampons provided faster pain relief, while oedema improvement remained comparable between groups.
Factors Associated with the Types of Chronic Suppurative Otitis Media Nafilah Ramadhanti; Abla Ghanie; Fiona Widyasari; Adelien; Depi Jufri
Sriwijaya Journal of Medicine Vol. 9 No. 2 (2026): Vol 9, No 2, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i2.400

Abstract

Chronic Suppurative Otitis Media (CSOM) is a common condition of the middle ear that may lead to serious complications if not properly managed. Several environmental and host-related factors are believed to influence the clinical presentation of CSOM. However, evidence examining their association with specific CSOM subtypes remains limited. This research was conducted to examine factors associated with different types of CSOM. A cross-sectional analytical approach was applied at Dr. Mohammad Hoesin General Hospital, Palembang, during July–September 2025, with a total of 68 CSOM patients participating in the study. Data on age, sex, cigarette smoke exposure, history of upper respiratory tract infections (URTIs), and allergic rhinitis were collected using structured interviews. The CSOM type was determined through otoscopic examination. The chi-square test was applied for bivariate analysis, and multivariable logistic regression analysis was performed to obtain adjusted odds ratios (aOR). Cigarette smoke exposure (aOR = 8.28; 95% CI: 1.85–37.01) and allergic rhinitis (aOR = 5.73; 95% CI: 1.31–24.99) were significantly associated with the atticoantral type of CSOM, whereas recurrent URTIs showed a positive association that was not statistically significant after controlling for other variables. (aOR = 2.64; 95% CI: 0.59–11.80). The results of this study imply that cigarette smoke exposure and allergic rhinitis are significantly associated with the atticoantral type of CSOM, while recurrent URTIs may act as a contributing factor.
Correlation Between Serum BDNF Levels and Specific Cognitive Domains of MoCA-Ina in Elderly with Mild Cognitive Impairment: An Exploratory Study Denis Puja Sakti; Yuniza; Ridzqie Dibyantari; Mgs. Irsan Saleh
Sriwijaya Journal of Medicine Vol. 9 No. 2 (2026): Vol 9, No 2, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i2.402

Abstract

Brain-Derived Neurotrophic Factor (BDNF) decline is closely linked to Mild Cognitive Impairment (MCI) in the elderly. However, sociodemographic variables frequently confound this neurobiological relationship. This study evaluates the correlation between baseline serum BDNF levels and specific MoCA-Ina cognitive domains in MCI patients, adjusting for age and educational background. This exploratory cross-sectional study included 30 MCI subjects (≥60 years) at Dr. Mohammad Hoesin General Hospital. Serum BDNF was quantified via ELISA. Cognitive performance was measured across seven MoCA-Ina domains. Data were analyzed using Spearman’s rank and non-parametric partial correlations. The initial unadjusted analysis showed no significant correlation between BDNF and total MoCA-Ina scores (r = 0.282, p = 0.131). However, statistically controlling for age and education revealed a significant moderate positive correlation (r = 0.428, 95% CI 0.07–0.69, p = 0.023). Domain-specific analysis demonstrated a significant positive correlation exclusively in the Abstraction domain (r = 0.392, 95% CI 0.02–0.67, p = 0.039). Adjusting for age and cognitive reserve unmasks a significant positive correlation between baseline serum BDNF, global cognition, and abstraction performance in MCI. Peripheral BDNF represents a potential biomarker for prefrontal cognitive dynamics when sociodemographic confounders are properly integrated.
Potential of Rosella Extract (Hibiscus sabdariffa L.) to Herbal Medicine: Focus on Body Weight, Islets Langerhans Cells Count, and Relative organ weight in Diabetes Mellitus Rats Trisnawati Mundijo; Siti Rohani; Sinta Julia Liona Putria; Nurshadrina Amalia Putri; Rury Tiara Oktariza
Sriwijaya Journal of Medicine Vol. 9 No. 2 (2026): Vol 9, No 2, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i2.403

Abstract

The Rosella (Hibiscus sabdariffa L.), is useful as an antidiabetic, but research reports on relative body weight, Islets of Langerhans cells, and relative organ weight are still limited. To investigate the potential of Rosella extract to herbal medicine in rat models of diabetes mellitus as confirmed in body weight, Islets of Langerhans cells, and relative organ weight. Thirty adult male Rattus novergicus L. rats divided into 6 main groups, as a normal control group (KN), a negative control group (K-) induced by alloxan, a positive control (K+) induced by alloxan and glibenkamid, and 3 treatment groups given alloxan and Rosella extract at doses of 15% (P1), 30% (P2), and 60% (P3). All rats were weighed until the end of the treatmen for 14 days. On the last day, we collected the relative weighed of liver and kidneys organ, also the histopatological islet Langerhans cells count. Data were analyzed univariately to describe the effect Rosella extract on the study variables. The body weight are tended to increase but was still within in normal range for rat body weight. The Islet Langerhans cells count value was highest in the treatment group with a 30% dose of 2396.6. Meanwhile, the relative weight of the kidney and liver organs in all groups given Rosella extract tended to be the same as the normal group. The Rosella extract has the potential as a herbal medicine through confirmation of normal body weight, islet Langerhans cell count, kidney and liver relative weight in rats diabetes mellitus models.

Page 33 of 34 | Total Record : 335

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