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SRIWIJAYA JOURNAL OF MEDICINE
Published by Universitas Sriwijaya
ISSN : -     EISSN : 26223589     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Sriwijaya Journal of Medicine (SJM) is a scientific journal managed by Faculty of Medicine Universitas Sriwijaya, Indonesia. It publishes original research articles and reviews in Biomedical Sciences, Medicine (Neurology, Cardiovascular, Respiratory, Gastrointestinal, Urogenital, Endocrine and Metabolism, Integument, Mental Health, Obstetry and Gynecology, Ophtalmology, ENT, Musculosceletal) and Public Health Medicine. Sriwijaya Journal of Medicine (SMJ) published three times a year (January, April, October).
Arjuna Subject : Kedokteran - Anatomi
Articles 325 Documents
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The Association Between Vitamin D Levels and Glycemic Control Parameters in Elderly Populations Gunawan, Shirly; Kosasih, Robert; Wijaya, Bryan Anna; Santoso, Alexander Halim; Firmansyah, Yohanes
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.357

Abstract

Diabetes is common in the elderly, and routine monitoring of HbA1c and blood glucose is required to prevent complications. HOMA-IR assesses insulin resistance, while vitamin D may influence glucose metabolism by enhancing insulin sensitivity. This study examines the relationship between vitamin D levels and glycemic control, including HbA1c, fasting glucose, insulin, and HOMA-IR. This cross-sectional observational study included 91 elderly residents of Panti Wreda Bina Bhakti, excluding those with acute illness or chronic conditions affecting Vitamin D and diabetes parameters. All participants provided informed consent. The study measured serum Vitamin D-25(OH) and insulin using ELISA, while fasting blood glucose and HbA1c were assessed via blood chemistry analysis. HbA1c control was categorized as good (<6.5%), moderate (6.5–8.0%), or poor (>8%). HOMA-IR was calculated using a standard formula. Pearson correlation analysis determined the relationship between Vitamin D levels and glycemic parameters, with statistical significance at p < 0.05. The correlation analysis found a significant negative relationship between vitamin D levels and HbA1c (r: -0.211; p: 0.044). However, no significant correlation was found between vitamin D and fasting blood glucose levels (r: 0.057; p: 0.590), insulin (r: -0.083; p: 0.432), and HOMA-IR (r: -0.040; p: 0.704).  Vitamin D levels show a significant negative correlation with HbA1c in the elderly, indicating its role in long-term glycemic control. Although no significant relationship was found with other glycemic parameters, these findings suggest that monitoring vitamin D status may be considered as part of a more comprehensive approach to diabetes management in the geriatric population.
Identification of Chemical Constituents in Ethanolic Extract of Hibiscus sabdariffa L. Calyces (Roselle) by FTIR and GC-MS: Preliminary Phytochemical Screening Rohani, Siti; Martha, Fadhil Rizki; Astri, Yesi; Putria, Sinta Julia Liona
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.360

Abstract

Indonesia is widely recognized for its rich biodiversity, which has long served as a valuable resource for traditional herbal medicine. In recent years, interest in plant-based therapies has grown significantly. One such plant, Hibiscus sabdariffa L., commonly known as Rosella, is valued for its therapeutic properties. These benefits arise from the combined effects of its bioactive compounds, allowing it to address a range of health issues. Research has shown that Rosella contains notable levels of flavonoids, saponins, tannins, and alkaloids—all of which contribute to its antibacterial activity. Techniques such as Fourier-transform infrared (FTIR) spectroscopy and gas chromatography–mass spectrometry (GC-MS) are employed to identify these chemical constituents. FTIR analysis has detected functional groups like amines, fatty acids, aldehydes, carboxylic acids, and aromatic rings. Additionally, GC-MS results have indicated the presence of major compounds belonging to the methyl ester group. Noteworthy identified substances include Hexadecanoic Acid Methyl Ester, Hexadecanoic Acid Ethyl Ester, and Benzenepropanoic Acid, 3,5-Bis(1,1-Dimethylethyl)-4-Hydroxy-, Methyl Ester. A review of existing prior research suggests that these compound groups exhibit significant pharmacological potential, including the usage for antioxidant, anticancer, antibacterial, antidiabetic, and anti-inflammatory effects.
Computational Insights into the Dual Inhibition of PfATP6 and PfCRT by Bioactive Compounds from Spatholobus littoralis Hassk. Wahyuningtias, Dita Sheilla Putri; Putra, Oktavian Arya; Turnip, Laurens Frestasya A.; Ananda, Putu Desy Sagita; Wibowo, Syahputra; Wisynu Kusuma Wardhani, Bantari
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.362

Abstract

The current study examined the antimalarial activity of bioactive compounds extracted from Spatholobus littoralis Hassk. (bajakah wood) by an in-silico approach targeting the Plasmodium falciparum PfCRT and PfATP6 receptors. A total of forty-six phytochemicals were subjected to screening, resulting in the selection of six compounds based on bioactivity prediction, ADMET profiling, and molecular docking analyses.  Ramachandran plots were used to check the accuracy of the model, which showed that the protein structures were reliable.  Milbemycin A4-oxime exhibited the most significant binding affinity (−9.6 kcal/mol for PfCRT and −9.9 kcal/mol for PfATP6). These findings are comparable to or slightly better than those observed for artemisinin in this in silico model. These findings are preliminary and require further experiment. The molecule exhibited persistent interactions and favorable pharmacokinetic properties, indicating its potential use as a multitarget inhibitor.  Quercetin and 8-O-methylretusin had significant efficacy.  These results underscore the potential of S. littoralis metabolites, especially Milbemycin A4-oxime, as candidates for antimalarial drug development; however, additional in vitro and in vivo validation is necessary to establish efficacy and safety.
Effect of Vitamin D Supplementation on Recurrence Risk in Graves’ Disease Measured By The GREAT Score at Dr. Mohammad Hoesin General Hospital Palembang Ali Rabbani, Muhammad Iqbal; Anggraini, Ratna Maila Dewi; Kusnadi, Yulianto; Maritska, Ziske
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.370

Abstract

Graves’ disease is the most common cause of primary hyperthyroidism with a prevalence of approximately 0.5%, predominantly affecting women (female-to- male ratio 6–7:1) aged 35–40 years. Predictors of treatment outcomes and recurrence risk have been studied, among them the GREAT Score, which combines age, goiter size, FT4, and TRAb levels. The aim of this study was to analyze changes in the GREAT Score after the addition of vitamin D supplementation in Graves' disease patients at Dr. Mohammad Hoesin General Hospital, Palembang, within 3 months. This was a double-blind randomized clinical trial involving 30 patients with Graves’ disease, both inpatients and outpatients, who met the inclusion criteria. Patients were randomly assigned into two groups: the intervention group received10,000 IU of vitamin D, while the control group received placebo. Recurrence risk was assessed using the GREAT Score at the first and third months, and data were analyzed with SPSS v.25. Analysis using the Wilcoxon test showed no significant change in the GREAT Score for the vitamin D group (p=0.102). At the first month, the distribution was 53.3% class I, 40.0% class II, and 5.7% class III, while at the third month it was 40.0% class I, 40.0% class II, and 20.0% class III. In the placebo group, results were also not significant (p=0.480), with the first-month distribution of 33.3% class I, 40.0% class II, and 26.7% class III, and the third month 40.0% class I, 33.3% class II, and 13.3% class III. In summary, Vitamin D supplementation has no significant effect in reducing the recurrence of Graves' disease compared to placebo.
Activity Assay and Determination of Active Larvicidal Compounds from Cat's Whiskers (Orthosiphon aristatus Blume miq.) Guntina, Rizka Khoirunnisa; Riyanti, Soraya; Faramayuda, Fahrauk
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.375

Abstract

The tropical climate of Indonesia presents a significant risk for the prevalence of various mosquito-borne diseases, particularly Dengue Hemorrhagic Fever (DHF), which has become a critical public health concern in recent years. The control of mosquito populations, specifically targeting larvae, is a strategic approach in managing the transmission of DHF. Traditional methods involving synthetic larvicidal agents, however, raise concerns regarding potential resistance among mosquito populations and adverse effects on human health. Consequently, there exists an urgent need for alternative solutions that are both effective and safe for human exposure. One promising avenue is the exploration of natural larvicidal agents sourced from local flora, such as the white-purple variety of cat's whiskers (Orthosiphon aristatus Blume miq.). This study investigates the larvicidal potential of this plant, focusing on its main secondary metabolites, namely flavonoids and phenolics, which are hypothesized to possess larvicidal activities. Conducted extensive larvicidal activity assaying on various extracts and fractions derived from the white-purple cat's whiskers. Notably, the ethyl acetate fraction demonstrated superior efficacy, evidenced by a calculated LC50 value of 737.71 ppm, underscoring its potential as a sustainable larvicidal agent. Subsequent analyzes of this active fraction revealed the presence of the compound sinensetin, which further validates the insecticidal application of this plant in controlling mosquito populations effectively. This research contributes to the paradigm shift toward natural alternatives in pest management, highlighting the importance of harnessing local biodiversity in the fight against vector-borne diseases.
Factors Influencing Maternal Mortality in The Bangka Belitung Archipelago Hastuti; Kamalia Layal
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.358

Abstract

Maternal mortality remains a key indicator of health system performance. Although Indonesia has seen a general decline in maternal mortality rates, they remain high, with notable fluctuations observed in the Bangka Belitung Islands, particularly an upward trend following the COVID-19 pandemic peak in 2021. This study aimed to identify factors associated with maternal mortality in the province. A case-control design was employed using secondary data from 2023, including Maternal Verbal Autopsy reports, medical records from the Maternal Perinatal Death Notification (MPDN) system, and maternal cohort data from local health centers. A total of 117 subjects were included, comprising 39 cases and 78 controls. Two variables were found to significantly influence maternal mortality in the Bangka Belitung Islands Province in 2023: parity (p = 0.020; OR = 0.306; 95% CI: 0.113–0.831) and antenatal care visits (p < 0.001; OR = 23.233; 95% CI: 7.266–74.226). Of these, antenatal care visits were identified as the most dominant predictor. These findings underscore the urgent need to strengthen maternal healthcare services in line with clinical standards, particularly ensuring comprehensive and timely antenatal care. Improving service governance may enhance early detection of high-risk pregnancies, facilitate safer deliveries, and ultimately reduce maternal mortality in the Bangka Belitung Islands.
Psychosocial Impact of Recurrent Pregnancy Loss in a G7P0A6 Patient with Hyperthyroidism: A Case Report Leonardus Yogie Ricardo; Hartati; Kemala Andini Prizara; Sisca Yulistiana
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.364

Abstract

Recurrent pregnancy loss presents significant physical and psychosocial challenges, especially when complicated by comorbidities such as Graves’ disease and polycystic ovary syndrome (PCO) with suspected insulin resistance. This case involves a G7P0A6 woman at 21 weeks’ gestation with euthyroid-phase Graves’ disease and PCO, expressing a desire for tubectomy if another miscarriage occurs. She has no living children and shows psychosocial distress related to previous losses. Termination at 21 weeks carries risks of hemorrhage, infection, and endocrine instability, particularly in patients with autoimmune and metabolic disorders. Continuing the pregnancy, however, also entails potential complications including endocrine imbalance, fetal growth restriction, preterm delivery, or intrauterine death. Psychologically, repeated miscarriage can provoke anxiety, guilt, and depressive symptoms, often influencing irreversible decisions like sterilization without full consideration of alternatives. Given her emotional vulnerability and absence of living offspring, permanent contraception should be deferred. A multidisciplinary approach—integrating obstetrics, internal medicine, psychiatry, and psychology—is essential to optimize maternal health and guide ethical decision-making. Continuing the pregnancy with close medical and psychological monitoring is preferable to termination, as both options carry comparable risks, but continuation preserves the possibility of a living child. Antenatal psychological support and comprehensive contraceptive counseling should be provided to help the patient make well-informed, emotionally balanced decisions regarding future fertility.
The Role of Blood Pressure, Diabetes Panel, Vitamin D, and Albumin in Sleep Quality Among the Elderly Population Anastasia Ratnawati Biromo; Paskalis Andrew Gunawan; Alexander Halim Santoso; Bryan Anna Wijaya; Raden Seliwat Agung Aditya; Anthon Eka Prayoga Khoto
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.369

Abstract

Sleep disturbances are common among the elderly, influenced by multiple physiological factors, including blood pressure regulation, metabolic markers, nutritional status, and inflammation. Poor sleep quality has been linked to cardiovascular diseases, cognitive decline, and reduced overall well-being. Understanding the relationship between blood pressure, diabetes markers, vitamin D, and albumin levels with sleep quality may provide insights into potential interventions to improve sleep health in older adults. This study aims to analyze the correlation between blood pressure, diabetes panel (fasting blood glucose, fasting insulin, and HbA1c), vitamin D, and albumin levels with sleep quality in the elderly population. This Cross-sectional study was conducted at Bina Bhakti Nursing Home in 2024 to 58 elderly participants selected through total sampling. Sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI), while physiological parameters were measured using validated clinical and laboratory methods. Data were analyzed using Spearman’s Rho test to determine correlations between these factors and sleep disturbances. This study found that diastolic blood pressure and HbA1c level showed weak correlations with sleep quality. Low diastolic blood pressure and poor glycemic control demonstrated weak but statistically significant correlations with sleep quality among older adults. These findings indicate that certain physiological and metabolic factors, particularly diastolic blood pressure and HbA1c, may be associated with variations in sleep regulation among the elderly. Future research should explore targeted interventions, such as blood pressure management and metabolic regulation, that may improve sleep quality and overall health in the aging population.  
Nonpharmacological Management of Postpartum Pain After Cesarean and Vaginal Delivery: A Systematic Review Muhammad Oliver
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.376

Abstract

Postpartum pain is a common and clinically significant issue following both cesarean and vaginal deliveries, affecting maternal comfort, mobility, breastfeeding, and early mother-infant bonding. While pharmacological analgesics are effective, they carry risks such as gastrointestinal disturbances, sedation, and interference with lactation, prompting interest in nonpharmacological alternatives. This systematic review evaluated randomized controlled trials (RCTs) published between 2015 and 2025 that assessed nonpharmacological interventions for postpartum pain including acupressure, transcutaneous electrical nerve stimulation (TENS), hand and back massage, abdominal binders, cryotherapy, and photobiomodulation. Ten studies were included, comprising 7 cesarean and 3 vaginal delivery trials. Acupressure, TENS, and massage consistently reduced pain scores, enhanced functional recovery, and improved maternal comfort without significant adverse effects, whereas abdominal binder use showed limited benefit. For vaginal deliveries, cryotherapy and photobiomodulation effectively decreased perineal pain and edema. Overall, nonpharmacological interventions were safe, low-cost, and patient-centered, offering meaningful reductions in postpartum pain and improvements in functional outcomes. However, variability in intervention protocols, dosing, and outcome measures limits direct comparisons, highlighting the need for further research to establish standardized approaches and optimize clinical application. These findings support incorporating nonpharmacological strategies as adjuncts or alternatives to pharmacological pain management in postpartum care.  
Case of Omphalocele Diagnosed Prenatally: A Case Report Kaisar Pahlawan; Al Amirah Zainab; Nuswil Bernolian; Shalita Dastamuar; Nurmala Dewi Maharani; Atika Akbari
Sriwijaya Journal of Medicine Vol. 9 No. 1 (2026): Vol 9, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v9i1.380

Abstract

Omphalocele is congenital malformation resulted from abnormal closure of anterior abdominal wall. Omphalocele may exist in isolation or a part of syndromic congenital malformations. Several etiologies of omphalocele are known, including genetic, teratogenic, nutritional, or idiopathic causes. We reported a case of isolated omphalocele with no known risk factor. Female, 29 years old, G2P1A0, 21 weeks pregnant with no remarkable history referred to our institution for evaluation and management of suspected pregnancy complicated with omphalocele. Upon ultrasonographic examination, we discovered live singleton pregnancy with clear evidence of omphalocele. Patient was then planned to undergo elective cesarean section at 37th week of pregnancy. Subsequently, neonate was managed by the team of neonatologist and pediatric surgeon and the defect was repaired successfully. Prenatal diagnosis of omphalocele lead into improved outcome due to preparedness of the team, particularly in case of isolated case of omphalocele with no other congenital anomalies present.  

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