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SRIWIJAYA JOURNAL OF MEDICINE
Published by Universitas Sriwijaya
ISSN : -     EISSN : 26223589     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Sriwijaya Journal of Medicine (SJM) is a scientific journal managed by Faculty of Medicine Universitas Sriwijaya, Indonesia. It publishes original research articles and reviews in Biomedical Sciences, Medicine (Neurology, Cardiovascular, Respiratory, Gastrointestinal, Urogenital, Endocrine and Metabolism, Integument, Mental Health, Obstetry and Gynecology, Ophtalmology, ENT, Musculosceletal) and Public Health Medicine. Sriwijaya Journal of Medicine (SMJ) published three times a year (January, April, October).
Arjuna Subject : Kedokteran - Anatomi
Articles 315 Documents
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The Association Between Vitamin D Levels and Glycemic Control Parameters in Elderly Populations Gunawan, Shirly; Kosasih, Robert; Wijaya, Bryan Anna; Santoso, Alexander Halim; Firmansyah, Yohanes
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.357

Abstract

Diabetes is common in the elderly, and routine monitoring of HbA1c and blood glucose is required to prevent complications. HOMA-IR assesses insulin resistance, while vitamin D may influence glucose metabolism by enhancing insulin sensitivity. This study examines the relationship between vitamin D levels and glycemic control, including HbA1c, fasting glucose, insulin, and HOMA-IR. This cross-sectional observational study included 91 elderly residents of Panti Wreda Bina Bhakti, excluding those with acute illness or chronic conditions affecting Vitamin D and diabetes parameters. All participants provided informed consent. The study measured serum Vitamin D-25(OH) and insulin using ELISA, while fasting blood glucose and HbA1c were assessed via blood chemistry analysis. HbA1c control was categorized as good (<6.5%), moderate (6.5–8.0%), or poor (>8%). HOMA-IR was calculated using a standard formula. Pearson correlation analysis determined the relationship between Vitamin D levels and glycemic parameters, with statistical significance at p < 0.05. The correlation analysis found a significant negative relationship between vitamin D levels and HbA1c (r: -0.211; p: 0.044). However, no significant correlation was found between vitamin D and fasting blood glucose levels (r: 0.057; p: 0.590), insulin (r: -0.083; p: 0.432), and HOMA-IR (r: -0.040; p: 0.704).  Vitamin D levels show a significant negative correlation with HbA1c in the elderly, indicating its role in long-term glycemic control. Although no significant relationship was found with other glycemic parameters, these findings suggest that monitoring vitamin D status may be considered as part of a more comprehensive approach to diabetes management in the geriatric population.
Identification of Chemical Constituents in Ethanolic Extract of Hibiscus sabdariffa L. Calyces (Roselle) by FTIR and GC-MS: Preliminary Phytochemical Screening Rohani, Siti; Martha, Fadhil Rizki; Astri, Yesi; Putria, Sinta Julia Liona
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.360

Abstract

Indonesia is widely recognized for its rich biodiversity, which has long served as a valuable resource for traditional herbal medicine. In recent years, interest in plant-based therapies has grown significantly. One such plant, Hibiscus sabdariffa L., commonly known as Rosella, is valued for its therapeutic properties. These benefits arise from the combined effects of its bioactive compounds, allowing it to address a range of health issues. Research has shown that Rosella contains notable levels of flavonoids, saponins, tannins, and alkaloids—all of which contribute to its antibacterial activity. Techniques such as Fourier-transform infrared (FTIR) spectroscopy and gas chromatography–mass spectrometry (GC-MS) are employed to identify these chemical constituents. FTIR analysis has detected functional groups like amines, fatty acids, aldehydes, carboxylic acids, and aromatic rings. Additionally, GC-MS results have indicated the presence of major compounds belonging to the methyl ester group. Noteworthy identified substances include Hexadecanoic Acid Methyl Ester, Hexadecanoic Acid Ethyl Ester, and Benzenepropanoic Acid, 3,5-Bis(1,1-Dimethylethyl)-4-Hydroxy-, Methyl Ester. A review of existing prior research suggests that these compound groups exhibit significant pharmacological potential, including the usage for antioxidant, anticancer, antibacterial, antidiabetic, and anti-inflammatory effects.
Computational Insights into the Dual Inhibition of PfATP6 and PfCRT by Bioactive Compounds from Spatholobus littoralis Hassk. Wahyuningtias, Dita Sheilla Putri; Putra, Oktavian Arya; Turnip, Laurens Frestasya A.; Ananda, Putu Desy Sagita; Wibowo, Syahputra; Wisynu Kusuma Wardhani, Bantari
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.362

Abstract

The current study examined the antimalarial activity of bioactive compounds extracted from Spatholobus littoralis Hassk. (bajakah wood) by an in-silico approach targeting the Plasmodium falciparum PfCRT and PfATP6 receptors. A total of forty-six phytochemicals were subjected to screening, resulting in the selection of six compounds based on bioactivity prediction, ADMET profiling, and molecular docking analyses.  Ramachandran plots were used to check the accuracy of the model, which showed that the protein structures were reliable.  Milbemycin A4-oxime exhibited the most significant binding affinity (−9.6 kcal/mol for PfCRT and −9.9 kcal/mol for PfATP6). These findings are comparable to or slightly better than those observed for artemisinin in this in silico model. These findings are preliminary and require further experiment. The molecule exhibited persistent interactions and favorable pharmacokinetic properties, indicating its potential use as a multitarget inhibitor.  Quercetin and 8-O-methylretusin had significant efficacy.  These results underscore the potential of S. littoralis metabolites, especially Milbemycin A4-oxime, as candidates for antimalarial drug development; however, additional in vitro and in vivo validation is necessary to establish efficacy and safety.
Effect of Vitamin D Supplementation on Recurrence Risk in Graves’ Disease Measured By The GREAT Score at Dr. Mohammad Hoesin General Hospital Palembang Ali Rabbani, Muhammad Iqbal; Anggraini, Ratna Maila Dewi; Kusnadi, Yulianto; Maritska, Ziske
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.370

Abstract

Graves’ disease is the most common cause of primary hyperthyroidism with a prevalence of approximately 0.5%, predominantly affecting women (female-to- male ratio 6–7:1) aged 35–40 years. Predictors of treatment outcomes and recurrence risk have been studied, among them the GREAT Score, which combines age, goiter size, FT4, and TRAb levels. The aim of this study was to analyze changes in the GREAT Score after the addition of vitamin D supplementation in Graves' disease patients at Dr. Mohammad Hoesin General Hospital, Palembang, within 3 months. This was a double-blind randomized clinical trial involving 30 patients with Graves’ disease, both inpatients and outpatients, who met the inclusion criteria. Patients were randomly assigned into two groups: the intervention group received10,000 IU of vitamin D, while the control group received placebo. Recurrence risk was assessed using the GREAT Score at the first and third months, and data were analyzed with SPSS v.25. Analysis using the Wilcoxon test showed no significant change in the GREAT Score for the vitamin D group (p=0.102). At the first month, the distribution was 53.3% class I, 40.0% class II, and 5.7% class III, while at the third month it was 40.0% class I, 40.0% class II, and 20.0% class III. In the placebo group, results were also not significant (p=0.480), with the first-month distribution of 33.3% class I, 40.0% class II, and 26.7% class III, and the third month 40.0% class I, 33.3% class II, and 13.3% class III. In summary, Vitamin D supplementation has no significant effect in reducing the recurrence of Graves' disease compared to placebo.
Activity Assay and Determination of Active Larvicidal Compounds from Cat's Whiskers (Orthosiphon aristatus Blume miq.) Guntina, Rizka Khoirunnisa; Riyanti, Soraya; Faramayuda, Fahrauk
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.375

Abstract

The tropical climate of Indonesia presents a significant risk for the prevalence of various mosquito-borne diseases, particularly Dengue Hemorrhagic Fever (DHF), which has become a critical public health concern in recent years. The control of mosquito populations, specifically targeting larvae, is a strategic approach in managing the transmission of DHF. Traditional methods involving synthetic larvicidal agents, however, raise concerns regarding potential resistance among mosquito populations and adverse effects on human health. Consequently, there exists an urgent need for alternative solutions that are both effective and safe for human exposure. One promising avenue is the exploration of natural larvicidal agents sourced from local flora, such as the white-purple variety of cat's whiskers (Orthosiphon aristatus Blume miq.). This study investigates the larvicidal potential of this plant, focusing on its main secondary metabolites, namely flavonoids and phenolics, which are hypothesized to possess larvicidal activities. Conducted extensive larvicidal activity assaying on various extracts and fractions derived from the white-purple cat's whiskers. Notably, the ethyl acetate fraction demonstrated superior efficacy, evidenced by a calculated LC50 value of 737.71 ppm, underscoring its potential as a sustainable larvicidal agent. Subsequent analyzes of this active fraction revealed the presence of the compound sinensetin, which further validates the insecticidal application of this plant in controlling mosquito populations effectively. This research contributes to the paradigm shift toward natural alternatives in pest management, highlighting the importance of harnessing local biodiversity in the fight against vector-borne diseases.

Page 32 of 32 | Total Record : 315

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