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Oto Rhino Laryngologica Indonesiana
Published by Perhimpunan Dokter Spesialis Telinga Hidung dan Tenggorok Bedah Kepala Leher Indonesia
ISSN : 02163667     EISSN : 25983970     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Journal Othorhinolaryngologica Indonesiana is a peer-reviewed and open access journal that focuses on promoting otorhinolaryngology-head and neck surgery that publishes research reports, case reports, and literature reviews, to increase knowledge and updating diagnostics procedurs on otorhinolaryngology-head and neck surgery.
Arjuna Subject : -
Articles 493 Documents
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Perbedaan sensitivitas tetes telinga antibiotik terhadap Pseudomonas aeruginosa pada otitis media supuratif kronik Anton Budhi Darmawan; Dwi Utami Anjarwati
Oto Rhino Laryngologica Indonesiana Vol 42, No 2 (2012): Volume 42, No. 2 July - December 2012
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (411.528 KB) | DOI: 10.32637/orli.v42i2.22

Abstract

Background: Chronic suppurative otitis media (CSOM) is one infectious disease of the middle ear, most commonly caused by Pseudomonas aeruginosa. A high number of patients come to the ENT outpatient clinic with active benign type of CSOM. The bacteria Pseudomonas aeruginosa is capable of producing biofilm which protects itself from penetration of antibiotics, and therefore creates resistance towards antibiotics and difficult to eradicate. Objective: The aim of this study was to compare the sensitivity levels of chloramphenicol, polymyxin-neomycin, cyprofloxacin and ofloxacine against Pseudomonas aeruginosa in patients with active benign type CSOM in ENT clinic. Method: The method used was across sectional study on 25 patients, from August 2010 until December 2010. Samples were taken withear swab and then put on sensitivity test to chloramphenicol, polymyxin-neomycin, cyprofloxacin andofloxacine using the diffusion disc method. The analysis used in this study was Cochran test. Results: Results showed a significant difference in sensitivity among chloramphenicol (38,70%), polymyxinneomycin(83,87%),cyprofloxacin(90,32%)andofloxacin(58,06%)withp=0,000(p<0,05).PostHocanalysisusing the Mc Nemar indicated that there were significant differences in sensitivity betweenpolymyxin-neomycin to chloramphenicol with p=0,000 (p<0,05), ciprofloxacin to chloramphenicol andciprofloxacin to ofloxacine with p= 0,002, but there were no significant differences between cyprofloxacinto polymyxin-neomycin with p=0,687, polymyxin-neomycin to ofloxacin p=0.057 and ofloxacin tochloramphenicol p=0,109.   There were significant differences in antibiotic ear dropssensitivity to Pseudomonas aeruginosa in patients with active benign type of CSOM. Cyprofloxacin andpolymyxin-neomycin were more sensitive than ofloxacin and chloramphenicol. Keywords: Pseudomonas aeruginosa, active benign type of chronic suppurative otitis media, antibioticear drops.  Abstrak :  Latar belakang: Otitis media supuratif kronik (OMSK) merupakan penyakit infeksi kronik telinga tengah yang sering dijumpai di klinik THT. Penyebab tersering OMSK adalah bakteri Pseudomonasaeruginosa. Pseudomonas aeruginosa mempunyai kemampuan untuk membentuk biofilm yangmelindunginya dari penetrasi antibiotik sehingga menimbulkan resistensi terhadap antibiotik dan sulituntuk eradikasinya. Tujuan: Untuk mengetahui perbandingan tingkat sensitivitas kloramfenikol,polimiksin-neomisin, ciprofloksasin dan ofloksasin terhadap isolat Pseudomonas aeruginosa padapasien OMSK benigna aktif di klinik THT RSMS. Metode: Metode yang digunakan adalah crosssectional terhadap 29 pasien OMSK di klinik THT RSMS periode bulan Agustus 2010 - Desember2010. Pengambilan sampel dilakukan dengan swab telinga. Uji sensitivitas terhadap kloramfenikol,polimiksin-neomisin, ciprofloksasin dan ofloksasin dilakukan dengan metode cakram secara difusi.Analisis yang digunakan dalam penelitian ini adalah Cochran dan analisis post hoc. Hasil: Didapatkansensitivitas kloramfenikol sebesar 38,70%, polimiksin-neomisin sebesar 83,87%, ciprofloksasin sebesar90,32% dan ofloksasin sebesar 58,06% dengan p=0,01 (P<0,05), yang menunjukkan adanya perbedaansensitivitas yang bermakna antara kloramfenikol, polimiksin-neomisin, ciprofloksasin dan ofloksasinterhadap Pseudomonas aeruginosa. Analisis post hoc menggunakan Mc Nemar menunjukkan bahwaterdapat perbedaan sensitivitas yang bermakna antara tetes telinga polimiksin-neomisin terhadapkloramfenikol, dan ciprofloksasin terhadap kloramfenikol p=0,000 (p<0,05), serta terdapat perbedaanyang bermakna antara tetes telinga ciprofloksasin terhadap ofloksasin, p=0,002, tetapi tidak terdapatperbedaan yang bermakna antara ciprofloksasin terhadap polimiksin-neomisin, p=0,687, polimiksinneomisinterhadap ofloksasin p=0,057, dan kloramfenikol terhadap ofloksasin p=0,109. Kesimpulan:Terdapat perbedaan sensitivitas yang bermakna tetes telinga antibiotik terhadap Pseudomonas aeruginosa pada pasien OMSK benigna aktif. Ciprofloksasin dan polimiksin-neomisin tetes telinga mempunyai sensitivitas yang lebih baik dibanding ofloksasin dan kloramfenikol. Kata kunci: Pseudomonas aeruginosa, otitis media supuratif kronik, tetes telinga antibiotik 
Komplikasi intratemporal dan intrakranial pada otitis media akut anak Harim Priyono; Ratna Dwi Restuti; Andre Iswara; Setyo Handryastuti
Oto Rhino Laryngologica Indonesiana Vol 41, No 1 (2011): Volume 41, No. 1 January - June 2011
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (346.733 KB) | DOI: 10.32637/orli.v41i1.55

Abstract

Background: Acute otitis media (AOM) is an acute inflammation in the middle ear caused by various factors such as blockage of Eustachian tube, infection and allergy. Purpose: The case report is to forewarn general practitioners and ENT specialists concerning AOM potentially causes intratemporal and intracranial complications. Case: We report an eleven-years-old girl with acute otitis media with intratemporal complications (labirynthitis and sensorineural hearingloss) and intracranial complication (meningitis). Case management: The recent management of acute otitis media with complications includes  empiric antibiotics, analgesic, anti-inflammatory drugs and miringotomy with ventilation tube insertion. Conclusion: The accuracy of diagnosing AOM with complication depends on the clinical symptomps such as vertigo, fever, seizure, meningism and unconsciousness. The pneumatic otoscopy examination is the gold standard in diagnosing AOM. Our patient was given antibiotics for 14 days, anti- inflamation and myringotomy with ventilation tube insertion procedure. Keywords: acute otitis media, intracranial complications, intratemporal complications    Abstrak :  Latar belakang: Otitis media akut (OMA) merupakan peradangan akut yang berlangsung di telinga tengah akibat berbagai faktor predisposisi seperti sumbatan tuba Eustachius, infeksi dan alergi.Tujuan: Kasus ini diajukan untuk mengingatkan dokter umum maupun spesialis THT mengenali gejala komplikasi OMA pada anak yang mempunyai potensi menimbulkan komplikasi intratemporal dan intrakranial. Kasus: Dilaporkan satu kasus OMA dengan komplikasi intratemporal (labirintitis dan tuli saraf) dan intrakranial (meningitis) pada anak perempuan usia 11 tahun.Penatalaksanaan: Penatalaksanaan otitis media akut dengan komplikasi intrakranial dan intratemporal mencakup pemberian antibiotik empiris, analgetik, anti-inflamasi dan tindakan miringotomi dengan pemasangan pipa ventilasi. Kesimpulan: Ketepatan dalam mendiagnosis OMA dengan komplikasi tergantung pada gejala klinis yang bisa dikenali seperti pusing berputar, demam, kejang, kaku kuduk dan penurunan kesadaran. Pemeriksaan otoskopi pneumatik merupakan gold standard dalam membantu diagnosis. Terapi untuk kasus ini terdiri atas antibiotik selama 14 hari, anti-inflamasi dan tindakan berupa miringotomi dengan pemasangan pipa ventilasi.Kata kunci: otitis media akut, komplikasi intrakranial, komplikasi temporal
Ekspresi protein P53 dan HSP70 pada sel punca karsinoma nasofaring yang resisten terhadap radioterapi Muhtarum Yusuf; Ahmad Chusnu Romdhoni; Widodo Ario Kentjono; Fedik Abdul Rantam
Oto Rhino Laryngologica Indonesiana Vol 44, No 2 (2014): Volume 44, No. 2 July - December 2014
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1061.659 KB) | DOI: 10.32637/orli.v44i2.93

Abstract

Latar belakang: Pada penderita Karsinoma Nasofaring (KNF) masih sering ditemukan kekambuhan meskipun sudah mendapat terapi yang lengkap. Penelitian terbaru membuktikan bahwa kekambuhan disebabkan oleh sel punca KNF yang resisten terhadap radioterapi. Mekanisme resistensi sel punca kanker terhadap radioterapi diduga karena hambatan terhadap apoptosis dan atau memicu proliferasi. Hambatan terhadap apoptosis disebabkan oleh penurunan protein p53 (wild type), selain over-ekspresiHsp70. Tujuan: Menjelaskan mekanisme resistensi sel punca KNF terhadap radioterapi berdasarkan profil ekspresi protein p53(wild type)dan Hsp70. Metode: Penelitian true experimental dengan menggunakan rancangan randomisasi kelompok kontrol sebelum dan sesudah tes. Kultur sel punca KNF dibagi menjadi dua kelompok, masing-masing 16 sampel. Pada kelompok perlakuan diberikan paparan radioterapi dengan dosis 1,5 Gy menggunakan pesawat Linac, lalu diinkubasi selama 24 jam. Sebelum dan sesudah perlakuan pada kedua kelompok diperiksa ekspresi p53 (wild type) dan Hsp70. Pemeriksaan menggunakan metode flowcytometry. Hasil: Ekspresi p53 (wild type) antara kelompok perlakuan dan kontrol terdapatperbedaan yang tidak bermakna dengan p=0,576 (p≥0,05). Ekspresi Hsp70, antara kelompok perlakuan dan kontrol terdapat perbedaan yang tidak bermakna dengan p=0,172 (p≥0,05). Kesimpulan: Tidak terdapatperubahan ekspresi p53 (wild type) dan Hsp70 pada sel punca KNF yang resisten terhadap radioterapi.Kata kunci : Sel punca KNF, p53 (wild type), Hsp70, karsinoma nasofaring ABSTRACTBackground: Recurrences are frequently occurred in nasopharyngeal  carcinoma (NPC) patients, eventhough they had received complete therapy. Recent studies have proved that those recurrences were caused by NPC cancer stem cells that resistant to radiotherapy. Mechanisms of resistance of cancer stem cells to radiotherapy is assumed due to the block of apoptosis and or proliferation inducing. The block of apoptosis was caused by the decrease of p53 (wild type) expression, in addition to Hsp70 over expression. Objective: To find out the mechanism of NPC stem cells that resistant to radiotherapy based on profiles of protein p53 (wild type) and Hsp70 expression. Methods: Using true experimental study by randomizedpre and post test control group design. The cultured NPC stem cells were divided into two groups, with 16 samples each. The treatment group had 1,5Gy dose of radiotherapy exposure with Linac device, then incubated for 24 hours. Both groups were examined for p53 (wild type) and Hsp70 expressions before and after treatment. The examinations were conducted by flowcytometry method. Result: The P53 (wild type) expression between the treatment and control group showed insignificant difference with p=0.576(p≥0.05). The Hsp70 expression between treatment and control group showed insignificant difference with p=0.172 (p≥0.05). Conclusion: There were no changes of p53 (wild type) and Hsp70 expressions on NPC stem cells that resistant to radiotherapyKeywords: NPC stem cells, p53 (wild type), Hsp70, nasopharyngeal carcinoma
Hubungan ekspresi p53, Bcl-2, c-Myc dan MMP-9 dengan gambaran klinikopatologi karsinoma sel skuamosa kepala-leher Azwar Azwar; Sofia Mubarika; Agus Surono
Oto Rhino Laryngologica Indonesiana Vol 46, No 1 (2016): Volume 46, No. 1 January - June 2016
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1152.508 KB) | DOI: 10.32637/orli.v46i1.147

Abstract

Latar belakang: Karsinoma sel skuamosa kepala dan leher merupakan salah satu kanker terseringdi seluruh dunia. Pendekatan pengobatan agresif dan multidisiplin telah dilakukan, namun belum adapeningkatan yang signifikan dalam kelangsungan hidup 5 tahun, selama 20 tahun terakhir. Kegagalanpengobatan terjadi dalam bentuk kekambuhan lokoregional, metastasis jauh, dan/atau tumor primer kedua.Berbagai penanda molekular tumor telah diteliti untuk mengetahui potensinya dalam memprediksi hasilpenyakit atau respon terhadap terapi.Tujuan: Mengetahui hubungan ekspresi protein p53, Bcl-2, c-Myc,dan MMP-9 berdasarkan gambaran klinikopatologis karsinoma sel skuamosa kepala dan leher di RumahSakit dr. Zainoel Abidin.Metode: Studi menggunakan desain cross sectional. Sampel terdiri dari 60blok parafin karsinoma sel skuamosa kepala dan leher. Prosedur pewarnaan imunohistokimia dilakukandengan menggunakan antibodi monoklonal terhadap p53, Bcl-2, c-Myc, dan MMP-9. Ekspresi proteinp53, Bcl-2, c-Myc, dan MMP-9 dianalisis secara imunohistokimia pada karsinoma sel skuamosa kepaladan leher kemudian hasilnya dihubungkan dengan parameter klinikopatologis seperti usia, jenis kelamin,lokasi tumor, diferensiasi tumor, metastasis kelenjar getah bening dan stadium tumor, kemudian dianalisisstatistik dengan Chi square.Hasil: Hasil penelitian menunjukkan terdapat hubungan bermakna tingkatekspresi p53 dengan metastasis lokal (p=0,021) dan ada hubungan bermakna tingkat ekspresi MMP-9dengan lokasi tumor (p=0,026). Tidak terdapat hubungan ekspresi p53, Bcl-2, cMyc, dan MMP-9 terhadapusia, jenis kelamin, stadium tumor, diferensiasi histologi, tingkat T, N, dan metastasis jauh.Kesimpulan:Ada hubungan ekpresi p53 dengan metastasis kelenjar limfe regional dan ekspresi MMP-9 dengan lokasitumor pada karsinoma sel skuamosa kepala dan leher. Kata kunci: Karsinoma sel skuamosa kepala dan leher, p53, Bcl-2, c-Myc, MMP-9 ABSTRACTBackground: Head and neck squamous cell carcinoma (HNSCC) is one of the most commoncancers world wide. Although aggressive and multidisciplinary approach to the treatment has been done,there is no significant improvement in 5-year survival in the last 20 years. Treatment failure occurredin the form of locoregional recurrence, distant metastasis, and/or a second primary tumor. A variety oftumor molecular markers have been studied to determine their potential in predicting disease outcome orresponse to the therapy. Purpose: To investigate correlation p53, Bcl-2, c-Myc, and MMP-9 expressionto clinicopathologic parameter in head and neck squamous cell carcinoma patient in dr. Zainoel Abidinhospital. Methods: Cross sectional design study. The sample was consisted of 60 paraffin blocks ofhead and neck squamous cell carcinoma. Procedure of immunohistochemical staining used monoclonalantibodies against p53, Bcl-2, c-Myc, and MMP-9. Expression of p53 protein, Bcl-2, c-Myc, and MMP-9were analyzed by immunohistochemistry in head and neck squamous cell carcinoma. Then, the results were linked to clinicopathologic parameters such as age, sex, tumor location, tumor differentiation,lymph node metastasis and tumor stage, and statistically analyzed with Chi square. Results: The resultsshowed there were significant correlation between p53 expression level with local metastasis (p=0,021)and significant correlation of MMP-9 expression levels with tumor location (p=0,026). There were norelationship of p53, Bcl-2, cMyc and MMP-9 expressions based on age, sex, stage tumor, histologicdifferentiation, level of T, N, and distant metastases. Conclusion: There were relationships between p53expression with local metastasis and MMP-9 expression with tumor location in head and neck squamouscell carcinoma. Keywords: Head and neck squamous cell carcinoma, p53, Bcl-2, c-Myc, MMP-9
Efektivitas salin hipertonik terhadap waktu transpor mukosiliar dan skor gejala hidung penderita rinitis alergi Woro Safitri; Dwi Reno Pawarti; Titiek Hidayati Ahadiah
Oto Rhino Laryngologica Indonesiana Vol 47, No 2 (2017): Volume 47, No. 2 July - December 2017
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (348.828 KB) | DOI: 10.32637/orli.v47i2.221

Abstract

Latar belakang: Rinitis alergi (RA) adalah suatu penyakit inflamasi mukosa hidung yang diperantara oleh imunoglobulin E (IgE), setelah mukosa hidung terpapar alergen. Tujuan: Mengidentifikasi efektivitas cuci hidung salin hipertonik terhadap waktu transpor mukosiliar dan skor gejala hidung total (SGHT) pada penderita RA. Metode: Penelitian dilaksanakan pada bulan Juli hingga Desember 2016 di Poli Telinga Hidung Tenggorok – Bedah Kepala Leher Rumah Sakit Dr. Soetomo Surabaya. Uji klinis acak terkontrol pada 2 kelompok dengan desain control group in clinical trial. Pengambilan sampel dilakukan secara consecutive sampling. Uji korelasi yang digunakan adalah uji t berpasangan dan uji Wilcoxon. Hasil: Didapatkan sampel 42 penderita, yaitu 21 penderita pada kelompok loratadin, serta 21 penderita pada kelompok loratadin dan cuci hidung salin hipertonik. Didapatkan rerata penurunan transpor mukosiliar kelompok loratadin dan cuci hidung salin hipertonik lebih bermakna daripada kelompok loratadin (p=0,001). Penurunan transpor mukosiliar kelompok loratadin didapatkan rerata -2,30 (SD=2,77), kelompok loratadin dan cuci hidung salin hipertonik didapatkan rerata -6,27 (SD=3,91). Penurunan SGHT kelompok loratadin didapatkan rerata -2,48 (SD=1,72), sedangkan kelompok loratadin dan cuci hidung salin hipertonik didapatkan rerata -4,3 (SD=1,20). Kesimpulan: Penambahan cuci hidung salin hipertonik pada terapi loratadin lebih efektif dibandingkan terapi tunggal loratadin dalam menurunkan transpor mukosiliar dan SGHT pada penderita RA. Kata kunci: Loratadin, cuci hidung salin hipertonik, transpor mukosiliar, skor gejala hidung total, rinitis alergi ABSTRACT Background: Allergic rhinitis (AR) is a nasal mucous membrane inflamatory which mediated by Imunoglobulin E (IgE) after allergen exposure in nasal mucosa. Purpose: To identify the effectiveness of nasal hypertonic saline irrigation on reduction of mucociliary transport time (MCTT) and total nasal symptom score (TNSS) in AR patients. Methods: The was conducted from July until December 2016 in Oto Rhino Laryngology - Head and Neck Surgery of Dr. Soetomo Hospital Surabaya. The study was randomized controlled clinical trials on two groups, with the control group in clinical trial design. Paired t and Wilcoxon test was used as the correlation test. Results: There was 42 patients, 21 patients in loratadine group, and 21 patients in loratadine with hypertonic nasal saline group. The average of mucociliary transport time decrease of loratadine with hypertonic nasal saline group was more significant than loratadine group (p=0.001). The mean of decreasing mucociliary transport time in loratadine group was -2.30 (SD=2.77) and loratadine with hypertonic nasal saline group was -6.27 (SD=3.91). The mean of decreasing TNSS in loratadin group was -2.48 (SD=1.72), and loratadin with hypertonic nasal saline group was -4.3 (SD=1.20). Conclusions: The addition of hypertonic nasal saline in loratadine was more effective, compared to monotherapy of loratadine in decreasing mucociliary transport time and TNSS in patient with AR. Keywords: Loratadine, hypertonic nasal saline, mucociliary transport, total nasal symptom score, allergic rhinitis
Hubungan Antara Kadar DNA Plasma Virus Epstein Barr Dengan Stadium Klinis Karsinoma Nasofaring WHO Tipe 3 Putranti Dyahayu Roziaty; Soehartono soehartono; Hendradi Surjotomo
Oto Rhino Laryngologica Indonesiana Vol 48, No 2 (2018): Volume 48, No. 2 July - December 2018
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (337.616 KB) | DOI: 10.32637/orli.v48i2.277

Abstract

Latar Belakang: Karsinoma nasofaring (KNF) merupakan keganasan yang tersering ditemukan, dan berdampak pada penurunan kualitas hidup serta memiliki mortalitas tinggi. Penanganan KNF selama ini terkendala oleh waktu tunggu yang cukup lama dalam menentukan staging KNF terutama untuk antrian pemeriksaan computed tomography scan (CT scan) dan Ultrasonography (USG). Pemeriksaan kadar DNA EBV (Deoxyribonucleic acid Epstein-Barr Virus) pada pasien yang relatif lebih mudah dan terjangkau dapat digunakan untuk memprediksi stadium dan prognosis KNF. Dengan mengetahui prognosis KNF lebih dini, maka diharapkan penanganan terhadap KNF dapat segera dilakukan. Tujuan: Mengetahui apakah kadar DNA EBV dapat dipakai untuk memprediksi stadium dan prognosis KNF dengan cara mencari hubungan antara kadar DNA EBV dengan stadium KNF. Metode: Penelitian cross sectional melibatkan 15 subjek penelitian yang terdiagnosis KNF WHO tipe 3 kemudian dilakukan staging dengan CT scan, USG abdomen, dan foto toraks, serta diambil sampel darah untuk diukur kadar DNA EBV. Hasil: Seluruh subjek penelitian mengalami peningkatan kadar DNA EBV sesuai dengan peningkatan stadium KNF. Peningkatan stadium KNF berhubungan signifikan dengan peningkatan kadar DNA EBV (p=0,001). Ukuran tumor (T) berhubungan signifikan dengan kadar DNA EBV (p=0,023), ukuran nodul (N) berhubungan signifikan dengan kadar DNA EBV (p=0,005), ada tidaknya metastasis tidak berhubungan signifikan dengan kadar DNA EBV (p=0,398). Nilai cut off kadar DNA EBV sebesar 952 kopi/ml. Kesimpulan: Terdapat hubungan yang signifikan antara kadar DNA EBV dengan stadium klinis, dengan demikian kadar DNA EBV dapat dipertimbangkan untuk digunakan sebagai prediktor stadium dan prognosis KNF. Background: Nasopharyngeal carcinoma (NPC) is the predominant tumor type arising in the nasopharynx,  with a high mortality and affecting quality of life.  NPC treatment  management is hindered by long queues of Computed Tomography Scan (CT scan) and Ultrasonography (USG) examinations to ascertain the NPC staging. The examination of Epstein-Barr Virus (EBV) DNA level is relatively simpler and inexpensive  to predict the NPC staging and prognosis, thus, it can speed up NPC treatment. Objective: To determine whether EBV DNA level can be used to predict the NPC  stage and prognosis by finding a correlation between EBV DNA level and NPC stage. Method: This was  a cross-sectional study involving 15 respondents who were diagnosed as WHO type 3 NPC, and examined by CT scan, abdominal ultrasound, chest X-ray,  and blood  test for measuring the levels of EBV DNA to determine the stage. Results: All respondents had elevated levels of EBV DNA in accordance with NPC stage elevation. Increased NPC stages were significantly correlated with elevated levels of EBV DNA (p=0.001). The size of tumor (T) was significantly correlated with EBV DNA (p=0.023), the size of nodule (N) was significantly correlated with EBV DNA (p=0.005).  The presence or absence of metastasis did not significantly correlate with EBV DNA (p=0.398). The EBV DNA cut off value was 952 copies/ml. Conclusions: There  was a significant correlation between EBV DNA levels and clinical stages, hence EBV DNA can be considered to be used as NPC staging and prognosis predictor.   
Pengaruh bising lalu lintas terhadap penurunan fungsi pendengaran pada juru parkir di kota Denpasar Ni Ketut Susilawati; Wayan Sudana; Eka Putra Setiawan
Oto Rhino Laryngologica Indonesiana Vol 40, No 2 (2010): Volume 40, No. 2 July - December 2010
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v40i2.3

Abstract

Background: Noise pollution or noise is an unwanted sound which is disturbing to human beings.However small or soft the sound, if it is undesirable it is considered as noise. Noise induced hearingloss is a sensorineural hearing loss that is commonly encountered second to presbycusis. Purpose: Toknow the effect of traffic noise exposure on hearing impairment to the employees of the Parking DistrictCompany of the Denpasar city and to improve diagnostic detection on hearing impairment caused bynoise. Method: A cross sectional study was conducted at the Parking District Company office. Thepopulations of this study were the employees of the Parking District Company. Samples of this study were the employees who were exposed to traffic noise and control samples were an employee who was unexposed. Samples were selected by simple random sampling. Results: From 40 parking attendants,27 persons (67.5%) aged above 35 years old. The parking attendants who had been working for ten to fifteen years were 36 persons (90%) and no history using ear protection when working. Seven persons(17.5%) had referred DPOAE upon examination with increase hearing threshold on audiogram result.In this study the parking attendants who had hearing deficit induced by noise were 7 persons (17.5%)and only one person (2.5%) in control group. There was a statistically significant effect of traffic noiseto hearing function deficit (p<0.05). Conclusion: Traffic noise has effect in hearing function deficit onthe parking attendants.ORLI Vol. 40 No. 2 Tahun 2010Key words: NIHL, parking attendant, audiometry, DPOAE.
Tumor Dabska sinonasal Suriya Suwanto; Gde Ardika Nuaba; Wayan Sucipta
Oto Rhino Laryngologica Indonesiana Vol 43, No 2 (2013): Volume 43, No. 2 July - December 2013
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.116 KB) | DOI: 10.32637/orli.v43i2.72

Abstract

Latar belakang: Tumor Dabska adalah salah satu jenis tumor pembuluh darah dengan keganasan intermediate dan dikenal sebagai angiosarkoma derajat rendah. Tumor ini merupakan neoplasma yang sangat jarang dan hanya 31 kasus dilaporkan di seluruh dunia.Tujuan: Memperkenalkan tumor Dabska berikut tatalaksana dalam bidang THT-KL. Kasus: Satu kasus tumor Dabska sinonasal pada seorang wanita berusia 35 tahun. Penatalaksanaan: Penatalaksanaan sesuai literatur adalah eksisi luas dan radioterapi. Pada pasien ini, eksisi luas tidak dapat dilaksanakan karena besarnya ukuran massa tumor sehingga radioterapi dipilih sebagai modalitas terapi. Pasien meninggal dunia pascaradioterapi.Kesimpulan: Tumor Dabska adalah tumor pembuluh darah yang jarang ditemukan. Penatalaksanaan adalah dengan eksisi luas dan radioterapi. Kata kunci: Tumor Dabska, endovascular papillary hemangioendothelioma, tumor vaskular.
Abses subgaleal sebagai komplikasi otitis media supuratif kronis Riska Adriana; Sally Mahdiani; Bogi Soeseno; Arif Dermawan
Oto Rhino Laryngologica Indonesiana Vol 45, No 1 (2015): Volume 45, No. 1 January - June 2015
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1545.434 KB) | DOI: 10.32637/orli.v45i1.107

Abstract

Latar belakang: Abses subgaleal merupakan salah satu komplikasi yang jarang dari otitis media supuratif kronis. Abses subgaleal ditemukan sekitar 32,4%, namun baru satu kasus mastoiditis dengankomplikasi abses subgaleal pada pasien dewasa yang pernah dilaporkan. Tujuan: Laporan kasus inidimaksudkan untuk mempresentasikan gambaran klinis dan diagnosis, serta penatalaksanaan dari otitismedia supuratif kronis dengan komplikasi abses subgaleal. Kasus: Satu kasus otitis media supuratifkronis dengan komplikasi mastoiditis dan terjadi perluasan infeksi ke ruang subgaleal pada seorang wanitaberumur 21 tahun, gravida 35 minggu. Penatalaksanaan: Dilakukan insisi drainase di temporoparietal,kemudian dilakukan mastoidektomi setelah tindakan terminasi kehamilan. Kesimpulan: Abses subgalealadalah salah satu komplikasi yang jarang terjadi akibat dari otitis media supuratif kronis. Diagnosis secaradini dan penatalaksanan yang tepat akan menentukan tingginya keberhasilan. Kata kunci: Otitis Media Supuratif Kronis, abses subgaleal, gravidaABSTRACT Background: Subgaleal abscess is a rare complication of chronic suppurative otitis media. Subgaleal abscess was found about 32,4%, but only one case of subgaleal abscess as a complication of mastoiditisin adult had been reported. Purpose: To present the clinical and diagnostic findings along with themanagement of subgaleal abscess with mastoidectomy. Case: A case of chronic suppurative otitis mediawith mastoiditis complication and extension into subgaleal space that was found in a 21 years old, 35weeks gravid woman. Management: Drainage incision at temporofacial region and later, mastoidectomyafter childbirth. Conclusion: Subgaleal abscess is one of the rare complications of chronic suppurativeotitis media. Early diagnosis and appropriate treatment will improve the outcome. Keywords: Chronic suppurative otitis media, subgaleal abscess, gravida
Gambaran disfagia pada anak dan karakteristiknya Indah Trisnawaty; Elvie Zulka; Susyana Tamin
Oto Rhino Laryngologica Indonesiana Vol 46, No 2 (2016): Volume 46, No. 2 July - December 2016
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (532.57 KB) | DOI: 10.32637/orli.v46i2.164

Abstract

Latar belakang: Disfagia pada anak merupakan kelainan yang sering ditemukan. Beberapa kelompok bayi dan anak dengan kelainan perkembangan dan/atau kondisi medis tertentu berisiko mengalami disfagia. Kondisi patologis yang melibatkan lokasi anatomi yang berperan dalam proses menelan, dapat berdampak negatif terhadap koordinasi fase-fase menelan. Hal ini dapat menimbulkan gejala disfagia ataupun kesulitan makan (feeding difficulties) yang akan berdampak buruk apabila tidak ditangani secara optimal. Tujuan: Mendapatkan gambaran tentang disfagia pada anak di Departemen Ilmu Penyakit Telinga Hidung Tenggorok - Bedah Kepala Leher Fakultas Kedokteran Universitas Indonesia, Rumah Sakit dr. Cipto Mangunkusumo. Metode: Studi deskriptif dengan desain potong lintang berdasarkan hasil pemeriksaan Flexible Endoscopic Evaluation of Swallowing (FEES) pada 19 pasien anak dengan disfagia. Data diambil dari status rekam medik pasien. Hasil: Didapatkan 7 feeding difficulties, 4 disfagia mekanik, 5 disfagia neurogenik, 1 disfagia campuran (disfagia mekanik dan neurogenik), 1 fungsi menelan normal sesuai usia, dan 1 disfagia neurogenik yang masih didiagnosis banding dengan disfagia mekanik fase esofageal dan feeding difficulties. Penyakit penyerta yang terbanyak adalah cerebral palsy, global delay development, hipertrofi tonsil dan adenoid, serta ensefalopati. Kesimpulan: Disfagia neurogenik pada anak paling banyak disebabkan oleh kelainan neurologik seperti cerebral palsy. Disfagia mekanik pada anak dapat disebabkan oleh hipertrofi tonsil dan adenoid.Kata kunci: Anak, disfagia, feeding difficulties, flexible endoscopic evaluation of swallowingABSTRACT Background: Dysphagia in the pediatric population are becoming more common. Certain groups of infants and children with specific developmental and/or medical conditions have been identified as being at high risk for developing dysphagia. If it does not managed properly, pathologic conditions involving any of the anatomic sites associated with the phases of swallowing can have negative impact on the coordination of these phases and lead to symptoms of dysphagia and feeding difficulties. Purpose: To obtain data in pediatric dysphagia in Otohinolaryngology-head and neck surgery, Medicine Faculty of Universitas Indonesia, dr. Cipto Mangunkusumo Hospital. Methods: A cross sectional and descriptive study of Flexible Endoscopic Evaluation of Swallowing (FEES) results in 19 pediatric patients with dysphagia. Data were collected from medical records. Results: Seven feeding difficulties, 4 mechanic dysphagia, 5 neurogenic dysphagia, 1 mixed (mechanic and neurogenic), 1 normal swallowing function and neurogenic dysphagia with the possibility of esophagea dysphagia. The comorbids were cerebral palsy, global delay development, adenoid-tonsil hypertrophy and ensephalopaty. Conclusion: The most common etiology of neurogenic dysphagia was cerebral palsy. Adenoid and tonsil hypertrophy were the common cause of mechanic dysphagia.Keywords: Children, dysphagia, feeding difficulties, flexible endoscopic evaluation of swallowing

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